197
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Structural insights into the extra cellular segment of integrinβ5 and molecular interaction studies

, , , , &
Pages 319-324 | Received 11 Jun 2013, Accepted 03 Jul 2013, Published online: 20 Aug 2013

References

  • Hynes RO, Marcantonio EE, Stepp MA, et al. Integrin Heterodimer and Receptor Complexity in Avian and Mammalian Cells. J Cell Bio 1989;109:409–20
  • Domínguez-Giménez P, Brown NH, Martín-Bermudo MD. Integrin-Ecm Interactions Regulate the Changes in Cell Shape Driving the Morphogenesis of the Drosophila Wing Epithelium. J Cell Sci 2007;120:1061–71
  • Casar B, Rimann I, Kato H, et al. In Vivo Cleaved Cdcp1 Promotes Early Tumor Dissemination Via Complexing with Activated Beta1 Integrin and Induction of Fak/Pi3k/Akt Motility Signaling. Oncogene 2012. [Epub ahead of print]
  • Lysaght J, Verma NK, Maginn EN, et al. The Microtubule Targeting Agent Pbox-15 Inhibits Integrin-Mediated Cell Adhesion and Induces Apoptosis in Acute Lymphoblastic Leukaemia Cells. Int J Oncol 2013;42:239–46
  • Eble JA. Collagen-Binding Integrins as Pharmaceutical Targets. Curr Pharm Des 2005;11:867–80
  • Yeung J, Holinstat M. Newer Agents in Antiplatelet Therapy: A Review. J Blood Med 2012;3:33–42
  • Schneider JG, Amend SR, Weilbaecher KN. Integrins and Bone Metastasis: Integrating Tumor Cell and Stromal Cell Interactions. Bone 2011;48:54–65
  • Cicala C, Arthos J, Fauci AS. Hiv-1 Envelope, Integrins and Co-Receptor Use in Mucosal Transmission of Hiv. J Transl Med 2011;9(Suppl. 1):S2
  • Legate KR, Wickstrom SA, Fassler R. Genetic and Cell Biological Analysis of Integrin Outside-in Signaling. Genes Dev 2009;23:397–418
  • Anthis NJ, Campbell LD. The Tail of Integrin Activation. Trends Biochem Sci 2011;36:191–8
  • Contois L, Akalu A, Brooks PC. Integrins as “Functional Hubs” in the Regulation of Pathological Angiogenesis. Semin Cancer Biol 2009;19:318–28
  • Mas-Moruno C, Rechenmacher F, Kessler H. Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate Design, Synthesis and Clinical Evaluation. Anticancer Agents Med Chem 2010;10:753–68
  • Reardon DA, Cheresh D. Cilengitide: A Prototypic Integrin Inhibitor for the Treatment of Glioblastoma and Other Malignancies. Genes Cancer 2011;2:1159–65
  • Brooks PC, Montgomery AM, Rosenfeld M, et al. Integrin Alpha V Beta 3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels. Cell 1994;79:1157–64
  • Ballut L, Sapay N, Chautard E, et al. Mapping of Heparin/Heparan Sulfate Binding Sites on Alphavbeta3 Integrin by Molecular Docking. J Mol Recognit 2013;26:76–85
  • Jallu V, Poulain P, Fuchs PF, et al. Modeling and Molecular Dynamics of Hpa-1a and -1b Polymorphisms: Effects on the Structure of the Beta3 Subunit of the Alphaiibbeta3 Integrin. PLoS One 2012;7:e47304
  • The UniProt Consortium. Reorganizing the Protein Space at the Universal Protein Resource (Uniprot). Nucleic Acids Res 2012;40:D71–75
  • Altschul SF, Gish W, Miller W, et al. Basic Local Alignment Search Tool. J Mol Biol 1990;215:403–10
  • Cole C, Barber JD, Barton GJ. The Jpred 3 Secondary Structure Prediction Server. Nucleic Acids Res 2008;36:W197–201
  • Kelley LA, Sternberg MJ. Protein Structure Prediction on the Web: A Case Study Using the Phyre Server. Nat Protoc 2009;4:363–71
  • Larkin MA, Blackshields G, Brown NP, et al. Version 2.0. Bioinformatics 2007;23:2947–8
  • Eswar N, Webb B, Marti-Renom MA, et al. Comparative Protein Structure Modeling Using Modeller. Curr Protoc Protein Sci 2007;9:209–50
  • Guex N, Peitsch MC. Swiss-Model and the Swiss-Pdbviewer: An Environment for Comparative Protein Modeling. Electrophoresis 1997;18:2714–23
  • Laskowski RA, MacArthur MW, Moss DS, Thornton JM. Procheck: A Program to Check the Stereochemical Quality of Protein Structures. J Appl Cryst 1993;26:283–91
  • Luthy R, Bowie JU, Eisenberg D. Assessment of protein models with three-dimensional profiles. Nature 1992;356:83–5
  • Wiederstein M, Sippl MJ. Prosa-Web: Interactive Web Service for the Recognition of Errors in Three-Dimensional Structures of Proteins. Nucleic Acids Res 2007;35:W407–10
  • Dundas J, Ouyang Z, Tseng J, et al. Castp: Computed Atlas of Surface Topography of Proteins with Structural and Topographical Mapping of Functionally Annotated Residues. Nucleic Acids Res 2006;34:W116–8
  • Laurie AT, Jackson RM. Q-Sitefinder: An Energy-Based Method for the Prediction of Protein-Ligand Binding Sites. Bioinformatics 2005;21:1908–16
  • Kozakov D, Hall DR, Beglov D, et al. Achieving Reliability and High Accuracy in Automated Protein Docking: Cluspro, Piper, Sdu, and Stability Analysis in Capri Rounds 13-19. Proteins 2010;78:3124–30
  • Schneidman-Duhovny D, Inbar Y, Nussinov R, Wolfson HJ. Patchdock and Symmdock: Servers for Rigid and Symmetric Docking. Nucleic Acids Res 2005;33:W363–7

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.