Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/ Rex-coding sequence

References

• Elovaara I, Koenig S, Brewah A Y, Woods R M, Lehky T, Jacobson S. High human T cell lymphotropic virus type 1 (HTLV-l)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease. J Exp Med 1993; 117: 1567–1573
   Google Scholar
• Felber B K, Paskalis H, Kleinman-Ewing C, Wong-Staal F, Pavlakis G N. The pX protein of HTLV-1 is a transcriptional activator of its long terminal repeats. Science 1985; 229: 675–679
   PubMed Web of Science ®Google Scholar
• Fujisawa J, Seiki M, Kiyokawa K, Yoshida M. Functional activation of the long terminal repeat of human T-cell leukemia virus type 1 by a trans-acting factor. Proc Natl Acad Sci USA 1985; 82: 2277–2281
   PubMed Web of Science ®Google Scholar
• Fujisawa J, Seiki M, Sato M, Yoshida M. A transcriptional enhancer of HTLV-1 is responsible for trans-activation mediated by p40x of HTLV-1. EMBO J 1986; 5: 713–718
   PubMedGoogle Scholar
• Gessain A, Barin F, Vernant J C, Gout O, Maurs L, Calende A, de The G. Antibodies to human T-lymphotropic virus type-1 in patients with tropical spastic paraparesis. Lancet 1985; ii: 1247–1248
   Google Scholar
• Gessain A, Gallo R C, Franchini G. Low degree of human T-cell leukemia/lymphoma virus type 1 genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations. J Virol 1992; 66: 2288–2295
   PubMed Web of Science ®Google Scholar
• Hinuma Y, Nagata K, Misaka M, Nakai M, Matsumoto T, Kinoshita K, Shirakawa S, Miyoshi I. Adult T cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981; 78: 6476–6480
   PubMed Web of Science ®Google Scholar
• Inoue J, Yoshida M, Seiki M. Transcriptional (p40x) and posttranscriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type 1 genes. Proc Natl Acad Sci USA 1987; 84: 3653–3657
   PubMed Web of Science ®Google Scholar
• Jacobson S, Shida H, McFarlin D E, Fauci A S, Koenig S. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-1 pX in patients with HTLV-1 associated neurological disease. Nature 1990; 348: 245–248
   PubMed Web of Science ®Google Scholar
• Kannagi M, Shida H, Igarashi H, Kuruma K, Murai H, Aono Y, Maruyama I, Osame M, Hattori T, Inoko H, Harada S. Target epitope in the Tax protein of human T-cell leukemia virus type-1 recognized by class I major histocompatibility complex-restricted cytotoxic T cells. J Virol 1992; 66: 2928–2933
   PubMedGoogle Scholar
• Kira J, Koyanagi Y, Yamada T, Itoyama Y, Tateishi J, Akizuki S, Kishikawa M, Baba E, Nakamura M, Suzuki J, Nakamura T, Nakamura N, Yamamoto N, Goto I. Sequence heterogeneity of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy. Ann Neurol 1994; 36: 149–156
   Google Scholar
• Kiyokawa T, Seiki M, Iwashita S, Imagawa K, Shimizu F, Yoshida M. Association of die pX gene product of human T-cell leukemia virus type-1 with nucleus. Virology 1985; 147: 462–465
   PubMedGoogle Scholar
• Maniatis T, Fritsch E F, Sambrook J. Molecular cloning. A laboratory manual Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. 1982
   Google Scholar
• Mochizuki M, Watanabe T, Yamaguchi K, Yoshimura K, Nakashima S, Shirao M, Araki S, Takatsuki K, Mori S, Miyata N. Uveitis associated with human T-cell lymphotropic virus type I. Am J Opthalmol 1992; 114: 123–128
   PubMed Web of Science ®Google Scholar
• Nagashima K, Yoshida M, Seiki M. A single species of pX mRNA of human T-cell leukemia virus type 1 encodes trans-activator p40x and two other phosphoproteins. J Virol 1986; 60: 394–399
   PubMed Web of Science ®Google Scholar
• Niewiesk S, Daenke S, Parker C E, Taylor G, Weber J, Nightingale S, Bangham C RM. The trans-activator gene of human T-cell leukemia virus type-1 is more variable within and between healthy carriers than patients with tropical spastic paraparesis. J Virol 1994; 68: 6778–6781
   Google Scholar
• Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M. HTLV-I associated myelopathy, a new clinical entity. Lancet 1986; i: 1031–1032
   Google Scholar
• Parker E P, Nightingale S, Taylor G P, Weber J, Bangham C RM. Circulating anti-Tax cytotoxic Tlymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. J Virol 1994; 68: 2860–2868
   Google Scholar
• Paskalis H, Felber B K, Pavlakis G N. Cis-acting sequences responsible for the transcriptional activation of a human T-cell leukemia virus type I constitute a conditional enhancer. Proc Natl Acad Sci USA 1986; 83: 6558–6562
   PubMedGoogle Scholar
• Poiesz B J, Ruscetti R W, Gazdar A F, Bunn P A, Minna J D, Gallo R C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T cell lymphoma. Proc Natl Acad Sci USA 1980; 77: 7415–7419
   PubMed Web of Science ®Google Scholar
• Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M. Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients, but is not specifically associated with the central nervous system lesions. J Neurovirol 1995; 1: 286–294
   Web of Science ®Google Scholar
• Seiki M, Hattori S, Hirayama Y, Yoshida M. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA 1983; 80: 3618–3622
   PubMed Web of Science ®Google Scholar
• Seiki M, Inoue J I, Takeda T, Yoshida M. Direct evidence that p40x of human T-cell leukemia virus type I is a trans-activating transcriptional activator. EMBO J 1986; 5: 561–565
   PubMed Web of Science ®Google Scholar
• Shimotohno K, Takano M, Teruuchi T, Miwa M. Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription. Proc. Natl Acad Sci USA 1986; 83: 8112–8116
   PubMed Web of Science ®Google Scholar
• Shirabe S, Nakamura T, Tsujihata M, Nagataki S, Seiki M, Yoshida M. Retrovirus from human T-cell leukemia virus type 1-associated myelopathy is the same strain as a prototype human T-cell leukemia virus type 1. Arch Neurol 1990; 47: 1258–1260
   PubMedGoogle Scholar
• Sodroski J G, Rosen C A, Haseltine W A. Transacting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science 1984; 225: 381–385
   PubMed Web of Science ®Google Scholar
• Toyoshima H, Itoh M, Inoue J, Seiki M, Takaku F, Yoshida M. Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and transport of unspliced RNAs. J Virol 1990; 64: 2825–2832
   PubMedGoogle Scholar
• Tsujimoto A, Teruuchi T, Imamura J, Shimotohno K, Miyoshi I, Miwa M. Nucleotide sequence analysis of a provirus derived from HTLV-1-associated myelopathy (HAM). Mol Biol Med 1988; 5: 29–42
   PubMedGoogle Scholar
• Umehara F, Izumo S, Nakagawa M, Ronquillo A T, Takahashi K, Matsumuro K, Sato E, Osame M. Immunocytochemical analysis of die infiltrate in the spinal cord lesions in HTLV-1-associated myelopadiy. J Neuropathol Exp Neurol 1993; 52: 424–430
   Google Scholar
• Yoshida M, Miyoshi I, Hinuma Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 1982; 79: 2031–2035
   PubMed Web of Science ®Google Scholar
• Yoshida M, Seiki M, Yamaguchi K, Takatsuki K. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in disease. Proc. Natl Acad Sci USA 1984; 81: 2534–2537
   PubMed Web of Science ®Google Scholar
• Yoshida M, Seiki M. Recent advances in molecular biology of HTLV-1. Annu Rev Immunol 1987; 5: 541–559
   PubMed Web of Science ®Google Scholar