Molecular circuitry regulating herpes simplex virus type 1 latency in neurons

References

• Ackland‐Berglund C E, Davido D J, Leib D A. The roles of the cAMP‐response element and TATA box in expression of the herpes simplex virus type 1 latency‐associated transcripts. Virology 1995; 210: 141–151
   Google Scholar
• Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). Faseb J 1990; 4: 2860–2867
   PubMed Web of Science ®Google Scholar
• Bader C, Crumpacker C S, Schnipp er L E, Ransil B, Clark J E, Arndt K, Freedberg I M. The natural history of recurrent facial‐oral infection with herpes simplex virus. J Infect Dis 1978; 138: 897–905
   PubMed Web of Science ®Google Scholar
• Bannister A J, Oehler T, Wilhelm D, Angel P, Kouzarides T. Stimulation of c‐Jun activity by CBP: c‐Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 1995; 11: 2509–2514
   PubMed Web of Science ®Google Scholar
• Baradaran K, Dabrowski C E, Schaffer P A. Transcriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed‐early gene product, OBPC. J Virol 1994; 68: 4251–4261
   Google Scholar
• Batchelor A H, O'Hare P. Localization of cis‐acting sequence requirements in the promoter of the latency‐associated transcripts of herpes simplex virus type 1 required for cell‐type‐specific activity. J Virol 1992; 66: 3573–3582
   Google Scholar
• Batterson W, Roizman B. Characterization of the herpes simplex virion‐associated factor responsible for the induction of α genes. J Virol 1983; 46: 371–377
   PubMed Web of Science ®Google Scholar
• Bisby M A, Telzlaff W, Brown M C. Cell body response to injury in motoneurons and primary sensory neurons of a mutant mouse, Ola (Wld), in which Wallerian degeneration is delayed. J Comp Neurol 1995; 359: 653–662
   Google Scholar
• Blondeau J M, Aoki F Y, Glavin G B. Stress‐induced reactivation of latent herpes simplex virus infection in rat lumbar dorsal root ganglia. J Psychosom Res 1993; 38: 843–849
   Google Scholar
• Bloom D C, Devi‐Rao G B, Hill J M, Stevens J G, Wagner E K. Molecular analysis of herpes simplex virus type 1 during epinephrine‐ induced reactivation of latently infected rabbits in vivo. J Virol 1994; 68: 1283–1292
   Google Scholar
• Bloom D C, Hill J M, Devi‐Rao G, Wagner E K, Feldman L T, Stevens J G. A 348‐base‐pair region in the latency‐associated transcript facilitates herpes simplex virus type 1 reactivation. J Virol 1996; 70: 2449–2459
   Google Scholar
• Bloom D C, Stevens J G, Hill J M, Tran R K. Mutagenesis of a cAMP response element within the latency‐associated transcript promoter of HSV‐1 reduces adrenergic reactivation. Virology 1997; 236: 202–207
   PubMed Web of Science ®Google Scholar
• Cai W, Astor T L, Liptak L M, Cho C, Coen D M, Schaffer P A. The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency. J Virol 1993; 67: 7501–7512
   PubMed Web of Science ®Google Scholar
• Cai W Z, Schaffer P A. Herpes simplex virus type 1 ICPO regulates expression of immediate‐early, early, and late genes in productively infected cells. J Virol 1992; 66: 2904–2915
   PubMed Web of Science ®Google Scholar
• Cai W Z, Schaffer P A. Herpes simplex virus type 1 ICPO plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA. J Virol 1989; 63: 4579–4589
   Google Scholar
• Campbell M E, Palfreyman J W, Preston C M. Identification of herpes simplex virus DNA sequences which encode a trans‐acting polypeptide responsible for stimulation of immediate early transcription. J Mol Biol 1984; 180: 1–19
   PubMed Web of Science ®Google Scholar
• Chen S H, Kramer M F, Schaffer P A, Coen D M. A viral function represses accumulation of transcripts from productive‐ cycle genes in mouse ganglia latently infected with herpes simplex virus. J Virol 1997; 71: 5878–5884
   PubMedGoogle Scholar
• Chen X, Schmidt M C, Goins W F, Glorioso J C. Two herpes simplex virus type 1 latency‐active promoters differ in their contributions to latency‐associated transcript expression during lytic and latent infections. J Virol 1995; 69: 7899–7908
   PubMed Web of Science ®Google Scholar
• Chrivia J C, Kwok R P, Lamb N, Hagiwara M, Montminy M R, Goodman R H. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 1993; 365: 855–859
   PubMed Web of Science ®Google Scholar
• Cook M L, Bastone V B, Stevens J G. Evidence that neurons harbor latent herpes simplex virus. Infect Immun 1974; 9: 946–951
   PubMed Web of Science ®Google Scholar
• Croen K D, Ostrove J M, Dragovic L J, Smialek J E, Straus S E. Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene ‘anti‐sense’ transcript by in situ hybridization. N Engl J Med 1987; 317: 1427–1432
   PubMed Web of Science ®Google Scholar
• Dabrowski C E, Carmillo P J, Schaffer P A. Cellular protein interactions with herpes simplex virus type 1 oriS. Mol Cell Biol 1994; 14: 2545–2555
   PubMedGoogle Scholar
• Dabrowski C E, Schaffer P A. Herpes simplex virus type 1 origin‐specific binding protein: oriS‐binding properties and effects of cellular proteins. J Virol 1991; 65: 3140–3150
   PubMedGoogle Scholar
• Danaher R J, Jacob R J, Chorak M D, Freeman C S, Miller C S. Heat stress activates production of herpes simplex virus type 1 from quiescently infected neurally differentiated PC12 cells. J Neurovirol 1999; 5: 374–383
   PubMed Web of Science ®Google Scholar
• Davido D J, Leib D A. Analysis of the basal and inducible activities of the ICPO promoter of herpes simplex virus type 1. J Gen Virol 1998; 79: 2093–2098
   Google Scholar
• Deatly A M, Spivack J G, Lavi E, Fraser N W. RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice. Proc Natl Acad Sci USA 1987; 84: 3204–3208
   PubMed Web of Science ®Google Scholar
• Deb S P, Deb S, Brown D R. Cell‐type‐specific induction of the UL9 gene of HSV‐1 by cell signaling pathway. Biochem Biophys Res Commun 1994; 205: 44–51
   Google Scholar
• Deshmane S L, Fraser N W. During latency, herpes simplex virus type 1 is associated with nucleosomes in a chromatin structure. J Virol 1989; 63: 943–947
   PubMed Web of Science ®Google Scholar
• Devi‐Rao G B, Bloom D C, Stevens J G, Wagner E K. Herpes simplex virus type 1 DNA replication and gene expression during explant‐induced reactivation of latently infected murine sensory ganglia. J Virol 1994; 68: 1271–1282
   Google Scholar
• Devi‐Rao G B, Goodart S A, Hecht L M, Rochford R, Rice M K, Wagner E K. Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency‐associated transcripts. J Virol 1991; 65: 2179–2190
   Google Scholar
• Dohson A T, Margolis T P, Gomes W A, Feldman L T. In vivo deletion analysis of the herpes simplex virus type 1 latency‐associated transcript promoter. J Virol 1995; 69: 2264–2270
   Google Scholar
• Dohson A T, Sederati F, Devi‐Rao G, Flanagan W M, Fan‐ell M J, Stevens J G, Wagner E K, Feldman L T. Identification of the latency‐associated transcript promoter by expression of rabbit β‐globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J Virol 1989; 63: 3844–3851
   Google Scholar
• Doerig C, Pizer L I, Wilcox G L. An antigen encoded by the latency‐associated transcript in neuronal cell cultures latently infected with herpes simplex virus typo 1. J Virol 1991; 65: 2724–2727
   Google Scholar
• Lfstathiou S, Minson A G, Field H J, Anderson J R, Wildy P. Detection of herpes simplex virus‐specific DNA sequences in latently infected mice and in humans. J Virol 1986; 57: 446–455
   Google Scholar
• Farrell M J, Dobson A T, Feldman L T. Herpes simplex virus latency‐associated transcript is a stable intron. Proc Natl Acad Sci USA 1991; 88: 790–794
   Google Scholar
• Farrell M J, Margolis T P, Gomes W A, Feldman L T. Effect of the transcription start region of the herpes simplex virus type 1 latency‐associated transcript promoter on expression of productively infected neurons in vivo. J Virol 1994; 68: 5337–5343
   Google Scholar
• Ferrer I, Barron S, Rodriquez‐Farre E, Planas A M. Ionizing radiation‐induced apoptosis is associated with c‐Jun expression and c‐Jun/AP‐1 activation in the developing cerebellum of the rat. Neurosci Lett 1995; 202: 105–108
   PubMedGoogle Scholar
• Frazier D P, Cox D, Godshalk E M, Schaffer P A. The herpes simplex virus type 1 latency‐associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells. J Virol 1996a; 70: 7424–7432
   PubMedGoogle Scholar
• Frazier D P, Cox D, Godshalk E M, Schaffer P A. Identification of cis‐acting sequences in the promoter of the herpes simplex virus type 1 latency‐associated transcripts required for activation by nerve growth factor and sodium butyrate in PCM2 cells. J Virol 1996b; 70: 7433–7444
   Google Scholar
• Gurber D A, Schaffer P A, Knipe D M. A LAT‐associated function reduces productive‐cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1. J Virol 1997; 71: 5885–5893
   Google Scholar
• Ginty D D, Bonni A, Greenberg M E. Nerve growth factor activates a Ras‐dependent protein kinase that stimulates c‐fos transcription via phosphorylation of CRFB. Coll 1994; 77: 713–725
   Google Scholar
• Coins W F, Sternberg L R, Croen K D, Krause P R, Hendricks R L, Fink D, Straus S E, Levine M, Glorioso J C. A novel latency‐active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J Virol 1994; 68: 2239–2252
   Google Scholar
• Goldenberg D, Mador N, Ball M J, Panet A, Steiner I. The abundant latency‐associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultures neuronal cells and during latent infection in mouse trigeminal ganglia. J Virol 1997; 71: 2897–2904
   Google Scholar
• Goldenberg D, Mador N, Panet A, Steiner J. fissile specific distribution of the herpes simplex virus type 1 latency‐associated transcripts on polyribosomes during latent infection. J Neurovirol 1998; 4: 426–432
   Web of Science ®Google Scholar
• Harbour D A, Hill T J, Blyth W A. Recurrent herpes simplex in the mouse: inflammation in the skin and activation of virus in the ganglia following peripheral stimulation. J Gen Virol 1983; 64: 1491–1498
   PubMed Web of Science ®Google Scholar
• Hardwicke M A, Schaffer P A. Cloning and characterization of herpes simplex virus type 1 oril: comparison of replication and protein‐DNA complex formation by oriL and oriS. J Virol 1995; 69: 1377–1388
   Google Scholar
• Hardwicke M A, Schaffer P A. Differential effects of nerve growth factor and dexamethasono on herpes simplex virus type 1 oriL‐ and oriS‐dependent DNA replication in PG12 cells. J Virol 1997; 71: 3580–3587
   Google Scholar
• Heine J W, Honess R W, Cassai E, Roizman B. Proteins specified by herpes simplex virus. XII. The virion polypeptides of type 1 strains. J Virol 1974; 14: 640–651
   PubMedGoogle Scholar
• Henken D B, Goldstein M E, Zhang Q L, Curtis R. Neuronal sprouting in mouse sensory ganglia infected with herpes simplex virus type 2 (HSV‐2): induction of growth‐associated protein (GAP‐43) and ultrastructural evidence. J Neurovirol 1995; 1: 157–164, see comments
   Web of Science ®Google Scholar
• Herdegen T, Skene P, Bahr M. The c‐Jun transcription factor‐bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 1997; 20: 227–231
   PubMed Web of Science ®Google Scholar
• Hill J M, Garza H H, Jr, Helmy M F, Cook S D, Osborne P A, Johnson E M, Jr, Thompson H W, Green L C, O'Callaghan R J, Gebhardt B M. Nerve growth factor antibody stimulates reactivation of ocular herpes simplex virus type 1 in latently infected rabbits. J Neurovirol 1997; 3: 206–211
   Web of Science ®Google Scholar
• Hill J M, Gebhardt B M, Wen R, Bouterie A M, Thompson H W, O'Callaghan R J, Halford W P, Kaufman, III. Quantitation of herpes simplex virus type I DNA and latency‐associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency. J Virol 1996a; 70: 3137–3141
   PubMedGoogle Scholar
• Hill J M, Kwon B S, Shimomura Y, Colborn G L, Yaghmai F, Gangarosa L P. Herpes simplex virus recovery in neural tissues after ocular HSV shedding induced by epinephrine iontophoresis to the rabbit cornea. Invest Ophthalmol Vis Sci 1983; 24: 243–247
   PubMed Web of Science ®Google Scholar
• Hill J M, Maggioncalda J B, Garza H H, Jr, Su Y H, Fraser N W, Block T M. In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370‐base‐pair region located between the promoter and the 5′ end of the 2.0 kilobase latency‐associated transcript. J Virol 1996b; 70: 7270–7274
   Google Scholar
• Hill T J, Blyth W A, Harbour D A. Trauma to the skin causes recurrence of herpes simplex in the mouse. J Gun Virol 1978; 39: 21–28
   PubMed Web of Science ®Google Scholar
• Ho D Y, Mocarski E S. Herpes simplex virus talent RNA (LAT) is not required for latent infection in the mouse. Proc Natl Acad Sci USA 1989; 86: 7596–7600
   PubMed Web of Science ®Google Scholar
• Honnus R W, Rpozman H. Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. Journal of Virology 1974; 14: 8–19
   Google Scholar
• Hull M, Bahr M. Regulation of immediate‐early gene expression in rat retinal ganglion cells after exotomy and during regeneration through a peripheral nerve graft. J Neurobiol 1994; 25: 92–105
   Google Scholar
• Jang K L, Pulverer B, Woodgett J R, Latchman D S. Activation of the cellular transcription factor API in herpes simplex virus infected cells is dependent on the viral immediate‐early protein ICPO. Nucleic Acids Res 1991; 19: 4879–4883
   Google Scholar
• Javier R T, Stevens J G, Dissette V B, Wagner E K. A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state. Virology 1988; 166: 254–257
   PubMed Web of Science ®Google Scholar
• Jenkins R, McMahon S B, Bond A B, Hunt S P. Expression of c‐Jun as a response to dorsal root and peripheral nerve section in damaged and adjacent intact primary sensory neurons in the rat. Eur J Neurosci 1993; 5: 751–759
   PubMed Web of Science ®Google Scholar
• Jones K A, Kadonaga J T, Luciw P A, Tjian R. Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science 1986; 232: 755–759
   PubMed Web of Science ®Google Scholar
• Kahn A. Transcriptional regulation by glucose in the liver. Biochimie 1997; 79: 113–118
   Google Scholar
• Kaufman H E, Varnell E D, Gebhardt B M, Thompson H W, Hill H M. Propranolol supp ression of ocular HSV‐1 recurrence and associated corneal lesions following spontaneous reactivation in the rabbit. Curr Eye Res 1996; 15: 680–684
   PubMed Web of Science ®Google Scholar
• Kemp E M, Dent C L, Latchman U S. Octamer motif mediates transcriptional repression of HSV immediate‐early genes and octamer‐containing cellular promoters in neuronal cells. Neuron 1990; 4: 215–222
   PubMed Web of Science ®Google Scholar
• Kendall G, Ensor E, Brar‐Rai A, Winter J, Latchman D S. Nerve Growth factor induces expression of immediate‐early genes NGFI.‐A (Egr‐1) and NGF1‐B (me 77) in adult rat dorsal root ganglion neurons. Brain Res Mol Brain Res 1994; 25: 73–79
   Google Scholar
• Kenny J J, Krebs F C, Hartle H T, Gartner A E, Chatton B, Leiden J M, Hoeffler J P, Weber P C, Wigdahl B. Identification of a second ATF/CREB‐like element in the herpes simplex virus type 1 (HSV‐1) latency‐associated transcript (LAT) promoter. Virology 1994; 200: 220–235
   Google Scholar
• Kenny J J, Millhouse S, Wotring M, Wigdahl B. Upstream stimulatory factor family binds to the herpes simplex virus type 1 latency‐associated transcript promoter. Virology 1997; 230: 381–391
   Google Scholar
• Kocisova M, Rajcani J, Szanto J. Comparative studies on activation of latent herpes simplex virus in rabbits. Acta Virol 1985; 29: 373–385
   Google Scholar
• Kramer M E, Coen D M. Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J Virol 1995; 69: 1389–1399
   Google Scholar
• Krause P R, Croen K D, Ostrove J M, Straus S E. Structural and kinetic analyses of herpes simplex virus type 1 latency‐ associated transcripts in human trigeminal ganglia and in cell culture. J Clin Invest 1990; 86: 235–241
   Google Scholar
• Kriesel J D, Gebhardt B M, Hill J M, Maulden S A, Hwang I P, Clinch T E, Cao X, Spruance S L, Araneo B A. Anti‐interleukin‐6 antibodies inhibit herpes simplex virus reactivation. J Inject Dis 1997a; 175: 821–827
   Google Scholar
• Kriesel J D, Ricigliano J, Spruance S L, Garza H H, Jr, Hill J M. Neuronal reactivation of herpes simplex virus may involve interleukin‐6. J Neurovirol 1997b; 3: 441–448
   Web of Science ®Google Scholar
• Kristensson K, Lycke E, Roytta M, Svennerholm B, Vahlne A. Neuritic transport of herpes simplex virus in rat sensory neurons in vitro. Effects of substances interacting with microtubular function and axonal flow ‘nocodazole. taxol and erythro‐9–3‐(2‐hydroxynonyl)adenine’. J Gen Virol 1986; 67: 2023–2028
   PubMed Web of Science ®Google Scholar
• Leah J D, Herdegen T, Murashov A, Dragunow M, Bravo R. Expression of immediate early gene proteins following axotomy and inhibition of axonal transport in the rat central nervous system. Neuroscience 1993; 57: 53–66
   Google Scholar
• Leib D A, Bogard C L, Kosz‐Vnenchak M, Hicks K A, Coen D M, Knipe D M, Schaffer P A. A deletion mutant of the latency‐associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J Virol 1989a; 63: 2893–2900
   PubMed Web of Science ®Google Scholar
• Leib D A, Coen D M, Bogard C L, Hicks K A, Yager D R, Knipe D M, Tyler K L, Schaffer P A. Immediate‐early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J Virol 1989b; 63: 759–768
   PubMed Web of Science ®Google Scholar
• Leib D A, Nadeau K G, Rundle S A, Schaffer P A. The promoter of the latency‐associated transcripts of herpes simplex virus type 1 contains a functional cAMP‐rosponse element: role of the latency‐associated transcripts and cAMP in reactivation of viral latency. Proc Natl Acad Sci USA 1991; 88: 48–52
   PubMedGoogle Scholar
• Lillycrop K A, Dent C L, Wheatley S C, Beech M N, Ninkina N N, Wood J N, Latchman D S. The octamer‐binding protein Oct‐2 represses HSV immediate‐early genes in cell lines derived from latently infectable sensory neurons. Neuron 1991; 7: 381–390
   PubMedGoogle Scholar
• Linnemann C C, Jr, First M R, Alvira M M, Alexander J W, Schiff C M. Herpesvirus hominis type 2 meningoencephalitis following renal transplantation. Am J Med 1976; 61: 703–708
   Google Scholar
• Liu T, Tang Q, Hendricks R L. Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. J Virol 1996; 70: 264–271
   PubMed Web of Science ®Google Scholar
• Lokensgard J R, Berthomme H, Feldman L T. The latency‐associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long‐term expression during latency. J Virol 1997; 71: 6714–6719
   PubMed Web of Science ®Google Scholar
• Lokensgard J R, Bloom D C, Dobson A T, Feldman L T. Long‐term promoter activity during herpes simplex virus latency. J Virol 1994; 68: 7148–7158
   PubMedGoogle Scholar
• Loutsch J M, Perng G C, Hill J M, Zheng X, Marquart M E, Block T M, Chiasi H, Nesburn A B, Wechsler S L. Identical 371‐Base‐Pair Deletion Mutations in the LAT Genes of Herpes Simplex Virus Type 1 McKrae and 17syn+ Result in Different In Vivo Reactivation Phenotypes. J Virol 1999; 73: 767–771
   PubMed Web of Science ®Google Scholar
• Luo X, Sawadogo M. Antiproliferative properties of the USF family of helix‐loop‐helix transcription factors. Proc Natl Acad Sci USA 1996; 93: 1308–1313
   PubMedGoogle Scholar
• Lycke E, Hamark B, Johansson M, Krotochwil A, Lycke J, Svennerholm B. Herpes simplex virus infection of the human sensory neuron. An electron microscopy study. Arch Virol 1988; 101: 87–104
   PubMed Web of Science ®Google Scholar
• Mackem S, Roizman B. Differentiation between α promoter and regulator regions of herpes simplex virus 1, the functional domains and sequence of a movable α regulator. Proc Natl Acad Sci USA 1982c; 79: 4917–4921
   PubMed Web of Science ®Google Scholar
• Mackem S, Roizman B. Regulation of α genes of herpes simplex virus: the α 27 gene promoter‐thymidine kinase chimera is positively regulated in converted L cells. J Virol 1982a; 43: 1015–1023
   PubMed Web of Science ®Google Scholar
• Mackem S, Roizman B. Structural features of the herpes simplex virus α gene 4, 0, and 27 promoter‐regulatory sequences which confer α regulation on chimeric thymidine kinase genes. J Virol 1982b; 44: 939–949
   PubMed Web of Science ®Google Scholar
• Mador N, Goldenberg D, Cohen O, Panet A, Steiner I. Herpes simplex virus type 1 latency‐associated transcripts supp ress viral replication and reduce immediate‐early gene mRNA levels in a neuronal cell line. J Virol 1998; 72: 5067–5075
   Google Scholar
• Margolis T P, Sedarati F, Dobson A T, Feldman L T, Stevens J G. Pathways of viral gene expression during acute neuronal infection with HSV‐1. Virology 1992; 189: 150–160
   Google Scholar
• Marshall C J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal‐regulated kinase activation. Cell 1995; 80: 179–185
   PubMed Web of Science ®Google Scholar
• Martin R E, Henken D B, Hill J M. Altered expression and changing distribution of the nerve growth associated protein GAP‐43 during ocular HSV‐1 infection in the rabbit. J Neurovirol 1996; 2: 127–135
   PubMed Web of Science ®Google Scholar
• McEwen B S, Biron C A, Brunson K W, Bulloch K, Chambers W H, Dhabhar F S, Goldfarb R H, Kitson R P, Miller A H, Spencer R L, Weiss J M. The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Brain Bes Bev 1997; 23: 79–133
   PubMed Web of Science ®Google Scholar
• McGeoch D J, Cunningham C, McIntyre G, Dolan A. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex virus types 1 and 2. J Gen Virol 1991; 72: 3057–3075
   Google Scholar
• McKnight J L, Kristie T M, Roizman B. Binding of the virion protein mediating α gene induction in herpes simplex virus type 1‐infected cells to its cis site requires cellular proteins. Proc Natl Acad Sci USA 1987; 84: 7061–7065
   PubMedGoogle Scholar
• Mehta A, Maggioncalda J, Bagasra O, Thikkavarapu S, Saikumari P, Valyi‐Nagy T, Fraser N W, Block T M. In situ DNA PCR and RNA hybridization detection of herpes simplex virus sequences in trigeminal ganglia of latently infected mice. Virology 1995; 206: 633–640
   Web of Science ®Google Scholar
• Mellerick D M, Fraser N W. Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state. Virology 1987; 158: 265–275
   PubMed Web of Science ®Google Scholar
• Michael N, Spector D, Mavromara‐Nazos P, Kristie T M, Roizman B. The DNA‐binding properties of the major regulatory protein α 4 of herpes simplex viruses. Science 1988; 239: 1531–1534
   PubMed Web of Science ®Google Scholar
• Millhouse S, Kenny J J, Quinn P G, Lee V, Wigdahl B. ATF/CREB elements in the herpes simplex virus type 1 latency‐associated transcript promoter interact with members of the ATF/CREB and AP‐1 transcription factor families. J Biomed Sci 1998; 5: 451–464
   Google Scholar
• Montminy M. Transcriptional regulation by cyclic AMP. Annu Rev Biochem 1997; 66: 807–822
   PubMed Web of Science ®Google Scholar
• Morgan J I, Curran T. Stimulus‐transcription coupling in neurons: role of cellular immediate‐early genes. Trends Neurosci 1989; 12: 459–462
   PubMed Web of Science ®Google Scholar
• Nesburn A B. Report of the corneal disease panel: vision research ‐ a national plan, 1983–1987. St Louis, MO 1983, II, part III
   Google Scholar
• Nguyen‐Huynh A T, Schaffer P A. Cellular transcription factors enhance herpes simplex virus type 1 oriS‐dependent DNA replication. J Virol 1998; 72: 3635–3645
   Google Scholar
• Nichol P F, Chang J Y, Johnson E M, Jr, Olivo P D. Herpes simplex virus gene expression in neurons: viral DNA synthesis is a critical regulatory event in the branch point between the lytic and latent pathways. J Virol 1990; 70: 5476–5486
   Google Scholar
• Nicosia M, Deshmane S L, Zabolotny J M, Valyi‐Nagy T, Fraser N W. Herpes simplex virus type 1 latency‐associated transcript (LAT) promoter deletion mutants can express a 2‐kilobase transcript mapp ing to the LAT region. J Virol 1993; 67: 7276–7283
   PubMedGoogle Scholar
• Nicosia M, Zabolotny J M, Lirette R P, Fraser N W. The HSV‐1 2‐kb latency‐associated transcript is found in the cytoplasm comigrating with ribosomal subunits during productive infection. Virology 1994; 204: 717–728
   Google Scholar
• North S, Espanel X, Bantignies F, Viollet B, Vallet V, Jalinot P, Brun G, Gillet G. Regulation of cdc2 gene expression by the upstream stimulatory factors (USFs). Oncogene 1999; 18: 1945–1955
   Google Scholar
• O'Rourke D, O'Hare P. Mutually exclusive binding of two cellular factors within a critical promoter region of the gene for the IE110k protein of herpes simplex virus. J Virol 1993; 67: 7201–7214
   PubMedGoogle Scholar
• Openshaw H, Stampalia L, Asher L S. Retrograde axoplasmic transport of herpes simplex virus. Trans Am Neurol Assoc 1978; 103: 238–239
   PubMedGoogle Scholar
• Padgett D A, Sheridan J F, Dome J, Berntson G G, Candelora J, Glaser R. Social stress and the reactivation of latent herpes simplex virus type 1. Proc Natl Acad Sci USA 1998; 95: 7231–7235
   PubMed Web of Science ®Google Scholar
• Pass R F, Whitley R J, Whelchel J D, Diethelm A G, Reynolds D W, Alford C A. Identification of patients with increased risk of infection with herpes simplex virus after renal transplantation. J Infect Dis 1979; 140: 487–492
   PubMed Web of Science ®Google Scholar
• Patel S A, Graunke D M, Pieper R O. Aberrant silencing of the CpG island‐containing human O6‐methylguanine DNA methyltransferase gene is associated with the loss of nucleosome‐like positioning. Mol Cell Biol 1997; 17: 5813–5822
   PubMedGoogle Scholar
• Penfold M E, Armati P, Cunningham A L. Axonal transport of herpes simplex virions to epidermal cells: evidence for a specialized mode of virus transport and assembly. Proc Natl Acad Sci USA 1994; 91: 6529–6533
   Google Scholar
• Perry L J, McGeoch D J. The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol 1988; 69: 2831–2846
   PubMedGoogle Scholar
• Qyang Y, Luo X, Lu T, Ismail P M, Krylov D, Vinson C, Sawadogo M. Cell‐type‐dependent activity of the ubiquitous transcription factor USF in cellular proliferation and transcriptional activation. Mol Cell Biol 1999; 19: 1508–1517
   PubMedGoogle Scholar
• Rader K A, Ackland‐Berglund C E, Miller J K, Pepose J S, Leih D A. In vivo characterization of site‐directed mutations in the promoter of the herpes simplex virus type 1 latency‐associated transcripts. J Gen Virol 1993; 74: 1859–1869
   Google Scholar
• Riccio A, Pierchala B A, Ciarallo C L, Ginty D D. An NGF.‐TrkA‐mediated retrograde signal to transcription factor CREB in sympathetic neurons ‘see comments’. Science 1997; 277: 1097–1100
   PubMed Web of Science ®Google Scholar
• Rivera L, Beuerman R W, Hill J M. Corneal nerves contain intra‐axonal HSV‐1 after virus reactivation by epinephrine iontophoresis. Curr Eye Res 1988; 7: 1001–1008
   PubMed Web of Science ®Google Scholar
• Rock D L, Fraser N W. Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region. J Virol 1985; 55: 849–852
   PubMed Web of Science ®Google Scholar
• Rock D L, Nesburn A B, Ghiasi H, Ong J, Lewis T L, Lokensgard J R, Wechsler S L. Detection of latency‐related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. J Virol 1987; 61: 3820–3826
   PubMed Web of Science ®Google Scholar
• Roizman B, Borman G S, Rousta M K. Macromolecular synthesis in cells infected with herpes simplex virus. Nature 1965; 206: 1374–1375
   PubMedGoogle Scholar
• Roizman B, Sears A E. Herpes simplex viruses and their replication. Fields Virology3 ed., B N Fields, D M Knipe, P M Howley. Lipp incott‐Raven Publishers, Philadelphia 1996; 2231–2295
   Google Scholar
• Sassone‐Corsi P. Coupling gene expression to cAMP signalling: role of CREB and CREM. Int J Biochem Cell Biol 1998; 30: 27–38
   PubMed Web of Science ®Google Scholar
• Sawtell N M. Comprehensive quantification of herpes simplex virus latency at the single‐cell level. J Virol 1997; 71: 5423–5431
   PubMed Web of Science ®Google Scholar
• Sawtell N M. The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglion. J Virol 1998; 72: 6888–6892
   PubMed Web of Science ®Google Scholar
• Sawtell N M, Poon D K, Tansky C S, Thompson R L. The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation. J Virol 1998; 72: 5343–5350
   PubMed Web of Science ®Google Scholar
• Sawtell N M, Thompson R L. Herpes simplex virus type 1 latency‐associated transcription unit promotes anatomical site‐dependent establishment and reactivation from latency. J Virol 1992a; 66: 2157–2169
   Google Scholar
• Sawtell N M, Thompson R L. Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. J Virol 1992b; 66: 2150–2156
   PubMed Web of Science ®Google Scholar
• Schmidt D D, Zyzanski S, Ellner J, Kumar M L, Arno J. Stress as a precipitating factor in subjects with recurrent herpes labialis. J Fam Pract 1985; 20: 359–366
   PubMedGoogle Scholar
• Schreyer D J, Skene J H. Injury‐associated induction of GAP‐43 expression displays axon branch specificity in rat dorsal root ganglion neurons. J Neurobiol 1993; 24: 959–970
   PubMedGoogle Scholar
• Sears A E, Hukkanen V, Labow M A, Levine A J, Roizman B. Expression of the herpes simplex virus type 1 α transinducing factor (VP16) does not induce reactivation of latent virus or prevent the establishment of latency in mice. J Virol 1991; 65: 2929–2935
   PubMed Web of Science ®Google Scholar
• Sirito M, Lin Q, Deng J M, Behringer R R, Sawadogo M. Overlapp ing roles and asymmetrical cross‐regulation of the USF proteins in mice. Proc Natl Acad Sci USA 1998; 95: 3758–3763
   PubMedGoogle Scholar
• Sirito M, Lin Qu, Maity T, Sawadogo M. Ubiquitous expression of the 43‐ and 44‐kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res 1994; 22: 427–433
   PubMed Web of Science ®Google Scholar
• Slobedman B, Efstathiou S, Simmons A. Quantitative analysis of herpes simplex virus DNA and transcriptional activity in ganglia of mice latently infected with wild‐type and thymidine kinase‐deficient viral strains. J Gen Virol 1994; 75: 2469–2474
   Google Scholar
• Smith R L, Escudero J M, Wilcox C L. Regulation of the herpes simplex virus latency‐associated transcripts during establishment of latency in sensory neurons in vitro. Virology 1994; 202: 49–60
   Google Scholar
• Spear P G, Roizman B. Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion. J Virol 1972; 9: 143–159
   PubMed Web of Science ®Google Scholar
• Spivack J G, Fraser N W. Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J Virol 1987; 61: 3841–3847, [published erratum appears in J Virol 1988 Feb; 62(2):663]
   PubMed Web of Science ®Google Scholar
• Spivack J G, Fraser N W. Expression of herpes simplex virus type 1 latency‐associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. J Virol 1988; 62: 1479–1485
   PubMed Web of Science ®Google Scholar
• Spruance S L, Overall J C, Kern E R, Krueger G G, Pliam V, Miller W. The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. N Engl J Med 1977; 297: 69–75
   PubMed Web of Science ®Google Scholar
• Spurney R V, Rosenthal M S. Ultraviolet‐induced recurrent herpes simplex virus keratitis. Am J Ophthalmol 1972; 73: 609–610
   PubMed Web of Science ®Google Scholar
• Steiner I, Spivack J G, Lirette R P, Brown S M, MacLean A R, Subak‐Sharpe J H, Fraser N W. Herpes simplex virus type 1 latency‐associated transcripts are evidently not essential for latent infection. EMBO J 1989; 8: 505–511
   PubMed Web of Science ®Google Scholar
• Stevens J G, Newburn A B, Cook M L. Latent herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection. Nature (New Biology) 1972; 235: 216–217
   PubMedGoogle Scholar
• Stevens J G, Wagner E K, Devi‐Rao G B, Cook M L, Feldman L T. RNA complementary to a herpesvirus α gene mRNA is prominent in latently infected neurons. Science 1987; 235: 1056–1059
   PubMed Web of Science ®Google Scholar
• Tal‐Singer R, Lasner T M, Podrzucki W, Skokotas A, Leary J J, Berger S L, Fraser N W. Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J Virol 1997; 71: 5268–5276
   Google Scholar
• Talarnwiez W A, Martin C E, Pekosz A S, Madden S L, Rauscher F J, 3rd, Chiang S Y, Beorman T A, Fraser N W. Repression of the HSV‐1 latency‐associated transcript (LAT) promoter by the early growth response (EGR) proteins: involvement of a binding site immediately downstream of the TATA box. J Neurovirol 1997; 3: 212–224
   Google Scholar
• Tetzlaff V V, Kobayashi N R, Giehl K M, Tsui B J, Cassar S L, Bedard A M. Response of rubrospinal and corticospinal neurons to injury and neurotrophins. Prog Brain Bes 1994; 103: 271–286
   PubMed Web of Science ®Google Scholar
• Thomas S K, Cough G, Latchman D R, Coffin R S. Herpes simplex virus latency‐associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate‐early gene expression, and is likely to function during reactivation from virus latency. J Virol 1999; 73: 6618–0625
   Google Scholar
• Thompson R L, Sawtell N M. The herpes simplex virus typo 1 latency‐associated transcript gene regulates the establishment of latency. J Virol 1997; 71: 5432–5440
   PubMedGoogle Scholar
• Topp K S, Meade L B, La Vail J H. Microtubule polarity in the peripheral processes of trigeminal ganglion cells: relevance; for the retrograde transport of herpes simplex virus. J Neurosci 1994; 14: 318–325
   PubMed Web of Science ®Google Scholar
• Wagner E K, Flanagan W M, Devi‐Rao G, Zhang Y F, Hill J M, Anderson K P, Stevens I G. The herpes simplex virus latency‐associated transcript is spliced during the latent phase of infection. J Virol 1988; 62: 4577–4585
   PubMed Web of Science ®Google Scholar
• Walz M A, Price R W, Notkins A L. Latent ganglionic infection with herpes simplex virus types 1 and 2, viral reactivation in vivo after neurectomy. Science 1974; 184: 1185–1187
   PubMed Web of Science ®Google Scholar
• Woehsler S L, Nesburn A B, Zwaagstra J, Ghiasi H. Sequence of the latency‐related gene of herpes simplex virus type 1. Virology 1989; 168: 168–172
   Google Scholar
• Wheatley S C, Dent C L, Wood J N, Latchman D S. Elevation of cyclic AMP levels in cell lines derived from latently infectable sensory neurons increases their permissivity for herpes virus infection by activating the viral immediate‐early 1 gene promoter. Bruin Res Mol Brain Res 1992; 12: 149–154
   Google Scholar
• Wheatley S C, Kemp L M, Wood J N, Latchman D S. Cell lines derived from dorsal root ganglion neurons are nonpermissive for HSV and express only the latency‐associated transcript following infection. Exp Cell Res 1990; 190: 243–246
   PubMedGoogle Scholar
• Wu T T, Su Y H, Block T M, Taylor J M. Evidence that two latency‐associated transcripts of herpes simplex virus type 1 are nonlinear. J Virol 1996; 70: 5962–5967
   Google Scholar
• WuDunn D, Spear P G. Initial interaction of herpes simplex virus with cells is binding to heparan sulfate. J Virol 1989; 63: 52–58
   PubMed Web of Science ®Google Scholar
• Young S K, Rowe N H, Buchanon R A. A clinical study for the control of facial mucocutaneous herpes virus infections. 1. Characterization of natural history in a professional school population. Oral Surg Oval Med Oral Pathol 1976; 41: 498–507
   PubMedGoogle Scholar
• Zabolotny J M, Krummenaoher C, Eraser N W. The herpes simplex virus type 1 2.0‐kilobase latency‐associated transcript is a stable intron which branches at a guanosine. J Virol 1997; 71: 4199–4208
   PubMedGoogle Scholar
• Zachos G, Clements B, Conner J. Herpes simplex virus type 1 infection stimulates p38/c‐Jun N‐terminal mitogen‐activated protein kinase pathways and activates transcription factor AP.‐I. J Biol Chem 1999; 274: 5097–5103
   Google Scholar
• Zwaagstra J, Ghiasi H, Nesburn A B, Woehsler S L. In vitro promoter activity associated with the latency‐associated transcript gene of herpes simplex virus type I. J Gen Virol 1989; 70: 2163–2169
   PubMed Web of Science ®Google Scholar
• Zwaagstra J, Ghiasi H, Nesburn A B, Wechsler S L. Identification of a major regulatory sequence in the latency associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV‐1). Virology 1991; 182: 287–297
   Web of Science ®Google Scholar
• Zwaagstra J C, Ghiasi H, Slanina S M, Nesburn A M, Wheatley S C, Lillycrop K, Wood J, Latchman D S, Patel K, Wechsler S L. Activity of herpes simplex virus type 1 latency‐associated transcript (LAT) promoter in neuron‐derived cells: evidence for neuron specificity and for a large LAT transcript. J Virol 1990; 64: 5019–5028
   PubMedGoogle Scholar