Withania somnifera (Ashwagandha), a Rejuvenating Herbal Drug Which Controls Alpha-2-Macroglobulin Synthesis During Inflammation

References

• Anbalagan K, Sadique J. Influence of an Indian medicine (Ashwagandha) on acute phase reactants in inflammation. Ind. J. Exp. Biol. 1981a; 19: 245–249
   PubMed Web of Science ®Google Scholar
• Anbalagan K., Sadioue J. Response of alpha- 1-globulins of serum during inflammation. Curr. Sci. 1981b; 50: 88–89
   Google Scholar
• Aylward M., Maddock J., Wheeldon R., Parker R. J. A study of the influence of various antirheumatic drug regimens on serum acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in rheumatoid arthritis. Rheumatol. Rehabil. 1975; 14: 101–114
   PubMedGoogle Scholar
• Baldo B. A., Chen Chow S., Euers C. A new screen for anti-inflammatory agents. Estimation of rat serum acute phase α2-macroglobulin assay. Agents and Actions. 1982; 11: 482–489
   Google Scholar
• Billingham M. E. J., Davies G. E. Experimental models of arthritis in animals a screening test for drugs to treat arthritis in man. Handbook of Experimental Pharmacology. Springer-Verlag, Berlin 1979; 50: II, 108–144
   Google Scholar
• Bogden A. E., Glenn E. M., Koslowski T., Rigiero C. S. α2-GP response in adjuvant-induced polyarthritis: An immunoassay for anti-inflammatory activity. Life Sci. 1967; 6: 965–973
   PubMedGoogle Scholar
• Bogden A. E., Gray J. H. Glycoprotein synthesis and steroids. 1. Relationship of trauma, Cortisol administration and alpha-2-GP synthesis. Endocrinology. 1968; 82: 1077–1084
   PubMedGoogle Scholar
• Darcy D. A. Immunological discrimination between the blood of normal and of tumour-bearing rats. Nature 1955; 176: 643–644
   PubMedGoogle Scholar
• Glenn E. M., Bowman B. J., Koslowski T. C. The systemic response to inflammation. Biochem. Pharmac. Suppl. 1968; 27–49
   Google Scholar
• Gordon A. H. The αl macroglobulins of rat serum. Biochem. J. 1976; 159: 643–650
   PubMedGoogle Scholar
• Jamieson JC., Morrison K. E., Molasky D., Turchen B. Studies on the acute phase proteins of rat serum. V. Effect of induced inflammation on the synthesis of albumin and α1 acid glycoprotein by liver slices. Canad. J. Biochem. 1975; 53: 401–414
   PubMedGoogle Scholar
• Kindmark C. O. Sequential changes in plasma proteins in various acute diseases. Plasma protein turnover. McMillan, London 1976; 395–402
   Google Scholar
• Kirtikar R., Basu B. D. Indian Medicinal Plants. Pub. L. M. Basu, Allahabad 1944; 3: 1774
   Google Scholar
• Koj A. Acute-phase proteins. Their synthesis, turnover and biological significance. Structure and Function of Plasma proteins. Plenum, New York 1975; 1: 73–131
   Google Scholar
• Laurell C. B. Quantitative estimation of proteins by electrophoresis in antibodycontaining agarose gel. Protides of the biological fluids. Elsevier, Amsterdam 1967; 14: 499–502
   Google Scholar
• Lowe J. S. Serum protein changes in rats with arthritis induced by mycobacterial adjuvant. Biochem. Pharmac. 1964; 13: 633–641
   PubMed Web of Science ®Google Scholar
• McConkey B. New drugs for inflammation - A clinical view point for their assessment. Agents and Actions. 1976; 6: 693–695
   Google Scholar
• Malhotra C. L., Mehta V. L., Prasad K., Das P. K. Studies on Withania (Ashwagandha). The effects of total alkaloids on cardiovascular system and respiration. Ind. J. Med. Res. 1961; 49: 448–453
   Google Scholar
• Malhotra C. L., Mehta V. L., Prasad K., Das P. K. Studies on Withania Effects of total alkaloids on the smooth muscles. Ind. J. Physiol. Pharmacol. 1965; 9: 10–19
   Google Scholar
• Nieuwenhuizen W., Emeis J. J., Hemmink J. Purification and properties of rat α2 acute-phase macroglobulin. Biochim. Biophys. Acta 1979; 58: 129–139
   Google Scholar
• Sadioue J., Somasundaram S., Anbalagan K., Hazeena Begum V., Sammathu M., Selvaraj R., Subramonium A., Joseph Thas J. Aswagandha - a remedy for arthritis. Gujarat Ayurved University Publications, Jamnagar 1980; 1–80, a monograph
   Google Scholar
• Sethi P. D., Thiagarjan A. R., Subramanian S. S. Studies on the anti-inflammatory and anti-arthritic activity of Withaferin A. Ind. J. Pharmacol. 1970; 2: 165–172
   Google Scholar
• Singh N., Nath R., Agarwal A. K., Kohli R. P. A pharmacological investigation of some indigenous drug of plant origin for evaluation of their anti-pyretic analgesic and anti-inflammatory activities. J. Res. Ind. Med. Yoga Homoeo. 1978a; 13: 53–62
   Google Scholar
• Singh N., Nath R., Singh D. R., Gupta M. L., Kohli R. P. An experimental evaluation of protective effects of some indigenous drugs on carbon tetrachloride-induced hepatotoxicity in mice and rats. Quart. J. Crude Drug Res. 1978b; 16: 8–16
   Google Scholar
• Singh N., Nath R., Lata A., Singh S. P., Kohli R. P., Bhargava K. P. Withania somnifera (Ashwagandha) a rejuvenating herbal drug which enhances survival during stress. Int. J. Crude Drug Res. 1982; 20: 29–35, Adaptogen
   Google Scholar
• Sohat B., Gitter S., Abraham A., Lavie D. Anti-tumour activity of Withaferin. Cancer Chemotherapy. 1967; 51: 5–271, No.
   Google Scholar
• Somasundaram S., Sadique J. Pathobioenergetics: Changes in Mg2+-de- pendent ATPase in rat liver mitochondria with peripheral inflammation. Biochemical Medicine 1982; 27: 266–268
   PubMedGoogle Scholar
• Urban J., Chan D., Schreiber G. A rat serum glycoprotein whose synthesis rate increases greatly during inflammation. J. Biol. Chem. 1979; 254: 10565–10568
   PubMedGoogle Scholar
• Weimer H. E., Benjamin D. C. Immunological detection of an acute phase protein in rat serum. Am. J. Physiol. 1965; 209: 736–744
   PubMedGoogle Scholar
• Winter C. A., Risley E. A., Nuss G. W. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs (27849). Proc. Soc. Exp. Bio. Med. 1962; 111: 544–547
   PubMed Web of Science ®Google Scholar