Measuring HIV-1 RNA and interferon-α in the cerebrospinal fluid of AIDS patients: insights into the pathogenesis of AIDS Dementia Complex

References

• Akwa Y, Hassett D E, Eloranta M L, Sandberg K, Masliah E, Powell H C, Whitton J L, Bloom F E, Campbell I L. Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration. J Immunol 1998; 161: 5016–5026
   PubMed Web of Science ®Google Scholar
• Bencherif B, Rottenberg D A. Neuroimaging of the AIDS dementia complex. AIDS 1998; 12: 233–244
   PubMed Web of Science ®Google Scholar
• Brew B J, Rosenblum M, Cronin K, Price R W. AIDS dementia complex and HFV-1 brain infection: clinical virological correlations. Ann Neurol 1995; 38: 563–570
   PubMed Web of Science ®Google Scholar
• Brew B J, Dunbar N, Pemberton L, Kaldor J. Predictive markers of ADC; CD4 cell count and CSF concentrations of β2-microglobulin and neopterin. J Infect Dis 1996; 174: 294–298
   PubMed Web of Science ®Google Scholar
• Brew B J, Pemberton L, Cunningham P, Law M G. Levels of HIV-1 RNA in cerebrospinal fluid correlates with AIDS dementia stage. J Infect Dis 1997; 175: 963–966
   PubMed Web of Science ®Google Scholar
• Brinkman K, Kroon F, Hugen P W, Burger D M. Therapeutic concentrations of indinavir in cerebro-spinal fluid of HIV-1-infected patients. AIDS 1998; 12: 537
   Google Scholar
• Cinque P, Vago L, Ceresa D, Mainini F, Terreni M R, Vagani A, Torri W, Bossolasco S, Lazzarin A. Cerebrospinal fluid HIV-1 RNA levels: correlation with HIV encephalitis. AIDS 1998; 12: 389–394
   PubMed Web of Science ®Google Scholar
• Dal Pan G J, McArthur J H, Aylward E, Seines O A, Nance-Sproson T E, Kumar A J, Melits E D, McArthur J C. Patterns of cerebral atrophy in HIV-1 infected individuals: Results of a quantitative MRI analysis. Neurology 1992; 42: 2125–2130
   PubMed Web of Science ®Google Scholar
• Di Stefano M, Monno L, Fiore J L, Angarano G. In vivo evidence for HIV-1 productive infection in cerebrospinal fluid of patients with HIV-1 encephalitis. AIDS 1997; 11: 133–135
   Google Scholar
• Ellis R J, Spector S A, Nelson J A, Heaton R K, Wallace M, Abramson I, Atkinson H, Grant I, McCutchan A, The HIV Neurobehavioral research center group. Cerebrospinal fluid HIV-1 RNA levels are elevated in neurocognitively impaired individuals with AIDS. Ann Neurol 1997; 42: 679–688
   PubMed Web of Science ®Google Scholar
• Epstein L G, Gendelman H E. HIV-1 infection of the nervous system: pathogenetic mechanisms. Ann Neurol 1993; 33: 429–436
   PubMed Web of Science ®Google Scholar
• Flexner C. HIV-Protease inhibitors. New Engl J Med 1998; 338: 1281–1292
   PubMed Web of Science ®Google Scholar
• Gendelman H E, Baca L M, Kubrac C A, Genis P, Burrous S, Friedman R M, Jacobs D, Meltzer M S. Induction of IFN-α in peripheral blood mononuclear cells by HIV-infected monocytes. J Immunol 1992; 148: 422–429
   Google Scholar
• Goutiàres F, Aicardi J, Barth P G, Lebon P. Aicardi-Goutières syndrome: an update and results of α-interferon studies. Ann Neurol 1998; 44: 900–907
   Google Scholar
• Griffin D E, McArthur J C, Cornblath D R. Neopterin and interferon-gamma in serum and CSF of patients with HIV-associated neurologic disease. Neurology 1991; 41: 69–74
   PubMed Web of Science ®Google Scholar
• Gutterman J U. Cytokine therapeutics: lessons from interferon a. Proc. Natl. Acad. Sci. USA 1994; 91: 1198–1205
   PubMed Web of Science ®Google Scholar
• Heyes M P, Brew B J, Martin A, Price R W, Salazar A M, Sidtis J J, Yergey J A, Mouradian M M, Sadler A E, Keilp J, Rubinow D, Markey S P. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol 1991; 29: 202–209
   PubMed Web of Science ®Google Scholar
• Kieburtz K, Ketonen L, Cox C, Grossman H, Holloway R, Booth H, Hickey C, Feigin A, Caine E D. Cognitive performance and regional brain volume in HIV-1 infection. Arch Neurol 1996; 53: 155–158
   PubMed Web of Science ®Google Scholar
• Lebon P, Badoual J, Ponsot G, Goutiàres F, Hémeury-Cukier F, Aicardi J. Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy. J Neurol Sci 1988; 84: 201–208
   PubMed Web of Science ®Google Scholar
• McArthur J C, Nance-Sproson N S, Griffin D E, Hoover D, Seines O A, Miller E N, Margolick J B, Cohen B A, Farzadegan H, Saah A, for the multicenter AIDS cohort study. The diagnostic utility of elevation in CSF β2-microglobulin in HIV-1 dementia. Neurology 1992; 42: 1707–1712
   PubMed Web of Science ®Google Scholar
• McArthur J C, McClernon D R, Cronin M F, Nance-Sproson T E, Saah A J, St Clair M, Lanier E R. Relationship between HIV-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol 1997; 42: 689–698
   PubMed Web of Science ®Google Scholar
• Morris L, Silber E, Sonnenberg P, Eintracht S, Nyoka S, Lyons S F, Saffer D, Koornhof H, Martin D J. High HIV-1 RNA load in the cerebrospinal fluid from patients with lymphocytic meningitis. J Infect Dis 1998; 177: 473–476
   Google Scholar
• Navia B A, Jordan B D, Price R W. The AIDS Dementia complex: Clinical features. Ann Neurol 1986; 19: 517–524
   PubMed Web of Science ®Google Scholar
• Price R W, Brew B, Sidtis J, Rosenblum M, Scheck A C, Cleary P. The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex. Science 1988; 239: 586–592
   PubMed Web of Science ®Google Scholar
• Rho M B, Wesselingh S, Glass J D, McArthur J C, Choi S, Griffin J, Tyor W R. A potential role for interferon alpha in the pathogenesis of HIV-associated dementia. Brain Behav Immunol 1995; 9: 366–377
   PubMed Web of Science ®Google Scholar
• Robertson K, Fiscus S, Kapoor C, Robertson W, Schneider G, Shepard R, Howe L, Silva S, Hall C. CSF, plasma viral load and HIV associated dementia. J Neurovirol 1998; 4: 90–94
   Web of Science ®Google Scholar
• Rohatiner A ZS, Prior P F, Burton A C, Smith A T, Balkwill F R, Lister T A. Central nervous system toxicity of interferon. Br J Cancer 1983; 47: 419–422
   PubMed Web of Science ®Google Scholar
• Rozenberg F, Lebon P. Amplification and characterizatioan of herpes virus DNA in cerebrospinal fluid from patients with acute encephalitis. J Clin Microbiol 1991; 29: 2412–2417
   PubMed Web of Science ®Google Scholar
• Sidtis J J, Price R W. Early HIV-1 infection and the AIDS dementia complex. Neurology 1990; 40: 323–326
   PubMed Web of Science ®Google Scholar
• Simpson D M, Tagliati M. Neurologic manifestations of HIV infection. Ann Intern Med 1994; 121: 769–785
   PubMed Web of Science ®Google Scholar
• Stellbrink H J, Eggers C, van Lunzen J, Albrecht H, Greten H. Rapid decay of HIV RNA in the cerebrospinal fluid during antiretroviral combination therapy. AIDS 1997; 11: 1655–1657
   Google Scholar
• Valentine A D, Meyers C A, Kling M A, Richelson E, Hauser P. Mood and cognitive side effects of interferon-alpha therapy. Semin Oncol 1998; 25: 39–47
   PubMed Web of Science ®Google Scholar
• Von Sydow M, Sönnenberg A, Gaines H, Strannegard ö. Interferon-alpha and tumor necrosis factor alpha in serum of patients in various stages of HIV-1 infection. AIDS Res Hum Retroviruses 1991; 7: 375–380
   PubMed Web of Science ®Google Scholar