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Research Article

β-methasone-containing biodegradable poly(lactide-co-glycolide) acid microspheres for intraarticular injection: effect of formulation parameters on characteristics and in vitro release

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Pages 1220-1229 | Received 19 Aug 2011, Accepted 18 Oct 2011, Published online: 01 Feb 2012

References

  • Gonzalez-Gay MA, Gonzalez-Juanatey C, Martin J. Rheumatoid arthritis: A disease associated with accelerated atherogenesis. Semin Arthritis Rheum 2005;35:8–17.
  • Boers M. Renal disorders in rheumatoid arthritis. Semin Arthritis Rheum 1990;20:57–68.
  • Marc C, Hochberg. New directions in symptomatic therapy for patients with oteoarthritis and rheumatoid arthritis. Arthritis and Rheum 2002;32:4–14.
  • Furst DE. The risk of infections with biologic therapies for rheumatoid arthritis. Semin Arthritis Rheum 2010;39:327–346.
  • Wilke WS, Clough JD. Therapy for rheumatoid arthritis: Combinations of disease-modifying drugs and new paradigms of treatment. Semin Arthritis Rheum 1991;21:21–34.
  • Liberman AC, Druker J, Perone MJ, Arzt E. Glucocorticoids in the regulation of transcription factors that control cytokine synthesis. Cytokine Growth Factor Rev 2007;18:45–56.
  • Ergang P, Leden P, Vagnerová K, Klusonová P, Miksík I, Jurcovicová J et al. Local metabolism of glucocorticoids and its role in rat adjuvant arthritis. Mol Cell Endocrinol 2010;323:155–160.
  • Cutolo M, Seriolo B, Pizzorni C, Secchi ME, Soldano S, Paolino S et al. Use of glucocorticoids and risk of infections. Autoimmun Rev 2008;8:153–155.
  • Hong D, Chen HX, Ge RS, Li JC. The biological roles of extracellular and intracytoplasmic glucocorticoids in skeletal cells. J Steroid Biochem Mol Biol 2008;111:164–170.
  • Gerwin N, Hops C, Lucke A. Intraarticular drug delivery in osteoarthritis. Adv Drug Deliv Rev 2006;58:226–242.
  • Butoescu N, Jordan O, Doelker E. Intra-articular drug delivery systems for the treatment of rheumatic diseases: A review of the factors influencing their performance. Eur J Pharm Biopharm 2009;73:205–218.
  • andez A, Herrero R, Molina IT, Pastoriza P. Biodegradable ibuprofen-lodaed PLGA microspheres for intraarticular administration: Effect of Labrafil addition on release in vitro. Int J Pharm 2004;279:33–41.
  • Klose D, Siepmann F, Willart JF, Descamps M, Siepmann J. Drug release from PLGA-based microparticles: Effects of the “microparticle:bulk fluid” ratio. Int J Pharm 2010;383:123–131.
  • Mao S, Shi Y, Li L, Xu J, Schaper A, Kissel T. Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method. Eur J Pharm Biopharm 2008;68:214–223.
  • Dorta MJ, Santoveña A, Llabrés M, Fariña JB. Potential applications of PLGA film-implants in modulating in vitro drugs release. Int J Pharm 2002;248:149–156.
  • Jain RA. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 2000;21:2475–2490.
  • Peng YJ, Wen CW, Chiou SH, Liu SJ. Sustained release of ganciclovir and foscarnet from biodegradable scleral plugs for the treatment of cytomegalovirus retinitis. Biomaterials 2010;31:1773–1779.
  • Wischke C, Schwendeman SP. Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. Int J Pharm 2008;364:298–327.
  • Ganji F, Abdekhodaie MJ. Chitosan–g-PLGA copolymer as a thermosensitive membrane. Carbohydr Polymers 2010;80:740–746.
  • Loo SCJ, Ooi CP, Boey YCF. Radiation effects on poly(lactide-co-glycolide) (PLGA) and poly(l-lactide) (PLLA). Polymer Degrad Stabil 2005;83:259–265.
  • Tan HX, Ye JD. Surface morphology and in vitro release performance of double-walled PLLA/PLGA microspheres entrapping a highly water-soluble drug. Appl Surf Sci 2008;255:353–356.
  • Stevenson G, Moulton SE, Innis PC, Wallace GG. Polyterthiophene as an electrostimulated controlled drug release material of therapeutic levels of dexamethasone. Synthetic Met 2010;160:1107–1114.
  • Silva GR, Silva-Cunha Jr A, Behar-Cohen F, Ayres E, Oréfice RL. Biodegradable polyurethane nanocomposites containing dexamethasone or ocular route. Mater Sci Eng C 2011;31:414–422.
  • Wang ZQ, Liu W, Xu HB, Yang XL. Preparation and in vitro studies of stealth PEG ylated PLGA nanoparticles as carrids for Arsenic Trioxide. Chin J Chen Eng 2007;15:795–801.
  • Sun Y, Wang J, Zhang X, Zhang Z, Zheng Y, Chen D et al. Synchronic release of two hormonal contraceptives for about one month from the PLGA microspheres: In vitro and in vivo studies. J Control Release 2008;129:192–199.
  • Ravivarapu HB, Burton K, DeLuca PP. Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres. Eur J Pharm Biopharm 2000;50:263–270.
  • Jain RA, Rhodes CT, Railkar AM, Malick AW, Shah NH. Controlled release of drugs from injectable in situ formed biodegradable PLGA microspheres: Effect of various formulation variables. Eur J Pharm Biopharm 2000;50:257–262.
  • Budhian A, Siegel SJ, Winey KI. Controlling the in vitro release profiles for a system of haloperidol-loaded PLGA nanoparticles. Int J Pharm 2008;346:151–159.
  • Zhang H, Lu Y, Zhang G, Gao S, Sun D, Zhong Y. Bupivacaine-loaded biodegradable poly(lactic-co-glycolic) acid microspheres I. Optimization of the drug incorporation into the polymer matrix and modelling of drug release. Int J Pharm 2008;351:244–249.
  • Aurizio ED, Nostrum CF, Steenbergen MJ, Sozio P, Siepmann F, Siepmann J, Hennink WE, Stefano DA. Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug. Int J Pharm 2011;409:289–296.
  • Klose D, Siepmann F, Elkharraz K, Siepmann J. PLGA-based drug delivery systems: Importance of the type of drug and device geometry. Int J Pharm 2008;354:95–103.
  • Mao S, Xu J, Cai C, Germershaus O, Schaper A, Kissel T. Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres. Int J Pharm 2007;334:137–148.
  • Zolnik BS, Burgess DJ. Effect of acidic pH on PLGA microsphere degradation and release. J Control Release 2007;122:338–344.
  • Singh UV, Udupa N. In vitro characterization of methotrexate loaded poly(lactic-co-glycolic) acid microspheres and antitumor efficacy in Sarcoma-180 mice bearing tumor. Pharm Acta Helv 1997;72:165–173.
  • Ramchandani M, Robinson D. In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants. J Control Release 1998;54:167–175.
  • Hickey T, Kreutzer D, Burgess DJ, Moussy F. Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices. Biomaterials 2002;23:1649–1656.
  • Ferrero C, Massuelle D, Doelker E. Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis. J Control Release 2010;141:223–233.
  • Dai YN, Li P, Zhang JP, Wang AQ, Wei Q. A novel pH sensitive N-succinyl chitosan/alginate hydrogel bead for nifedipine delivery. Biopharm Drug Dispos 2008;29:173–184.
  • Giovagnoli S, Blasi P, Ricci M, Schoubben A, Perioli L, Rossi C. Physicochemical characterization and release mechanism of a novel prednisone biodegradable microsphere formulation. J Pharm Sci 2008;97:303–317.

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