1,546
Views
27
CrossRef citations to date
0
Altmetric
Original Article

Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells

, &
Pages 1302-1310 | Received 03 Jun 2014, Accepted 09 Oct 2014, Published online: 10 Apr 2015

References

  • Abdel Nour AM, Ringot D, Gue'ant JL, Chango A. (2007). Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency. Carcinogenesis 28:2291–7
  • Abel S, Gelderblom WC. (1998). Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo. Toxicology 131:121–31
  • Aranda M, Perez-Alzola LP, Ellahuene MF, Sepulveda C. (2000). Assessment of in vitro mutagenicity in Salmonella and in vivo genotoxicity in mice of the mycotoxin fumonisin B1. Mutagenesis 15:469–71
  • Asada K, Asada R, Yoshiji H, et al. (2006). DNA cytosine methylation profile in various cancer-related genes is altered in cultured rat hepatocyte cell lines as compared with primary hepatocytes. Oncol Rep 15:1241–8
  • Baccarelli A, Bollati V. (2009). Epigenetics and environmental chemicals. Curr Opin Pediatr 21:243–51
  • Baylin SB, Herman JG, Graff JR, et al. (1998). Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res 72:141–96
  • Bombail V, Moggs JG, Orphanides G. (2004). Perturbation of epigenetic status by toxicants. Toxicol Lett 149:51–8
  • Chen T, Mally A, Ozden S, Chipman JK. (2010). Low doses of the carcinogen furan alter cell cycle and apoptosis gene expression in rat liver independent of DNA methylation. Environ Health Perspect 118:1597–602
  • Chuturgoon AA, Phulukdaree A, Moodley D. (2014). Fumonisin B1 induces global DNA hypomethylation in HepG2 cells – An alternative mechanism of action. Toxicology 315:65–9
  • Domijan AM, Zeljezic D, Kopjar N, Peraica M. (2006). Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B1-treated rats. Toxicology 222:53–9
  • Domijan AM, Zeljezic D, Milic M, Peraica M. (2007). Fumonisin B(1): Oxidative status and DNA damage in rats. Toxicology 232:163–9
  • Domijan A, Zeljezic D, Peraica M, et al. (2008). Early toxic effects of fumonisin B1 in rat liver. Hum Exp Toxicol 27:895–900
  • Domijan AM, Abramov AY. (2011). Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis-implication to mechanism of cell toxicity. Int J Biochem Cell Biol 43:897–904
  • Du YP, Peng JS, Sun A, et al. (2009). Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model. BMC Cancer 9:1–9
  • Esteller M. (2002). CpG island hypermethylation and tumor suppressor genes: A booming present, a brighter future. Oncogene 21:5427–40
  • Fragou D, Fragou A, Kouidou S, et al. (2011). Epigenetic mechanisms in metal toxicity. Toxicol Mech Methods 21:343–52
  • Frommer M, McDonald LE, Millar DS, et al. (1992). A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 89:1827–31
  • Galvano F, Campisi A, Russo A, et al. (2002). DNA damage in astrocytes exposed to fumonisin B1. Neurochem Res 27:345–51
  • Gelderblom WCA, Kriek NPJ, Marasas WFO, Thiel PG. (1991). Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. Carcinogenesis 12:1247–51
  • Gelderblom WC, Snyman SD. (1991). Mutagenicity of potentially carcinogenic mycotoxins produced by Fusarium moniliforme. Mycotoxin Res 7:46–52
  • Gelderblom WC, Semple E, Marasas WF, Farber E. (1992). The cancer-initiating potential of the fumonisin B mycotoxins. Carcinogenesis 13:433–7
  • Gelderblom WC, Marasas WF, Lebepe-Mazur S, et al. (2008). Cancer initiating properties of fumonisin B1 in a short-term rat liver carcinogenesis assay. Toxicology 250:89–95
  • Gelderblom WC, Marasas WF. (2012). Controversies in fumonisin mycotoxicology and risk assessment. Hum Exp Toxicol 31:215–35
  • Gelineau-van Waes J, Starr L, Maddox J, et al. (2005). Maternal fumonisin exposure and risk for neural tube defects: Mechanisms in an in vivo mouse model. Birth Defects Res 73:487–97
  • Harrison LR, Colvin BM, Greene JT, et al. (1990). Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. J Vet Diagn Invest 2:217–21
  • Herman JG, Graff JR, Myöhänen S, et al. (1996). Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93:9821–6
  • Herman JG, Latif F, Weng Y, et al. (1994). Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91:9700–4
  • International Agency for Research on Cancer. (2002). Fumonisin B1, IARC monographs on the evaluation of carcinogenic risks to humans: Some traditional medicines, some mycotoxins, naphthalene and styrene. IARC 82:301–66
  • Jones PA, Baylin SB. (2002). The fundamental role of epigenetic events in cancer. Nat Rev Genet 3:415–28
  • Kato A, Shimizu Y, Fujii H, et al. (2006). Aberrant DNA methylation of E-cadherin and p16 genes in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. Mol Carcinog 45:106–11
  • Kellerman TS, Marasas WF, Thiel PG, et al. (1990). Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort J Vet Res 57:269–75
  • Knasmueller S, Bresgen N, Kassie F, et al. (1997). Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes. Mutat Res-Genet Toxicol Environ Mutagen 391:39–48
  • Koturbash I, Beland FA, Pogribny IP. (2011). Role of epigenetic events in chemical carcinogenesis – A justification for incorporating epigenetic evaluations in cancer risk assessment. Toxicol Mech Methods 21:289–97
  • Kouadio JH, Dano SD, Moukha S, et al. (2007). Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells. Toxicon 49:306–17
  • Kouadio JH, Mobio TA, Baudrimont I, et al. (2005). Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology 213:56–65
  • LeBaron MJ, Rasoulpour RJ, Klapacz J, et al. (2010). Epigenetics and chemical safety assessment. Mutat Res 705:83–95
  • Li LC, Dahiya R. (2002). MethPrimer: Designing primers for methylation PCRs. Bioinformatics 18:1427–31
  • Marasas WF, Riley RT, Hendricks KA, et al. (2004). Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: A potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. J Nutr 134:711–16
  • Marasas WFO, Kellerman TS, Gelderblom WCA, et al. (1988). Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J Vet Res 55:197–203
  • McRonald FE, Morris MR, Gentle D, et al. (2009). CpG methylation profiling in vhl related and VHL unrelated renal cell carcinoma. Mol Cancer 8:1–11
  • Methyl Primer Express Software 1. Applied Biosystems (Designed and created by M.F. Fraga, C. Ferrero, M. Esteller)
  • Mobio TA, Anane R, Baudrimont I, et al. (2000). Epigenetic properties of fumonisin B(1): Cell cycle arrest and DNA base modification in C6 glioma cells. Toxicol Appl Pharmacol 164:91–6
  • Mobio TA, Tavan E, Baudrimont I, et al. (2003). Comparative study of the toxic effects of fumonisin B1 in rat C6 glioma cells and p53-null mouse embryo fibroblasts. Toxicology 183:65–75
  • Moggs JG, Goodman JI, Trosko JE, Roberts RA. (2004). Epigenetics and cancer: Implications for drug discovery and safety assessment. Toxicol Appl Pharmacol 196:422–30
  • Müller S, Dekant W, Mally A. (2012). Fumonisin B1 and the kidney: Modes of action for renal tumor formation by fumonisin B1 in rodents. Food Chem Toxicol 50:3833–46
  • Niwa T, Yamashita S, Tsukamoto T, et al. (2005). Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat stomach carcinomas. Cancer Sci 96:409–13
  • Norred WP, Plattner RD, Vesonder RF, et al. (1992). Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes. Food Chem Toxicol 30:233–7
  • National Toxicology Program. (2001). Toxicology and carcinogenesis studies of fumonisin B1 (CAS no. 116355-83-0) in F344/N rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser 496:1–352
  • Pellanda H, Forges T, Bressenot A, et al. (2012). Fumonisin FB1 treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3- and H4-histone methylation patterns in fetuses. Mol Nutr Food Res 56:976–85
  • Pereira MA, Wang W, Kramer PM, Tao L. (2004). DNA hypomethylation induced by non-genotoxic carcinogens in mouse and rat colon. Cancer Lett 212:145–51
  • Pogribny IP, Tryndyak VP, Boureiko A, et al. (2008). Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutat Res 644:17–23
  • Rasoulpour RJ, LeBaron MJ, Ellis-Hutchings RG, et al. (2011). Epigenetic screening in product safety assessment: Are we there yet? Toxicol Mech Methods 21:298–311
  • Riley RT, Enongene E, Voss KA, et al. (2001). Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environ Health Perspect 109:301–8
  • Riley RT, Hinton DM, Chamberlain WJ, et al. (1994). Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague–Dawley rats: A new mechanism of nephrotoxicity. J Nutr 124:594–603
  • Stevens VL, Tang J. (1997). Fumonisin B1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinosotol-anchored folate uptake. J Biol Chem 272:18020–5
  • Stockmann-Juvala H, Mikkola J, Naarala J, et al. (2004). Oxidative stress induced by fumonisin B1 in continuous human and rodent neural cell cultures. Free Radic Res 38:933–42
  • Stockmann-Juvala H, Savolainen K. (2008). A review of the toxic effects and mechanisms of action of fumonisin B1. Hum Exp Toxicol 27:799–809
  • Swafford DS, Middleton SK, Palmisano WA, et al. (1997). Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Mol Cell Biol 17:1366–74
  • Sydenham EW, Thiel PG, Marasas WFO, et al. (1990). Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, southern Africa. J Agric Food Chem 38:1900–3
  • Voss KA, Chamberlain WJ, Bacon CW, et al. (1995). Subchronic feeding study of the mycotoxin fumonisin B1 in B6C3F1 mice and Fischer 344 rats. Fundam Appl Toxicol 24:102–10
  • Watson RE, Goodman JI. (2002). Epigenetics and DNA methylation come of age in toxicology. Toxicol Sci 67:11–16
  • World Health Organization. (2002). Evaluation of Certain Mycotoxins in Food. Fifty-sixth Report of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). WHO Technical Report 906:16–27
  • Yu MU, Yoo JM, Lee YS, et al. (2004). Altered de novo sphingolipid biosynthesis is involved in the serum deprivation-induced cell death in LLC-PK1 cells. J Toxicol Environ Health A 67:2085–94

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.