4
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Transgenic expression of interleukin-6 in the central nervous system confers protection against acute herpes simplex virus type-1 infection

&
Pages 449-457 | Received 27 Jan 1999, Accepted 03 May 1999, Published online: 10 Jul 2009

References

  • Bencsik A, Malcus C, Akaoka H, Giraudon P, Belin M-F, Bernard A. Selective induction of cytokines in mouse brain infected with canine distemper virus: structural, cellular, and temporal expression. J Neuroimmunol 1996; 65: 1–9
  • Benveniste E N. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am J Physiol 1992; 263: C1–C16
  • Benveniste E N. Cytokines: Influence on glial cell gene expression and function. Chem Immunol 1997; 69: 31–75
  • Bouley D M, Kanangat S, Wire W, Rouse B T. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-γ knockout mice. J Immunol 1995; 155: 3964–3971
  • Campbell I L, Abraham C R, Masliah E, Kemper P, Inglis J D, Oldstone M BA, Mucke L. Neurologic disease induced in transgenic mice by cerebral over expression of interleukin 6. Proc Natl Acad Sci USA 1993; 90: 10061–10065
  • Campbell I L, Stadler A, Chiang C-S, Bellinger R, Heyser C J, Steffensen S, Masliah E, Powell H C, Gold L H, Hendricks S J, Siggins G R. Transgenic models to assess the pathogenic actions of cytokines in the central nervous system. Mol Psych 1997; 2: 125–129
  • Cantin E M, Hinton D R, Chen J, Openshaw H. Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J Virol 1995; 69: 4898–4905
  • Carr D JJ, Veress L A, Noisakran S, Campbell I L. Astrocyte targeted expression of interferon-α1 protects mice from acute ocular herpes simplex virus type 1 infection. J Immunol 1998; 161: 4859–4865
  • Carr J A, Rogerson J, Mulqueen M J, Roberts N A, Booth R FG. Interleukin-12 exhibits potent antiviral activity in experimental herpesvirus infections. J Virol 1997; 71: 7799–7803
  • Gijbels K, Van Damme J, Proost P, Put W, Carton H, Billiau A. Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis. Eur J Immunol 1990; 20: 233–235
  • Greene A L, Makrigiannis A P, Fitzpatrick L, Hoskin D W. Anti-CD3-activated major histocompatibility complex-unrestricted cytotoxicity and the expression of genes coding for cytotoxic effector molecules. J IFN Cytokine Res 1997; 17: 727–737
  • Halford W P, Gebhardt B M, Carr D JJ. Persistent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus type 1. J Immunol 1996; 157: 3542–3549
  • Halford W P, Veress L A, Gebhardt B M, Carr D JJ. Immunization with HSV-1 antigen rapidly protects against HSV-1-induced encephalitis and is IFN-γ independent. J IFN Cytokine Res 1998; 18: 151–158
  • Halford W P, Veress L A, Gebhardt B M, Carr D JJ. Innate and acquired immunity to herpes simplex virus type 1. Virology 1997; 236: 328–337
  • Hendricks R L, Weber P C, Taylor J L, Koumbis A, Tumpey T M, Glorioso J C. Endogenously produced interferon α protects mice from herpes simplex virus type 1 corneal disease. J Gen Virol 1991; 72: 1601–1610
  • Heyser C J, Masliah E, Samini A, Campbell I L, Gold L H. Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc Natl Acad Sci USA 1997; 94: 1500–1505
  • Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Masuda T, Kashiwamamura S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce Ig. Nature 1986; 324: 73–76
  • Hirota H, Kiyama H, Kishimoto T, Taga T. Accelerated nerve regeneration in mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. J Exp Med 1996; 183: 2627–2634
  • Humphrey M F, Chu Y, Mann K, Rakoczy P. Retinal GFAP and bFGF expression after multiple argon laser photocoagulation injuries assessed by both immunoreactivity and mRNA levels. Exp Eye Res 1997; 64: 361–369
  • Kanangat S, Thomas J, Gangappa S, Babu J S, Rouse B T. Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. J Immunol 1996a; 156: 1110–1116
  • Kanangat S, Babu J S, Knipe D M, Rouse B T. HSV-1-mediated modulation of cytokine gene expression in a permissive cell line: Selective upregulation of IL-6 gene expression. Virology 1996b; 219: 295–300
  • Kriesel J D, Gebhardt B M, Hill J M, Maulden S A, Hwang I P, Clinch T E, Cao X, Spruance S L, Araneo B A. Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation. J Infect Dis 1997a; 175: 821–827
  • Kriesel J D, Ricigliano J, Spruance S L, Garza H H, Jr, Hill J M. Neuronal reactivation of herpes simplex virus involves interleukin-6. J Neurovirology 1997b; 3: 441–448
  • Larsen D L, Dybdahl-Sissoko N, McGregor M W, Drape R, Neumann V, Swain W F, Lunn D P, Olsen C W. Coadministration of DNA encoding interleukin-6 and hemagglutinin confers protection from influenza virus challenge in mice. J Virol 1998; 72: 1704–1708
  • Lewandowski G, Hobbs M V, Bloom F E. Alteration of intracerebral cytokine production in mice infected with herpes simplex virus type 1 and 2. J Neuroimmunol 1994; 55: 23–34
  • Lieberman A P, Pitha P M, Shin H S, Shin M L. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc Natl Acad Sci USA 1989; 86: 6348–6352
  • Liu T, Tang Q, Hendricks R L. Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. J Virol 1996; 70: 264–271
  • Lyson K, McCann S M. The effect of interleukin-6 on pituitary hormone release in vivo and in vitro. Neuroendocrinol 1991; 54: 262–266
  • Montgomery R I, Warner M S, Lum B J, Spear P G. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 1996; 87: 427–436
  • Noisakran S, Halford W P, Veress L, Carr D JJ. The role of the hypothalamic pituitary adrenal axis and IL-6 in stress-induced reactivation of latent HSV-1. J Immunol 1998; 160: 5441–5447
  • Ozmen L, Aguet M, Trinchieri G, Garotta G. The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon. J Virol 1995; 69: 8147–8150
  • Raber J, O'Shea R D, Bloom F E, Campbell I L. Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice. J Neurosci 1997; 17: 9473–9480
  • Renauld J-C, Vink A, Van Snick J. Accessory signals in murine cytolytic T cell responses. J Immunol 1989; 143: 1894–1898
  • Riol H, Tardy M, Rolland B, Levesque G, Murthy M R. Detection of the peripheral nervous system (PNS)-type glial fibrillary acidic protein (GFAP) and its mRNA in human lymphocytes. J Neurosci Res 1997; 48: 53–62
  • Staats H F, Lausch R N. Cytokine expression in vivo during murine herpetic stromal keratitis. J Immunol 1993; 151: 277–283
  • Su Y-H, Yan X-T, Oakes J E, Lausch R N. Protective antibody therapy is associated with reduced chemokine transcripts in herpes simplex virus type 1 corneal infection. J Virol 1996; 70: 1277–1281
  • Tal-Singer R, Lasner T M, Podrzucki W, Skokotas A, Leary J J, Berger S L, Fraser N W. Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J Virol 1997; 71: 5268–5276
  • Walev I, Podlech J, Falke D. Enhancement by TNF-α of reactivation and replication of latent herpes simplex virus from trigeminal ganglia of mice. Arch Virol 1995; 140: 987–992

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.