133
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice

, , &
Pages S107-S113 | Received 19 Apr 2010, Accepted 11 Sep 2010, Published online: 18 Oct 2010

References

  • Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 1999; 12: 310–350.
  • Clemons KV, Stevens DA. The contribution of animal models of aspergillosis to understanding pathogenesis, therapy and virulence. Med Mycol 2005; 43: S101–110.
  • Castonguay-Vanier J, Vial L, Tremblay J, Deziel E. Drosophila melanogaster as a model for the Burkholderia cepacia complex. PLoS One 2010; 12: e11467
  • Irazoqui I, Troemel ER, Feinbaum RL, . Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathogen 2010; 1: e1000982.
  • Dunphy GB, Morton DB, Kropinski A, Chadwick JM. Pathogenicity of lipopolysaccharide mutants of Pseudomonas aeruginosa for larvae of G. mellonella: bacterial properties associated with virulence. J Insect Pathology 1986; 47: 48–55.
  • Brennan M, Thomas DY, Whiteway M, Kavanagh K. Correlation between virulence of Candida albicans mutants in mice and G. mellonella larvae. FEMS Immunol Med Microbiol 2002; 34: 153–157
  • Peleg AY, Monga D, Pillai S, . Reduced susceptibility to vancomycin influences pathogenicity in Staphylococcus aureus infection. J Inf Dis 2009; 199: 532–536.
  • Reeves EP, Messina CG, Doyle S, Kavanagh K. Correlation between gliotoxin production and virulence of A. fumigatus in G. mellonella. Mycopathologia 2004; 158: 73–79
  • Jackson JC, Higgins LA, Lin X. Conidiation of color mutants of A. fumigatus are highly pathogenic to the heterologous insect host G. mellonella. PLoS One 2009; 4: e4224
  • Brown JS, Aufauvre-Brown A, Brown J, . Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity. Mol Microbiol 2000; 36: 1371–1380.
  • Sandhu DK, Sandhu RS, Khan ZU, Damodaran VN. Conditional virulence of a p-aminobenzoic acid-requiring mutant of Aspergillus fumigatus. Infect Immun 1976; 13: 527–532.
  • Carsiotis M, Jones RF. Cross-pathway regulation: tryptophan-mediated control of histidine and arginine biosynthetic enzymes in Neurospora crassa. J Bacteriolog 1974; 119: 889–892.
  • Krappmann S, Bignell EM, Reichard U, . The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Mol Microbiol 2004; 52: 785–799.
  • Sasse C, Bignell EM, Hasenberg M, . Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. Fungal Genet Biol 2008; 45: 693–704.
  • Schrettl M, Bignell E, Kragl C, . Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med 2004; 200: 1213–1219.
  • Schrettl M, Bignell E, Kragl C, . Distinct roles for intra-and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathol 2007; 3: 1195–1207.
  • Kavanagh K, Reeves EP. Exploiting the potential of insects for in vivo pathogenicity testing of microbial Pathogens. FEMS Microbiol Rev 2004; 28: 101–112.
  • Chamilos G, Bignell EM, Schrettl M, . Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies. Med Mycol 2010; 48: 506–510.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.