Inhibitory effects of ERβ on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells-prognostication for the use of ERβ-selective therapy

References

• Ali S, Coombes RC. (2002). Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer, 2, 101–112.
   PubMed Web of Science ®Google Scholar
• Allred CD, Allred KF, Ju YH, Virant SM, Helferich WG. (2001). Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res, 61, 5045–5050.
   PubMed Web of Science ®Google Scholar
• Bardin A, Boulle N, Lazennec G, Vignon F, Pujol P. (2004). Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer, 11, 537–551.
   PubMed Web of Science ®Google Scholar
• Behrens D, Gill JH, Fichtner I. (2007). Loss of tumourigenicity of stably ERbeta-transfected MCF-7 breast cancer cells. Mol Cell Endocrinol, 274, 19–29.
   PubMedGoogle Scholar
• Deroo BJ, Korach KS. (2006). Estrogen receptors and human disease. J Clin Invest, 116, 561–570.
   PubMed Web of Science ®Google Scholar
• Duong V, Licznar A, Margueron R, Boulle N, Busson M, Lacroix M, Katzenellenbogen BS, Cavaillès V, Lazennec G. (2006). ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors. Oncogene, 25, 1799–1806.
   PubMed Web of Science ®Google Scholar
• Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA. (1997). Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab, 82, 4258–4265.
   PubMed Web of Science ®Google Scholar
• Gottardis MM, Robinson SP, Jordan VC. (1988). Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic action of tamoxifen. J Steroid Biochem, 30, 311–314.
   PubMedGoogle Scholar
• Gruvberger-Saal SK, Bendahl PO, Saal LH, Laakso M, Hegardt C, Edén P, Peterson C, Malmström P, Isola J, Borg A, Fernö M. (2007). Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res, 13, 1987–1994.
   PubMed Web of Science ®Google Scholar
• Hartman J, Lindberg K, Morani A, Inzunza J, Ström A, Gustafsson JA. (2006). Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. Cancer Res, 66, 11207–11213.
   PubMed Web of Science ®Google Scholar
• Hartman J, Ström A, Gustafsson JA. (2009). Estrogen receptor beta in breast cancer–diagnostic and therapeutic implications. Steroids, 74, 635–641.
   PubMed Web of Science ®Google Scholar
• Henderson BE, Ross R, Bernstein L. (1988). Estrogens as a cause of human cancer: The Richard and Hinda Rosenthal Foundation award lecture. Cancer Res, 48, 246–253.
   PubMed Web of Science ®Google Scholar
• Hodges-Gallagher L, Valentine CD, El Bader S, Kushner PJ. (2008). Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells. Breast Cancer Res Treat, 109, 241–250.
   PubMed Web of Science ®Google Scholar
• Honma N, Horii R, Iwase T, Saji S, Younes M, Takubo K, Matsuura M, Ito Y, Akiyama F, Sakamoto G. (2008). Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. J Clin Oncol, 26, 3727–3734.
   PubMedGoogle Scholar
• Hsieh CY, Santell RC, Haslam SZ, Helferich WG. (1998). Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res, 58, 3833–3838.
   PubMed Web of Science ®Google Scholar
• Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. (1996). Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA, 93, 5925–5930.
   PubMed Web of Science ®Google Scholar
• Kumagai Y, Fujita T, Ozaki M, Yokota S, Maeda M, Shida M, Otani Y, Yamaya H, Tsuruta H. (2009). Safety, tolerability and pharmacokinetics of TAS-108, a novel anti-oestrogen, in healthy post-menopausal Japanese women: A phase I single oral dose study. Basic Clin Pharmacol Toxicol, 104, 352–359.
   PubMedGoogle Scholar
• Lazennec G, Bresson D, Lucas A, Chauveau C, Vignon F. (2001). ER beta inhibits proliferation and invasion of breast cancer cells. Endocrinology, 142, 4120–4130.
   PubMed Web of Science ®Google Scholar
• Levy N, Tatomer D, Herber CB, Zhao X, Tang H, Sargeant T, Ball LJ, Summers J, Speed TP, Leitman DC. (2008). Differential regulation of native estrogen receptor-regulatory elements by estradiol, tamoxifen, and raloxifene. Mol Endocrinol, 22, 287–303.
   PubMed Web of Science ®Google Scholar
• Leygue E, Dotzlaw H, Watson PH, Murphy LC. (1998). Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesis. Cancer Res, 58, 3197–3201.
   PubMed Web of Science ®Google Scholar
• Lindberg K, Ström A, Lock JG, Gustafsson JA, Haldosén LA, Helguero LA. (2010). Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer cells. J Cell Physiol, 222, 156–167.
   PubMed Web of Science ®Google Scholar
• Messina M, Barnes S. (1991). The role of soy products in reducing risk of cancer. J Natl Cancer Inst, 83, 541–546.
   PubMed Web of Science ®Google Scholar
• Moore JT, McKee DD, Slentz-Kesler K, Moore LB, Jones SA, Horne EL, Su JL, Kliewer SA, Lehmann JM, Willson TM. (1998). Cloning and characterization of human estrogen receptor beta isoforms. Biochem Biophys Res Commun, 247, 75–78.
   PubMed Web of Science ®Google Scholar
• Mosselman S, Polman J, Dijkema R. (1996). ER beta: Identification and characterization of a novel human estrogen receptor. FEBS Lett, 392, 49–53.
   PubMed Web of Science ®Google Scholar
• Novelli F, Milella M, Melucci E, Di Benedetto A, Sperduti I, Perrone-Donnorso R, Perracchio L, Venturo I, Nisticò C, Fabi A, Buglioni S, Natali PG, Mottolese M. (2008). A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: An observational prospective study. Breast Cancer Res, 10, R74.
   Google Scholar
• Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL, Leitman DC. (2004). Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res, 64, 423–428.
   PubMed Web of Science ®Google Scholar
• Peng J, Sengupta S, Jordan VC. (2009). Potential of selective estrogen receptor modulators as treatments and preventives of breast cancer. Anticancer Agents Med Chem, 9, 481–499.
   PubMed Web of Science ®Google Scholar
• Pettersson K, Gustafsson JA. (2001). Role of estrogen receptor beta in estrogen action. Annu Rev Physiol, 63, 165–192.
   PubMed Web of Science ®Google Scholar
• Rochefort H, Platet N, Hayashido Y, Derocq D, Lucas A, Cunat S, Garcia M. (1998). Estrogen receptor mediated inhibition of cancer cell invasion and motility: An overview. J Steroid Biochem Mol Biol, 65, 163–168.
   Google Scholar
• Rody A, Holtrich U, Solbach C, Kourtis K, von Minckwitz G, Engels K, Kissler S, Gätje R, Karn T, Kaufmann M. (2005). Methylation of estrogen receptor beta promoter correlates with loss of ER-beta expression in mammary carcinoma and is an early indication marker in premalignant lesions. Endocr Relat Cancer, 12, 903–916.
   PubMed Web of Science ®Google Scholar
• Roger P, Sahla ME, Mäkelä S, Gustafsson JA, Baldet P, Rochefort H. (2001). Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res, 61, 2537–2541.
   PubMed Web of Science ®Google Scholar
• Shaaban AM, Green AR, Karthik S, Alizadeh Y, Hughes TA, Harkins L, Ellis IO, Robertson JF, Paish EC, Saunders PT, Groome NP, Speirs V. (2008). Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients. Clin Cancer Res, 14, 5228–5235.
   PubMed Web of Science ®Google Scholar
• Skliris GP, Leygue E, Curtis-Snell L, Watson PH, Murphy LC. (2006). Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. Br J Cancer, 95, 616–626.
   PubMedGoogle Scholar
• Williams C, Edvardsson K, Lewandowski SA, Ström A, Gustafsson JA. (2008). A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells. Oncogene, 27, 1019–1032.
   PubMed Web of Science ®Google Scholar
• Xing W, Archer TK. (1998). Upstream stimulatory factors mediate estrogen receptor activation of the cathepsin D promoter. Mol Endocrinol, 12, 1310–1321.
   PubMedGoogle Scholar
• Zhao C, Dahlman-Wright K, Gustafsson JA. (2008). Estrogen receptor beta: An overview and update. Nucl Recept Signal, 6, e003.
   PubMedGoogle Scholar
• Zhao C, Lam EW, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA, Dahlman-Wright K. (2003). Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: Regulation by methylation. Oncogene, 22, 7600–7606.
   PubMed Web of Science ®Google Scholar