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REVIEW

Calcium and bone health ‐ goodbye, calcium supplements?

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Pages 702-714 | Received 09 Nov 2014, Accepted 04 Feb 2015, Published online: 08 Apr 2015

References

  • Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, et al., eds. Dietary Reference Intakes for Calcium and Vitamin D. Washington,DC: National Academies Press (US), 2011. Online resource: http://www.ncbi.nlm.nih.gov/books/NBK56070/
  • Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007;370:657–66
  • Reid IR, Mason B, Horne A, et al. Randomized controlled trial of calcium in healthy older women. Am J Med 2006;119: 777–85
  • Reid IR, Ames R, Mason B, et al. Randomized controlled trial of calcium supplementation in healthy, nonosteoporotic, older men. Arch Intern Med 2008;168:2276–82
  • Shea B, Wells G, Cranney A, et al.;Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group. Meta-analyses of therapies for postmenopausal osteoporosis. VII. Meta-analysis of calcium supplementation for the prevention of postmenopausal osteoporosis. Endocr Rev 2002;23:552–9
  • National Osteoporosis Foundation. Clinician's Guide to Prevention and Treatment of Osteoporosis. Washington, DC: National Osteoporosis Foundation, 2014. Online resource: http://nof.org/files/nof/public/content/file/2791/upload/919.pdf
  • DVO-Leitlinie 2015 zur Prophylaxe, Diagnostik und Therapie der Osteoporose bei Männern ab dem 60. Lebensjahr und bei postmenopausalen Frauen.S3-Leitlinie des Dachverbands der Deutschsprachigen Wissenschaftlichen Osteologischen Gesellschaften e. V. Online resource: http://www.dv-osteologie.org/uploads/Leitlinie%202014/DVO-Leitlinie%20Osteoporose%20 2014%20Kurzfassung%20und%20Langfassung%2018.%2009.%202014.pdf
  • Papaioannou A, Morin S, Cheung AM, et al.; Scientific Advisory Council of Osteoporosis Canada. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ 2010;182:1864–73
  • Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY;Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and the Committee of Scientific Advisors of the International Osteoporosis Foundation. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 2013;24:23–57
  • Schweizerische Vereinigung gegen die Osteoporose (SVGO). Osteoporose. Prävention ‐ Diagnostik ‐ Behandlung. Empfehlungen 2010. Online resource: http://www.svgo.ch/content/documents/SVGO_Empfehlungen2010_V19April2010.pdf
  • Rizzoli R, Stevenson JC, Bauer JM, et al. for the ESCEO Task Force. The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: A consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Maturitas 2014;79:122–32
  • van Mierlo LA, Arends LR, Streppel MT, et al. Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J Hum Hypertens 2006;20: 571–80
  • Houston MC, Harper KJ. Potassium, magnesium, and calcium: their role in both the cause and treatment of hypertension. J Clin Hypertens 2008;10(7 Suppl 2):3–11
  • Reid IR. Effects of calcium supplementation on circulating lipids: potential pharmacoeconomic implications. Drugs Aging 2004;21:7–17
  • de Oliveira Freitas DM, Stampini Duarte Martino H, Machado Rocha Ribeiro S, Gonçalves Alfenas RC. Calcium ingestion and obesity control. Nutr Hosp 2012;27:1758–71
  • Larsson SC, Orsini N, Wolk A. Dietary calcium intake and risk of stroke: a dose–response meta-analysis. Am J Clin Nutr 2013; 97:951–7
  • Huncharek M, Muscat J, Kupelnick B. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr Cancer 2009;61:47–69
  • Heuer T, Walter C, Krems C, Hoffmann I. Nährstoffzufuhr über Supplemente – Ergebnisse der Nationalen Verzehrsstudie. II. In: Deutsche Gesellschaft für Ernährung e. V. (DGE): 12. Ernährungsbericht. Bonn, 2012, S. 86–97, 2012
  • Gahche J, Bailey R, Burt V, et al. Dietary supplement use among U.S. adults has increased since NHANES III (1988–1994). NCHS Data Brief 2011;61:1–8
  • Michaëlsson K, Melhus H, Warensjö Lemming E, Wolk A, Byberg L. Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study. BMJ 2013;346:f228
  • Li K, Kaaks R, Linseisen J, Rohrmann S. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart 2012;98:920–5
  • Radford LT, Bolland MJ, Gamble GD, Grey A, Reid IR. Subgroup analysis for the risk of cardiovascular disease with calcium supplements. Bonekey Rep 2013;2:293
  • Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 2008;336:262–6
  • Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341:c3691
  • Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ 2011; 342:d2040
  • Reid IR, Bolland MJ. Calcium supplementation and vascular disease. Climacteric 2008;11:280–6
  • Reid IR. Cardiovascular endocrinology: Controversy – cardiovascular effects of calcium supplementation. Nat Rev Endocrinol 2014;10:641–2
  • Nordin BE, Lewis JR, Daly RM, et al. The calcium scare – what would Austin Bradford Hill have thought? Osteoporos Int 2011;22:3073–7
  • Bhattacharya RK. Does widespread calcium supplementation pose cardiovascular risk? No: concerns are unwarranted. Am Fam Physician 2013;87(3):Online
  • Reid IR, Bolland MJ. Does widespread calcium supplementation pose cardiovascular risk? Yes: the potential risk is a concern. Am Fam Physician 2013;87(3):Online
  • Meier C, Kränzlin ME. Calcium supplementation, osteoporosis and cardiovascular disease. Swiss Med Wkly 2011;141:w13260
  • Rojas-Fernandez CH, Maclaughlin EJ, Dore NL, Ebsary S. Assessing the potential adverse consequences of supplemental calcium on cardiovascular outcomes: should we change our approach to bone health? Ann Pharmacother 2012;46:696–702
  • Heaney RP, Kopecky S, Maki KC, Hathcock J, Mackay D, Wallace TC. A review of calcium supplements and cardiovascular disease risk. Adv Nutr 2012;3:763–71
  • McDaniel MH, Williams SE. Calcium primer: current controversies and common clinical questions. J Clin Densitom 2013;16:389–93
  • Challoumas D, Cobbold C, Dimitrakakis G. Effects of calcium intake on the cardiovascular system in postmenopausal women. Atherosclerosis 2013;231:1–7
  • Weaver CM. Calcium is not only safe but important for health. In Burckhardt P, Dawson-Hughes B, Weaver C. Nutritional Influences on Bone Health. London: Springer, 2013:359–63
  • Weaver CM. Calcium supplementation: is protecting against osteoporosis counter to protecting against cardiovascular disease? Curr Osteoporos Rep 2014;12:211–18
  • Spence LA, Weaver CM. Calcium intake, vascular calcification, and vascular disease. Nutr Rev 2013;71:15–22
  • Dvorak-Ewell MM, Chen TH, Liang N, et al. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res 2011;26:2935–47
  • Marie PJ. The calcium-sensing receptor in bone cells: a potential therapeutic target in osteoporosis. Bone 2010;46:571–6
  • Peterlik M, Cross HS. Vitamin D and calcium insufficiency- related chronic diseases: molecular and cellular pathophysiology. Eur J Clin Nutr 2009;63:1377–86
  • Deutsche Gesellschaft für Ernährung (DGE), Österreichische Gesellschaft für Ernährung (ÖGE), Schweizerische Gesellschaft für Ernährungsforschung (SGE), Schweizerische Vereinigung für Ernährung (SVE). Referenzwerte für die Nährstoffzufuhr. Calcium. Neuer Umschau Buchverlag, Neustadt a. d. Weinstraße, 1. Auflage, 5., korrigierter Nachdruck,2013, S. 189–217
  • Peterlik M, Kállay E, Cross HS. Calcium nutrition and extracellular calcium sensing: relevance for the pathogenesis of osteoporosis, cancer and cardiovascular diseases. Nutrients 2013; 5:302–27
  • Pearce S. Extracellular ‘calcistat’ in health and disease. Lancet 1999;353:83–4
  • Joo NS, Dawson-Hughes B, Kim YS, Oh K, Yeum KJ. Impact of calcium and vitamin D insufficiencies on serum parathyroid hormone and bone mineral density: analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-3, 2009 and KNHANES V-1, 2010). J Bone Miner Res 2013;28:764–70
  • Paik JM, Farwell WR, Taylor EN. Demographic, dietary, and serum factors and parathyroid hormone in the National Health and Nutrition Examination Survey. Osteoporos Int 2012; 23:1727–36
  • Steingrimsdottir L, Gunnarsson O, Indridason OS, Franzson L, Sigurdsson G. Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 2005;294:2336–41
  • Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, et al. Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res 2009;24:935–42
  • Kochersberger G, Bales C, Lobaugh B, Lyles KW. Calcium supplementation lowers serum parathyroid hormone levels in elderly subjects. J Gerontol 1990;45:M159–62
  • Riggs BL, O’Fallon WM, Muhs J, O’Connor MK, Kumar R, Melton LJ 3rd. Long-term effects of calcium supplementation on serum parathyroid hormone level, bone turnover, and bone loss in elderly women. J Bone Miner Res 1998;13:168–74
  • McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL. Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption. J Clin Endocrinol Metab 1996;81:1699–703
  • Ströhle A, Hahn A. [Food supplements in primary prevention—methodological aspects]. Med Monatsschr Pharm 2014;37: 13–26
  • Bonjour JP, Kraenzlin M, Levasseur R, Warren M, Whiting S. Dairy in adulthood: from foods to nutrient interactions on bone and skeletal muscle health. J Am Coll Nutr 2013;32:251–63
  • Weaver CM, Hill KM. Estimating calcium requirements. In Burckhardt P, Dawson-Hughes B, Weaver C. Nutritional Influences on Bone Health. London: Springer, 2008:41–9
  • Wu L, Martin BR, Braun MM, et al. Calcium requirements and metabolism in Chinese-American boys and girls. J Bone Miner Res 2010;25:1842–9
  • Braun M, Martin BR, Kern M, et al. Calcium retention in adolescent boys on a range of controlled calcium intakes. Am J Clin Nutr 2006;84:414–18
  • Jackman LA, Millane SS, Martin BR, et al. Calcium retention in relation to calcium intake and postmenarcheal age in adolescent females. Am J Clin Nutr 1997;66:327–33
  • Hunt CD, Johnson LK. Calcium requirements: new estimations for men and women by cross-sectional statistical analyses of calcium balance data from metabolic studies. Am J Clin Nutr 2007;86:1054–63
  • Heaney RP, Recker RR, Saville PD. Menopausal changes in calcium balance performance. J Lab Clin Med 1978;92:953–63
  • Zhu K, Prince RL. Calcium and bone. Clin Biochem 2012;45:936–42
  • Nordin BE. The effect of calcium supplementation on bone loss in 32 controlled trials in postmenopausal women. Osteoporos Int 2009;20:2135–43
  • Lips P, Gielen E, van Schoor NM. Vitamin D supplements with or without calcium to prevent fractures. Bonekey Rep 2014; 3:512
  • Bauer DC. Clinical practice. Calcium supplements and fracture prevention. N Engl J Med 2013;369:1537–43
  • Avenell A, Mak JC, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 2014; 4:CD000227
  • Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA. Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ 1994;309:691–5
  • Kenny AM, Prestwood KM. Osteoporosis. Pathogenesis, diagnosis, and treatment in older adults. Rheum Dis Clin North Am 2000;26:569–91
  • Sowers MR, Zheng H, Jannausch ML, et al. Amount of bone loss in relation to time around the final menstrual period and follicle-stimulating hormone staging of the transmenopause. J Clin Endocrinol Metab 2010;95:2155
  • Siris ES, Chen YT, Abbott TA, et al. Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med 2004;164:1108–12
  • Ilich JZ, Brownbill RA, Tamborini L. Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density. Eur J Clin Nutr 2003;57: 554–65
  • Uusi-Rasi K, Sievänen H, Pasanen M, Beck TJ, Kannus P. Influence of calcium intake and physical activity on proximal femur bone mass and structure among pre- and postmenopausal women. A 10-year prospective study. Calcif Tissue Int 2008; 82:171–81
  • Suzuki Y, Whiting SJ, Davison KS, Chilibeck PD. Total calcium intake is associated with cortical bone mineral density in a cohort of postmenopausal women not taking estrogen. J Nutr Health Aging 2003;7:296–9
  • Suleiman S, Nelson M, Li F, Buxton-Thomas M, Moniz C. Effect of calcium intake and physical activity level on bone mass and turnover in healthy, white, postmenopausal women. Am J Clin Nutr 1997;66:937–43
  • Uusi-Rasi K, Sievänen H, Pasanen M, Oja P, Vuori I. Association of physical activity and calcium intake with the maintenance of bone mass in premenopausal women. Osteoporos Int 2002; 13:211–17
  • Uusi-Rasi K, Sievänen H, Pasanen M, Oja P, Vuori I. Maintenance of body weight, physical activity and calcium intake helps preserve bone mass in elderly women. Osteoporos Int 2001;12:373–9
  • Cussler EC, Going SB, Houtkooper LB, et al. Exercise frequency and calcium intake predict 4-year bone changes in postmenopausal women. Osteoporos Int 2005;16:2129–41
  • Devine A, Dhaliwal SS, Dick IM, Bollerslev J, Prince RL. Physical activity and calcium consumption are important determinants of lower limb bone mass in older women. J Bone Miner Res 2004;19:1634–9
  • Specker BL. Evidence for an interaction between calcium intake and physical activity on changes in bone mineral density. J Bone Miner Res 1996;11:1539–44
  • Shea B, Wells G, Cranney A, et al.;Osteoporosis Methodology Group; Osteoporosis Research Advisory Group. WITHDRAWN: Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev 2007;(1):CD004526
  • Nieves JW, Lindsay R. Calcium and fracture risk. Am J Clin Nutr 2007;86:1579–80
  • Anderson JJ, Roggenkamp KJ, Suchindran CM. Calcium intakes and femoral and lumbar bone density of elderly U.S. men and women: National Health and Nutrition Examination Survey 2005–2006 analysis. J Clin Endocrinol Metab 2012; 97:4531–9
  • Zhong Y, Okoro CA, Balluz LS. Association of total calcium and dietary protein intakes with fracture risk in postmenopausal women: the 1999–2002 National Health and Nutrition Examination Survey (NHANES). Nutrition 2009;25:647–54
  • Fardellone P, Cotté FE, Roux C, Lespessailles E, Mercier F, Gaudin AF. Calcium intake and the risk of osteoporosis and fractures in French women. Joint Bone Spine 2010;77:154–8
  • Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr 2007;86:1780–90
  • Warensjö E, Byberg L, Melhus H, et al. Dietary calcium intake and risk of fracture and osteoporosis: prospective longitudinal cohort study. BMJ 2011;342:d1473
  • Dawson-Hughes B. Calcium insufficiency and fracture risk. Osteoporos Int 1996;6(Suppl 3):37–41
  • Nakamura K, Kurahashi N, Ishihara J, Inoue M, Tsugane S;Japan Public Health Centre-based Prospective Study Group. Calcium intake and the 10-year incidence of self-reported vertebral fractures in women and men: the Japan Public Health Centre-based Prospective Study. Br J Nutr 2009;101:285–94
  • Cranney A, Guyatt G, Griffith L, Wells G, Tugwell P, Rosen C;Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group. Meta-analyses of therapies for postmenopausal osteoporosis. IX: Summary of meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev 2002;23:570–8
  • Chung M, Balk EM, Brendel M, et al. Vitamin D and calcium: a systematic review of health outcomes. Evid Rep Technol Assess (Full Rep) 2009;(183):1–420
  • Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011;155:827–38
  • Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 2007;92:1415–23
  • Reid IR, Bolland MJ, Grey A. Effect of calcium supplementation on hip fractures. Osteoporos Int 2008;19:1119–23
  • Bischoff-Ferrari HA, Willett WC, Orav EJ, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012;367:40–9. Erratum in N Engl J Med 2012;367:481
  • Lappe JM, Heaney RP. Why randomized controlled trials of calcium and vitamin D sometimes fail. Dermatoendocrinology 2012;4:95–100
  • Jackson RD, LaCroix AZ, Gass M, et al.; Women’s Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669–83. Erratum in N Engl J Med 2006;354:1102
  • Sahni S, Cupples LA, McLean RR, et al. Protective effect of high protein and calcium intake on the risk of hip fracture in the Framingham offspring cohort. J Bone Miner Res 2010;25:2770–6. Erratum in J Bone Miner Res 2011;26:439
  • Jackson C, Gaugris S, Sen SS, Hosking D. The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis. QJM 2007;100:185–92
  • DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 2010;340:b5463
  • Bolland MJ, Grey A, Gamble GD, Reid IR. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol 2014;2:307–20
  • Prince RL, Devine A, Dhaliwal SS, Dick IM. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 2006;166:869–75
  • Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, et al. Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies. J Bone Miner Res 2011;26:833–9
  • EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific opinion on the tolerable upper intake level of calcium. EFSA J 2012;10:2814
  • Prentice RL, Pettinger MB, Jackson RD, et al. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Osteoporos Int 2013;24:567–80
  • Paik JM, Curhan GC, Sun Q, et al. Calcium supplement intake and risk of cardiovascular disease in women. Osteoporos Int 2014;25:2047–56
  • Wang L, Manson JE, Sesso HD. Calcium intake and risk of cardiovascular disease: a review of prospective studies and randomized clinical trials. Am J Cardiovasc Drugs 2012;12: 105–16
  • Van Hemelrijck M, Michaelsson K, Linseisen J, Rohrmann S. Calcium intake and serum concentration in relation to risk of cardiovascular death in NHANES III. PLoS One 2013; 8:e61037
  • Lewis JR, Calver J, Zhu K, Flicker L, Prince RL. Calcium supplementation and the risks of atherosclerotic vascular disease in older women: results of a 5-year RCT and a 4.5-year follow-up. J Bone Miner Res 2011;26:35–41
  • Rautiainen S, Wang L, Manson JE, Sesso HD. The role of calcium in the prevention of cardiovascular disease – a review of observational studies and randomized clinical trials. Curr Atheroscler Rep 2013;15:362
  • Lewis JR, Radavelli-Bagatini S, Rejnmark L, et al. The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: a collaborative meta-analysis of randomized controlled trials. J Bone Miner Res 2015;30:165–75
  • Szklo M. The evaluation of epidemiologic evidence for policy-making. Am J Epidemiol 2001;154(12 Suppl):S13–17
  • Samelson EJ, Booth SL, Fox CS, et al. Calcium intake is not associated with increased coronary artery calcification: the Framingham Study. Am J Clin Nutr 2012;96:1274–80
  • Manson JE, Allison MA, Carr JJ, et al.; Women’s Health Initiative and Women’s Health Initiative-Coronary Artery Calcium Study Investigators. Calcium/vitamin D supplementation and coronary artery calcification in the Women’s Health Initiative. Menopause 2010;17:683–91
  • Lewis JR, Zhu K, Thompson PL, Prince RL. The effects of 3 years of calcium supplementation on common carotid artery intimal medial thickness and carotid atherosclerosis in older women: an ancillary study of the CAIFOS randomized controlled trial. J Bone Miner Res 2014;29:534–41
  • Hsu HH, Culley NC. Effects of dietary calcium on atherosclerosis, aortic calcification, and icterus in rabbits fed a supplemental cholesterol diet. Lipids Health Dis 2006;5:16
  • Bauer DC. The calcium supplement controversy: now what? J Bone Miner Res 2014;29:531–3
  • Lewis JR, Zhu K, Prince RL. Adverse events from calcium supplementation: relationship to errors in myocardial infarction selfreporting in randomized controlled trials of calcium supplementation. J Bone Miner Res 2012;27:719–22
  • Khan A, Fortier M; Menopause and Osteoporosis Working Group. Osteoporosis in menopause. J Obstet Gynaecol Can 2014;36:839–40
  • Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 2009;339:b3692
  • Bockman RS, Zapalowski C, Kiel DP, Adler RA. Commentary on calcium supplements and cardiovascular events. J Clin Densitom 2012;15:130–4

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