Hypercholesterolemia accelerates bone loss in postmenopausal women

References

• Rosen CJ, Klibanski A. Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis. Am J Med 2009;122:409–414
   PubMed Web of Science ®Google Scholar
• Ezura Y, Nakajima T, Urano T, et al Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women. Bone 2007;40:997–1005
   PubMed Web of Science ®Google Scholar
• van Meurs JB, Trikalinos TA, Ralston SH, et al Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA 2008;19:1277–1290
   Web of Science ®Google Scholar
• Buhaescu I, Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications. Clin Biochem 2007;40:575–584
   PubMed Web of Science ®Google Scholar
• Majima T, Shimatsu A, Komatsu Y, et al Short-term effects of pitavastatin on biochemical markers of bone turnover in patients with hypercholesterolemia. Intern Med 2007;46:1967–1973
   PubMed Web of Science ®Google Scholar
• Vogt MT, San Valentin R, Forrest KY, Nevitt MC, Cauley JA. Bone mineral density and aortic calcification: the Study of Osteoporotic Fractures. J Am Geriatr Soc 1997;45:140–145
   PubMed Web of Science ®Google Scholar
• Hak AE, Pols HA, van Hemert AM, Hofman A, Witteman JC. Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vasc Biol 2000;20:1926–1931
   PubMed Web of Science ®Google Scholar
• Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O'Donnell CJ, Wilson PW. Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int 2001;68:271–276
   PubMed Web of Science ®Google Scholar
• Ouchi Y, Akishita M, de Souza AC, Nakamura T, Orimo H. Age-related loss of bone mass and aortic/aortic valve calcification – reevaluation of recommended dietary allowance of calcium in the elderly. Ann NY Acad Sci 1993;676:297–307
   PubMed Web of Science ®Google Scholar
• Hirose K, Tomiyama H, Okazaki R, et al Increased pulse wave velocity associated with reduced calcaneal quantitative osteo-sono index: possible relationship between atherosclerosis and osteopenia. J Clin Endocrinol Metab 2003;88:2573–2278
   PubMed Web of Science ®Google Scholar
• Parhami F, Basseri B, Hwang J, Tintut Y, Demer LL. High-density lipoprotein regulates calcification of vascular cells. Circ Res 2002;91:570–576
   PubMed Web of Science ®Google Scholar
• Tintut Y, Morony S, Demer LL. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol 2004;24:e6–e10
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Sugimoto T, Yano S, et al Plasma lipids and osteoporosis in postmenopausal women. Endocr J 2002;49:211–217
   PubMed Web of Science ®Google Scholar
• Cui LH, Shin MH, Chung EK, et al Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporos Int 2005;16:1975–1981
   PubMed Web of Science ®Google Scholar
• Brownbill RA, Ilich JZ. Lipid profile and bone paradox: higher serum lipids are associated with higher bone mineral density in postmenopausal women. J Womens Health (Larchmt) 2006;15:261–270
   PubMed Web of Science ®Google Scholar
• Makovey J, Chen JS, Hayward C, Williams FM, Sambrook PN. Association between serum cholesterol and bone mineral density. Bone 2009;44:208–213
   PubMed Web of Science ®Google Scholar
• Solomon DH, Avorn J, Canning CF, Wang PS. Lipid levels and bone mineral density. Am J Med 2005;118:1414
   Google Scholar
• Vargas SJ, Naprta A, Glaccum M, Lee SK, Kalinowski J, Lorenzo JA. Interleukin-6 expression and histomorphometry of bones from mice deficient in receptors for interleukin-1 or tumor necrosis factor. J Bone Miner Res 1996;11:1736–1744
   PubMed Web of Science ®Google Scholar
• Pfeilschifter J, Köditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr Rev 2002;23:90–119
   PubMed Web of Science ®Google Scholar
• Weitzmann MN, Pacifici R. Estrogen regulation of immune cell bone interactions. Ann NY Acad Sci 2006;1068:256–274
   PubMed Web of Science ®Google Scholar
• Charatcharoenwitthaya N, Khosla S, Atkinson EJ, McCready LK, Riggs BL. Effect of blockade of TNF-α and interleukin-1 action on bone resorption in early postmenopausal women. J Bone Miner Res 2007;22:724–729
   PubMed Web of Science ®Google Scholar
• De Laet C, Kanis JA, Odén A, et al Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 2005;16:1330–1338
   PubMed Web of Science ®Google Scholar
• Beck TJ, Petit MA, Wu G, LeBoff MS, Cauley JA, Chen Z. Does obesity really make the femur stronger? BMD, geometry, and fracture incidence in the Women's Health Initiative observational study. J Bone Miner Res 2009;24:1369–1379
   PubMed Web of Science ®Google Scholar
• Revilla M, Villa LF, Sánchez-Atrio A, Hernández ER, Rico H. Influence of body mass index on the age-related slope of total and regional bone mineral content. Calcif Tissue Int 1997;61:134–138
   PubMed Web of Science ®Google Scholar
• Reid IR, Ames RW, Evans MC, Sharpe SJ, Gamble GD. Determinants of the rate of bone loss in normal postmenopausal women. J Clin Endocrinol Metab 1994;79:950–954
   PubMed Web of Science ®Google Scholar
• Barrett-Connor E, Kritz-Silverstein D. Does hyperinsulinemia preserve bone? Diabetes Care 1996;19:1388–1392
   PubMed Web of Science ®Google Scholar
• Hsu YH, Venners SA, Terwedow HA, et al Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr 2006;83:146–154
   PubMed Web of Science ®Google Scholar
• Taes YE, Lapauw B, Vanbillemont G, et al Fat mass is negatively associated with cortical bone size in young healthy male siblings. J Clin Endocrinol Metab 2009;94:2325–2331
   PubMed Web of Science ®Google Scholar
• Takeda S, Karsenty G. Molecular bases of the sympathetic regulation of bone mass. Bone 2008;42:837–840
   PubMed Web of Science ®Google Scholar
• Lorentzon M, Landin K, Mellström D, Ohlsson C. Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men. J Bone Miner Res 2006;21:1871–1878
   PubMed Web of Science ®Google Scholar
• Luo XH, Guo LJ, Xie H, et al Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res 2006;21:1648–1656
   PubMed Web of Science ®Google Scholar