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Research Article

Antibodies directed to restricted sequences of the c-Erb a α hinge domain interfere with hormone or dna binding to recombinant α-type triiodothyronine receptor (c-Erb a α1) and detect structural changes

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Pages 715-735 | Published online: 26 Sep 2008

References

  • Evans R. E. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889–894
  • Glass C. K., Holloway J. M. Regulation of gene expression by the thyroid hormone receptor. Biochim. Biophys. Acta 1990; 1032: 157–176
  • Lazar M. A. Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr. Rev. 1993; 14: 184–193
  • Fukuda T., Willingham M. C., Cheng S. Y. Antipeptide antibodies recognize c-erb A and a related protein in human A 431 carcinoma cells. Endocrinology 1988; 123: 2646–2652
  • Torresani J., Ghysdael J., Bismuth J., Teboul M., Ghiringhelli O., Savary J. Heterogeneous distribution of nuclear triiodothyronine receptors in liver and preadipose cells as evidenced by their reactivity to antibodies against different protein products of erb A oncogenes. FEBS Lett. 1989; 250: 251–256
  • Macchia E., Nakai A., Janiga A., Sakurai A., Fisfalen M. E., Gardner P., Soltani K., De Groot L. J. Characterization of site-specific polyclonal antibodies to c-erb A peptides recognizing human thyroid hormone receptors αl α2 and β and native 3,5,3'-triiodothyronine receptor, and study of tissue distribution of the antigen. Endocrinology 1990; 126: 3232–3239
  • Tagami T., Nakamura H., Sasaki S., Imura H. Characterization of interaction between nuclear T3 receptors and antiserum against cellular erb A peptide. Endocrinology 1990; 126: 1105–1111
  • Macchia E., Falcone M., Giorgilli G., Bogazzi F., Antonangeli L., Baccarini S., Fontanini G., Torresani J., De Groot L. J., Pinchera A. Site specific anti c-erb A antibodies recognizing native thyroid hormone receptors their use to detect the expression and localization of α and β c-erb A proteins in rat liver. J. Receptor Res. 1992; 12: 201–215
  • Yen P. M., Sunday M. E., Darling D. S., Chin W. W. Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries. Endocrinology 1992; 130: 1539–1546
  • Sap J., Munoz A., Damm K., Goldberg Y., Ghysdael J., Leutz A., Beug H., Vennstrom B. The c-erb A protein is a high affinity receptor for thyroid hormone. Nature 1986; 324: 635–640
  • Teboul M., Bismuth J., Ghiringhelli O., Bonne J., Torresani J. Developmental and thyroidal regulation of the nuclear T3 receptors, c-erb A products in the Ob 17 preadipocyte cell line. J. Receptor Res. 1991; 11: 865–882
  • Bismuth J., Lenoir C., Teboul M., Daadi M., Giorgilli G., Bonne J., Macchia E., Planells R., Torresani J. Antibodies against restricted sequences in c-Erb A hinge domain differentially recognize natural α-or β-type T3 receptors and differently interfere with hormone binding. Eur.J.Endocrinol., in print
  • Thompson C. C., Weinberger C., Lebo R., Evans R. M. Identification of a novel thyroid hormone receptor expressed in mammalian central nervous system. Science 1987; 237: 1610–1614
  • Miyamoto T., Sakurai A., De Groot L. J. Effects of zinc and other divalent metals on deoxyribonucleic acid binding and hormone-binding activity of human α 1 thyroid hormone receptor expressed in E. coli. Endocrinology 1991; 129: 3027–3033
  • Glass C. K., Holloway J. M., Devary O. V., Rosenfeld M. G. The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements. Cell. 1988; 54: 313–323
  • Murray M. B., Towle HC. Identification of nuclear factors that enhance binding of the thyroid hormone receptor to a thyroid hormone response element. Mol. Endocrinol. 1989; 3: 1434–1442
  • Torresani J., De Groot L. J. Triiodothyronine binding to liver nuclear solubilized proteins in vitro. Endocrinology 1975; 96: 1201–1209
  • Falcone M., Miyamoto T., Fierro-Renoy F., Macchia E., De Groot L. J. Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform. Endocrinology 1992; 131: 2419–2429
  • Williams G. R., Harney J. W., Forman B. M., Samuels H. H., Brent G. A. Oligomeric binding of T3 receptor is required for maximal T3 response. J. Biol. Chem. 1991; 266: 19636–19644
  • Anselmet A., Gharbi-Chihi J., Torresani J. Nuclear triiodothyronine receptor in differentiating preadipocytes cloned from obese and lean mice. Endocrinology 1984; 114: 450–455
  • Yen P. M., Sugawara A., Forgione M., Spanjaard R. A., Macchia E., Cheng S. Y., Chin W. W. Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization. Mol. Cell. Endocr. 1993; 97: 93–99
  • Rosen E. D., O'Donnell A. L., Koenig R. J. Protein-protein interactions involving erb A superfamily receptors, through the TRAP door. Mol. Cell. Endocrinol. 1991; 78: C83–C88
  • Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zakarewski T., Chen J., Staub A., Garnier J. M., Mader S., Chambon P. Purification, cloning and RXR identity of the Hela cell factor with which RAR and TR heterodimerizes to bind target sequences efficiently. Cell 1992; 68: 377–395
  • Horowitz Z. D., Yang C., Forman B. M., Casanova J., Samuels H. H. Characterization of the domain structure of chick c-erb A by deletion mutation: in vitro translation and cell transfection studies. Mol. Endocrinol. 1989; 3: 148–156
  • Lin K. H., Parkinson C., McPhie P., Cheng S. Y. An essential role of domain D in the hormone nuclear receptor. Mol. Endocrinol. 1991; 5: 485–492
  • Lee Y., Mahdavi V. The D domain of the thyroid hormone receptor α1 specifies positive and negative transcriptional regulation functions. J. Biol. Chem. 1993; 268: 2021–2028
  • Torresani J., Anselmet A. Partial purification and characterization of nuclear triiodothyronine binding proteins. Biochem. Biophys. Res. Commun. 1978; 81: 147–153
  • Ichikawa K., Hashizume K., Furuta S., Osumi T., Miyamoto T., Yamauchi K., Takeda T., Yamada T. Human c-erb A protein expressed in Escherichia Coli: changes in hydrophobicity upon thyroid hormone binding. Mol. Cell. Endocrinol. 1990; 70: 175–184
  • Toney J. H., Wu L., Summerfield A. E., Sanyal G., Forman B. M., Zhu J., Samuels H. H. Conformational changes in chicken thyroid hormone receptor αl induced by binding to ligand or to DNA. Biochemistry 1993; 32: 2–6
  • Bhat M. K., Parkison C., McPhie P., Liang C. M., Cheng S. Y. Conformational changes of human β1 thyroid hormone receptor induced by binding of 3,5,3'-triiodo-L-thyronine. Biochem. Biophys. Res. Commun. 1993; 195: 385–392

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