Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia

Reference

• Adamson D. C., Dawson T. M., Zink M. C., Clements J. E., Dawson V. L. Neurovimlent simian immunodeficiency virus infection induces neuronal, endothelial, and glial apoptosis. Mol Med 1996; 2: 417–428
   PubMed Web of Science ®Google Scholar
• Adie-Biassette H., Levy Y., Colombel M., Poron F., Natcher S., Keohane C., Gray F. Neuronal apoptosis in HIV infection in adults. Neuropath and Appi Neuro-biol 1995; 21: 218–227
   Google Scholar
• An S. F., Giometto B., Scaravilli T., Tavolato B., Gray F., Scaravilli F. Programmed cell death in brains of HIV-1 positive AIDS and pre-AIDS patients. Acta Neuropathol 1996; 91: 169–173
   Google Scholar
• Bagasra O., Lavi E., Bobroski L., Khalili K., Pestaner J. P., Tawadros R., Pomerantz R. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohisto-chemistry. AIDS 1996; 10: 573–585
   PubMed Web of Science ®Google Scholar
• Beal M. F. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995; 38: 357–366
   PubMed Web of Science ®Google Scholar
• Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., Lipton S. A. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proa Natl Acad Sci USA 1995; 92: 7162–7166
   Google Scholar
• Brew B. J., Rosenblum M., Cronin K., Price R. W. AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations. Ann Neurol 1995; 38: 563–570
   PubMed Web of Science ®Google Scholar
• Busciglio J. B., Yankner B. A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 1995; 378: 776–779
   PubMed Web of Science ®Google Scholar
• Busciglio J., Yeh J., Yankner B. A. β5-amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. J Neurochem 1993; 61: 1565–1668
   PubMedGoogle Scholar
• Castagna A., Le Grazie C., Accordini A., Gulidori P., Cavalli G., Bottiglieri T., Lazzarin A. Cerebrospinal fluid S-adenosyl-methionine (SAMe) and glutathione concentrations in HIV infection: Effect of parenteral treatment with SAMe. Neurology 1995; 45: 1678–1683
   PubMed Web of Science ®Google Scholar
• Chang H-K, Gallo R. C., Ensoli B. Regulation of cellular gene expression and function by the human immunodeficiency virus Type 1 Tat protein. Biomed Sci 1995; 2: 189–202
   Google Scholar
• Chen P., Mayne M., Nath A. The Tat protein of HIV-1 induces tumor necrosis factor-a production: implications for HIV-1-associated neurological diseases. J Biol Chem 1997; 272: 22385–22388
   PubMed Web of Science ®Google Scholar
• Coyle J. T., Puttfarcken P. Oxidative stress, gluta-mate, and neurodegenerative disorders. Science 1993; 262: 689–695
   PubMed Web of Science ®Google Scholar
• Dugan L. L., Choi D. W. Excitotoxicity, tree radicals, and cell membrane changes. Ann Neurol 1994; 35: S17–S21
   PubMed Web of Science ®Google Scholar
• Ehret A., Westendorp M. O., Herr I., Debatin K-M, Heeney J. L., Frank R., Krammer P. H. Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis. Virol 1996; 70: 6502–6507
   Google Scholar
• Epstein L. G., Gendelman H. E. Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann Neurol 1993; 33: 429–430
   PubMed Web of Science ®Google Scholar
• Fine S. M., Angel R. A., Perry S. W., Epstein L. G., Rothstein J. D., Dewhurst S., Gelbard H. A. Tumor necrosis factor a inhibits glutamate uptake by primary human astrocytes. J Biol Chem 1996; 271: 15303–15306
   PubMed Web of Science ®Google Scholar
• Gabuzda D. H., Ho D. D., De La Monte S. M., Rota T. R. Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann Neurol, 20: 289–295
   Google Scholar
• Genis P., Jett M., Bernton E. W., Boyle T., Gelbard H. A., Dzenki K., Keane R. W., Resnick L., Mizrachi Y., Volsky D. J., Epstein L. G., Gendelman H. E. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HlV)-infected macrophage-astroglia interactions: Implications for the neuropathogenesis of HIV disease. Exp Med 1992; 176: 1703–1718
   Google Scholar
• Gelbard H. A., Dzenko K. A., Diloreto D., Del Cerro C., Del Cerro M., Epstein L. G. Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: Implication for AIDS neuropathogenesis. Dev Neurosci 1993; 15: 417–422
   PubMed Web of Science ®Google Scholar
• Gelbard H. A., James H. J., Sharer L. R., Perry S. W., Saito Y., Kazee A. M., Blumberg B. M., Epstein L. M. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropath and Appl Neurobiol 1995; 21: 208–217
   PubMed Web of Science ®Google Scholar
• Giulian D., Yu J., Li X., Tom D., Li J., Wendt E., Lin S. N., Schwarcz R., Noonan C. Study of receptor-mediated neurotoxins released by HIV-1-infected mononuclear phagocytes found in human brain. Neuroscience 1996; 16: 3139–3153
   Google Scholar
• Glass J. D., Wesselingh S. L., Seines O. A., Mcarthur J. C. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 1993; 43: 2230–2237
   PubMedGoogle Scholar
• Greenlund U. S., Deckwerth T. L., Johnson E. M. Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 1995; 14: 303–315
   PubMed Web of Science ®Google Scholar
• Hayman M., Arburhnott G., Harkiss G., Brace H., Filippi P., Philippon V., Thomson D., Vigne R., Wright A. Neurotoxicity of peptide analogues of the transactivat-ing protein tat from maedi-visna virus and human immunodeficiency virus. Neuroscience 1993; 53: 1–6
   PubMed Web of Science ®Google Scholar
• Kane E. J., Sarafian T. A., Anton R., Hahn R., Gralla E. B., Valentine J. S., Ord T., Bredeson D. E. Bcl-2 inhibition by neural death: decreased generation of reactive oxygen species. Science 1993; 262: 1274–1277
   PubMed Web of Science ®Google Scholar
• Ketzier S., Weis S., Haug H., Budika H. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol 1990; 80: 92–94
   Google Scholar
• Krajewski S., James H. J., Ross J., Biumberg B. M., Epstein L. G., Gendelman H. G., Gummuluru S., Dewhurst S., Sharer L. R., Reed J. C., Gelbard H. A. Expression of pro-and anti-apoptosis gene products in brain from paediatric patients with HIV-1 encephalitis. Neuropath and Appl Neurobiol 1997; 23: 242–253
   Google Scholar
• Kure K., Llena J. F., Lyman W. D. Human immunodeficiency virus-1 infection of the nervous system: an autopsy study of 268 adult, pediatric, and fetal brains. Hum Pathol 1991; 22: 700–710
   PubMed Web of Science ®Google Scholar
• Li C. J., Friedman D. J., Wang C., Metelev V., Pardee A. B. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 1995; 268: 429–431
   PubMed Web of Science ®Google Scholar
• Lipton S. A., Gendelman H. E. Dementia associated with the acquired immuno-deficiency syndrome. N Engl J Med 1995; 332: 934–940
   PubMed Web of Science ®Google Scholar
• Ma M., Nath A. Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. Virol 1997; 71: 2495–2499
   Google Scholar
• Magnuson DSK, Knudsen B. E., Geiger J. D., Brownstone R. M., Nath A. Human immunodeficiency virus type 1 Tat activates non-N-methyl-D-asparate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995; 37: 373–380
   PubMed Web of Science ®Google Scholar
• Masliah E., Achim C. L., Ge N., Deteresa R., Terry R. D., Wiley C. A. Spectrum of human immunodeficiency virus-associated neocortical damage. Ann Neurol 1992; 32: 321–329
   PubMed Web of Science ®Google Scholar
• Mccloskey T. W., Ott M., Tribble Eu, Khan S. A., Teichberg S., Paul M. O., Pahwa S., Verdin E., Chirmule N. Dual role of HIV Tat in regulation of apoptosis in T cells. J Immunol 1997; 158: 1014–1019
   PubMed Web of Science ®Google Scholar
• MÜLler W., Schroder H. C., Ushjima H., Dapper J., Bormann J. gpl20 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine. Eur J Pharm 1992; 226: 209–214
   PubMed Web of Science ®Google Scholar
• Nath A., Psooy K., Martin C., Knudsen B., Magnuson D.S.K, Haughey N., Geiger J. D. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. Virol 1996; 70: 1475–1480
   Google Scholar
• Navia B., Cho E. S., Petito C. K., Price R. W. The AIDS dementia complex. II. Neuropathology. Ann Neurol 1986; 19: 525–535
   PubMed Web of Science ®Google Scholar
• New D. R., Ma M., Epstein L. G., Nath A., Gelbard H. A. Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures. Neurovirology 1997; 3: 168–173
   PubMed Web of Science ®Google Scholar
• Nuovo G. J., Alfieri M. L. AIDS dementia is associated with massive, activated HIV-1 infection and concomitant expression of several cytokines. Molec Med 1996; 2: 358–366
   PubMed Web of Science ®Google Scholar
• Persidsky Y., Limoges J., Mccomb R., Bock P., Baldwin T., Tyor W., Patil A., Nottet H. S., Epstein L., Gelbard H., Flanagan E., Reinhard J., Pirruccello S. J., Gendelman H. E. Human immunodeficiency virus encephalitis in SCID mice. Am J Pathol 1996; 149: 1027–1053
   Google Scholar
• Petito C. K., Roberts B. Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 1995; 146: 1121–1130
   PubMed Web of Science ®Google Scholar
• Philippon V., Vellutini C., Gambarelli D., Harkiss G., Arbuthnott G., Metzger D., Roubin R., Filippi P. The basic domain of the lentiviral Tat protein is responsible for damages in mouse brain: Involvement of cytokines. Virology 1994; 205: 519–529
   PubMed Web of Science ®Google Scholar
• Price R. W. Neurological complications of HIV infection. Lancet 1996; 348: 445–452
   PubMed Web of Science ®Google Scholar
• Purvis S. F., Jacobberger J.M.I, Sramikoski R. M., Patki A. H., Lederman M. M. HIV type 1 Tat protein induces apoptosis and death in Jurkat cells. AIDS Res Hum Retro 1995; 11: 443–450
   PubMed Web of Science ®Google Scholar
• Sabatier J. M., Vives E., Mabrouk K., Benjouad A., Rochat H., Duval A., Hue B., Bahraou E. Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. Virol 1991; 65: 961–967
   Google Scholar
• Shi B., De Girolami U., He J., Wang S., Lorenzo A., Busciglio J., Gabuzda D. Apoptosis induced by HIV-1 infection of the central nervous system. Clin Invest 1996; 98: 1979–1990
   Google Scholar
• Takahashi K., Wesselingh S. L., Griffin D. E., Mcarthur J. E., Johnson R. T., Glass J. D. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann Neurol 1996; 39: 705–711
   PubMed Web of Science ®Google Scholar
• Talley A. K., Dewhurst S., Perry S. W., Dollard S. C., Gummu-Luru S., Fine S. M., New D., Epstein L. G., Gendelman H. E., Gelbard H. A. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by an antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Mol Cell Biol 1995; 15: 2359–2366
   Google Scholar
• Tyor W.I.R, Glass J., Griffin J.M.I, Becker P., Mcarthur J. C., Bezman L., Griffin D. E. Cytokine expression in the brain during AIDS. Ann Neurol 1992; 31: 349–360
   PubMed Web of Science ®Google Scholar
• Vallat A. V., De Girolami U., He J., Washilkar A., Marasco W., Shi B., Gray F., Bell J., Keohane Q, Smith T. W., Gabuzda D. Localization of HIV-1 coreceptors CCR5 and CXCR4 in the brain of children with AIDS. Am J Pathol 1998; 152: 167–178
   PubMed Web of Science ®Google Scholar
• Weeks B. S., Lieberman D. M., Johnson B., Roque E., Green M., Loewenstein P., Oldfield E. H., Kleinman H. K. Neurotoxicity of the human immunodeficiency virus type 1 Tat transactivator to PC12 cells requires the Tat amino acid 49–58 basic domain. Neuroscience Res 1995; 42: 34–40
   Google Scholar
• Wesselingh S. L., Power C., Glass J. D., Tyor W. R., Mcarthur J. C., Farber J. M., Griffin J. W., Griffin D. E. Intracerebral cytokine messenger RNA expression in AIDS dementia. Ann Neurol 1993; 33: 576–582
   PubMedGoogle Scholar
• Westendorp M. O., Frank R., Ochsenbauer C., Strieker K., Dhein J., Waiczak H., Debatin K-M, Kiammer P. H. Sentitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gpl20. Nature 1995a; 375: 497–500
   PubMed Web of Science ®Google Scholar
• Westendorp M. O., Shatrov V. A., Schuize-Osthoff K., Frank R., Kraft M., Los M., Krammer P. H., Droge W., Lehmann V. HIV-1 Tat potentiates TNF-induced NF-kB activation and cytotoxicity by altering the cellular redox state. EMBO J 1995b; 14: 546–554
   PubMed Web of Science ®Google Scholar
• Wiley C. A., Masliah E., Morey M., Lemere C., Deteresa R., Grafe M., Hausen L., Terry R. Neocortical damage during HIV infection. Ann Neurol 1991; 29: 651–657
   PubMed Web of Science ®Google Scholar