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Opening lecture

AA amyloidosis: potential therapy with antisense oligonucleotides

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Pages 200-202 | Published online: 18 Aug 2011

References

  • Gillmore JD, Lovat LB, Persey MR, Pepys MB, Hawkins PN. Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet 2001;358:24–29.
  • Yu RZ, Kim TW, Hong A, Watanabe TA, Gaus HJ, Geary RS. Cross-species pharmacokinetic comparison from mouse to man of second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100. Drug Metab Dispos 2007;35:460–468.
  • Thomas T, Ginsberg H. Development of apolipoprotein B antisense molecules as a therapy for hyperlipidemia. Curr Atheroscler Rep 2010;12:58–65.
  • Manoharan M. 2′-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and modification. Biochim Biophys Acta 1999;1489: 117–130.
  • Crooke ST. Progress in antisense technology; the end of the beginning. Methods Enzymol 2000;313:3–45.

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