Synthetic phosphoinositolglycans regulate lipid metabolism between rat adipocytes via release of GPI-protein-harbouring adiposomes

References

• Aoki N, Jin-no S, Nakagawa Y, Asai N, Arakawa E, Tamura N, Tamura T, Matsuda T. (2007). Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles. Endocrinology 148:3850–62.
   PubMed Web of Science ®Google Scholar
• Brown D, London L. (1998). Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14:111–36.
   PubMed Web of Science ®Google Scholar
• Chakraborty N, d’Alarcao M. (2005). An anionic inositol phosphate glycan pseudotetrasaccharide exhibits high insulin-mimetic activity in rat adipocytes. Bioorg Med Chem 13:6732–41.
   PubMed Web of Science ®Google Scholar
• Cocucci E, Racchetti G, Meldolesi J. (2009). Shedding microvesicles: artefacts no more. Trends Cell Biol 19:43–51.
   PubMed Web of Science ®Google Scholar
• Deeg MA, Humphrey DR, Yang SH, Ferguson TR, Reinhold VR, Rosenberry TL. (1992). Glycan components in the glycoinositol phospholipid anchor of human erythrocyte acetylcholinesterase. Novel components produced by trifluoroacetic acid. J Biol Chem 267:18573–80.
   PubMed Web of Science ®Google Scholar
• Deeg MA, Brass EP, Rosenberry TL. (1993). Inositol glycan phosphate derived from human erythrocyte acetylcholinesterase glycolipid anchor and inositol cyclic 1,2-phosphate antagonize glucagon activation of glycogen phosphorylase. Diabetes 42:1318–23.
   PubMed Web of Science ®Google Scholar
• Dietrich H, Espina JF, Chiara JL, Jimenez-Barbero J, Leon Y, Varela-Nieto I, Mato JM, Cano FH, Foces-Foces C, Martin-Lomas M. (1999). Glycosyl inositol derivatives related to inositolphosphoglycan mediators: Synthesis, structure, and biological activity. Chem-Eur J 5:320–36.
   Web of Science ®Google Scholar
• Ducharme NA, Bickel PE. (2008). Lipid droplets in lipogenesis and lipolysis. Endocrinology 149:942–9.
   PubMed Web of Science ®Google Scholar
• Farese RV, Standaert ML, Yamada K, Huang LC, Zhang C, Cooper  DR, Wang Z, Yang Y, Suzuki S, Toyota T, Larner  J. (1994). Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. Proc Natl Acad Sci USA 91:11040–4.
   PubMed Web of Science ®Google Scholar
• Fevrier B, Raposo G. (2004). Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 16:415–21.
   PubMed Web of Science ®Google Scholar
• Frick W, Bauer A, Bauer J, Wied S, Müller G. (1998). Structure–activity relationship of synthetic phosphoinositolglycans mimicking metabolic insulin action. Biochemistry 37:13421–36.
   PubMed Web of Science ®Google Scholar
• Fujimoto T, Ohsaki Y, Cheng J, Suzuki M, Shinohara Y. (2008). Lipid droplets: a classic organelle with new outfits. Histochem Cell Biol 130:263–79.
   PubMed Web of Science ®Google Scholar
• Gaulton GN, Pratt JC. (1994). Glycosylated phosphatidylinositol molecules as second messengers. Semin Immunol 6:97–104.
   PubMedGoogle Scholar
• Geisen K. (1988). Special pharmacology of the new sulfonylurea glimepiride. Drug Res 38:1120–30.
   Web of Science ®Google Scholar
• Ikezawa H. (2002). Glyosylphosphatidylinositol (GPI)-anchored proteins. Biol Pharm Bull 25:409–17.
   PubMed Web of Science ®Google Scholar
• Jones DR, Varela–Nieto I. (1998). The role of glycosyl-phosphatidylinositol in signal transduction. Int J Biochem Cell Biol 30:313–26.
   PubMed Web of Science ®Google Scholar
• Kessler A, Müller G, Wied S, Crecelius A, Eckel J. (1998). Signalling pathways of an insulin-mimetic phosphoinositolglycan-peptide in muscle and adipose tissue. Biochem J 330:277–86.
   PubMed Web of Science ®Google Scholar
• Misek DE, Saltiel AR. (1992). An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl-phosphatidylinositol mimics some of the metabolic actions of insulin. J Biol Chem 267:16266–73.
   PubMed Web of Science ®Google Scholar
• Müller G, Ertl J, Gerl M, Preibisch G. (1997a). Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 272:10585–93.
   PubMed Web of Science ®Google Scholar
• Müller G, Hanekop N, Kramer W, Bandlow W, Frick W. (2002) Interaction of phosphoinositolglycan(-peptides) with plasma membrane lipid rafts of rat adipocytes. Arch Biochem Biophys 408:17–32.
   PubMed Web of Science ®Google Scholar
• Müller G, Jordan H, Jung C, Kleine H, Petry S. (2003). Analysis of lipolysis in adipocytes using a fluorescent fatty acid derivative. Biochimie 85:1245–56.
   PubMed Web of Science ®Google Scholar
• Müller G, Jung C, Straub J, Wied S. (2009a). Induced release of membrane vesicles and exosomes from rat adipocytes containing lipid droplet, lipid raft and glycosylphosphatidylinositol-anchored proteins. Cellular Signalling 21:324–38.
   PubMed Web of Science ®Google Scholar
• Müller G, Jung C, Wied S, Biemer-Daub G. (2009b). Induced translocation of glycosylphosphatidylinositol-anchored proteins from lipid droplets to adiposomes in rat adipocytes. Br J Pharmacol 158:749–70.
   PubMed Web of Science ®Google Scholar
• Müller G, Jung C, Wied S, Welte S, Jordan H, Frick W. (2001). Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes. Mol Cell Biol 21:4553–67.
   PubMed Web of Science ®Google Scholar
• Müller G, Over S, Wied S, Frick W. (2008a). Association of (c)AMP-degrading glycosylphosphatidylinositol-anchored proteins with lipid droplets is induced by palmitate, H2O2 and the sulfonylurea drug, glimepiride, in rat adipocytes. Biochemistry 47:1274–87.
   PubMed Web of Science ®Google Scholar
• Müller G, Schulz A, Wied S, Frick W. (2005). Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes. Biochem Pharmacol 69:761–80.
   PubMed Web of Science ®Google Scholar
• Müller G, Wied S. (1993). The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin resistant rat adipocytes in vitro. Diabetes 42:1852–67.
   PubMed Web of Science ®Google Scholar
• Müller G. Wied S, Crecelius A, Kessler A, Eckel J. (1997b). Phosphoinositolglycan-peptides from yeast potently induce metabolic insulin actions in isolated rat adipocytes, cardiomyocytes and diaphragms. Endocrinology 138:3459–75.
   PubMed Web of Science ®Google Scholar
• Müller G, Wied S, Jung C, Biemer-Daub G, Frick W. (2010b). Transfer of glycosylphosphatidylinositol-anchored 5'-nucleotidase CD73 from adiposomes into rat adipocytes stimulates lipid synthesis. Br J Pharmacol: In Press.
   Web of Science ®Google Scholar
• Müller G, Wied S, Jung C, Frick W, Biemer-Daub G. (2010a). Inhibition of lipolysis by adiposomes containing glycosylphosphatidylinositol-anchored Gce1 protein in rat adipocytes. Arch Physiol Biochem 116:28–41.
   PubMedGoogle Scholar
• Müller G, Wied S, Jung C, Over S. (2008b). Translocation of glycosylphosphatidylinositol-anchored proteins to lipid droplets and inhibition of lipolysis in rat adipocytes is mediated by reactive oxygen species. Br J Pharmacol 154:901–13.
   PubMed Web of Science ®Google Scholar
• Müller G, Wied S, Jung C, Straub J. (2008c). Coordinated regulation of esterification and lipolysis by palmitate, H2O2 and the anti-diabetic sulfonylurea drug, glimepiride, in rat adipocytes. Eur J Pharmacol 597:6–18.
   PubMed Web of Science ®Google Scholar
• Müller G, Wied S, Over S, Frick W. (2008d). Inhibition of lipolysis by palmitate, H2O2 and the sulfonylurea drug, glimepiride, in rat adipocytes depends on cAMP degradation by lipid droplets. Biochemistry 47:1259–73.
   PubMed Web of Science ®Google Scholar
• Müller G, Wied S, Walz N, Jung C. (2008e). Translocation of glycosylphosphatidylinositol-anchored proteins from plasma membrane microdomains to lipid droplets in rat adipocytes is induced by palmitate, H2O2 and the sulfonylurea drug, glimepiride. Mol Pharmacol 73:1513–29.
   PubMed Web of Science ®Google Scholar
• Nosjean O, Briolay A, Roux B. (1997). Mammalian GPI proteins: sorting, membrane residence and functions. Biochim Biophys Acta 1331:153–86.
   PubMed Web of Science ®Google Scholar
• Orlean P, Menon AK. (2007). Thematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids. J Lipid Res 48:993–1011.
   PubMed Web of Science ®Google Scholar
• Plourde R, d’Alarcao M, Saltiel AR. (1992). Synthesis and characterization of an insulin-mimetic disaccharide. J Org Chem 57:2606–10.
   Web of Science ®Google Scholar
• Schoelch C, Kuhlmann J, Gossel M, Müller G, Neumann-Haefelin  C, Belz U, Kalisch J, Biemer-Daub G, Kramer W, Juretschke HP, Herling AW. (2004). Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies. Diabetes 53:1920–6.
   PubMed Web of Science ®Google Scholar
• Schofield L, Hewitt MC, Evans K, Siomos MA, Seeberger PH. (2002). Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria. Nature 418:785–9.
   PubMed Web of Science ®Google Scholar
• Turner DI, Chakraborty N, d’Alarcao M. (2005). A fluorescent inositol phosphate glycan stimulates stimulates lipogenesis in rat adipocytes by extracellular activation alone. Bioorg Med Chem Lett 15:2023–5.
   PubMed Web of Science ®Google Scholar
• Varma R, Mayor S. (1998). GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394:798–801.
   PubMed Web of Science ®Google Scholar
• Vila MC, Milligan G, Standaert ML, Farese RV. (1990). Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Gi and activation of a phospholipase C. Biochemistry 29:8735–40.
   PubMed Web of Science ®Google Scholar
• Wallenstein S, Zucker CL, Fleiss JL. (1980). Some statistical methods useful in circulation research. Circ Res 47:1–9.
   PubMed Web of Science ®Google Scholar
• Zamze SE, Ferguson MAJ, Collins R, Dwek RA, Rademacher TW. (1988). Characterization of the cross-reacting determinant (CRD) of the glycosyl-phosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein. Eur J Biochem 176:527–34.
   PubMedGoogle Scholar
• Zapata A, Leon Y, Mato JM, Varela-Nieto I, Penades S, Martin-Lomas M. (1994). Synthesis and investigation of the possible insulin-like activity of 1D-4-O- and 1D-6-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-myo-inositol 1-phosphate and 1D-6-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-myo-inositol 1,2-(cyclic phosphate). Carbohydr Res 264:21–31.
   PubMed Web of Science ®Google Scholar
• Zechner R, Strauss JG, Haemmerle G, Lass A, Zimmermann R. (2005). Lipolysis: pathway under construction. Curr Opin Lipidol 16:333–40.
   PubMed Web of Science ®Google Scholar