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Original Article

Artificial Cells in Immobilization Biotechnology

Pages 1121-1143 | Published online: 11 Jul 2009

References

  • Sundarum P V, Pye E K, Chang T MS, Edwards V H, Humphrey A E, Kaplan N O, Katchalski E, Levin Y, Lilly M D, Manecke G, Mosbach K, Patchornik A, Porath J, Weetall H H, Wingard LB, Jr. Recommendations for standardization of nomenclature in enzyme technology. Biotechnol. & Bioeng. 1972; 14: 15–18, Symp. vol. 3:15-18.
  • Chang T MS. Hemoglobin corpasulea. Research Report for Honours Physiology, Medical Library. McGill University. 1957
  • Chang T MS. Semipermeable microcapsules. Science 1964; 146: 524–525
  • Chang T MS. Semipermeable aqueous microcapsules (“artificial cells”): with emphasis on experiments in an extracorporeal shunt system. Trans Am Soc Artif Intern Organs 1966; 12: 13–19
  • Chang T MS. Semipermeable aqueous microcapsules. McGill University. 1965, Ph. D. Thesia
  • Chang T MS, Macintosh F C, Mason SG. Semipermeable aqueous microcapsules: I. Preparation and properties. Can. J. Physiol. Pharmacol. 1966; 44: 115–128
  • Chang T MS, Macintosh F C, Mason SG. Encapsulated hydrophilic compositions and methods of making them. Canadian Patent 1971; 873: 815
  • Chang T MS. Artificial Cells. C.C. Thomas Publisher, Springfield 1972
  • Chang T MS. Biotechnological and medical applications based on immobilization of hepatocytes, microorganisms or enzyme systems by microencapsulation in artificial cells. Enzyme Engineering 1990; 10(613)109–115, in Annals, New York Academy of Sciences.
  • Chang T MS. Artificial Cells. Encyclopedia of Human Biology, R. Dulbecco. Academic Press, San Diego 1991; 1: 377–83
  • Chang T MS. Recent advances in artificial cells with emphasis on biotechnological and medical approaches based on microencapsulation. Chapter in Microcapsules and Nanoparticles in Medicine and Pharmacology, M Donbrow. CRC Press, USA 1992; 323–339
  • Chang T MS. Biotechnology of artificial cells including application to artificial organs. Comprehensive Biotechnology: The Principles, applications and Regulations of Biotechnology in Industry Agriculture and Medicine, M Moo-Young. Pergamon Press, New York 1985; 53–72
  • Chang T MS. Removal of endogenous and exogenous toxins by a microencapsulated absorbent. Can. J. Physiol. Pharmacol. 1969; 47(12)1043–5
  • Chang T MS. Nonthrombogenic microcapsules. U.S. Patent 1970; 3: 346, 522
  • Chang T MS. Nonthrombogenic microcapsules. Canadian Patent 1971; 876: 100
  • Chang T MS. Blood compatible microcapsules containing detoxicants. U.S. Patent 1973; 3: 113, 725
  • Chang T MS. Blood compatible microcapsules containing detoxicants. Canadian Patent 1976; 982: 941
  • Chang T MS. Microencapsulated adsorbent hemoperfusion for uremia, intoxication and hepatic failure. Kidney Int. 1975; 7: S387–S392
  • May S W, Li NN. The circulation of urease using liquid-surfactant membranes. Biochem. Bioph. Res. Comm. 1972; 47: 1179
  • Gregoriadis F. Liposomes as drug carriers: Recent trends and progress. John Wiley & Sons, New York 1989
  • Chang T MS. Biodegradable semipermeable microcapsules containing enzymes, hormones, vaccines, and other biologicals. J Bioengineering 1976; 1: 25–32
  • Jalil R, Nixon JR. Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microspheres. J. Microencaps. 1990; 7: 297
  • Mathiowitz E, Langer R. Polyanhydride microspheres as drug delivery systems from Microcapsules and Nanoparticles in Medicine and Pharmacology, M Donbrow. CRC Press, Boca Raton, USA 1992; 99–123
  • Chang T MS, Coffey J F, Lister C, Taroy E, Stark A. Methaqualone, methyprylon, and glutethimdie clearance by the ACAC microcapsule artificial kidney: in vitro and in patients with acute intoxication. Trans Am Soc Artif Intern Organs 1973; 19: 87–91
  • Chang T MS, Coffey J F, Barre P, Gonda A, Dirks J H, Levy M, Lister C. Microcapsule artificial kidney: treatment of patients with acute drug intoxication. Can. Med. Assoc. J. 1973; 108: 429–433
  • Chang T MS, Espinosa-Melendez E, Francoeur T E, Eade NR. Albumin-collodion activated coated charcoal hemoperfusion in the treatment of severe theophylline intoxication in a 3-year-old patient. Pediatrics 1980; 65(4)811–814
  • Winchester JF. Hemoperfusion. Replacement of Renal Function by Dialysis, J F Maher. Kluwer Academic Publisher, Boston 1988; 439–59
  • Chang T MS, Gonda A, Dirks J H, Malave N. Clinical evaluation of chronic, intermittent, and short-term hemoperfusions in patients with chronic renal failure using semipermeable microcapsules (artifical cells) formed from membrane-coated activated charcoal. Trans. Am. Soc. Artif. Intern. Organs 1971; 17: 246–252
  • Chang T MS, Gonda A, Dirks J H, Coffey J F, Lee-Burns T. ACAC microcapsule artificial kidney for the long term and short term management of eleven patients with chronic renal failure. Trans. Am. Soc. Artif. Intern. Organs 1972; 18: 465–472
  • Chang T MS, Chirito E, Barre P, Cole C, Hewish M. Clinical peformance characteristics of a new combined system for simultaneous hemoperfusion-hemodialsys-ultrafiltration in series. Trans. Am. Soc. Artif. Intern. Organs 1975; 21: 502–508
  • Chang T MS. Hemoperfusion alone and in series with ultrafiltration or dialysis for uremia, poisoning and liver failure. Kidney Int 1976; S305–S311
  • Chang T MS, Chirito E, Barre P, Cole C, Lister C, Resurreccion E. Clinical evaluation of the clearance profiles of a portable, compact, dialysate-free system incorporating microenapsulated charcoal hemoperfusion for blood purification with ultrafiltration for fluid removal. J. Dialysis 1977; 1(3)239–259
  • Chang T MS, Chirito E, Barre P, Cole C, Lister C, Resurreccion E. Long-term clinical assessment of combined ACAC hemoperfusion-ultrafiltration in uremia. Artif. Organs 1979; 3(2)127–131
  • Chang T MS, Barre P, Kuruvilla S, Messier D, Man N, Resurreccion E. Phase one clinical trial of a new composite artificial kidney: A single unit combining dialysis with hemoperfusion. Trans. Am. Soc. Artif. Intern. Organs 1982; 28: 43–48
  • Chang T MS, Barre P, Kuruvilla S. Long-term reduced time hemoperfusion-hemodialysis compared to standard dialysis: A preliminary crossover analysis. Trans. Am. Soc. Artif. Intern. Organs 1985; 31: 572–576
  • Bonomini V, Stefoni S, Feliciangeli G, Coli L, Scolari M P, Orai C, Nanni Costa A, Prandmi R, Galanti S. Shortened treatment time by combined hemodialysis and hemoperfusion. Contr. Nephrol. 1985; 44: 57
  • Bonomini V, Sefton S, Casciani C U, Taccone Gallucci M, Albertazzi A, Cappelli P, Mioli V, Mastrangelo F, Rizzelli S. Multicentre experience with hemodiaiysis/hemoperfusion in chronic renal failure. Contr. Nephrol. 1982; 29: 133–142
  • Agishi T, Yamashita N, Ota K. Clinical results of direct charcoal hemoperfusion for endogenous and oxogenous intoxication. Hemoperfusion: Kidney and Liver Support and Detoxification, Part I, S Sideman, T MS Chang. Hemisphere, Washington, DC 1980; 255–263
  • Odaka M, Tabata Y, Kobayashi H, Nomura Y, Soma M, Hirasawa H, Sato H, Suenga E, Nabeta K. Three hour maintenance hemodialysis combining direct hemoperfusion and hemodialysis. Proc. Eur. Dial. Transplant. Assoc. 1976; 13: 257
  • Ota K, Ohta T, Kobayashi M, Yoshida S, Kaneko I, Agishi T, Sugihara M. Petroleum based activated charcoal for direct hemoperfusion. Proc. Eur. Dial. Transplant. Assoc. 1976; 13: 250
  • Hemoperfusion Contribution to Nephology, V Bonomini, T MS Chang. Karger, London 1982; 148
  • Hemoperfusion: I. Artificial Kidney and Liver Support and Detoxification, S Sideman, T MS Chang. Hemisphere Publishing Corp., Washington, DC 1980; 473
  • Hemoperfusion and Artificial Organs Artificial Organs Society, E Piskin, T MS Chang, 1982; 187
  • Hemoperfusion and Artificial Organs, T MS Chang, B L Ho. China Academic Publishers, Beijing, China 1985; 464
  • Hemoperfusion Symposium volume Int. J. Artificial Organs, T MS Chang, A Trevino-Becerra, 1986; 9: 279–368
  • Hemoperfusion, Sorbent and Immobilized Bioreactants. Special Symposium volume, Int. J. Biomaterials, Artificial Cells and Artificial Organs, T MS Chang, N Nicolaev. 1987; 15: 1–321
  • Hemoperfusion, Sorbent and Immobilized Bioreactants. Special symposium volume, Biomaterials, Artificial Cells and Immobilization Biotechnology, H Klinkmann, D Falkenhagen, T MS Chang. 1990; 18: 455–568
  • Hemoperfusion, Sorbent and Immobilized Bioreactants. Special Symposium volume, Biomaterials, Artificial Cells and Immobilization Biotechnology, an international journal, T MS Chang, M Odaka. 1991; 19: 1–298
  • Hemoperfusion, Sorbent and Immobilized Bioreactants. Special Symposium volumes, Biomaterials, Artificial Cells and Immobilization Biotechnology, Part 1, 1992, this issue; Part 2, C Casciani, G Splendiani, T MS Chang. 1993
  • Chang T MS. Hemoperfusion over microencapsulated adsorbent in a patient with hepatic coma. Lancet 1972; ii: 1371–2
  • Chang T MS, Migchelsen M. Characterization of possible “toxic” metabolites in uremia and hepatic coma based on the clearance spectrum for larger molecules by the ACAC microcapsule artificial kidney. Trans. Am. Soc. Artif. Intern. Organs 1973; 19: 314–319
  • Gazzard B G, Portmann B A, Weston M J, Langley P G, Murray-Lyon I M, Dunlop E H, Flax H, Mellon P J, Record C O, Ward M B, Williams R. Charcoal hemoperfusion in the treatment of fulminant hepatic failure. Lancet 1974; 1: 1301
  • Hughes R, Williams R. Clinical experience with charcoal and resin hemoperfusion. Semin. Liver Dis. 1986; 6: 164
  • Chang T MS, Lister C, Chirito E, O'Keefe P, Resurreccion E. Effects of hemoperfusion rate and time of initiation of ACAC charcoal hemoperfusion on the survival of fulminant hepatic failure rats. Trans Am Soc Artif Inter Organs 1978; 24: 243–5
  • Tabata Y, Chang T MS. Comparisons of six artificial liver support regimes in fulminant hepatic coma rats. Trans. Am. Soc. Artif. Intern. Organs 1980; 26: 394–399
  • Chang T MS, Barre P. Effect of desferrioxamine on removal of aluminium and iron by coated charcoal hemoperfusion and hemodialysis. Lancet Nov, 1983; 1051–3
  • Chang T MS, Barre P, Lister C, Kuruvilla S. Artificial cells in medical applications with emphasis on hemoperfusion for aluminium removal and crossover control clinical trial on hemoperfusion-hemodialysis. Contributions to Nephrology 1989; 70: 237–249
  • Hakim R M, Schulman J M, Lazarus JM. Hemoperfusion in the treatment of aluminum (Al) and iron (Fe) induced bone disease. Abstracts Am. Soc. Nephrol. 1985; 18: 65A
  • Chang T MS. Blood compatible coating of synthetic immunoadsorbents. Trans Am Soc Artif Intern Organs 1980; 26: 546–9
  • Lim F, Sun AM. Microencapsulated islets as bioartificial endocrine pancreas. Science 1980; 210: 908–909
  • Goosen M FA, O'Shea G M, Gharapetian H M, Chou S, Sun AM. Optimization of microencapsulation parameters: Semipermeable microcapsules as a bioartificial pancreas. Biotechnol. Bioeng. 1985; 27: 146–50
  • Soon-Shiong P, Otterlie M, Skjak-Braek G, Smidsrod O, Heintz R, Lanza R P, Espevik T. An immunologic basia for the fibrotic reaction to implanted microcapsules. Transpl. P. 1991; 23: 758–59
  • Wong H, Chang T MS. Bioartificial liver: implanted artificial cells microencapsulated living hepatocytes increases survival of liver failure rats. Int. J. Artif Organs 1986; 9: 335–6
  • Wong H, Chang T MS. The viability and regeneration of artificial cell microencapsulated rat hepatocyte xenograft transplants in mice. J Biomat Artif Cells and Artif Organs 1988; 16: 731–40
  • Kaahani S, Chang T MS. Physical chemical characteristics of hepatic stimulatory factor prepared from cell free supernatant of hepatocyte cultures. J. Biomaterials, Artificial Cells and Immobilization Biotechnology 1991; 19: 565–578
  • Kashani S, Chang T MS. Effects of hepatic stimulatory factor released from free or microencapsulated hepatocyteaon galactosamine induced fulminant hepatic failure animal model. J. Biomaterials, Artificial Cells and Immobilization Biotechnology 1991; 19: 579–598
  • Bruni S, Chang T MS. Hepatocytes immobilized by microencapsulation in artificial cells: Effects on hyperbilirubinemia in Gunn Rats. J Biomat Artif Cells and Artif Organs 1989; 17: 403–12
  • Bruni S, Chang T MS. Encapsulated hepatocytes for controlling hyperbilirubinemia in Gunn Rats. Int. J. Artificial Organs 1991; 14: 239–241
  • Dixit V, Darvasi R, Arthur M, Brezina M, Lewin K, Gitnick G. Restoration of liver function in Gunn rats without immunosuppression using transplanted microencapsulated hepatocytes. Hepatol. 1990; 12: 1342–49
  • Wong H, Chang T MS. A novel two step procedure for immobilizing living cells in microcapsules for improving xenograft survival. Biomaterials, Artificial Cells and Immobilizing Biotechnology 1991; 19: 687–698
  • Chang T MS, Wong H. A novel method for cell encapsulation. Patent U.S.A. granted. 1991
  • Wong H, Chang T MS. Microencapsulation of cells within alginate poly-L-lysine microcapsules prepared with standard single step drop technique: Histologically identified membrane imperfections and the associated graft rejection. J. Biomaterials. Artificial Cells and Immobilization Biotechnology 1991; 675–686
  • Garofalo F, Chang T MS. Immobilization of P. pictorum in open pore agar, alginate polylysine-alginate microcapsules for serum cholesterol depletion. J Biomat Artif Cells and Artif Organs 1989; 17: 271–90
  • Garofalo F, Chang TMS. Effects of mass transfer and reaction kinetics on serum cholesterol depletion rates of free and immobilised Pseudomonas pictorum. Applied Biochemistry and Biotechnology 1991; 27: 75–91
  • Goosen M FA, King G A, McKnight C A, Marcotte N. Animal cell culture engineering using alginate polycation microcpasules of controlled membrane molecular weight cut-off. Journal of Membrane Science 1989; 40: 233–243
  • Kjellstrand C, Borges H, Pru C, Guduer D, Fink D. On the clinical use of microencapsulated zirconium phosphate urease for treatment of chronic renal failure. Trans. Am. Soc. Artif. Intern. Organs 1981; 27: 24–30
  • Wolfe E A, Chang T MS. Orally ingested microencapsulated urease and an adsorbent, zirconium phosphate, to remove urea in kidney failure. Int. J. Artif. Organs 1987; 10: 269–275
  • Cattaneo M, Chang T MS. The potential of microencapsulated ureaae-zeolite oral sorbent for the removal of urea in uremia. TASAIO - Official Journal of the American Society of Artificial Internal Organs 1991; 37: 80–87
  • Chang T MS, Potnansky MJ. Semipermeable microcapsules containing catalase for enzyme replacement in acatalsaemic mice. Nature 1968; 218(5138)242–245
  • Poznansky M J, Chang T MS. Comparison of the enzyme kinetics and immunological properties of catalase immobilized by microencapsulation and catalase in free solution forentyme replacement. Biochim. Biophys. Acta 1974; 334: 103–115
  • Chang T MS. The in vivo effects of semipermeable microcapsules containing L-asparaginase on 6C3 HED lymphosarcoma. Nature 1971; 229(528)117–118
  • Chang T MS. L-Asparaginase immobilized within semipermeable microcapsules: In vitro and in vivo atability. Eneyme 1973; 14(2)95–104
  • Chong E S, Chang T MS. In vivo effects of intraperitoneally injected L-asparaginaae solution and L-asparaginase immobilized within semipermeable nylon microcapsules with emphasis on blood L-asparaginse, ‘body’ L-asparaginase, and plasma L-asparagine levels. Enzyme 1974; 18: 218–239
  • Chong E D, Chang T MS. L-Asparaginase as a model for enzyme therapy of substrate- dependentn tumors. Biomedical Applications of Immobilized Enzymes and Proteins, T MS Chang. Plenum Press, New York 1977; 00: 105–120
  • Shu C D, Chang T MS. Tyrosinase immobilized within artificial cells for detoxification in liver failure. I. Preparation and in vitro studies. Int. J. Artif. Organs 1980; 3(5)287–291
  • Shu C D, Chang T MS. Tyrosinase immobilized within artificial cells for detoxification in liver failure. II. In vivo atudiea in fulminant hepatic failure rats. Int. J Artif. Organs 1981; 4: 82–84
  • Bourget L, Chang T MS. Phenylalanine ammonia-lyase immobilized in semipermeable microcapsules for enzyme replacement in phenylketonuria. Federation of Euopean Biochemical Societies (FEBS Letters) 1985; 180: 5–8
  • Bourget L, Chang T MS. Phenylalanine ammonia-lyase immobilized in microcapsules for the depleture of phenylalanine in plasma in phenylketonuric rat model. Biochim. Biophys. Acta. 1986; 883: 432–438
  • Bourget L, Chang T MS. Effects of oral administration of artificial cells immobilized phenylalanine ammonia-lyase on intestinal amino acids of phenylketonuric rats. J. Biomat. Art. Cells and Art. Organs 1989; 17: 161–182
  • Khanna R, Chang T MS. Characterization of L-histidine ammonia-lyase immobilized by microencapsulation in artificial cells: Preparation kinetics, stability, and in vitro depletion of histidine. Int. J. Art. Org. 1990; 13: 189–195
  • Chang T MS. Preparation and characterization of xanthine oxidase immobilized by microencapsulation in artificial cells for the removal of hypoxanthine. J Biomat, Artif Cells and Artif Organs 1989; 17: 611–16
  • Palmour R M, Goodyer P, Reade T, Chang T MS. Microencapsulated xanthine oxidase as experiment altherapy in Lesch-Nyhan Disease. Lancet 1989; 2(8664)687–8
  • Wang X L, Shao JY. An approach to the preparation of digestive enzyme-drug for oral administration: Complex lactase microcapsules. Acta Academiae Medicinae Sinicae 1991; 13: 435–438
  • Chang T MS, Lister C. Plasma/Intestinal concentration patterns suggestive of entero-portal recirculation of amino acids: Effects of oral administration of asparaginase, glutaminase and tyrosinase immobilized by microencapsulation in artificial cells. J Biomat, Artif Cells and Artif Organs 1988/89; 16: 915–26
  • Chang T MS, Bourget L, Lister C. 1992, US patent granted
  • Campbell J, Chang T MS. Enzymatic recycling of coenzymes by a. multi-enzyme system immobilized within semipermeable collodion microcapsules. Biochim. Biophys. Acta 1975; 397: 101–109
  • Cousineau J, Chang T MS. Formation of amino acid from urea and ammonia by sequential enzyme reaction using a microencapsulated multienzyme system. Biochem. Biophys. Res. Commun. 1977; 79(1)24–31
  • Grunwald J, Chang T MS. Continuous recycling of NAD+ using an immobilized system of collodion microcapsules containing dextran-NAD+, alcohol dehydrogenase, and malic dehydrogenase. J. Applied Biochem 1979; 1: 104–114
  • Chang T MS, Malouf C. Effects of glucose dehydrogenase in converting urea and ammonia into amino acid using artificial cells. Artif Organs 1979; 3(1)38–41
  • Grunwald J, Chang T MS. Immobilization of alcohol dehydrogenase, malic dehydrogenase and dextran-NAD+ within nylon-polyethyleneimine microcapsules: Preparation and cofactor recyling. J. Molecular Catalysis 1981; 11: 83–90
  • Wahl H P, Chang T MS. Recycling of NAD+ cross-linked to albumin or hemoglobin immobilized with multienzyme systems in artificial cells. J of Molecular Catalysis 1986; 39: 147–154
  • Chang T MS. Recycling of NAD (P) by multienzyme systems immobilized by microencapsulation in artificial cells. Methods in Enzymology 1987; 136: 67–82
  • Gu K F, Chang T MS. Conversion of ammonia or urea into L-leucine, L-vatine, and L-isoleucine using artificial cell immobilizing multienzyme system and dextran-NADH+. I. Glucose dehydrogenase for cofactor recycling. ASAIO - Official J Am Soc Artif Intern Organs 1988; 11: 24–8
  • Gu K F, Chang T MS. Conversion of -ketoglutar ate into L-glutamic acid with urea as ammonium source using multienzyme system and dextran-NAD+ immobilized by microencapsulation with artificial cells in a bioreactor. J. Bioeng. Biotech. 1988; 32: 363–368
  • Gu K F, Chang T MS. Production of essential L-branched-chained amino acids, in bioreactors containing artificial cells immobilized multienzyme systems and dextran-NAD+. Applied Biochemistry and Biotechnology 1990; 26: 263–269
  • Daka J N, Chang T MS. Bilirubin removal by the pseudoperoxidase activity of free and immobilized hemoglobin and hemoglobin co-immobilized with glucose oxidase. J Biomat, Artif Cells and Artif Organs 1989; 17: 553–62
  • Chang T MS, Daka JN. Removal of bilirubin by the pseudoperoxidase activity of immobilized hemoglobin. 1989, U.S. Patent No. 4820416
  • Blood substitutes, T MS Chang, R Geyer. Marcel Dekker Publisher, New York 1988
  • Chang T MS, Geyer R. Blood substitutes. J. Biomaterials, Artificial Cells and Artificial Organs 1989; 16: 1–704
  • Blood Substitutes and Oxygen Carriers, T MS Chang. Marcel Dekker Publisher, New York 1992
  • Blood Substitutes and Oxygen Carriers. J. Biomaterials, Artificial Cells and Immobilization Biotechnology, T MS Chang, 1992; 20: 154–941
  • Chang T MS, Lister C. A screening test of modified hemoglobin blood substitute before clinical use in patients - based on complement activation of human plasma. J. Biomat, Artif Cells and Artif Organs 1990; 18(5)693–702
  • Chang T MS, Lister C. An in-vitro screening test for modified hemoglobin to bridge the gap between animal safety studies and clinical use in patients. J. Biomaterials, Artificial Cells and Immobilization Biotechnology 1992; 20: 481–487
  • Zhou M X, Chang T MS. Control release of prostaglandin E2 from polylactic acid and microcapsules, microparticlea and modified microparticles. J. Microenap. 1988; 5: 27–32
  • Zhou M X, Chang T MS. Effect of poly actic acid microcapsules containing prostaglandin E2 on the survival rates of grade II galactosamine-induced fulminant heaptic failure rate. J. Biomat. Art. Cells, and Art-Organs 1987; 15: 549–558
  • Ike O, Hitoni, Shimiqu Y, et al. Administration of adriamycin containing poly(lactic acid) microspheres into the pleural cavity of patients with malignant pleural effusion. Drug Delivery System 1990; 5: 23
  • Chang T MS. Lipid coated spherical ultrathin membranes of polymer or cross-linked protein as possible cell membrane model. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1969; 28: 461
  • Rosenthal A M, Chang T MS. The incorporation of lipid and Na+-K+-ATPaae into the membranes of semipermeable microcapsules. J. Membrane Science 1980; 6(3)329–338
  • Yu Y T, Chang T MS. Lipid-polymer membrane artificial cells containing multienzyme systems, cofactors and substrates for the removal of ammonia and urea. Trans. Am. Soc. Artif. Intern. Organs 1981; 27: 535–538
  • Yu Y T, Chang T MS. Immobilization of multienzymes and cofactors within lipid-polyamide membrane microcapsules for the multistep conversion of lipophilic and lipophobic substrates. Enzyme Microb. Technol. 1982; 4: 327–331
  • Ilan E, Chang T MS. Modification of lipid-poly amide microcapsules for immobilization of free cofactors and multienzyme system for the conversion of ammonia to glutamate. Applied Biochemistry and Biotechnology 1986; 13: 221–230
  • Chang T MS. The one shot vaccine. Socio-Economic and Ethical Implications of Enzyme Engineering. International Federation of Institutes for Advanced Studies, C G Heden, Stockholm, Sweden 1975; 17–18
  • Sipehia R, Bannard R AB, Chang T MS. Adsorption of large lipophilic molecules with exclusion of small hydrophilic molecules by microencapsulated activated charcoal formed by coating with polyethylene membrane. Journal of Membrane Science 1986; 29: 277–286
  • Sipehia R, Bannard R AB, Chang T MS. Poly(vinylidene fluoride) or poly(vinylidene chloride/vinyl chloride) - coated activated charcoal for the adsorption of large lipophilic molecules with exclusion of small hydorphilic molecules. J. Membrane Science 1989; 47: 293–301
  • Yuan Z Y, Chang T MS. Rat microsomes and cytoaol immobilized by microencapsulation in artificial cells. Int. J. Artif. Organs 1986; 9(1)63–68
  • Spirin A. S. Cell free protein synthesis bioreactor from Frontiers in Bioprocessing II, P Todd, SK Sikdur, M Bier, 1991

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