Controlled initial surge despite high drug fraction and high solubility

References

• O’Donnell PB, McGinity JW. Preparation of microspheres by the solvent evaporation technique. Adv Drug Delivery Rev 1997;28:25–42
   PubMed Web of Science ®Google Scholar
• Wu XS. Preparation, characterization, and drug delivery applications of microspheres based on biodegradable lactic/glycolic acid polymers. In: Wise, DL, Trantolo, DJ, Altobelli, DE, et al., eds. Encyclopedic handbook of biomaterials and bioengineering. New York: Marcel Dekker; 1995:1151–1200
   Google Scholar
• Arshady R. Preparation of biodegradable microspheres and microcapsules: 2. Polyactides and relates polyesters. J Control Rel 1991;17:1–22
   Web of Science ®Google Scholar
• Kim CS, Saylor DM, McDermott MK, et al. Modeling solvent evaporation during the manufacture of controlled drug-release coatings and the impact on release kinetics. J Biomed Mater Res Part B: Applied Biomater 2009;90:688–699
   PubMed Web of Science ®Google Scholar
• Yan N, Zhang X, Cai Q, et al. The effects of lactidyl/glycolidyl ratio and molecular weight of poly(D, L-lactide-co-glycolide) on the tetracycline entrapment and release kinetics of drug-loaded nanofibers. J Biomater Sci Polym Ed 2012;23:1005–1019
   PubMed Web of Science ®Google Scholar
• Webber WL, Lago F, Thanos C, Mathiowitz E. Characterization of soluble, salt-loaded, degradable PLGA films and their release of tetracycline. J Biomed Mater Res 1998;41:18–29
   PubMed Web of Science ®Google Scholar
• Esposito E, Cortesi R, Cervellati F, et al. Biodegradable microparticles for sustained delivery of tetracycline to the periodontal pocket: formulatory and drug release studies. J Microencapsul 1997;14:175–187
   PubMed Web of Science ®Google Scholar
• Vienneau DS, Kindberg CG. Development and validation of a sensitive method for tetracycline in gingival crevicular fluid by HPLC using fluorescence detection. J Pharm Biomed Anal 1997;16:111–117
   PubMed Web of Science ®Google Scholar
• Aggarwal RK, Robinson DH, Maze GI, Reinhardt RA. Development and characterization of tetracycline-poly (lactide/glycolide) films for the treatment of periodontitis. J Control Rel 1993;23:137–146
   Web of Science ®Google Scholar
• McDermott MK, Saylor DM, Casas R, et al. Microstructure and elution of tetracycline from block copolymer coatings. J Pharm Sci 2010;99:2777–2785
   PubMed Web of Science ®Google Scholar
• Trotta F, Baggiani C, Luda MP, et al. A molecular imprinted membrane for molecular discrimination of tetracycline hydrochloride. J Membrane Sci 2005;254:13–19
   Web of Science ®Google Scholar
• Barichello JM, Morishita M, Takayama K, Nagai T. Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method. Drug Dev Ind Pharm 1999;25:471–476
   PubMed Web of Science ®Google Scholar
• Ryu WH, Vyakarnam M, Greco RS, et al. Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers. Biomed Microdevices 2007;9:845–853
   PubMed Web of Science ®Google Scholar
• Jain RA. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 2000;21:2475–2490
   PubMed Web of Science ®Google Scholar
• Jain R, Shah NH, Malick AW, Rhodes CT. Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches. Drug Dev Ind Pharm 1998;24:703–727
   PubMed Web of Science ®Google Scholar
• Makadia HK, Siegel SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 2011;3:1377–1397
   PubMed Web of Science ®Google Scholar
• Park TG. Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition. Biomaterials 1995;16:1123–1130
   PubMed Web of Science ®Google Scholar
• Lemos PA, Surruys PW, Sousa JE. Drug eluting stents: cost versus clinical benefit. Circulation 2003;107:3003–3007
   PubMed Web of Science ®Google Scholar
• Faxon DP. Bringing reality to drug-eluting stents. Circulation 2004;109:104–142
   Web of Science ®Google Scholar
• Yeo Y, Kohane DS. Polymers in the prevention of peritoneal adhesions. Eur J Pharm Biopharm 2008;68:57–66
   PubMed Web of Science ®Google Scholar
• Kamberi M, Nayak S, Myo-Min K, et al. A novel accelerated in vitro release method for biodegradable coating of drug eluting stents: insight to the drug release mechanisms. Eur J Pharm Sci, 2009;37:217–222
   PubMed Web of Science ®Google Scholar
• Owen GR, Jackson JK, Chehroudi B, et al. An in vitro study of plasticized poly(lactic-co-glycolic acid) films as possible guided tissue regeneration membranes: material properties and drug release kinetics. Wiley Online Library; 2010. Available from: wileyonlinelibrary.com
   Google Scholar
• Siegel SJ, Kahn JB, Metzger K, et al. Effect of drug type on the degradation rate of PLGA matrices. Eur J Pharm Biopharm 2006;64:287–293
   PubMed Web of Science ®Google Scholar
• Florence AT, Attwood D. Physiochemical principles of pharmacy, 4th ed. London: Pharmaceutical Press; 2005
   Google Scholar
• Varanda F, Pratas de Melo MJ, Caco AI, et al. Solubility of antibiotics in different solvents. 1. hydrochloride forms of tetracycline, moxifloxacin, and ciprofloxacin. Ind Eng Chem Res 2006;45:6368–6374
   Web of Science ®Google Scholar
• Stitzel JD, Bowlin GL, Mansfield K, et al. Electrospraying and electrospinning of polymers for biomedical applications: poly (lactic-co-glycolic acid) and poly (ethylene-co-vinylacetate). Proceedings of the 32nd Annual SAMPE Meeting, Boston, MA, November 2000, 205–11
   Google Scholar
• US Pharmacopeia Standard 36-NF31(2013): Validation of compendia procedures Ch.1225, p. 983
   Google Scholar
• Gabor F, Eetl B, Wirth M, Mallinger R. Ketoprofen-poly(D, L-lactic-co-glycolic acid) microspheres: influence of manufacturing parameters and type of polymer on the release characteristics. J Microencap 1999;16:1–12
   PubMed Web of Science ®Google Scholar
• The National Institute of Health, Bethesda, MD. Version 1.50f 3 January 2016. Available from: http://www.macbiophotonics.ca/imagej/, or http://rsbweb.nih.gov/ij/
   Google Scholar
• Grayson ACR, Cima MJ, Langer R. Molecular release from a polymeric microreservoir device: influence of chemistry, polymer swelling, and loading on device performance. J Biomed Mater Res 2004;69A:502–512
   Web of Science ®Google Scholar
• Mukherjee A, Vishwanatha JK. Formulation, characterization, and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 2009;29:3867–3876
   PubMed Web of Science ®Google Scholar
• Li S, Shen Y, Li W, Hao X. A common profile for polymer-based controlled releases and its logical interpretation to general release process. J Pharm Pharmaceut Sci 2006;9:231–237. (www.cspsCanada.org)
   PubMed Web of Science ®Google Scholar
• Ritger PI, Peppas NA. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Rel 1987;5:37–42
   Google Scholar
• Pang J, Luan Y, Li F, et al. Ibuprofen-loaded poly (lactic-co-glycolic acid) films for controlled drug release. Int J Nanomed 2011;6:659–665
   PubMed Web of Science ®Google Scholar
• Siepmanna J, Peppas NA. Higuchi equation: derivation, applications, use and misuse. Int J Pharm 2011;418:6–12
   PubMed Web of Science ®Google Scholar
• Grassi M, Grassi G. Mathematical modelling and controlled drug delivery: matrix systems. Current Drug Delivery, 2005;2:97–116
   PubMedGoogle Scholar
• Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 2010;67:217–223
   PubMed Web of Science ®Google Scholar
• Klosea D, Delplace C, Siepmann J. Unintended potential impact of perfect sink conditions on PLGA degradation in microparticles. Int J Pharm 2011;404:75–82
   PubMed Web of Science ®Google Scholar
• Collins R. Mathematical modelling of controlled release from implanted drug-impregnated monoliths. Pharm Sci Technol Today 1998;1:269–276
   Google Scholar
• Pool H, Quintanar D, de Dios Figueroa J, et al. Antioxidant effects of quercetin and catechin encapsulated into PLGA nanoparticles. J Nanomater 2012;2012: Article ID 145380. Available from: http://dx.doi.org/10.1155/2012/145380
   Web of Science ®Google Scholar
• Collins AEM, Deasy PB, MacCarthy DJ, Shanley DB. Evaluation of controlled-release compact containing tetracycline hydrochloride bonded to tooth for the treatment of periodontal disease. Int J Pharm 1989;51:103–114
   Web of Science ®Google Scholar
• Dong J, Foley JD, Frethem CD, et al. Multimodal dynamic imaging of therapeutic biomedical coatings in aqueous medium. Langmuir 2009;25:5442–5445
   PubMed Web of Science ®Google Scholar
• Bawa R, Siegel RA, Marasca B, et al. An explanation for the controlled release of macromolecules from polymers. J Control Rel 1985;1:259–267
   Google Scholar
• Siegel RA, Langer R. Controlled release of polypeptides and other macromolecules. Pharm Res 1984;1:2–10
   PubMed Web of Science ®Google Scholar
• Mittal G, Sahana DK, Bhardwaj V, Ravi Kumar MNV. Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release 2007;119:77–85
   PubMed Web of Science ®Google Scholar
• Catiker E, Gumusderelioglu M, Guner A. Degradation of PLA, PLGA homo- and copolymers in the presence of serum albumin: a spectroscopic investigation. Polym Int 2000;49:728–734
   Web of Science ®Google Scholar
• Saylor DM, Forrey C, Kim C-S, Warren JA. Diffuse interface methods for modeling drug-eluting stent coatings. Annals Biomed Eng 2015;1–12 Available from: http://doi.org/10.1007/s10439-015-1375-7
   PubMed Web of Science ®Google Scholar
• Tan LP, Venkatraman SS, Sung PF, Wang XT. Effect of plasticization on heparin release from biodegradable matrices. Int J Pharm 2004;283:89–96
   PubMed Web of Science ®Google Scholar