Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review

References

• Avis NE, Stellato R, Crawford S, et al. Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med 2001;52:345–56
   PubMed Web of Science ®Google Scholar
• Oldenhave A, Jaszmann LJ, Haspels AA, Everaerd WT. Impact of climacteric on well-being. A survey based on 5213 women 39 to 60 years old. Am J Obstet Gynecol 1993;168:772–80
   PubMed Web of Science ®Google Scholar
• Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321–33
   PubMed Web of Science ®Google Scholar
• Depypere HT, Comhaire FH. Herbal preparations for the menopause: beyond isoflavones and black cohosh. Maturitas 2014;77:191–4
   PubMed Web of Science ®Google Scholar
• Shou C, Li J, Liu Z. Complementary and alternative medicine in the treatment of menopausal symptoms. Chin J Integr Med 2011;17:883–8
   PubMed Web of Science ®Google Scholar
• Ismail R, Taylor-Swanson L, Thomas A, et al. Effects of herbal preparations on symptoms clusters during the menopausal transition. Climacteric 2014 Mar 8. Epub ahead of print
   Web of Science ®Google Scholar
• Bedell S, Nachtigal M, Naftolin F. The pros and cons of plant estrogens for menopause. J Steroid Biochem Mol Biol 2014;139:225–36
   PubMed Web of Science ®Google Scholar
• Thompson LU, Robb P, Serraino M, Cheung F. Mammalian lignan production from various foods. Nutr Cancer 1991;16:43–52
   PubMed Web of Science ®Google Scholar
• Freeman EW, Sherif K. Prevalence of hot flushes and night sweats around the world: a systematic review. Climacteric 2007; 10:197–214
   PubMed Web of Science ®Google Scholar
• Messina M, Nagata C, Wu AH. Estimated Asian adult soy protein and isoflavone intakes. Nutr Cancer 2006;55:1–12
   PubMed Web of Science ®Google Scholar
• Lewis JE, Nickell LA, Thompson LU, Szalai JP, Kiss A, Hilditch JR. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Menopause 2006;13:631–42
   PubMed Web of Science ®Google Scholar
• Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev 2013;12:CD001395
   Google Scholar
• Verhagen AP, de Vet HC, de Bie RA, et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol 1998;51:1235–41
   PubMed Web of Science ®Google Scholar
• Kupperman HS, Wetchler BB, Blatt MH. Contemporary therapy of the menopausal syndrome. JAMA 1959;171:1627–37
   PubMed Web of Science ®Google Scholar
• Aso T, Uchiyama S, Matsumura Y, et al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health (Larchmt) 2012;21:92–100
   PubMed Web of Science ®Google Scholar
• Atkinson C, Warren RM, Sala E, et al. Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]. Breast Cancer Res 2004;6:R170–9
   PubMed Web of Science ®Google Scholar
• Cancellieri F, De Leo V, Genazzani AD, et al. Efficacy on menopausal neurovegetative symptoms and some plasma lipids blood levels of an herbal product containing isoflavones and other plant extracts. Maturitas 2007;56:249–56
   PubMed Web of Science ®Google Scholar
• del Giorno C, Fonseca AM, Bagnoli VR, Assis JS, Soares JM Jr, Baracat EC. Effects of Trifolium pratense on the climacteric and sexual symptoms in postmenopause women. Rev Assoc Med Bras 2010;56:558–62
   PubMed Web of Science ®Google Scholar
• Ferrari A. Soy extract phytoestrogens with high dose of isoflavones for menopausal symptoms. J Obstet Gynaecol Res 2009;35:1083–90
   PubMed Web of Science ®Google Scholar
• Han KK, Soares JM Jr, Haidar MA, de Lima GR, Baracat EC. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet Gynecol 2002;99:389–94
   PubMed Web of Science ®Google Scholar
• Nahas EA, Nahas-Neto J, Orsatti FL, Carvalho EP, Oliveira ML, Dias R. Efficacy and safety of a soy isoflavone extract in postmenopausal women: a randomized, double-blind, and placebo-controlled study. Maturitas 2007;58:249–58
   PubMed Web of Science ®Google Scholar
• Penotti M, Fabio E, Modena AB, Rinaldi M, Omodei U, Viganó P. Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Fertil Steril 2003;79:1112–17
   PubMed Web of Science ®Google Scholar
• Petri Nahas E, Nahás Neto J, De Luca L, Traiman P, Pontes A, Dalben I. Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas 2004;48:372–80
   PubMed Web of Science ®Google Scholar
• Riesco E, Choquette S, Audet M, Tessier D, Dionne IJ. Effect of exercise combined with phytoestrogens on quality of life in postmenopausal women. Climacteric 2011;14: 573–80
   PubMed Web of Science ®Google Scholar
• Sammartino A, Tommaselli GA, Gargano V, di Carlo C, Attianese W, Nappi C. Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric- related symptoms in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Gynecol Endocrinol 2006;22:646–50
   PubMed Web of Science ®Google Scholar
• Tice JA, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings SR. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003;290:207–14
   PubMed Web of Science ®Google Scholar
• van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187–93
   PubMed Web of Science ®Google Scholar
• Van Patten CL, Olivotto IA, Chambers GK, et al. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol 2002;20:1449–55
   PubMed Web of Science ®Google Scholar
• Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005;13:13
   Google Scholar
• Jacobs A, Wegewitz U, Sommerfield C, Grossklaus R, Lampen A. Efficacy of isoflavones in relieving vasomotor menopausal symptoms-A systematic review. Mol Nutr Food Res 2009;53: 1084–97
   PubMed Web of Science ®Google Scholar
• Eden JA. Phytoestrogens for menopausal symptoms: a review. Maturitas 2012;72:157–9
   PubMed Web of Science ®Google Scholar
• Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15:115–24
   PubMed Web of Science ®Google Scholar
• Bolanos R, Del Castillo A, Francia J. Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and metaanalysis. Menopause 2010;17: 660–6
   PubMed Web of Science ®Google Scholar
• Carmignani LO, Pedro AO, Costa-Paiva LH, Pinto-Neto AM. The effect of dietary soy supplementation compared to estrogen and placebo on menopausal symptoms: a randomized controlled trial. Maturitas 2010;67:262–9
   PubMed Web of Science ®Google Scholar
• Crisafulli A, Marini H, Bitto A, et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause 2004; 11:400–4
   PubMed Web of Science ®Google Scholar
• Marini H, Bitto A, Altavilla D, et al. Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J Clin Endocrinol Metab 2008;93:4787–96
   PubMed Web of Science ®Google Scholar
• Bitto A, Polito F, Atteritano M, et al. Genistein aglycone does not affect thyroid function: results from a three year, randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 2010;95:3067–72
   PubMed Web of Science ®Google Scholar
• Quaas AM, Kono N, Mack WJ, et al. Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized, controlled trial. Menopause 2013;20:840–4
   PubMed Web of Science ®Google Scholar
• Simbalista RL, Sauerbronn AV, Aldrighi JM, Arêas JA. Consumption of a flaxseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. J Nutr 2010;140:293–7
   PubMed Web of Science ®Google Scholar
• Pruthi S, Qin R, Terstreip SA, et al. A phase III, randomized, placebo-controlled, double-blind trial of flaxseed for the treatment of hot flashes: North Central Cancer Treatment Group N08C7. Menopause 2012;19:48–53
   PubMed Web of Science ®Google Scholar
• D’Adamo CR, Sahin A. Soy foods and supplementation: a review of commonly perceived health benefits and risks. Altern Ther Health Med 2014;20(Suppl 1):39–51
   PubMed Web of Science ®Google Scholar
• Tempfer CB, Froese G, Heinze G, Bentz EK, Hefler LA, Huber JC. Side effects of phytoestrogens: a meta-analysis of randomized trials. Am J Med 2009;122:939–46
   PubMed Web of Science ®Google Scholar