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Review Article

Hepatoprotective properties of extensively studied medicinal plant active constituents: Possible common mechanisms

, &
Pages 781-791 | Received 04 Apr 2014, Accepted 25 Jul 2014, Published online: 09 Dec 2014

References

  • Abenavoli L, Capasso R, Milic N, Capasso F. (2010). Milk thistle in liver disease: Past, present, future. Phytother Res 24:1423–32
  • Adewusi EA, Afolayan AJ. (2010). A review of natural products with hepatoprotective activity. J Med Plant Res 4:1318–34
  • Aftab N, Likhitwitayawuid K, Vieira A. (2010). Comparative antioxidant activities and synergism of resveratrol and oxyresveratrol. Nat Prod Res 24:1726–33
  • Ahmed MS, Wong CF, Shawki H, et al. (2008). Rapidly deteriorating renal function with membranoproliferative glomerulonephritis type 1 associated with hepatitis C treated successfully with steroids and antiviral therapy: A case report and review of literature. Clin Nephrol 69:298–301
  • Akachi T, Shiina Y, Ohishi Y, et al. (2010). Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against d-galactosamine-induced liver injury in rats. J Nutr Sci Vitaminol 56:60–7
  • Alonso FT, Garmendia ML, de Aguirre M, Searle J. (2010). Mortality trend from liver cirrhosis in Chile from 1990 to 2007. Rev Med Chile 138:1253–8
  • Alvari A, Mehrnaz SO, Ahmad FJ, Abdin MZ. (2012). Contemporary overview on clinical trials and future prospects of hepato-protective herbal medicines. Rev Recent Clin Trials 7:214–23
  • Ansari JA, Ali S, Ansari MA. (2011). A brief focus on hepatoprotective leads from herbal origin. Int J Pharmacol 7:212–16
  • Arrieta O, Rodriguez-Diaz JL, Rosas-Camargo V, et al. (2006). Colchicine delays the development of hepatocellular carcinoma in patients with hepatitis virus-related liver cirrhosis. Cancer 107:1852–8
  • Asgarpanah J, Kazemivash N. (2012). Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum L. Afr J Pharm Pharmacol 6:2340–5
  • Asuku O, Atawodi SE, Onyike E. (2012). Antioxidant, hepatoprotective, and ameliorative effects of methanolic extract of leaves of Grewia mollis Juss. on carbon tetrachloride-treated Albino rats. J Med Food 15:83–8
  • Athar M, Back JH, Kopelovich L, et al. (2009). Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys 486:95–102
  • Avila DS, Palma AS, Colle D, et al. (2011). Hepatoprotective activity of a vinylic telluride against acute exposure to acetaminophen. Eur J Pharmacol 661:92–101
  • Bereswill S, Munoz M, Fischer A, et al. (2010). Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. Plos One [Online]. Available from: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015099 [last accessed 23 Jun 2014]
  • Bilgi N, Bell K, Ananthakrishnan AN, Atallah E. (2010). Imatinib and Panax ginseng: A potential interaction resulting in liver toxicity. Ann Pharmacother 44:926–8
  • Bishayee A, Darvesh AS, Politis T, McGory R. (2010). Resveratrol and liver disease: From bench to bedside and community. Liver Int 30:1103–14
  • Blachier M, Leleu H, Peck-Radosavljevic M, et al. (2013). The burden of liver disease in Europe: A review of available epidemiological data. J Hepatol 58:593–608
  • Brinda BJ, Zhu HJ, Markowitz JS. (2012). A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma. J Chromatogr B 902:1–9
  • Canova NK, Kmonickova E, Martinek J, et al. (2007). Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. Cell Biol Toxicol 23:337–54
  • Carluccio MA, Ancora MA, Massaro M, et al. (2007). Homocysteine induces VCAM-1 gene expression through NF-kappa B and NAD(P)H oxidase activation: Protective role of Mediterranean diet polyphenolic antioxidants. Am J Physiol-Heart C 293:H2344–54
  • Cerny D, Canova NK, Martinek J, et al. (2009). Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1. Nitric Oxide-Biol Ch 20:1–8
  • Cerny D, Lekic N, Vanova K, et al. (2011). Hepatoprotective effect of curcumin in lipopolysaccharide/d-galactosamine model of liver injury in rats: Relationship to HO-1/CO antioxidant system. Fitoterapia 82:786–91
  • Chattopadhyay RR. (2003). Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: Part II. J Ethnopharmacol 89:217–19
  • Chen Q, Lai HF. (2013). Plant-derived virus-like particles as vaccines. Hum Vacc Immunother 9:32–55
  • Chirumbolo S. (2010). The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy-Drug Targets 9:263–85
  • Chow HHS, Garland LL, Hsu CH, et al. (2010). Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res 3:1168–75
  • Del Prete A, Scalera A, Iadevaia MD, et al. (2012). Herbal products: Benefits, limits, and applications in chronic liver disease. Evid-Based Compl Alt [Online]. Available from: http://www.hindawi.com/journals/ecam/2012/837939/ [last accessed 23 Jun 2014]
  • Dhiman A, Nanda A, Ahmad S. (2012). A recent update in research on the antihepatotoxic potential of medicinal plants. J Chinese Integr Med 10:117–27
  • Ding RB, Tian K, Huang LL, et al. (2012). Herbal medicines for the prevention of alcoholic liver disease: A review. J Ethnopharmacol 144:457–65
  • Egert S, Bosy-Westphal A, Seiberl J, et al. (2009). Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study. Br J Nutr 102:1065–74
  • El-Kamary SS, Shardell MD, Abdel-Hamid M, et al. (2009). A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine 16:391–400
  • Falasca K, Ucciferri C, Mancino P, et al. (2008). Treatment with silybin-vitamin E-phospholipid complex in patients with hepatitis C infection. J Med Virol 80:1900–6
  • Farghali H, Sakr M, Gasbarrini A, et al. (1991a). Effect of FK 506 chronic administration on bromsulphthalein hepatic excretion in rats. Transpl P 23:2802–4
  • Farghali H, Gasbarrini A, Borle AB, et al. (1991b). FK 506 modulates d-galactosamine-induced hepatitis in rats. Transpl P 23:2809–11
  • Farghali H, Rilo H, Zhang WG, et al. (1994). Liver regeneration after partial hepatectomy in the rat: Sequential events monitored by P-31-nuclear magnetic resonance spectroscopy and biochemical studies. Lab Invest 70:418–25
  • Farghali H, Bencko V, Kamenikova L, Hynie S. (1996a). Response of immobilized hepatocytes in a perfusion system to anoxia/rexygenation: Effect of cyclosporine A pretreatment. Physiol Res 45:227–333
  • Farghali H, Martinek J, Kameniková L, Hynie H. (1996b). Amelioration of chemically-induced hepatocytes injury by cyclosporine A. Pharmacol Res 34:211–18
  • Farghali H, Zidek Z, Hynie S. (1997). Effects of nitroprusside as a nitric oxide donor on anoxia/reoxygenation and d-galactosamine hepatic injuries: A study in perfused hepatocytes. Physiol Res 46:363–9
  • Farghali H, Masek K. (1998). Immunopharmacologic agents in the amelioration of hepatic injuries. Int J Immuinopharmacol 20:125–39
  • Farghali H, Kamenikova L, Hynie S, Kmonickova E. (2000a). Silymarin effects on intracellular calcium and cytotoxicity: A study in perfused rat hepatocytes after oxidative stress injury. Pharmacol Res 41:231–7
  • Farghali H, Kmonickova E, Lotkova H, Martinek J. (2000b). Evaluation of calcium channel blockers as potential hepatoprotective agents in oxidative stress injury of perfused hepatocytes. Physiol Res 49:261–8
  • Farghali H, Canova N, Gaier N, et al. (2002). Inhibition of endotoxemia-induced nitric oxide synthase expression by cyclosporin A enhances hepatocyte injury in rats: Amelioration by NO donors. Int Immunopharmacol 2:117–27
  • Farghali H, Canova N, Kucera T, et al. (2003). Nitric oxide synthase inhibitors modulate lipopolysaccharide-induced hepatocyte injury: Dissociation between in vivo and in vitro effect. Int Immunopharmacol 3:1627–38
  • Farghali H, Cerny D, Kamenikova L, et al. (2009). Resveratrol attenuates lipopolysaccharide-induced hepatitis in d-galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1. Nitric Oxide-Biol Ch 21:216–25
  • Ferenci P, Dragosics B, Dittrich H, et al. (1989). Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol 9:105–13
  • Fullerton MD, Steinberg GR. (2010). SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes 59:551–3
  • Gasbarrini A, Borle AB, Farghali H, et al. (1992a). Effect of anoxia on intracellular ATP, Na+, Cai2+ and cytotoxicity in rat hepatocytes. J Biol Chem 267:6654–63
  • Gasbarrini A, Borle AB, Caraceni P, et al. (1992b). Hepatocytes anoxic injury is prevented by high concentration of fructose. Transpl P 24:2810–12
  • Gasbarrini A, Borle AB, Farghali H, et al. (1993). Fasting enhances the effect of anoxia on ATP Ca2+ and cell injury in isolated rat hepatocytes. Biochim Biophys Acta 1178:9–19
  • Gharagozloo M, Moayedi B, Zakerinia M, et al. (2009). Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: A randomized double-blind clinical trial. Fund Clin Pharmacol 23:359–65
  • Ghosh N, Ghosh R, Mandal V, Mandal SC. (2011). Recent advances in herbal medicine for treatment of liver diseases. Pharm Biol 49:970–88
  • Girish C, Pradhan SC. (2012). Indian herbal medicines in the treatment of liver diseases: Problems and promises. Fund Clin Pharmacol 26:180–9
  • Glauert HP, Calfee-Mason K, Stemm DN, et al. (2010). Dietary antioxidants in the prevention of hepatocarcinogenesis: A review. Mol Nutr Food Res 54:875–96
  • Gupta SS. (1994). Prospects and perspectives of natural plant products in medicine. Indian J Pharmacol 26:1–12
  • Gupta SC, Kismali G, Aggarwal BB. (2013). Curcumin, a component of turmeric: From farm to pharmacy. Biofactors 39:2–13
  • Gutierrez RMP, Gonzalez AMN, Hoyo-Vadillo C. (2013). Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium alkaloids from piper: A review of its phytochemistry and pharmacology. Mini-Rev Med Chem 13:163–93
  • Haddad Y, Vallerand D, Brault A, Haddad PS. (2011). Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis. Evid-based Complement Altern Med [Online]. Available from: http://www.hindawi.com/journals/ecam/2011/647903/ [last accessed 23 Jun 2014]
  • Ho WY, Yeap SK, Ho CL, et al. (2012). Hepatoprotective activity of Elephantopus scaber on alcohol-induced liver damage in mice. Evid-based Complement Altern Med [Online]. Available from: http://www.hindawi.com/journals/ecam/2012/417953/ [last accessed 23 Jun 2014]
  • Hong JY, Lebofsky M, Farhood A, Jaeschke H. (2009). Oxidant stress-induced liver injury in vivo: Role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. Am J Physiol Gastrointest Liver Physiol 296:G572–81
  • Jaeschke H. (2011). Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts. J Gastroenterol Hepatol 26:173–9
  • Jaeschke H, McGill MR, Ramachandran A. (2012). Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev 44:88–106
  • Javed S, Kohli K, Ali M. (2011). Reassessing bioavailability of silymarin. Altern Med Rev 16:239–49
  • Jayaprakasam B, Doddaga S, Wang R, et al. (2009). Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro. J Agric Food Chem 57:820–5
  • Khan S, Khan I, Walker L. (2008). Botanical supplement and hepatotoxicity. In: Smart RC, Hodgson E, eds. Molecular and Biochemical Toxicology, 4th ed. USA: John Wiley & Sons Inc, 591–606
  • Kim YA, Kim GY, Park KY, Choi YH. (2007). Resveratrol inhibits nitric oxide and prostaglandin E-2 production by lipopolysaccharide-activated C6 microglia. J Med Food 10:218–24
  • Kim SW, Ha KC, Choi EK, et al. (2013). The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: A randomised controlled study. BMC Complem Altern M [Online]. Available from: http://www.biomedcentral.com/1472-6882/13/58 [last accessed 23 Jun 2014]
  • Kmonickova E, Drahota Z, Kamenikova L, et al. (2001). Modulatory effect of cyclosporin A on tert-butyl hydroperoxide-induced oxidative damage in hepatocytes. Immunopharmacol Immunotoxicol 23:43–54
  • Lee BH, Huang YY, Duh PD, Wu SC. (2012). Hepatoprotection of emodin and Polygonum multiflorum against CCl4-induced liver injury. Pharm Biol 50:351–9
  • Lekic N, Cerny D, Horinek A, et al. (2011). Differential oxidative stress responses to d-galactosamine-lipopolysaccharide hepatotoxicity based on real time PCR analysis of selected oxidant/antioxidant and apoptotic gene expressions in rat. Physiol Res 60:549–58
  • Lekic N, Canova NK, Horinek A, Farghali H. (2013). The involvement of heme oxygenase 1 but not nitric oxide synthase 2 in a hepatoprotective action of quercetin in lipopolysaccharide-induced hepatotoxicity of d-galactosamine sensitized rats. Fitoterapia 87:20–6
  • Leung J, Bonis PA, Kaplan MM. (2011). Colchicine or methotrexate, with ursodiol, are effective after 20 years in a subset of patients with primary biliary cirrhosis. Clin Gastroenterol H 9:776–80
  • Li L, Hai J, Li Z, et al. (2014). Resveratrol modulates autophagy and NF-κB activity in murine model for treating non-alcoholic fatty liver disease. Food Chem Toxicol 63:166–73
  • Loguercio C, Andreone P, Brisc C, et al. (2012). Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial. Free Radical Bio Med 52:1658–65
  • Maiti K, Mukherjee K, Gantait A, et al. (2007). Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. Int J Pharm 330:155–63
  • Mereish KA, Bunner DL, Ragland DR, Creasia DA. (1991). Protection against microcystin-LR-induced hepatotoxicity by silymarin: Biochemistry, histopathology, and lethality. Pharm Res 8:273–7
  • Mihailovic V, Mihailovic M, Uskokovic A, et al. (2013). Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. Food Chem Toxicol 52:83–90
  • Moghe A, Joshi-Barve S, Ghare S, et al. (2011). Histone modifications and alcohol-induced liver disease: Are altered nutrients the missing link? World J Gastroenterol 17:2465–72
  • Mukherjee PK, Sahoo AK, Narayanan N, et al. (2009). Lead finding from medicinal plants with hepatoprotective potentials. Expert Opin Drug Dis 4:545–76
  • Muntoni S, Rojkind M, Muntoni S. (2010). Colchicine reduces procollagen III and increases pseudocholinesterase in chronic liver disease. World J Gastroenterol 16:2889–94
  • Muriel P. (2008). Some experimental models in liver damage. In: Sahu SC, ed. Hepatotoxicity: From Genomics to In Vitro and In Vivo Models. 1st ed. London, UK: John Wiley & Sons Inc., 119–37
  • Muriel P, Rivera-Espinoza Y. (2008). Beneficial drugs for liver diseases. J Appl Toxicol 28:93–103
  • Nagalekshmi R, Menon A, Chandrasekharan DK, Nair CKK. (2011). Hepatoprotective activity of Andrographis paniculata and Swertia chirayita. Food Chem Toxicol 49:3367–73
  • National End of Life Care Intelligence Network (NEoLCIN). (2013). Deaths from liver disease: Implications for end of life care in England. Public Health England [Online]. Available from: http://www.endoflifecare-intelligence.org.uk/resources/publications/deaths_from_liver_disease [last accessed 25 Feb 2014]
  • Ni YF, Kuai JK, Lu ZF, et al. (2011). Glycyrrhizin treatment is associated with attenuation of lipopolysaccharide-induced acute lung injury by inhibiting cyclooxygenase-2 and inducible nitric oxide synthase expression. J Surg Res 165:E29–35
  • Nikolaidis N, Kountouras J, Giouleme O, et al. (2006). Colchicine treatment of liver fibrosis. Hepato-Gastroenterol 53:281–5
  • Nithianantham K, Shyamala M, Chen Y, et al. (2011). Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice. Molecules 16:10134–45
  • Nobili V, Carter-Kent C, Feldstein AE. (2011). The role of lifestyle changes in the management of chronic liver disease. BMC Med. [Online], 9, Article Number: 70 [Epub ahead of print]. doi:10.1186/1741-7015-9-70
  • Orlent H, Hansen BE, Willems M, et al. (2006). Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: A randomized phase II trial. J Hepatol 45:539–46
  • Panahi Y, Ghamarchehreh ME, Beiraghdar F, et al. (2012). Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: A randomized clinical trial. Hepato-Gastroenterol 59:2099–103
  • Patel KR, Scott E, Brown VA, et al. (2011). Clinical trials of resveratrol. Ann NY Acad Sci 1215 (Resveratrol and Health):161–9
  • Paul S, Hwang JK, Kim HY, et al. (2013). Multiple biological properties of macelignan and its pharmacological implications. Arch Pharm Res 36:264–72
  • Peng YH, Rideout D, Rakita S, et al. (2012). Source: Diet-induced obesity associated with steatosis, oxidative stress, and inflammation in liver. Surg Obes Relat Dis 8:73–81
  • Pradhan SC, Girish C. (2006). Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 124:491–504
  • Rana SV, Pal R, Vaiphei K, et al. (2011). Garlic in health and disease. Nutr Res Rev 24:60–71
  • Rayfield B. (2013). Why we need extra liver protection. Sinclair Method [Online]. Available from: http://www.sinclairmethod.com/index_files/Page563.htm [last accessed 25 Feb 2014]
  • Sakr MF, Zetti GM, Hassanein TH, et al. (1991a). Van Thiel, DH: FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats. Hepatology 13:947–51
  • Sakr MF, Zetti GM, Farghali H, et al. (1991b). Protective effect of FK 506 against hepatic ischemia in rats. Transpl P 23:340–1
  • Salamone F, Galvano F, Marino A, et al. (2012a). Silibinin improves hepatic and myocardial injury in mice with non-alcoholic steatohepatitis. Digest Liver Dis 44:334–42
  • Salamone F, Galvano F, Cappello F, et al. (2012b). Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental non-alcoholic steatohepatitis. Transl Res 159:477–86
  • Sanchez-Valle V, Chavez-Tapia NC, Uribe M, Mendez-Sanchez N. (2012). Role of oxidative stress and molecular changes in liver fibrosis: A review. Curr Med Chem 19:4850–60
  • Sarwar M, Attitalla IH, Abdollahi M. (2011). A review on the recent advances in pharmacological studies on medicinal plants: Animal studies are done but clinical studies needs completing. Asian J Anim Vet Adv 6:867–83
  • Shivananjappa MM, Mhasavade D, Joshi MK. (2013). Aqueous extract of Terminalia arjuna attenuates tert-butyl hydroperoxide-induced oxidative stress in HepG2 cell model. Cell Biochem Funct 31:129–35
  • Singab ANB, Ayoub NA, Ali EN, Mostafa NM. (2010). Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats. Pharm Biol 48:1255–64
  • Singh H, Sharma YK. (2011). Clinical evaluation of the hepatoprotective effect of Katuki (Picrorhiza kurroa Royle ex Benth.) processed in Guduchi (Tinospora cordifolia Wild.) Miers in patients receiving lipid lowering drugs (statins). Indian J Tradit Know 10:657–60
  • Singh M, Sasi P, Gupta VH, et al. (2012). Protective effect of curcumin, silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model. Hum Exp Toxicol 31:788–97
  • Smoliga JM, Rundell KW. (2011). Oxidative stress: Friend and foe of the elite marathoner. J Appl Physiol 110:287–7
  • Smoliga JM, Vang O, Baur JA. (2012). Challenges of translating basic research into therapeutics: Resveratrol as an example. J Gerontol A-Biol 67:158–67
  • Subramanian R, Asmawi MZ, Sadikun A. (2012). A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata. Phytochem Rev 11:39–75
  • Suchankova G, Nelson LE, Gerhart-Hines Z, et al. (2009). Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Comman 378:836–41
  • Thabrew MI, Hughes RD. (1996). Phytogenic agents in the therapy of liver disease. Phytother Res 10:461–7
  • Timmers S, Auwerx J, Schrauwen P. (2012). The journey of resveratrol from yeast to human. Aging-US 4:146–58
  • Torres DM, Williams CD, Harrison SA. (2012). Features, diagnosis, and treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 10:837–58
  • Torres-Gonalez L, Munoz-Espinosa LE, Rivas-Estilla AM, et al. (2011). Protective effect of four Mexican plants against CCl4-induced damage on the Huh7 human hepatoma cell line. Ann Hepatol 10:73–9
  • Upadhyay R, Tiwari KN, Singh K. (2013). High frequency shoots regeneration for mass multiplication of Phyllanthus fraternus Webster – An important antiviral and hepatoprotective plant. Appl Biochem Biotechnol 169:2303–14
  • Valan MF, Britto AJB, Venkataraman R. (2010). Phytoconstituens with hepatoprotective activity. Int J Chem Sci 8:1421–32
  • Wagner H, Horhammer L, Munster R. (1968). The chemistry of silymarin (silybin), the active principle of the fruits of Silybum marianum (L.) Gaertn. (Carduus marianus) (L.). Aarzneimittelfoschung/Drug Res 18:688–96
  • Wagner H, Diesel P, Seitz M. (1974). Chemistry and analysis of silymarin from Silybum marianum (L.). Arzneimittelforschung/Drug Res 24:466–71
  • Wan XY, Luo M, Li XD, He P. (2009). Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine. Chem-Biol Interact 181:15–19
  • Wang HJ, Gao B, Zakhari S, Nagy LE. (2012). Inflammation in alcoholic liver disease. Ann Rev Nutr 32:343–68
  • Wendeburg L, de Oliveira ACP, Bhatia HS, et al. (2009). Resveratrol inhibits prostaglandin formation in IL-1 beta-stimulated SK-N-SH neuronal cells. J Neuroinflamm. [Online], 6, Article Number: 26, [Epub ahead of print]. doi:10.1186/1742-2094-6-26
  • Wong YT, Gruber J, Jenner AM, et al. (2009). Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: Protection by chronic oral intake of resveratrol. Free Radical Bio Med 46:799–809
  • Wong VWS, Wong GLH, Chan AWH, et al. (2013). Treatment of non-alcoholic steatohepatitis with Phyllanthus urinaria: A randomized trial. J Gastroenterol Hepatol 28:57–62
  • Xavier JR, Gnanam R, Murugan MP, Pappachan A. (2012). Clonal propagation of Phyllanthus amarus: A hepatoprotector. Pharmacogn Mag 8:78–82
  • Xiong SQ, Salazar G, Patrushev N, Alexander RW. (2011). FoxO1 mediates an autofeedback loop regulating SIRT1 expression. J Biol Chem 286:5289–99
  • Yasui S, Fujiwara K, Tawada A, et al. (2011). Efficacy of intravenous glycyrrhizin in the early stage of acute onset autoimmune hepatitis. Digest Dis Sci 56:3638–47
  • Yeum KJ, Russel RM, Aldini G. (2010). Biomarkers for reassemble the results and re-create the whole by human studies. In: Aldini G, Yeum KJ, Niki E, Russel RM, eds. Biomarkers for Antioxidant Defence and Oxidative Damage: Principles and Practical Applications. Ames, Iowa: Blackwell Publishing, 3–19
  • Zakhari S, Li TK. (2007). Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease. Hepatology 46:2032–9
  • Zhang H, Yu CH, Jiang YP, et al. (2012). Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. Plos One [Online]. Available from: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046574 [last accessed 23 Jun 2014]
  • Zhang A, Sun H, Wang X. (2013a). Recent advances in natural products from plants for treatmen of liver diseases. Eur J Med Chem 63:570–7
  • Zhang YX, Hai J, Cao M, et al. (2013b). Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly throughtargeting IRS-1/PI3K/Akt pathway. Int Immunopharmacol 17:714–20
  • Zhao LT, Wu JQ, Yang JJ, et al. (2011). Dietary quercetin supplementation increases serum antioxidant capacity and alters hepatic gene expression profile in rats. Exp Biol Med 236:701–6
  • Zhou HY, Beevers CS, Huang SL. (2011). The targets of curcumin. Curr Drug Targets 12:332–47

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