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Review Article

Pharmacological effects of Trigonella foenum-graecum L. in health and disease

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Pages 243-254 | Received 26 Apr 2013, Accepted 14 Jul 2013, Published online: 09 Oct 2013

References

  • Abdel-Barry JA, Abdel-Hassan IA, Al-Hakiem MH. (1997). Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. J Ethnopharmacol 58:149–55
  • Abdo MS, Al-Kafawi AA. (1969). Experimental studies on the effect of Trigonella foenum-graecum. Planta Med 17:14–18
  • Ahmad I, Beg AZ. (2001). Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. J Ethnopharmacol 74:113–23
  • Al-Habori M, Raman A, Lawrence MJ, Skett P. (2001). In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A. In J Exp Diabet Res 2:91–9
  • Alvari A, Ohadi Rafsanjani MS, Ahmad FJ, Abdin MZ. (2012). Current status and future prospects of hepatoprotective herbal medicines: Contemporary overview into the clinical trials. Rev Recent Clin Trials 7:214–23
  • Amin A, Alkaabi A, Al-Falasi S, Daoud SA. (2005). Chemopreventive activities of Trigonella foenum-graecum (Fenugreek) against breast cancer. Cell Biol Int 29:687–94
  • Annida B, Stanely Mainzen, Prince P. (2004). Supplementation of fenugreek leaves lower lipid profile in streptozotocin-induced diabetic rats. J Med Food 7:153–6
  • Annida B, Stanely Mainzen, Prince P. (2005). Supplementation of fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats. J Med Food 8:382–5
  • Anonymous. (1998). The Wealth of India A Dictionary of Indian Raw Materials and Industrial Procedures. New Delhi, India: National Institute of Science and Communication, Council of Scientific and Industrial Research, Vol. X Sp-W
  • Anuradha CV, Ravikumar P. (1998). Anti-lipidperoxidative activity of seeds of fenugreek (Trigonella foenum-graecum). Med Sci Res 26:317–21
  • Aqil F, Ahmad I. (2007). Antibacterial properties of traditionally used Indian medicinal plants. Methods Find Exp Clin Pharmacol 29:79–92
  • Araee M, Norouzi M, Habibi G, Sheikhvatan M. (2009). Toxicity of Trigonella foenum-graecum (Fenugreek) in bone marrow cell proliferation in rat. Pak J Pharm Sci 22:126–30
  • Baquer NZ, Kumar P, Taha A, et al. (2011). Metabolic and molecular action of Trigonella foenum-graecum (fenugreek) and trace metals in experimental diabetic tissues. J Biosci 36:383–96
  • Basch E, Ulbricht C, Kuo G, et al. (2003). Therapeutic applications of fenugreek. Altern Med Rev 8:20–7
  • Belaïd-Nouira Y, Bakhta H, Bouaziz M, et al. (2012). Study of lipid profile and parieto-temporal lipid peroxidation in AlCl3 mediated neurotoxicity. Modulatory effect of fenugreek seeds. Lipids Health Dis 11:16–23
  • Bell LN, Chalasani N. (2009). Epidemiology of idiosyncratic drug-induced liver injury. Semin Liver Dis 29:337–47
  • Bellentani S, Saccoccio G, Costa G, et al. (1997). Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group. Gut 41:845–50
  • Bhatia K, Kaur M, Atif F, et al. (2006). Aqueous extract of Trigonella foenum-graecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice. Food Chem Toxicol 44:1744–50
  • Bhatt RH, Khorana ML, Patel JR, et al. (1958). Pharmacological studies of saponins of the fruits of Luffa echinata Roxb. and seeds of Trigonelia foenum-graecum Linn. Indian J Psychol 2:309–21
  • Bingel AS, Farnsworth NR. (1991). Higher plants as potential sources of galactagogues. Econ Med Plant Res 6:1–54
  • Bin-Hafeez B, Haque R, Parvez S, et al. (2003). Immunomodulatory effects of fenugreek (Trigonella foenum-graecum L.) extract in mice. Int Immunopharmacol 3:257–65
  • Bordia A, Verma SK, Srivastava KC. (1997). Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenum-graecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 56:379–84
  • Brinker F. (1998). Herb Contradictions and Drug Interactions. 1st ed. Sandy (OR): Eclectic Medical Publications, 70–1
  • Broca C, Breil V, Cruciani-Guglielmacci C, et al. (2004). Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat. Am J Physiol Endocrinol Metab 287:E463–71
  • Broca C, Gross R, Petit P, et al. (1999). 4-Hydroxyisoleucine: Experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol 277:617–23
  • Chevassus H, Gaillard JB, Farret A, et al. (2010). A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 66:449–55
  • Chevassus H, Molinier N, Costa F, et al. (2009). A fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteers. Eur J Clin Pharmacol 65:1175–8
  • Devasena T, Menon PV. (2007). Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis. Ital J Biochem 56:28–34
  • Dhiman A, Nanda A, Ahmad S. (2012). A recent update in research on the antihepatotoxic potential of medicinal plants. Zhong Xi Yi Jie He Xue Bao 10:117–27
  • Dhiman RK, Chawla YK. (2005). Herbal medicines for liver diseases. Dig Dis Sci 50:1807–12
  • DiSilvestro RA, Verbruggen MA, Offutt EJ. (2011). Anti-heartburn effects of a fenugreek fiber product. Phytother Res 25:88–91
  • Dixit P, Ghaskadbi S, Mohan H, Devasagayam TP. (2005). Antioxidant properties of germinated fenugreek seeds. Phytother Res 19:977–83
  • Dixit PP, Misar A, Mujumdar AM, Ghaskadbi S. (2010). Pre-treatment of Syndrex protects mice from becoming diabetic after streptozotocin injection. Fitoterapia 81:403–12
  • El-Mahdy AR, El-Sebaiy LA. (1983). Changes in carbohydrates of germinating fenugreek seeds (Trigonella foenum-graecum L.). J Sci Food Agric 34:951–6
  • Escot N. (1994/95). Fenugreek. Atoms Summar:7–12
  • Flammang AM. (2004). Genotoxicity testing of a fenugreek extract. Food Chem Toxicol 42:1769–75
  • Gangoué-Piéboji J, Eze N, Ngongang Djintchui A, et al. (2009). The in vitro antimicrobial activity of some medicinal plants against beta-lactam-resistant bacteria. J Infect Dev Ctries 3:671–80
  • Genet S, Kale RK, Baquer NZ. (2002). Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: Effect of vanadate and fenugreek (Trigonella foenum-graecum). Mol Cell Biochem 236:7–12
  • Giordani R, Regli P, Buc J. (2002). Antifungal effect of Hevea brasiliensis latex with various fungi. Its synergistic action with amphotericin B against Candida albicans. Mycoses 45:476–81
  • Gupta R, Nair S. (1999). Antioxidant flavonoids in common Indian diet. South Asian J Prev Cardiol 3:83–94
  • Haefelé C, Bonfils C, Sauvaire Y. (1997). Characterization of a dioxygenase from Trigonella foenum-graecum involved in 4-hydroxyisoleucine biosynthesis. Phytochemistry 44:563–6
  • Haeri MR, Izaddoost M, Ardekani MR, et al. (2009). The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats. Phytother Res 23:61–4
  • Hamden K, Jaouadi B, Carreau S, et al. (2010). Potential protective effect on key steroidogenesis and metabolic enzymes and sperm abnormalities by fenugreek steroids in testis and epididymis of surviving diabetic rats. Arch Physiol Biochem 116:146–55
  • Hannan JM, Ali L, Rokeya B, et al. (2007). Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br J Nutr 97:514–21
  • Hannan JM, Rokeya B, Faruque O, et al. (2003). Effect of soluble dietary fibre fraction of Trigonella foenum-graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rat. J Ethnopharmacol 88:73–7
  • Haouala R, Hawala S, El-Ayeb A, et al. (2008). Aqueous and organic extracts of Trigonella foenum-graecum L. inhibit the mycelia growth of fungi. J Environ Sci (China) 20:1453–7
  • Hibasami H, Moteki H, Ishikawa K, et al. (2003). Protodioscin isolated from fenugreek (Trigonella foenum-graecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III. Int J Mol Med 11:23–6
  • Hooda S, Jood S. (2004). Nutritional evaluation of wheat-fenugreek blends for product making. Plant Foods Hum Nutr 59:149–54
  • Ikeuchi M, Yamaguchi K, Koyama T, et al. (2006). Effects of fenugreek seeds (Trigonella foenum-greaecum) extract on endurance capacity in mice. J Nutr Sci Vitaminol (Tokyo) 52:287–92
  • Jayaweera DMA. (1981). Medicinal Plant: Part III. Peradeniya: Sri Lanka Royal Botanic Garden. pp. 225
  • Kannappan S, Anuradha CV. (2009). Insulin sensitizing actions of fenugreek seed polyphenols, quercetin & metformin in a rat model. Indian J Med Res 129:401–8
  • Kaviarasan S, Anuradha CV. (2007). Fenugreek (Trigonella foenum-graecum) seed polyphenols protect liver from alcohol toxicity: A role on hepatic detoxification system and apoptosis. Pharmazie 62:299–304
  • Kaviarasan S, Naik G, Gangabhagirathi R, et al. (2007). In vitro studies on antiradical and antioxidant activities of fenugreek (Trigonella foenum-graecum) seeds. Food Chem 103:31–7
  • Kaviarasan S, Ramamurty N, Gunasekaran P, et al. (2006). Fenugreek (Trigonella foenum-graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells. Alcohol Alcohol 41:267–73
  • Kaviarasan S, Sundarapandiyan R, Anuradha CV. (2008). Protective action of fenugreek (Trigonella foenum-graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver. Cell Biol Toxicol 24:391–400
  • Kaviarasan S, Vijayalakshmi K, Anuradha CV. (2004). Polyphenol-rich extract of fenugreek seeds protect erythrocytes from oxidative damage. Plant Foods Hum Nutr 59:143–47
  • Kawabata T, Cui MY, Hasegawa T, et al. (2011). Anti-inflammatory and anti-melanogenic steroidal saponin glycosides from Fenugreek (Trigonella foenum-graecum L.) seeds. Planta Med 77:705–10
  • Khalki L, Bennis M, Sokar Z, Ba-M'hamed S. (2012). The developmental neurobehavioral effects of fenugreek seeds on prenatally exposed mice. J Ethnopharmacol 139:672–7
  • Khalki L, M'hamed SB, Bennis M, et al. (2010). Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice. J Ethnopharmacol 131:321–5
  • Khan V, Najmi AK, Akhtar M, et al. (2012). A pharmacological appraisal of medicinal plants with antidiabetic potential. J Pharm Bioallied Sci 4:27–42
  • Khodaie L, Delazar A, Lotfipour F, Nazemiyeh H. (2012). Antioxidant and antimicrobial activity of Pedicularis sibthorpii Boiss and Pedicularis wilhelmsiana Fisch ex. Adv Pharmaceut Bull 2:89–92
  • Li F, Fernandez PP, Rajendran P, et al. (2010). Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett 292:197–207
  • Li H, Wang QJ, Zhu DN, Yang Y. (2008). A triterpene saponin of Polygala aureocauda Dunn, exerts hypolipidemic effect on hyperlipidemic mice. Phytother Res 22:159–64
  • Ligumsky M, Sestieri M, Okon E, Ginsburg I. (1995). Antioxidants inhibit ethanol-induced gastric injury in the rat. Role of manganese, glycine and carotene. Scand J Gastroenterol 30:854–60
  • Madar Z, Shomer I. (1990). Polysaccharide composition of a gel fraction derived from fenugreek and its effect on starch digestion and bile acid absorption in rats. J Agric Food Chem 38:1535–39
  • Mahdavi MR, Roghani M, Baluchnejadmojarad T. (2008). Mechanisms responsible for the vascular effect of aqueous Trigonella foenum-graecum leaf extract in diabetic rats. Indian J Pharmacol 40:59–63
  • Mandegary A, Pournamdari M, Sharififar F, et al. (2012). Alkaloid and flavonoid rich fractions of fenugreek seeds (Trigonella foenum-graecum L.) with antinociceptive and anti-inflammatory effects. Food Chem Toxicol 50:2503–7
  • Mansour EH, El-Adawy TA. (1994). Nutritional potential and functional properties of heat treated and germinated fenugreek seeds. Lebensmittel-Wissenschaft und Technologie 27:568–73
  • Martinez RM, Nordt SP, Cantrell FL. (2012). Prescription acetaminophen ingestions associated with hepatic injury and death. J Community Health 37:1249–52
  • Meera R, Devi P, Kameswari B, et al. (2009). Antioxidant and hepatoprotective activities of Ocimum basilicum Linn. and Trigonella foenum-graecum Linn. against H2O2 and CCl4 induced hepatotoxicity in goat liver. Indian J Exp Biol 47:584–90
  • Mercan N, Guvensen A, Celik A, Katircioglu H. (2007). Antimicrobial activity and pollen composition of honey samples collected from different provinces in Turkey. Nat Prod Res 21:187–95
  • Mital N, Gopaldas T. (1986). Effect of fenugreek (Trigonella foenum-graecum) seed based diets on the lactational performance in albino rats. Nutrition Rep Int 33:477–84
  • Mohammad S, Taha A, Bamezai RN, Baquer NZ. (2006). Modulation of glucose transporter (GLUT4) by vanadate and Trigonella in alloxan-diabetic rats. Life Sci 78:820–4
  • Morani AS, Bodhankar SL, Mohan V, Thakurdesai PA. (2012). Ameliorative effects of standardized extract from Trigonella foenum-graecum L. seeds on painful peripheral neuropathy in rats. Asian Pac J Trop Med 5:385–90
  • Muraki E, Hayashi Y, Chiba H, et al. (2011). Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rat. Lipids Health Dis 10:240–6
  • Ody P. (1999). Herbs to avoid during pregnancy. In: Ody P, ed. Herbs for a Healthy Pregnancy. Los Angeles: Keats Publishing, 81
  • Olli S, Kirti PB. (2006). Cloning, characterization and antifungal activity of defensin Tfgd1 from Trigonella foenum-graecum L. J Biochem Mol Biol 39:278–83
  • O'Mahony R, Al-Khtheeri H, Weerasekera D, et al. (2005). Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World J Gastroenterol 11:7499–507
  • Pandian RS, Anuradha CV, Viswanathan P. (2002). Gastroprotective effect of fenugreek seeds (Trigonella foenum-graecum) on experimental gastric ulcer in rats. J Ethnopharmacol 81:393–7
  • Passano P. (1995). The many uses of methi. Manushi November:31–4
  • Patsenker E, Stoll M, Millonig G, et al. (2011). Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. Mol Med 17:1285–94
  • Petit PR, Sauvaire YD, Hillaire-Buys DM, et al. (1995). Steroid saponins from fenugreek seeds: Extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol. Steroids 60:674–80
  • Prabhu A, Krishnamoorthy M. (2010). Anticancer activity of Trigonella foenum-graecum on Ehrlich Ascites carcinoma in Mus musculus system. J Pharm Res 3:1181–3
  • Puri D. (1998). Therapeutic potentials of fenugreek. Indian J Physiol Pharmacol 42:423–4
  • Rabe T, van Staden J. (1997). Antibacterial activity of South African plants used for medicinal purposes. J Ethnopharmacol 56:81–7
  • Rajalakshmi R, Subbulakshmi G. (1964). Effect of fenugreek (Trigonella foenum-graecum Linn.) supplementation on the biological value of rice & black gram (Phaseolus mungo) diet. Indian J Biochem 11:104–6
  • Raju J, Bird RP. (2006). Alleviation of hepatic steatosis accompanied by modulation of plasma and liver TNF-alpha levels by Trigonella foenum-graecum (fenugreek) seeds in Zucker obese (fa/fa) rats. Int J Obese (Lond) 30:1298–307
  • Raju J, Gupta D, Rao AR, et al. (2001). Trigonella foenum-graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol Cell Biochem 224:45–51
  • Raju J, Patlolla JM, Swamy MV, Rao CV. (2004). Diosgenin, a steroid saponin of Trigonella foenum-graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev 13:1392–8
  • Randhir R, Lin YT, Shetty K. (2004). Phenolics, their antioxidant and antimicrobial activity in dark germinated fenugreek sprouts in response to peptide and phytochemical elicitors. Asia Pac J Clin Nutr 13:295–307
  • Randhir R, Shetty K. (2007). Improved alpha-amylase and Helicobacter pylori inhibition by fenugreek extracts derived via solid-state bioconversion using Rhizopus oligosporus. Asia Pac J Clin Nutr 16:382–92
  • Rastogi RP, Mehrotra BN. (1990). Compendium of Indian Medicinal Plants. New Delhi: PID. Vol. II. pp. 422
  • Reddy RL, Srinivasan K. (2009). Fenugreek seeds reduce atherogenic diet-induced cholesterol gallstone formation in experimental mice. Can J Physiol Pharmacol 87:933–43
  • Reddy R, Srinivasan K. (2011a). Dietary fenugreek and onion attenuate cholesterol gallstone formation in lithogenic diet-fed mice. Int J Exp Pathol 92:308–19
  • Reddy RR, Srinivasan K. (2011b). Effect of dietary fenugreek seeds on biliary proteins that influence nucleation of cholesterol crystals in bile. Steroids 76:455–63
  • Riordan J, Auerbach K. (1998). Human Lactation and Breastfeeding. 2nd ed. Boston (MA): Jones & Bartlett
  • Roberts KT. (2011). The potential of fenugreek (Trigonella foenum-graecum) as a functional food and nutraceutical and its effects on glycemia and lipidemia. J Med Food 14:1485–9
  • Satheeshkumar N, Mukherjee PK, Bhadra S, Saha BP. (2010). Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum-graecum L. and its constituents. Phytomedicine 17:292–5
  • Saurez J, Herrera MD, Marhuenda, E. (1996). Hesperidine and neohesperidin dihydrochalcone on different experimental models of induced gastric ulcer. Phytother Res 10:616–18
  • Sebastian KS, Thampan RV. (2007). Differential effects of soybean and fenugreek extracts on the growth of MCF-7 cells. Chem Biol Interact 170:135–43
  • Shabbeer S, Sobolewski M, Anchoori RK, et al. (2009). Fenugreek: A naturally occurring edible spice as an anticancer agent. Cancer Biol Ther 8:272–8
  • Sharma RD, Raghuram TC, Rao NS. (1990). Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 44:301–6
  • Shim SH, Lee EJ, Kim JS, et al. (2008). Rat growth-hormone release stimulators from fenugreek seeds. Chem Biodivers 5:1753–61
  • Siddiqui MR, Taha A, Moorthy K, et al. (2005). Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains. J Biosci 30:483–90
  • Sreeja S, Anju VS, Sreeja S. (2010). In vitro estrogenic activities of fenugreek Trigonella foenum-graecum seeds. Indian J Med Res 131:814–19
  • Srichamroen A, Thomson AB, Field CJ, Basu TK. (2009). In vitro intestinal glucose uptake is inhibited by galactomannan from Canadian fenugreek seed (Trigonella foenum-graecum L.) in genetically lean and obese rats. Nutr Res 29:49–54
  • Srinivasan K. (2006). Fenugreek (Trigonella foenum-graecum): A review of health beneficial physiological effects. Food Rev Int 22:203–24
  • Stark A, Madar Z. (1993). The effect of an ethanol extract derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption and cholesterol levels in rats. Br J Nutr 69:277–87
  • Sur P, Das M, Gomes A, et al. (2001). Trigonella foenum-graecum (fenugreek) seed extract as an antineoplastic agent. Phytother Res 15:257–9
  • Suresh P, Kavitha CN, Babu SM, et al. (2012). Effect of ethanol extract of Trigonella foenum-graecum (fenugreek) seeds on freund's adjuvant-induced arthritis in albino rats. Inflammation 35:1314–21
  • Thirunavukkarasu V, Anuradha CV, Viswanathan P. (2003). Protective effect of fenugreek (Trigonella foenum-graecum) seeds in experimental ethanol toxicity. Phytother Res 17:737–43
  • Trinh HT, Han SJ, Kim SW, et al. (2007). Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng. J Microbiol Biotech 17:1127–33
  • Tripathi UN, Chandra D. (2009). The plant extracts of Momordica charantia and Trigonella foenum-graecum have antioxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus. Oxid Med Cell Longev 2:290–6
  • Uemura T, Goto T, Kang MS, et al. (2011). Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr 141:17–23
  • Verma SK, Singh SK, Mathur A. (2010). In vitro cytotoxicity of Calotropis procera and Trigonella foenum-graecum against human cancer cell lines. J Chem Pharm Res 2:861–5
  • Vyas S, Agrawal RP, Solanki P, Trivedi P. (2008). Analgesic and anti-inflammatory activities of Trigonella foenum-graecum (seed) extract. Acta Pol Pharm 65:473–6
  • Williams CD, Antoine DJ, Shaw PJ, et al. (2011). Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. Toxicol Appl Pharmacol 252:289–97
  • Xue W, Lei J, Li X, Zhang R. (2011). Trigonella foenum-graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity. Nutr Res 31:555–62
  • Yadav UC, Moorthy K, Baquer NZ. (2004). Effects of sodium-orthovanadate and Trigonella foenum-graecum seeds on hepatic and renal lipogenic enzymes and lipid profile during alloxan diabetes. J Biosci 29:81–91
  • Yoshikawa M, Murakami T, Komatsu H, et al. (1997). Medicinal Foodstuffs: IV. Fenugreek seeds (1): Structures of trigoneosides Ia, Ib, IIb, IIIa and IIIb new furostanol saponins from the seeds of Indian Trigonella foenum- graecum L. Chem Pharmacol Bull 45:81–7
  • Zia T, Hasnain SN, Hasan SK. (2001). Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice. J Ethnopharmacol 75:191–5

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