203
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Solidification drug nanosuspensions into nanocrystals by freeze-drying: a case study with ursodeoxycholic acid

, , , , &
Pages 180-188 | Received 08 Jul 2014, Accepted 28 Oct 2014, Published online: 27 Nov 2014

References

  • Kocbek P, Baumgartner P, Kristl J. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int J Pharm 2006;312:179–186
  • Rabinow BE. Nanosuspensions in drug delivery. Nat Rev Drug Discov 2004;3:785–796
  • Yue PF, Wan J, Hu PY, et al. Progress and thoughts on solidification nanosuspensions drug delivery system of traditional Chinese medicine. Chin Tradit Herb Drugs 2012;43:625–629
  • Yue PF, Wang Y, Wan J, et al. The research progress of preparation methods of solid nanocrystal delivery system. Acta Pharm Sin 2012;47:1120–1127
  • Wang, BH, Zhang WB, Zhang W. Progress in drying technology for nano-materials. Drying Technol 2005;23:7–32
  • Jakob B, Sabine I, Albertina A, et al. Freeze drying of nanosuspensions, 2: the role of the critical formulation temperature on stability of drug nanosuspensions and its practical implication on process design. J Pharm Sci 2011;100:4471–4481
  • Van Eerdenbrugh B, Vercruysse S, Martens JA, et al. Microcrystalline cellulose, a useful alternative for sucrose as a matrix former during freeze-drying of drug nanosuspensions–a case study with itraconazole. Eur J Pharm Biopharm 2008;70:590–596
  • Pu XH, Sun J, Qin YM, et al. Pharmaceutical evaluation of hydroxycamptothecin nanosuspensions with the action of inhibiting P-gp. Acta Pharmaceutica Sinica 2011;46:834–838
  • Eerdenbrugh BV, Ludo F, Jan VH, et al. Alternative matrix formers for nanosuspension solidification: dissolution performance and X-ray microanalysis as an evaluation tool for powder dispersion. Eur J Pharm Sci 2008;35:344–353
  • Sujung K, Jonghwi L. Effective polymeric dispersants for vacuum, convection and freeze drying of drug nanosuspensions. Int J Pharm 2010;397:218–224
  • Lai F, Pini E, Angioni G, et al. Nanocrystals as tool to improve piroxicam dissolution rate in novel orally disintegrating tablets. Eur J Pharm Biopharm 2011;79:552–558
  • Van Eerdenbrugh B, Froyen L, Martens JA, et al. Characterization of physico-chemical properties and pharmaceutical performance of sucrose co-freeze-dried solid nanoparticulate powders of the anti-HIV agent loviride prepared by media milling. Int J Pharm 2007;338:198–206
  • Kesisoglou F, Panmai S, Wu Y. Nanosizing-oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev 2007;59:631–644
  • Ventura CA, Tirendi S, Puglisi G, et al. Improvement of water solubility and dissolution rate of ursodeoxycholic acid and chenodeoxycholic acid by complexation with natural and modified β-cyclodextrins. Int J Pharm 1997;149:1–13
  • Yue PF, Li Y, Wan J, et al. Study on formability of solid nanosuspensions during nanodispersion and solidification: I. Novel role of stabilizer/drug property. Int J Pharm 2013;454:269–277
  • Li Y, Wang Y, Yue PF, et al. A novel high-pressure precipitation tandem homogenization technology for drug nanocrystals production-a case study with ursodeoxycholic acid. Pharm Dev Technol 2014;19:662–670
  • Lee J. Drug nano-and microparticles processed into solid dosage forms: physical properties. J Pharm Sci 2003;92:2057–2068
  • Lee J, Cheng Y. Critical freezing rate in freeze drying nanocrystal dispersions. J Contr Release 2006;111:185–192
  • Searles JA, Carpenter JF, Randolph TW. The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf. J Pharm Sci 2001;90:860–871
  • Wang BH, Zhang WB, Zhang W. Progress in drying technology for nano-materials. Drying Technol 2005;23:7–32
  • Adamson AW, Gast AP. Physical chemistry of surfaces. New York: John Wiley and Sons; 1997
  • Saez A, Guzman M, Molpeceres J, Aberturas MR. Freeze drying of poly-caprolactone and poly(d,l-lactic-glycolic) nanoparticles induce minor particles size changes affecting the oral pharmacokinetics of loaded drugs. Eur J Pharm Biopharm 2000;50:379–387
  • Wolfe J, Bryant G. Freezing, drying and/or vitrification of membrane-solute-water systems. Cryobiology 1999;39:103–129

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.