Plant-derived alternative treatments for the aging male: facts and myths

References

• Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321–333.
   PubMed Web of Science ®Google Scholar
• Adlercreutz H. Phyto-oestrogens and cancer. Lancet Oncol 2002;3:364–373.
   PubMed Web of Science ®Google Scholar
• Munro IC, Harwood M, Hlywka JJ, Stephen AM, Doull J, Flamm WG, Adlercreutz H. Soy isoflavones: a safety review. Nutr Rev 2003;61:1–33.
   PubMed Web of Science ®Google Scholar
• Mueller SO, Simon S, Chae K, Metzler M, Korach KS. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol Sci 2004;80:14–25.
   PubMed Web of Science ®Google Scholar
• Lamartiniere CA. Timing of exposure and mammary cancer risk. J Mammary Gland Biol Neoplasia 2002;7:67–76.
   PubMed Web of Science ®Google Scholar
• Rowell C, Carpenter DM, Lamartiniere CA. Chemoprevention of breast cancer, proteomic discovery of genistein action in the rat mammary gland. J Nutr 2005;135:2953S–2959S.
   PubMed Web of Science ®Google Scholar
• Ziegler RG, Hoover RN, Pike MC, Hildesheim A, Nomura AM, West DW, Wu-Williams AH, Kolonel LN, Horn-Ross PL, Rosenthal JF, Hyer MB. Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst 1993;85:1819–1827.
   PubMed Web of Science ®Google Scholar
• Shu XO, Jin F, Dai Q, Wen W, Potter JD, Kushi LH, Ruan Z, Gao YT, Zheng W. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 2001;10:483–488.
   PubMed Web of Science ®Google Scholar
• Rimoldi G, Christoffel J, Seidlova-Wuttke D, Jarry H, Wuttke W. Effects of chronic genistein treatment in mammary gland, uterus, and vagina. Environ Health Perspect 2007;115 (Suppl 1):62–68.
   PubMedGoogle Scholar
• Thelen P, Burfeind P, Schweyer S, Scharf JG, Wuttke W, Ringert RH. Molecular principles of alternative treatment approaches for hormone-refractory prostate cancer. Urologe A 2007;46:1271–1274.
   Google Scholar
• Yan L, Spitznagel EL. Meta-analysis of soy food and risk of prostate cancer in men. Int J Cancer 2005;117:667–669.
   PubMed Web of Science ®Google Scholar
• Vatanparast H, Chilibeck PD. Does the effect of soy phytoestrogens on bone in postmenopausal women depend on the equol-producing phenotype. Nutr Rev 2007;65:294–299.
   Google Scholar
• Vafeiadou K, Hall WL, Williams CM. Does genotype and equol-production status affect response to isoflavones? Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal women. Proc Nutr Soc 2006;65:106–115.
   PubMed Web of Science ®Google Scholar
• Wisniewski AB, Cernetich A, Gearhart JP, Klein SL. Perinatal exposure to genistein alters reproductive development and aggressive behavior in male mice. Physiol Behav 2005;84:327–334.
   Google Scholar
• Jung EY, Lee BJ, Yun YW, Kang JK, Baek IJ, Jurg MY, Lee YB, Sohn HS, Lee JY, Kim KS, Yu WJ, Do JC, Kim YC, Nam SY. Effects of exposure to genistein and estradiol on reproductive development in immature male mice weaned from dams adapted to a soy-based commercial diet. J Vet Med Sci 2004;66:1347–1354.
   PubMed Web of Science ®Google Scholar
• Roberts D, Veeramachaneni DN, Schlaff WD, Awoniyi CA. Effects of chronic dietary exposure to genistein, a phytoestrogen, during various stages of development on reproductive hormones and spermatogenesis in rats. Endocrine 2000;13:281–286.
   Google Scholar
• Chavarro JE, Toth TL, Sadio SM, Hauser R. Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Hum Reprod 2008;23:2584–2590.
   PubMed Web of Science ®Google Scholar
• Hamilton-Reeves JM, Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messina MJ. Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis. Fertil Steril 2009. [Epub ahead of print].
   PubMed Web of Science ®Google Scholar
• Steiner C, Arnould S, Scalbert A, Manach C. Isoflavones and the prevention of breast and prostate cancer: new perspectives opened by nutrigenomics. Br J Nutr 2008;99E (Suppl 1):ES78–ES108.
   Google Scholar
• Yan L, Spitznagel EL. Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis. Am J Clin Nutr 2009;89:1155–1163.
   PubMed Web of Science ®Google Scholar
• Ravindranath MH, Muthugounder S, Presser N, Viswanathan S. Anticancer therapeutic potential of soy isoflavone, genistein. Adv Exp Med Biol 2004;546:121–165.
   PubMed Web of Science ®Google Scholar
• Bektic J, Berger AP, Pfeil K, Dobler G, Bartsch G, Klocker H. Androgen receptor regulation by physiological concentrations of the isoflavonoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor beta. Eur Urol 2004;45:245–251; discussion 251.
   PubMed Web of Science ®Google Scholar
• Thelen P, Peter T, Hunermund A, Kaulfuss S, Seidlova-Wuttke D, Wuttke W, Ringert RH, Seseke F. Phytoestrogens from Belamcanda chinensis regulate the expression of steroid receptors and related cofactors in LNCaP prostate cancer cells. BJU Int 2007;100:199–203.
   PubMedGoogle Scholar
• Harkonen PL, Makela SI. Role of estrogens in development of prostate cancer. J Steroid Biochem Mol Biol 2004;92:297–305.
   PubMed Web of Science ®Google Scholar
• Imamoto T, Suzuki H, Yano M, Kawamura K, Kamiya N, Araki K, Komiya A, Nihei N, Naya Y, Ichikawa T. The role of testosterone in the pathogenesis of prostate cancer. Int J Urol 2008;15:472–480.
   Google Scholar
• Loutchanwoot P, Wuttke W, Jarry H. Effects of a 5-day treatment with vinclozolin on the hypothalamo-pituitary-gonadal axis in male rats. Toxicology 2008;243:105–115.
   Google Scholar
• Eng MH, Charles LG, Ross BD, Chrisp CE, Pienta KJ, Greenberg NM, Hsu CX, Sanda MG. Early castration reduces prostatic carcinogenesis in transgenic mice. Urology 1999;54:1112–1119.
   PubMedGoogle Scholar
• Ellem SJ, Risbridger GP. The dual, opposing roles of estrogen in the prostate. Ann N Y Acad Sci 2009;1155:174–186.
   PubMedGoogle Scholar
• Risbridger GP, Ellem SJ, McPherson SJ. Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling. J Mol Endocrinol 2007;39:183–188.
   PubMedGoogle Scholar
• Ho CK, Nanda J, Chapman KE, Habib FK. Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and local formation from androgen. J Endocrinol 2008;197:483–491.
   PubMed Web of Science ®Google Scholar
• Weihua Z, Makela S, Andersson LC, Salmi S, Saji S, Webster JI, Jensen EV, Nilsson S, Warner M, Gustafsson JA. A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Proc Natl Acad Sci USA 2001;98:6330–6335.
   PubMed Web of Science ®Google Scholar
• Carruba G. Estrogen and prostate cancer: an eclipsed truth in an androgen-dominated scenario. J Cell Biochem 2007;102:899–911.
   PubMed Web of Science ®Google Scholar
• Legg RL, Tolman JR, Lovinger CT, Lephart ED, Setchell KD, Christensen MJ. Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. Reprod Biol Endocrinol 2008;6:57.
   Google Scholar
• Pollard M, Suckow MA. Dietary prevention of hormone refractory prostate cancer in Lobund-Wistar rats: a review of studies in a relevant animal model. Comp Med 2006;56:461–467.
   PubMed Web of Science ®Google Scholar
• Davis JN, Muqim N, Bhuiyan M, Kucuk O, Pienta KJ, Sarkar FH. Inhibition of prostate specific antigen expression by genistein in prostate cancer cells. Int J Oncol 2000;16:1091–1097.
   PubMed Web of Science ®Google Scholar
• Dillingham BL, McVeigh BL, Lampe JW, Duncan AM. Soy protein isolates of varying isoflavone content exert minor effects on serum reproductive hormones in healthy young men. J Nutr 2005;135:584–591.
   PubMedGoogle Scholar
• Food labeling: health claims; soy protein and coronary heart disease. Food and Drug Administration, HHS. Final rule. Fed Regist 1999;64:57700–57733.
   PubMedGoogle Scholar
• Cutler GJ, Nettleton JA, Ross JA, Harnack LJ, Jacobs DR Jr., Scrafford CG, Barraj LM, Mink PJ, Robien K. Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women's Health Study. Int J Cancer 2008;123:664–671.
   PubMed Web of Science ®Google Scholar
• Doerge DR, Sheehan DM. Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect 2002;110 (Suppl 3):349–353.
   PubMedGoogle Scholar
• Schmutzler C, Gotthardt I, Hofmann PJ, Radovic B, Kovacs G, Stemmler L, Nobis I, Bacinski A, Mentrup B, Ambrugger P, Gruters A, Malendowicz LK, Christoffel J, Jarry H, Seidlova-Wuttke D, Wuttke W, Kohrle J. Endocrine disruptors and the thyroid gland – a combined in vitro and in vivo analysis of potential new biomarkers. Environ Health Perspect 2007;115 (Suppl 1):77–83.
   Google Scholar
• Dillingham BL, McVeigh BL, Lampe JW, Duncan AM. Soy protein isolates of varied isoflavone content do not influence serum thyroid hormones in healthy young men. Thyroid 2007;17:131–137.
   PubMedGoogle Scholar
• Malkowicz SB. The role of diethylstilbestrol in the treatment of prostate cancer. Urology 2001;58:108–113.
   PubMed Web of Science ®Google Scholar
• Thompson IM, Tangen CM, Goodman PJ, Lucia MS, Klein EA. Chemoprevention of prostate cancer. J Urol 2009;182:499–507; discussion 508.
   PubMed Web of Science ®Google Scholar
• Vis AN, Schroder FH. Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5alpha-reductase. BJU Int 2009;104:1191–1197.
   Google Scholar
• Kurahashi N, Iwasaki M, Inoue M, Sasazuki S, Tsugane S. Plasma isoflavones and subsequent risk of prostate cancer in a nested case–control study: the Japan Public Health Center. J Clin Oncol 2008;26:5923–5929.
   PubMed Web of Science ®Google Scholar
• Ward H, Chapelais G, Kuhnle GG, Luben R, Khaw KT, Bingham S. Lack of prospective associations between plasma and urinary phytoestrogens and risk of prostate or colorectal cancer in the European Prospective into Cancer-Norfolk study. Cancer Epidemiol Biomarkers Prev 2008;17:2891–2894.
   PubMed Web of Science ®Google Scholar
• Travis RC, Spencer EA, Allen NE, Appleby PN, Roddam AW, Overvad K, Johnsen NF, Olsen A, Kaaks R, Linseisen J, Boeing H, Nothlings U, Bueno-de-Mesquita HB, Ros MM, Sacerdote C, Palli D, Tumino R, Berrino F, Trichopoulou A, Dilis V, Trichopoulos D, Chirlaque MD, Ardanaz E, Larranaga N, Gonzalez C, Suarez LR, Sanchez MJ, Bingham S, Khaw KT, Hallmans G, Stattin P, Rinaldi S, Slimani N, Jenab M, Riboli E, Key TJ. Plasma phyto-oestrogens and prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 2009;100:1817–1823.
   PubMed Web of Science ®Google Scholar
• Urban D, Irwin W, Kirk M, Markiewicz MA, Myers R, Smith M, Weiss H, Grizzle WE, Barnes S. The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. J Urol 2001;165:294–300.
   PubMed Web of Science ®Google Scholar
• Adams KF, Chen C, Newton KM, Potter JD, Lampe JW. Soy isoflavones do not modulate prostate-specific antigen concentrations in older men in a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 2004;13:644–648.
   PubMed Web of Science ®Google Scholar
• Spentzos D, Mantzoros C, Regan MM, Morrissey ME, Duggan S, Flickner-Garvey S, McCormick H, DeWolf W, Balk S, Bubley GJ. Minimal effect of a low-fat/high soy diet for asymptomatic, hormonally naive prostate cancer patients. Clin Cancer Res 2003;9:3282–3287.
   PubMed Web of Science ®Google Scholar
• Hussain M, Banerjee M, Sarkar FH, Djuric Z, Pollak MN, Doerge D, Fontana J, Chinni S, Davis J, Forman J, Wood DP, Kucuk O. Soy isoflavones in the treatment of prostate cancer. Nutr Cancer 2003;47:111–117.
   PubMed Web of Science ®Google Scholar
• Pendleton JM, Tan WW, Anai S, Chang M, Hou W, Shiverick KT, Rosser CJ. Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy. BMC Cancer 2008;8:132.
   PubMed Web of Science ®Google Scholar