24
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Insulin receptor transmembrane signaling: Evidence for an intermolecular oligomerization mechanism of activation

&
Pages 887-904 | Published online: 26 Sep 2008

References

  • Lee J., Pilch P. F. The insulin receptor: structure. function, and signaling. Am. J. Physiol. 1994; 266: C319–34
  • Riedel H., Dull T. J., Schlessinger J., Ullrich A. A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor. Nature 1986; 324: 68–70
  • Bormann B. J., Engelman D. M. Intramembrane helix-helix association in oligomerization and transmembrane signaling. Ann. Rev. Biophys. Biomol. Struct. 1992; 21: 223–42
  • Ullrich A., Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61: 203–12
  • Ellis L., Sissom J., Levitan A. Truncation of the ectodomain of the human insulin receptor results in secretion of a soluble insulin binding protein from transfected CHO cells. J. Mol. Rec. 1988; 1: 25–31
  • Johnson J. D., Wong M. L., Rutter W. J. Properties of the insulin receptor ectodomain. Proc. Natl. Acad. Sci. (USA) 1988; 85: 7516–20
  • Markussen J., Halstrom J., Wiberg F. C., Schaffer L. Immobilized insulin for high capacity affinity chromatography of insulin receptors. J. Biol. Chem. 1991; 266: 18814–8
  • Whittaker J., Okamoto A. K. Secretion of soluble functional insulin receptors by transfected NIH3T3 cells. J. Biol. Chem. 1988; 263: 3063–6
  • Ellis L., Levitan A., Cobb M. H., Ramos P. Efficient expression in insect cells of a soluble active human insulin receptor protein-tyrosine kinase domain by use of a baculovirus vector. J. Virol. 1988; 62: 1634–9
  • Herrera R., Lebwohl D., Garcia de Herreros A., Kallen R. G., Rosen O. M. Synthesis purification, and characterization of the cytoplasmic domain of the human insulin receptor using a baculovirus expression system. J. Biol. Chem. 1988; 263: 5560–8
  • Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. Second Edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York 1989
  • Harlow E., Lane D. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York 1988
  • Ebina Y., Ellis L., Jarnagin K., Edery M., Graf L., Clauser E., Ou J. H., Masiarz F., Kan Y.-W., Goldfine I. D., Roth R. A., Rutter W. J. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell 1985; 40: 747–58
  • Horton R. M., Ho S. N., Pullen J. K., Hunt H. D., Cai Z., Pease L. R. Gene splicing by overlap extension. Methods Enzymol. 1993; 217: 270–9
  • Kunkel T. A., Bebenek K., McClary J. Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol. 1991; 204: 125–39
  • Chen C., Okayama H. High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 1987; 7: 2745–2752
  • Whittaker J., Okamoto A. K., Thys R., Bell G. I., Steiner D. F., Hofmann C. A. High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells. Proc. Natl. Acad. Sci. (USA) 1987; 84: 5237–41
  • Hedo J. A., Harrison L. C., Roth J. Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors. Biochem. 1981; 20: 3385–3393
  • Frattali A. L., Treadway J. L., Pessin J. E. Evidence supporting a passive role for the insulin receptor transmembrane domain in insulin-dependent signal transduction. J. Biol. Chem. 1991; 266(15)9829–34
  • Munson P. J., Rodbard D. LIGAND: A versatile computerized approach for characterization of ligand binding systems. Anal. Biochem. 1980; 107: 220–239
  • Argos P. An investigation of oligopeptides linking domains in protein tertiary structures and possible candidates for general gene fusion. J. Mol. Biol. 1990; 211: 943–58
  • Thies R. S., Webster N. J., McClain D. A. A domain of the insulin receptor required for endocytosis in rat fibroblasts. J. Biol. Chem. 1990; 65: 10132–7
  • Due C., Simonsen M., Olsson L. The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens. Proc. Natl. Acad. Sci. (USA) 1986; 83: 6007–11
  • Samson M., Cousin J. L., Fehlmann M. Cross-linking of insulin receptors to MHC antigens in human B lymphocytes: evidence for selective molecular interactions. J. Immunol. 1986; 137: 2293–8
  • O'Brien R. M., Soos M. A., Siddle K. Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules. EMBO J. 1987; 6: 4003–10
  • Biener Y., Zick Y. Basic polycations activate the insulin receptor kinase and a tightly associated serine kinase. Eur. J. Biochem. 1990; 194: 243–50
  • Zick Y., Rees-Jones R. W., Taylor S. I., Gorden P., Roth J. The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor. J. Biol. Chem. 1984; 259: 4396–400
  • Ballotti R., Lammers R, Scimeca J. C., Dull T. J., Schlesssinger J., Van Obbberghen E. Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae. EMBO J. 1989; 8: 3303–9
  • Shia M. A., Rubin J. B., Pilch P. F. The insulin receptor protein kinase. Physicochemical requirements for activity. J. Biol. Chem. 1983; 258: 14450–5

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.