382
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Notch signaling is involved in human articular chondrocytes de-differentiation during osteoarthritis

, , , , , , , , & show all
Pages 48-57 | Received 27 Sep 2013, Accepted 15 Oct 2013, Published online: 19 Nov 2013

References

  • Guingamp C, Pap T, Schadel J, et al. Gene therapy in osteoarthritis. Joint Bone Spine 2000;67:570–1
  • Poole AR, Kobayashi M, Yasuda T, et al. Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann Rheum Dis 2002;61:78–81
  • Laadhar L, Zitouni M, Kallel-Sellami M, et al. Physiopathology of osteoarthritis: from normal cartilage to osteoarthritic cartilage: risk factors and inflammatory mechanisms. Rev Med Interne 2007;28:531-6
  • Van't Hof RJ, Ralston SH. Nitric oxide and bone. Immunology 2001;103:255–61
  • Van Beuningen HM, Stoop R, Buma P, et al. Phenotypic differences in murine chondrocyte cell lines from mature articular cartilage. Osteoarth Cartil 2002;10:977–86
  • Cai SA, Fu X, Sheng Z. De-differentiation: a new approach in stem cell research. Bioscience 2007;57:655-62
  • Schweisguth F. Fonctions et regulation de l’activité de signalisation du recepteur Notch. Med Sci 2000;16:186–91
  • Tsakonas SA, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999;284:770–6
  • Tsakonas SA, Matsuno K, Fortini ME. Notch signaling. Science 1995;268:225–32
  • Fiùza UM, Arias AM. Cell and molecular biology of Notch. J Endocrinol 2007;194:459–74
  • Fortini M. Notch and presenilin: a proteolytic mechanism emerges. Curr Opin Cell Biol 2001;13:627–34
  • Schweisguth F. Regulation of Notch signaling activity. Curr biol 2004;14:R129–38
  • Ohtsuka T, Ishibashi M, Gradwohl G, et al. Hes1 and Hes5 as notch eff ectors in mammalian neuronal diff erentiation. EMBO J 1999;18:2196–207
  • Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003;194:237–55
  • Dovey HF, John V, Anderson JP, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem 2001;76:173–81
  • Hayes AJ, Dowthwaite GP, Webster SV, Archer CW. The distribution of Notch receptors and their ligands during articular cartilage development. J Anat 2003;202:495–502
  • Sassi N, Laadhar L, Mahjoub M, et al. Expression of Notch family members in cultured murine articular chondrocytes. Biotech histochem 2009;84:313–20
  • Watanabe N, Tezuka Y, Matsuno K, et al. Suppression of differentiation and proliferation of early chondrogenic cells by Notch. J Bone Miner Metab 2003;21:344–52
  • Karlsson C, Jonsson M, Asp J, et al. Notch and HES5 are regulated during human cartilage differentiation. Cell Tissue Res 2007;327:539–51
  • Mahjoub M, Sassi N, Driss M, et al. Expression patterns of Notch receptors and their ligands in osteoarthritic and healthy human knee cartilage. Tissue and Cell 2012;44:182–94
  • Grundmann K, Zimmermann B, Barrach HJ, Merker HJ. Behaviour of epiphyseal mouse chondrocyte populations in monolayer culture: morphological and immunohistochemical studies. Virchows Arch A Pathol Anat Histol 1980;389:167–87
  • Sassi N, Laadhar L, Driss M, et al. The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies. Art Res Ther 2011;13:208
  • Bougault C, Paumier A, Aubert-Foucher E. Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression. BMC Biotechnol 2008;8:71
  • Dehne T, Schenk R, Perka C, et al. Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals pattern of recovery, maintenance, re- and de-differentiation. Gene 2010;462:8–17
  • Blaise R, Mahjoub M, Salvat C, et al. Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the de-differentiation of articular chondrocytes in murine cartilage. Arthritis Rheum 2009;60:428–39
  • Teixeira C, Ischiropoulos H, Leboy P, et al. Nitric oxide–nitric oxide synthase regulates key maturational events during chondrocyte terminal differentiation. Bone 2005;37:37–45
  • Yan Q, Feng Q, Beier F. Endothelial nitric oxide synthase deficiency in mice results in reduced chondrocyte proliferation and endochondral bone growth. Arthritis Rheum 2010;62:2013–22
  • Hiraoka K, Grogan S, Olee T, Lotz M. Mesenchymal progenitor cells in adult human articular cartilage. Biorheology 2006;43:447–54
  • Karlsson C, Brantsing C, Egell S, Lindahl A. Notch1, Jagged1, and HES5 are abundantly expressed in osteoarthritis. Cells Tissues Organs 2008;188:287–98
  • Ustunel I, Ozenci AM, Sahin Z, et al. The immunohistochemical localization of notch receptors and ligands in human articular cartilage, chondroprogenitor culture and ultrastructural characteristics of these progenitor cells. Acta Histochem 2008;110:397–407
  • Dowthwaite G, Bishop J, Redman S, et al. The surface of articular cartilage contains a progenitor cell population. J Cell Sci 2004;117:889–97
  • Oldershaw R, Murdoch A, Brennan K. The putative role of the Notch ligand, jagged1, in the mediation of the early events of human mesenchymal stem cell chondrogenesis. Int J Exp Pathol 2005;86:47–8
  • Salvat C, Pigenet A, Humbert L, et al. Immature murine articular chondrocytes in primary culture: a new tool for investigating cartilage. Osteoarthritis Cartilage 2005;13:243–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.