650
Views
15
CrossRef citations to date
0
Altmetric
Research Article

Circulating testosterone and estradiol, autonomic balance and baroreflex sensitivity in middle-aged and elderly men with heart failure

, , , , , , & show all
Pages 58-66 | Received 08 Mar 2012, Accepted 18 Jan 2013, Published online: 12 Apr 2013

References

  • Dart AM, Du XJ, Kingwell BA. Gender, sex hormones and autonomic nervous control of the cardiovascular system. Cardiovasc Res 2002;53:678–87
  • Du XJ, Riemersma RA, Dart AM. Cardiovascular protection by oestrogen is partly mediated through modulation of autonomic nervous function. Cardiovasc Res 1995;30:161–5
  • Stoffel-Wagner B. Neurosteroid metabolism in the human brain. Eur J Endocrinol 2001;145:669–79
  • Silver Thorn DU. Human physiology. London: Benjamin Cummings; 2001
  • Tada H, Kashiwai T, Amino N. Endocrine diseases and aging. Rinsho Byori 2000;48:233–8
  • Verdú E, Ceballos D, Vilches JJ, Navarro X. Influence of aging on peripheral nerve function and regeneration. J Peripher Nerv Syst 2000;5:191–208
  • Jankowska EA, Ponikowski P, Piepoli MF, et al. Autonomic imbalance and immune activation in chronic heart failure – pathophysiological links. Cardiovasc Res 2006;70:434–45
  • Saccà L. Heart failure as a multiple hormonal deficiency syndrome. Circ Heart Fail 2009;2:151–6
  • Morris PD, Channer KS. Testosterone and cardiovascular disease in men. Asian J Androl 2012;14:428–35
  • Jankowska EA, Biel B, Majda J, et al. Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival. Circulation 2006;114:1829–37
  • Ponikowski PP, Clark AL, Leyva F, et al. Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure. Eur Heart J 1999;20:683–93
  • Jankowska EA, Rozentryt P, Ponikowska B, et al. Circulating estradiol and mortality in men with systolic chronic heart failure. JAMA 2009;301:1892–901
  • Zheng H, Li Y, Dai W, et al. Role of endogenous estrogen on the incidence of coronary heart disease in men. Angiology 2012;63:591–6
  • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666–72
  • Jankowska EA. Wystepowanie zespolu andropauzalnego a stan hormonalny mezczyzn, mieszkancow Wroclawia. Rozprawa doktorska. Biblioteka Zakładu Antropologii PAN, Wroclaw; 2002
  • DeGroot LJ, Jameson JL. Endocrinology. 5th ed. Philadelpia: Elsevier Saunders; 2006
  • Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31–41
  • Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996;93:1043–65
  • Imholz BP, Wieling W, van Montfrans GA, et al. Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res 1998;38:605–16
  • Sokolski M, Rydlewska A, Krakowiak B, et al. Comparison of invasive and non-invasive measurements of haemodynamic parameters in patients with advanced heart failure. J Cardiovasc Med (Hagerstown) 2011;12:773–8
  • Huikuri HV, Pikkujämsä SM, Airaksinen KE, et al. Sex-related differences in autonomic modulation of heart rate in middle-aged subjects. Circulation 1996;94:122–5
  • Davies LC, Francis D, Jurák P, et al. Reproducibility of methods for assessing baroreflex sensitivity in normal controls and in patients with chronic heart failure. Clin Sci (Lond). 1999;97:515–22
  • McCraty R, Atkinson M, Tomasino D, Stuppy WP. Analysis of twenty-four hour heart rate variability in patients with panic disorder. Biol Psychol 2001;56:131–50
  • Mortara A, La Rovere MT, Signorini MG, et al. Can power spectral analysis of heart rate variability identify a high risk subgroup of congestive heart failure patients with excessive sympathetic activation? A pilot study before and after heart transplantation. Br Heart J 1994;71:422–30
  • Aronson D, Burger AJ. Effect of beta-blockade on heart rate variability in decompensated heart failure. Int J Cardiol 2001;79:31–9
  • Ponikowska B, Jankowska EA, Reczuch K, et al. Abnormal indices of autonomic function are no longer predictors of poor outcome in diabetic patients without neuropathy but with coexisting coronary artery disease who receive optimal pharmacological therapy. Kardiol Pol 2009;67:1325–32
  • Davies LC, Francis DP, Scott AC, et al. Effect of altering conditions of the sequence method on baroreflex sensitivity. J Hypertens 2001;19:1279–87. See also 112
  • Lanfranchi PA, Somers VK. Arterial baroreflex function and cardiovascular variability: interactions and implications. Am J Physiol Regul Integr Comp Physiol 2002;283:815–26
  • La Rovere MT, Pinna GD, Raczak G. Baroreflex sensitivity: measurement and clinical implications. Ann Noninvasive Electrocardiol 2008;13:191–207
  • Vanoli E, Adamson PB. Baroreflex sensitivity: methods, mechanisms, and prognostic value. Pacing Clin Electrophysiol 1994;17:434–45
  • Pitzalis MV, Mastropasqua F, Passantino A, et al. Comparison between noninvasive indices of baroreceptor sensitivity and the phenylephrine method in postmyocardial infarction patients. Circulation 1998;97:1362–7
  • Glass ML, Wood SC. Cardio-respiratory control in vertebrates: comparative and evolutionary aspects. Berlin: Springer; 2009
  • Furlan R, Guzzetti S, Crivellaro W, et al. Continuous 24-hour assessment of neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation 1990;81:537–47
  • Parati G, Saul JP, Di Rienzo M, Mancia G. Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation: a critical appraisal. Hypertension 1995;25:1267–86
  • Parati G, Di Rienzo M, Bertinieri G, et al. Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans. Hypertension 1988;12:214–22
  • Witkowski T, Jankowska EA, Ponikowska B, et al. Application of noninvasive baroreflex assessment methods in patients with cardiovascular diseases. Pol Przegl Kardiol 2004;6:159–65
  • Güder G, Frantz S, Bauersachs J, et al. Low circulating androgens and mortality risk in heart failure. Heart 2010;96:504–9
  • Pascual-Figal DA, Tornel PL, Nicolás F, et al. Sex hormone-binding globulin: a new marker of disease severity and prognosis in men with chronic heart failure. Rev Esp Cardiol 2009;62:1381–7
  • Moriyama Y, Yasue H, Yoshimura M, et al. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrinol Metab 2000;85:1834–40
  • Jankowska EA, Ponikowska B, Węgrzynowska-Teodorczyk K, et al. Impaired exercise capacity is determined by testosterone deficiency and depressive symptoms in men with chronic heart failure. Eur Heart J 2008;29 [abstract suppl.; s.305/P1976; European Society of Cardiology Congress 2008. Munich (Germany), August–September 2008]
  • Jankowska EA, Drohomirecka A, Ponikowska B, et al. Deficiencies in circulating testosterone and dehydroepiandrosterone sulphate, and depression in men with systolic chronic heart failure. Eur J Heart Fail 2010;12:966–73
  • Stanworth RD, Jones TH. Testosterone in obesity, metabolic syndrome and type 2 diabetes. Front Horm Res 2009;37:74–90
  • Malkin CJ, Jones TH, Channer KS. The effect of testosterone on insulin sensitivity in men with heart failure. Eur J Heart Fail 2007;9:44–50
  • Jankowska EA, Maj J, Ponikowska B, et al. Deficiencies in testosterone and insulin-like growth factor type 1 predict the occurrence of anaemia in men with systolic chronic heart failure. Eur Heart J 2009;30 [abstract suppl.; s.830/P4893, European Society of Cardiology Congress 2009. Barcelona, August–September 2009]
  • Smeets L, Legros JJ. Heart and androgens. Rev Med Liege 2004;59:439–44
  • Chahla EJ, Hayek ME, Morley JE. Testosterone replacement therapy and cardiovascular risk factors modification. Aging Male 2011;14:83–90
  • Wehr E, Pilz S, Boehm BO, et al. Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography. Eur J Heart Fail 2011;13:482–8
  • Ermis N, Deniz F, Kepez A, et al. Heart rate variability of young men with idiopathic hypogonadotropic hypogonadism. Auton Neurosci 2010;152:84–7
  • Liao D, Barnes RW, Chambless LE, et al. Age, race, and sex differences in autonomic cardiac function measured by spectral analysis of heart rate variability – the ARIC study. Atherosclerosis risk in communities. Am J Cardiol 1995;76:906–12
  • Wranicz JK, Rosiak M, Cygankiewicz I, et al. Sex steroids and heart rate variability in patients after myocardial infarction. Ann Noninvasive Electrocardiol 2004;9:156–61
  • Caminiti G, Volterrani M, Iellamo F, et al. Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. J Am Coll Cardiol 2009;54:919–27
  • Basaria S, Coviello AD, Travison TG, et al. Adverse events associated with testosterone administration. N Engl J Med 2010;363:109–22
  • Phillips GB. Adverse events associated with testosterone administration. N Engl J Med 2010;363:1866; author reply 1866–7
  • Maggio M, Ceda GP, Lauretani F, et al. Gonadal status and physical performance in older men. Aging Male 2011;14:42–7
  • Sosa ZY, Palmada MN, Fóscolo MR, et al. Administration of noradrenaline in the autonomic ganglia modifies the testosterone release from the testis using an ex vivo system. Int J Androl 2009;32:391–8
  • Anker SD, Chua TP, Ponikowski P, et al. Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia. Circulation 1997;96:526–34
  • Yamaji M, Tsutamoto T, Kawahara C, et al. Serum cortisol as a useful predictor of cardiac events in patients with chronic heart failure: the impact of oxidative stress. Circ Heart Fail 2009;2:608–15
  • Ponikowski P, Piepoli M, Chua TP, et al. The impact of cachexia on cardiorespiratory reflex control in chronic heart failure. Eur Heart J 1999;20:1667–75
  • Schifitto G, McDermott MP, Evans T, et al. Autonomic performance and dehydroepiandrosterone sulfate levels in HIV-1-infected individuals: relationship to TH1 and TH2 cytokine profile. Arch Neurol 2000;57:1027–32
  • Petrov RV, Kuzina IN, Kilikovskiĭ VV, Smirnova OV. Age-dependent changes in the concentration of active sex steroids, their precursors, metabolites, and regulating agents in male blood. Ontogenez 2009;40:456–65
  • Herman WA, Senko A, Korczowska I, Lacka K. Assessment of selected serum inflammatory markers of acute phase response and their correlations with adrenal androgens and metabolic syndrome in a population of men over the age of 40. Pol Arch Med Wewn 2009;119:704–11
  • Doğru MT, Başar MM, Yuvanç E, et al. The relationship between serum sex steroid levels and heart rate variability parameters in males and the effect of age. Turk Kardiyol Dern Ars 2010;38:459–65
  • Volterrani M, Rosano G, Iellamo F. Testosterone and heart failure. Endocrine 2012;42:272–7
  • Wu HY, Wang XF, Wang JH, Li JY. Testosterone level and mortality in elderly men with systolic chronic heart failure. Asian J Androl 2011;13:759–63
  • Bocchi EA, Carvalho VO, Guimaraes GV. Inverse correlation between testosterone and ventricle ejection fraction, hemodynamics and exercise capacity in heart failure patients with erectile dysfunction. Int Braz J Urol 2008;34:302–12
  • Nakamura S, Yoshimura M, Nakayama M, et al. Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart. Circulation 2004;110:1787–93
  • Pastor-Pérez FJ, Manzano-Fernández S, Garrido Bravo IP, et al. Anabolic status and functional impairment in men with mild chronic heart failure. Am J Cardiol 2011;108:862–6
  • Abel EL, Kruger M, Pandya K. Sopranos but not tenors live longer. Aging Male 2012;15:109–10
  • Saleh TM, Connell BJ. The role of 17b-estradiol in the modulation of baroreflex sensitivity in male rats. Am J Physiol 1998;275:R770–78
  • Saleh TM, Connell BJ. Centrally mediated effect of 17beta-estradiol on parasympathetic tone in male rats. Am J Physiol 1999;276:R474–R81
  • Morley JE, Patrick P, Perry HM III. Evaluation of assays available to measure free testosterone. Metabolism 2002;51:554–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.