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Research Article

p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease

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Pages 299-306 | Received 23 Nov 2013, Accepted 17 Feb 2014, Published online: 05 Mar 2014

References

  • Willemse BWM, Postma DS, Timens W, et al. The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation. Eur Respir J 2004;23:464–76
  • Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet 2012;379:1341–51
  • Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006;3:e442
  • The Global Initiative for Chronic Obstructive Lung Disease. Global strategy for diagnosis, management, and prevention of COPD: updated 2013. Available at: http://www.goldcopd.org/uploads/users/files/GOLD_Report_2014_Feb07.pdf
  • Wright JL, Churg A. Animal models of cigarette smoke-induced chronic obstructive pulmonary disease. Expert Rev Respir Med 2010;4:723–34
  • Shapiro SD. Animal models for COPD. Chest 2000;117:223S–7S
  • Mizutani N, Fuchikami J, Takahashi M, et al. Pulmonary emphysema induced by cigarette smoke solution and lipopolysaccharide in guinea pigs. Biol Pharm Bull 2009;32:1559–64
  • Kumar S, Boehm J, Lee JC. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003; 2:717–26
  • Namiki K, Matsunaga H, Yoshioka K, et al. Mechanism for p38α-mediated experimental autoimmune encephalomyelitis. J Biol Chem 2012;287:24228–38
  • Takanami-Ohnishi Y, Amano S, Kimura S, et al. Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J Biol Chem 2002;277:37896–903
  • Okuda R, Hagiwara E, Baba T, et al. Safety and efficacy of pirfenidone in idiopathic pulmonary fibrosis in clinical practice. Respir Med 2013;107:1431–7
  • Renda T, Baraldo S, Pelaia G, et al. Increased activation of p38 MAPK in COPD. Eur Respir J 2008;31:62–9
  • Saetta M, Shiner RJ, Angus GE, et al. Destructive index: a measurement of lung parenchymal destruction in smokers. Am Rev Respir Dis 1985;131:764–9
  • Ishizaki S, Kasuya Y, Kuroda F, et al. Role of CD69 in acute lung injury. Life Sci 2012;90:657–65
  • Brass DM, Hollingsworth JW, Cinque M, et al. Chronic LPS inhalation causes emphysema-like changes in mouse lung that are associated with apoptosis. Am J Respir Cell Mol Biol 2008;39:584–90
  • Schwartz DA, Thorne PS, Yagla SJ, et al. The role of endotoxin in grain dust-induced lung disease. Am J Respir Crit Care Med 1995;152:603–8
  • Vohlonen I, Tupi K, Terho EO, et al. Prevalence and incidence of chronic bronchitis and farmer’s lung with respect to the geographical location of the farm and to the work of farmers. Eur J Respir Dis Suppl 1987;152:37–46
  • Andersson A, Qvarfordt I, Laan M, et al. Impact of tobacco smoke on interleukin-16 protein in human airways, lymphoid tissue and T lymphocytes. Clin Exp Immunol 2004;138:75–82
  • Cao J, Zhang L, Li D, et al. IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10. Chest 2012;141:121–30
  • Traves SL. Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD. Thorax 2002;57:590–5
  • Broekhuizen R, Vernooy JHJ, Schols AMWJ, et al. Leptin as local inflammatory marker in COPD. Respir Med 2005;99:70–4
  • Hunninghake GM, Cho MH, Tesfaigzi Y, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med 2009;361:2599–608
  • Hautamaki RD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997;277:2002–4
  • Demedts IK, Morel-Montero A, Lebecque S, et al. Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 2006;61:196–201
  • Ying S, O’Connor B, Ratoff J, et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol 2008;181:2790–8
  • Villarino AV, Huang E, Hunter CA. Understanding the pro- and anti-inflammatory properties of IL-27. J Immunol 2004;173:715–20
  • Miller M, Cho JY, Pham A, et al. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol 2009;182:684–91
  • Tomoda K, Yoshikawa M, Itoh T, et al. Elevated circulating plasma adiponectin in underweight patients with COPD. Chest 2007;132:135–40
  • Dahl M, Vestbo J, Lange P, et al. C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:250–5
  • Pinto-Plata V, Toso J, Lee K, et al. Profiling serum biomarkers in patients with COPD: associations with clinical parameters. Thorax 2007;62:595–601
  • Xiao W, Hsu Y-P, Ishizaka A, et al. Sputum cathelicidin, urokinase plasminogen activation system components, and cytokines discriminate cystic fibrosis, COPD, and asthma inflammation. Chest 2005;128:2316–26
  • Laumen H, Saningong AD, Heid IM, et al. Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes 2009;58:984–91
  • Kim HB, Kim WH, Han KL, et al. cAMP-response element binding protein (CREB) positively regulates mouse adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2010;391:634–9
  • Oh H, Yang S, Park M, et al. Matrix metalloproteinase (MMP)-12 regulates MMP-9 expression in interleukin-1beta-treated articular chondrocytes. J Cell Biochem 2008;105:1443–50
  • Smith SJ, Fenwick PS, Nicholson AG, et al. Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br J Pharmacol 2006;149:393–404
  • Singh D, Smyth L, Borrill Z, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol 2010;50:94–100
  • Singh D. p38 inhibition in COPD; cautious optimism. Thorax 2013;68:705–6

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