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Original Article

Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers

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Pages 547-553 | Received 17 Jun 2009, Accepted 07 Aug 2009, Published online: 14 Dec 2009

References

  • Atawodi SE, Richter E. (1996). Bacterial reduction of N-oxides of tohbacco-specific nitrosamines (TSNA). Hum Exp Toxicol 15:329–34.
  • Baker RR. (1999). Smoke chemistry. In: Davis DL, Nielsen MT, editors. Tobacco – Production, Chemistry and Technology. Malden, MA: Blackwell Science. p. 398–439.
  • Baker RR, Dixon M. (2006). The retention of tobacco smoke constituents in the human respiratory tract. Inhal Toxicol 18:255–94.
  • Bernert JT, Jain RB, Pirkle JL, Wang L, Miller BB, Sampson EJ. (2005). Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes. Nicotine Tobacco Res 7:729–38.
  • Brunnemann KD, Hoffmann D. (1991). Analytical studies on tobacco- specific N-nitrosamines in tobacco and tobacco smoke. Crit Rev Toxicol 21:235–40.
  • Carmella SG, Borukhova A, Akerkar SA, Hecht SS. (1997). Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen. Cancer Epidemiol Biomarkers Prev 6:113–20.
  • Chamberlain WJ, Severson RF, Chortyk OT, Sisson VE. (1992). Effects of curing and fertilization on ntirosamine formation in Bright and Burley tobacco. Beitr Tabakforsch Int 15:87–92.
  • de Roton C, Wiernik A, Wahlberg I, Vidal B. (1992). Factors influencing the formation of tobacco-specific nitrosamines in French air-cured tobaccos in trials and at the farm level. Beitr Tabakforsch Int 216:305–20.
  • Fischer S, Spiegelhalder B, Preussmann R. (1989). Preformed tobacco-specific nitrosamines in tobacco-role of nitrate and influence of tobacco type. Carcinogenesis 10:1511–17.
  • Food and Drug Administration (FDA). (2001). Guidance for Industry – Bioanalytical Method Validation. Washington, DC: US Department of Health and Human Services 1. Available at: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070107.pdf (last accessed 17 April 2009).
  • Gregg E, Hill C, Hollywood M et al. (2004). The UK smoke constituents testing study. Summary of results and comparison with other studies. Beitr Tabakforsch Int 21:117–38.
  • Hecht SS. (1998). Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol 11:559–603.
  • Hecht SS. (2002). Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. Carcinogenesis 23:907–22.
  • Hecht SS, Chen CHB, Young R, Hoffmann D. 1981. Mass spectra of tobacco alkaloid-derived nitrosamines, their metabolites, and related compounds. Beitr Tabakforsch Int 11:57–66.
  • Hecht SS, Hoffmann D. (1989). The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv 8:273–94.
  • Institute of Medicine. (2001). Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction. Washington, DC: National Academy Press.
  • International Agency for Research on Cancer (IARC). (2004). Tobacco smoke and involuntary smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 83:1–1438.
  • International Agency for Research on Cancer (IARC). (2007). Smokeless Tobacco and Some Tobacco-specific N-Nitrosamines. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 89:1–626.
  • Kavvadias D, Scherer G, Urban M, Cheung F, Errington G, Shepperd J, McEwan M. (2009). Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine. J Chromatogr B Analyt Technol Biomed Life Sci 877:1185–92.
  • Parsons WD, Carmella SG, Akerkar S, Bonilla LE, Hecht SS. (1998). A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the urine of hospital workers exposed to environmental tobacco smoke. Cancer Epidemiology, Biomarkers & Prevention 7:257–60.
  • Shepperd CJ, Eldridge AC, Mariner DC, McEwan M, Dixon M. (2009). A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure. Regul Toxicol Pharmacol June 16 [Epub ahead of print].
  • Shepperd CJ, St Charles FK, Lien M, Dixon M. (2006). Validation of methods for determining consumer smoked cigarette yields from cigarette filter analysis. Beitr Tabakforsch Int 22:176–84.
  • St Charles FK, Krautter GR, Dixon M, Mariner DC. (2006). A comparison of nicotine dose estimates in smokers between filter analysis, salivary cotinine, and urinary excretion of nicotine metabolites. Psychopharmacology (Berl) 189:345–54.
  • Stepanov I, Hecht SS. (2005). Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users. Cancer Epidemiol Biomarkers Prev 14:885–91.
  • Tyroller S, Zwickenpflug W, Richter E. (2002). New sources of dietary myosmine uptake from cereals, fruits, vegetables, and milk. J Agric Food Chem 50:4909–15.
  • Urban M, Scherer G, Kavvadias D, Hagedorn HW, Feng S, Serafin R, Kapur S, Muhammad R, Jin Y, Mendes P, Roethig H. (2009). Quantitation of N’-Nitrosonornicotine (NNN) in smokers’ urine by liquid chromatography– tandem mass spectrometry. J Anal Toxicol 33:260–5.
  • Wiernik A, Christakopoulos A, Johansson L, Wahlberg I. (1995). Effect of air-curing on the chemical composition of tobacco. Recent Adv Tobacco Sci 21:39–80.
  • Xia Y, McGuffey JE, Bhattacharyya S, Sellergren B, Yilmaz E, Wang L, Bernert JT. (2005). Analysis of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine by extraction on a molecularly imprinted polymer column and liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. Anal Chem 77:7639–45.

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