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Review Article

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

, &
Pages 2340-2352 | Received 17 Jun 2015, Accepted 30 Jan 2016, Published online: 09 Mar 2016

References

  • Abdel-Azeem AS, Hegazy AM, Ibrahim KS, Farraq AR, El-Sayed EM. 2013. Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats. J Diet Suppl. 10:195–209.
  • Abou Zid S. 2012. Silymarin, natural flavonolignans from milk thistle. In: Venketeshwer R, editor. Phytochemicals – a global perspective of their role in nutrition and health. Rijeka: In Tech. p. 255–272.
  • Adzet T, Camarasa J, Laguna JC. 1987. Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes. J Nat Prod. 50:612–617.
  • Aeschbach R, Loliger J, Scott BC, Murcia A, Butler J, Halliwell B, Aruoma OL. 1994. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone, and hydroxytyrosol. Food Chem Toxicol. 32:31–36.
  • Ahn J, Cho I, Kim S, Kwon D, Ha T. 2008. Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet. J Hepatol. 49:1019–1028.
  • Ajabnoor MA. 1990. Effect of Aloes on blood glucose levels in normal and alloxan diabetic mice. J Ethnopharmacol. 28:215–220.
  • Ajmo JM, Liangm X, Rogers CQ, Pennock B, You M. 2008. Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol. 295:G833–G842.
  • Ak T, Gulcin I. 2008. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact. 174:27–37.
  • Al-Rehaily AJ, El-Tahir KEH, Mossa JS, Rafatulla S. 2001. Pharmacological studies of various extracts and the major constituent lupeol obtained from hexane extract of Teclea nobilis in rodents. Nat Prod Sci. 7:76–82.
  • Alvarez-Suarez JM, Giampieri F, Battino M. 2013. Honey as a source of dietary antioxidants: structures, bioavailability and evidence of protective effects against human chronic diseases. Curr Med Chem. 20:621–638.
  • Alvarez-Suarez JM, Giampieri F, Damiani E, Astolfi P, Fattorini D, Reqoli F, Quiles JL, Battino M. 2012. Radical-scavenging activity, protective effect against lipid peroxidation and mineral contents of monofloral Cuban honeys. Plant Foods Hum Nutr. 67:31–38.
  • Alvarez-Suarez JM, Gonzalez-Paramas AM, Santos-Buelga C, Battino M. 2010a. Antioxidant characterization of native monofloral Cuban honeys. J Agric Food Chem. 8:9817–9824.
  • Alvarez-Suarez JM, Tulipani S, Diaz D, Estevez Y, Romandini S, Giampieri F, Damiani E, Astolfi P, Bompadre S, Battino M. 2010b. Antioxidant and antimicrobial capacity of several monofloral Cuban honeys and their correlation with color, polyphenol content and other chemical compounds. Food Chem Toxicol. 48:2490–2499.
  • Anuradha B, Varalakshmi P. 1999. Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation. Pharmacol Res. 39:67–80.
  • Aruoma OI, Spencer JP, Warren D, Jenner P, Butler J, Halliwell B. 1997. Characterization of food antioxidants, illustrated using commercial garlic and ginger preparations. Food Chem. 60:49–156.
  • Bako IG, Mabrouk MA, Maje IM, Buraimoh AA, Abubakar MS. 2009. Hypotensive effects of aqueous seed extract of Hibiscus sabdariffa Linn (Malvaceae) on normotensive cat. Int J Anim Vet Sci. 2:23–29.
  • Bariliak IR, Berdyshev GD, Dugan AM. 1996. The antimutagenic action of apiculture products. Tsitol Genet. 30:48–55.
  • Baur JA, Pearson KJ, Price NL, Jamieson SA, Lerin C, Kalra A, Prabhu W, Allard JS, Lopez-Lluch G, Lewis K, et al. 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 444:337–342.
  • Bektur NE, Sahin E, Baycu C, Unver G. 2013. Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice. Toxicol Ind Health. [Epub ahead of print]. doi: 10.1177/0748233713502841.
  • Beppu H, Nagamura Y, Fujita K. 1993. Hypoglycaemic and antidiabetic effects in mice of Aloe arborescens Miller var. natalensis Berger. Phytother Res. 7:S37–S42.
  • Bishayee A, Darvesh AS, Politis T, McGory R. 2010. Resveratrol and liver disease: from bench to bedside and community. Liver Int. 30:1103–1114.
  • Blazovics A, Szentmihalyi K, Lugasi A, Balázs A, Hagymási K, Bányai E, Then M, Rapavi E, Héthelyi E. 2003. In vitro analysis of the properties of Beiqishen tea. Nutrition. 19:869–875.
  • Bulku E, Stohs SJ, Cicero L, Brooks T, Halley H, Ray SD. 2012. Curcumin exposure modulates multiple proapoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Curr Neurovasc Res. 9:58–71.
  • Bunchorntavakul C, Reddy KR. 2013. Acetaminophen-related hepatotoxicity. Clin Liver Dis. 17:587–607.
  • Carvalho NR, da Rosa EF, da Silva MH, Tassi CC, Dalla Corte CL, Carbajo-Pescador S, Mauriz JL, González-Gallego J, Soares FA. 2013. New therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failure. PLoS One. 8:e81961.
  • Chandrasekaran VR, Hsu DZ, Liu MY. 2009. The protective effect of sesamol against mitochondrial oxidative stress and hepatic injury in acetaminophen-overdosed rats. Shock. 32:89–93.
  • Chang WS, Chang YH, Lu FJ, Chiang HC. 1994. Inhibitory effects of phenolics on xanthine oxidase. Anticancer Res. 14:501–506.
  • Chaturvedi PK, Bhui K, Shukla Y. 2008. Lupeol: connotations for chemoprevention. Cancer Lett. 263:1–13.
  • Chen CC, Hsu JD, Wang SF, Chiang HC, Yang MY, Kao ES, Ho YC, Wang CJ. 2003. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem. 51:5472–5477.
  • Chitra P, Sajithlal GB, Chandrakasan G. 1998. Influence of Aloe vera on the healing of dermal wounds in diabetic rats. J Ethnopharmacol. 59:195–201.
  • Chu PY, Hsu DZ, Hsu PY, Liu MY. 2010. Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation. Innate Immun. 16:333–339.
  • Chun LJ, Tong MJ, Busuttil RW, Busuttil RW, Hiatt JR. 2009. Acetaminophen hepatotoxicity and acute liver failure. J Clin Gastroenterol. 43:342–349.
  • Corsi MM, Bertelli AA, Gaja G, Fulgenzi A, Ferrero ME. 1998. The therapeutic potential of Aloe vera in tumor-bearing rats. Int J Tissue React. 20:115–118.
  • Dalziel JM. 1937. The useful plants of West Tropical Africa. Crown agent for overseas government and administrations. London, United Kingdom: Published under the authority of the Secretary of State for Colonies for the Crown agents for the Colonies.
  • Devasagayam TP, Di Mascio P, Kaiser S, Sies H. 1991. Singlet oxygen induced singlestrand breaks in plasmid pBR322 DNA: the enhancing effect of thiols. Biochim Biophys Acta. 1088:409–412.
  • Devasagayam TP, Subramanian M, Pradhan DS, Sies H. 1993. Prevention of singlet oxygen-induced DNA damage by lipoate. Chem Biol Interact. 86:79–92.
  • Dinkova-Kostova AT, Kostov RV. 2012. Glucosinolates and isothiocyanates in health and disease. Trends Mol Med. 18:337–347.
  • Dinkova-Kostova AT, Talalay P. 2008. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res. 52:S128–S138.
  • Du K, McGill MR, Xie Y, Bajt ML, Jaeschke H. 2015. Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity. Food Chem Toxicol. 81:62–70.
  • El-Kholy WM, Hassan HA, Nour SE. 2010. Assessment the role of Nigella sativa and bees honey as hepatoprotective agents against the hazard effects of some food additives in male rats. J Egypt Soc Toxicol. 42:55–63.
  • El Morsy EM, Kamel R. 2015. Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats. Pharm Biol. 53:167–173.
  • Elshazly SM, El-Moselhy MA, Barakat W. 2014. Insights in the mechanism underlying the protective effect of α-lipoic acid against acetaminophen-hepatotoxicity. Eur J Pharmacol. 726:116–123.
  • Erazo S, Rocco G, Zaldivar M, Delporte C, Backhouse N, Castro C, Belmonte E, Delle Monache F, García R. 2008. Active metabolites from Dunalia spinosa resinous exudates. Z Naturforsch C: J Biosci. 63:492–496.
  • Esselen WB, Sammy GM. 1975. Roselle: a natural red colorant for foods? Food Prod Dev. 7:80–82.
  • Fantini N, Colombo G, Giori A, Riva A, Morazzoni P, Bombardelli E, Carai MA. 2011. Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats. Phytother Res. 25:463–466.
  • Fernandez A, Alvarez A, Garcia MD, Sáenz MT. 2001a. Anti-inflammatory effect of Pimenta racemosa var. ozua and isolation of the triterpene lupeol. Farmaco. 56:335–338.
  • Fernandez MA, de las Heras B, Garcia MD, Sáenz MT, Villar A. 2001b. New insights into the mechanism of action of the anti-inflammatory triterpene Lupeol. J Pharm Pharmacol. 53:1533–1539.
  • Ferreira ICFR, Aires E, Barreira JCM, Estevinho LM. 2009. Antioxidant activity of Portuguese honey samples: different contributions of the entire honey and phenolic extract. Food Chem. 114:1438–1443.
  • Fujisawa S, Atsumi T, Ishihara M, Kadoma Y. 2004. Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds. Anticancer Res. 24:563–569.
  • Fukuda Y. 1990. Food chemical studies on the antioxidants in sesame seed. Nippon Shokuhin Kogyo Gakkaishi. 37:484–492.
  • Galal RM, Zaki HF, Seif El-Nasr MM, Agha AM. 2012. Potential protective effect of honey against paracetamol-induced hepatotoxicity. Arch Iran Med. 15:674–680.
  • Gaona-Gaona L, Molina-Jijon E, Tapia E, Zazueta C, Hernández-Pando R, Calderón-Oliver M, Zarco-Márquez G, Pinzón E, Pedraza-Chaverri J. 2011. Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats. Toxicology. 286:20–27.
  • Gebhardt R. 1997. Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol Appl Pharmacol. 144:279–286.
  • Ghannam N, Kingston M, Al-Meshaal IA, Tariq M, Parman NS, Woodhouse N. 1986. The antidiabetic activity of Aloes: preliminary clinical and experimental observations. Horm Res. 24:288–294.
  • Ghasemzadeh A, Jaafar HZ, Rahmat A, Wahab PE, Halim MR. 2010. Effect of different light intensities on total phenolics and flavonoids synthesis and anti-oxidant activities in young ginger varieties (Zingiber officinale Roscoe). Int J Mol Sci. 11:3885–3897.
  • Girish C, Koner BC, Jayanthi S, Ramachandra Rao K, Rajesh B, Pradhan SC. 2009. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharmacol. 23:735–745.
  • Golbidi S, Badran M, Laher I. 2011. Diabetes and alpha lipoic acid. Front Pharmacol. 2:69.
  • Gopi KS, Reddy AG, Jyothi K, Kumar BA. 2010. Acetaminophen-induced hepato-and nephrotoxicity and amelioration by silymarin and Terminalia chebula in rats. Toxicol Int. 17:64–66.
  • Grindlay D, Reynolds T. 1986. The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. J Ethnopharmacol. 16:117–151.
  • Guerrero-Beltran CE, Mukhopadhyay P, Horvath B, Rajesh M, Tapia E, García-Torres I, Pedraza-Chaverri J, Pacher P. 2012. Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy. J Nutr Biochem. 23:494–500.
  • Haenen GR, Bast A. 1991. Scavenging of hypochlorous acid by lipoic acid. Biochem Pharmacol. 42:2244–2246.
  • Han D, Sen CK, Roy S, Kobayashi MS, Tritschler HJ, Packer L. 1997. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol. 273:R1771–R1778.
  • Hassan-Khabbar S, Cottart CH, Wendum D, Vibert F, Clot JP, Savouret JF, Conti M, Nivet-Antoine V. 2008. Postischemic treatment by trans-resveratrol in rat liver ischemia-reperfusion: a possible strategy in liver surgery. Liver Transpl. 14:451–459.
  • Hassan-Khabbar S, Vamy M, Cottart CH, Wendum D, Vibert F, Savouret JF, Thérond P, Clot JP, Waligora AJ, Nivet-Antoine V. 2010. Protective effect of postischemic treatment with trans-resveratrol on cytokine production and neutrophil recruitment by rat liver. Biochimie. 92:405–410.
  • Heggers JP, Kucukcelebi A, Stabenau CJ, Ko F, Broemeling LD, Robson MC, Winters WD. 1995. Wound healing effects of Aloe gel and other topical antibacterial agents on rat skin. Phytother Res. 9:455–457.
  • Heidarian E, Rafieian-Kopaei M. 2013. Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat. Pharm Biol. 51:1104–1109.
  • Henriques A, Jacksin S, Cooper RA, Burton N. 2006. Free radical production and quenching in honeys with wound healing potential. J Antimicrob Chemother. 58:773–777.
  • Hsu DZ, Chen KT, Li YH, Chuang YC, Liu MY. 2006. Sesamol delays mortality and attenuates hepatic injury after cecal ligation and puncture in rats: role of oxidative stress. Shock. 25:528–532.
  • Hsu DZ, Chien SP, Chen KT, Liu MY. 2007. The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice. Shock. 28:596–601.
  • Hsu DZ, Wan CH, Hsu HF, Lin YM, Liu MY. 2008. Theprophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice. Food Chem Toxicol. 46:2736–2741.
  • Imanishi K. 1993. Aloctin A, an active substance of Aloe arborescens Miller as an immunomodulator. Phytother Res. 7:S20–S22.
  • Inoue K, Murayama S, Seshimo F, Takeba K, Yoshimura Y, Nakazawa H. 2005. Identification of phenolic compound in manuka honey as specific superoxide anion radical scavenger using electron spin resonance (ESR) and liquid chromatography with coulometric array detection. J Sci Food Agric. 85:872–878.
  • Jaeschke H, Williams CD, Ramachandran A, Bajt ML. 2012. Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int. 32:8–20.
  • Kaiser S, di Mascio P, Sies H. 1989. LipoatundSingulettsauerstoff. In: Borbe HO, Ulrich H, editors. Thioctsäure. Frankfurt: Verlag GmbH. p. 69–76.
  • Kikuzaki H, Nakatani N. 1993. Antioxidant effect of some ginger constituents. J Food Sci. 58:1407–1410.
  • Koo MWL. 1994. Aloe vera: antiulcer and antidiabetic effects. Phytother Res. 8:461–464.
  • Koriyama Y, Nakayama Y, Matsugo S, Kato S. 2013. Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline. Brain Res. 1499:145–157.
  • Krishna-Kishorea R, Sukari-Halima A, Nurul-Syazanaa MSK, Sirajudeen KN. 2011. Tualang honey has higher phenolic content and greater radical scavenging activity compared with other honey sources. Nutr Res. 31:322–325.
  • Kubra IR, Rao LJ. 2012. An impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe). Crit Rev Food Sci Nutr. 52:651–688.
  • Kucuk M, Kolayli S, Karaolu S, Ulusoya E, Baltacıa C, Candanc F. 2007. Biological activities and chemical composition of three honeys of different types from Anatolia. Food Chem. 100:526–534.
  • Kumar P, Kalonia H, Kumar A. 2009. Sesamol attenuate 3-nitropropionic acid-induced Huntington-like behavioral, biochemical, and cellular alterations in rats. J Asian Nat Prod Res. 11:439–450.
  • Kumari A, Kakkar P. 2012. Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade. Life Sci. 90:561–570.
  • Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, et al. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha. Cell. 127:1109–1122.
  • Lancaster EM, Hiatt JR, Zarrinpar A. 2015. Acetaminophen hepatotoxicity: an updated review. Arch Toxicol. 89:193–199.
  • Lee CH, Kuo CY, Wang CJ, Wang CP, Lee YR, Hung CN, Lee HJ. 2012. A polyphenol extract of Hibiscus sabdariffa L. ameliorates acetaminophen-induced hepatic steatosis by attenuating the mitochondrial dysfunction in vivo and in vitro. Biosci Biotechnol Biochem. 76:646–651.
  • Lefort EC, Blay J. 2013. Apigenin and its impact on gastrointestinal cancers. Mol Nutr Food Res. 57:126–144.
  • Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. 2002. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-l-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci USA. 99:2356–2361.
  • Madrigal-Santillan E, Madrigal-Bujaidar E, Cruz-Jaime S, etal. 2013. The chemoprevention of chronic degenerative disease through dietary antioxidants: progress, promise and evidences. In: Morales-Gonzalez JA, editor. Oxidative stress and chronic degenerative diseases-a role for antioxidants. Rijeka: In Tech. p. 155–185.
  • Masubuchi Y, Sugiyama S, Horie T. 2009. Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury. Chem Biol Interact. 179:273–279.
  • Meda A, Lamien CE, Romito M, Millogo J, Nacoulma OG. 2005. Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem. 91:571–577.
  • Mehmetcik G, Ozdemirler G, Kocak-Toker N, Cevikbaş U, Uysal M. 2008. Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. Exp Toxicol Pathol. 60:475–480.
  • Metwally NS, Kholeif TE, Ghanem KZ, Farrag AR, Ammar NM, Abdel-Hamid AH. 2011. The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats. Eur Rev Med Pharmacol Sci. 15:1429–1444.
  • Michaut A, Moreau C, Robin MA, Fromenty B. 2014. Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease. Liver Int. 34:e171–e179.
  • Mileo AM, Di Venere D, Linsalata V, Fraioli R, Miccadei S. 2012. Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231. J Cell Physiol. 227:3301–3309.
  • Min Y, Liang X, Ajmo JM, Ness GC. 2008. Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. Am J Physiol Gastrointest Liver Physiol. 294:G892–G898.
  • Morazzoni P, Bombardelli E. 1995. Silybum marianum (Cardusarianum). Fitoterapia. 66:3–42.
  • Noh JR, Kim YH, Hwang JH, Choi DH, Kim KS, Oh WK, Lee CH. 2015. Sulforaphane protects against acetaminophen-induced hepatotoxicity. Food Chem Toxicol. 80:193–200.
  • Odigie IP, Ettarh RR, Adigun SA. 2003. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J Ethnopharmacol. 86:181–185.
  • Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N. 2001. Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models. Phytother Res. 15:157–161.
  • Padmalayam I, Hasham S, Saxena U, Pillarisetti S. 2009. Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial function, and insulin resistance. Diabetes. 58:600–608.
  • Patel D, Shukla S, Gupta S. 2007. Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol. 30:233–245.
  • Pecere T, Gazzola MV, Mucignat C, Parolin C, Vecchia FD, Cavaggioni A, Basso G, Diaspro A, Salvato B, Carli M, et al. 2000. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res. 60:2800–2804.
  • Perez E, Rodriguez-Malaver AJ, Vit P. 2006. Antioxidant capacity of Venezuelan honey in wistar rat homogenates. J Med Food. 9:510–516.
  • Plin C, Tillement JP, Berdeaux A, Morin D. 2005. Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver. Eur J Pharmacol. 528:162–168.
  • Qiu Z, Jones K, Wylie M, Jia Q, Orndorff S. 2000. Modified Aloe barbadensis polysaccharide with immunoregulatory activity. Planta Med. 66:152–156.
  • Rajendran A, Narayanan V, Gnananvel I. 2007. Evaluation of therapeutic efficacy of Aloe vera sap in diabetes and treating wounds and inflammation in animals. J Appl Sci Res. 3:1434–1436.
  • Rajesekaran S, Sivagnanam K, Ravi K, Subramanian S. 2004. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food. 7:61–66.
  • Rajkumar DV, Rao MNA. 1993. Dehydrozingerone and isoeugenol as inhibitors of lipid peroxidation and as free radical scavengers. Biochem Pharmacol. 46:2067–2072.
  • Rao PU. 1996. Nutrient composition and biological evaluation of mesta (Hibiscus Sabdariffa) seeds. Plant Foods Hum Nutr. 49:27–34.
  • Reddy AC, Lokesh BR. 1994. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol Cell Biochem. 137:1–8.
  • Rice-Evans C. 2001. Flavonoid antioxidants. Curr Med Chem. 8:797–807.
  • Rivera H, Shibayama M, Tsutsumi V, Perez-Alvarez V, Muriel P. 2008. Resveratrol and trimethylated resveratrol protect fromacute liver damage induced by CCl4 in the rat. J Appl Toxicol. 28:147–155.
  • Rodriguez Rodriguez E, Darias Martin J, Diaz Romero C. 2010. Aloe vera as a functional ingredient in foods. Crit Rev Food Sci Nutr. 50:305–326.
  • Ross IA. 2003. Hibiscus sabdariffa. In: Ross IA, editor. Medicinal plants of the world, Vol 1. Chemical constituents, traditional and modern medicinal uses. New Jersey: Humana Press. p. 267–275.
  • Saito H. 1993. Purification of active substances of Aloe arborescens Miller and their biological and pharmacological activity. Phytother Res. 7:S14–S19.
  • Saleem M. 2009. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett. 285:109–115.
  • Samy MS. 1980. Chemical and nutritional studies on roselle seeds (Hibiscus sabdariffa L.). Z Ernahrungswiss. 19:47–49.
  • Schilling A, Corey R, Leonard M, Eghtesad B. 2010. Acetaminophen: old drug, new warnings. Cleve Clin J Med. 77:19–27.
  • Scott BC, Aruoma OI, Evans PJ, O'Neill C, Van der Vliet A, Cross CE, Tritschler H, Halliwell B. 1994. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radic Res. 20:119–133.
  • Sekiwa Y, Kubota K, Kobayashi A. 2000. Isolation of novel glucosides related to gingerdiol from ginger and their antioxidative activities. J Agric Food Chem. 48:373–377.
  • Sener G, Toklu HZ, Sehirli AO, Velioğlu-Oğünç A, Cetinel S, Gedik N. 2006. Protective effects of resveratrol against acetaminophen-induced toxicity in mice. Hepatol Res. 35:62–68.
  • Shimpo K, Ida C, Chihara T, Beppu H, Kaneko T, Kuzuya H. 2002. Aloe arborescens extract inhibitsTPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin. Phytother Res. 16:491–493.
  • Shishodia S, Chaturvedi MM, Aggarwal BB. 2007. Role of curcumin in cancer therapy. Curr Probl Cancer. 31:243–305.
  • Shukla S, Gupta S. 2010. Apigenin: a promising molecule for cancer prevention. Pharm Res. 27:962–978.
  • Simanek V, Kren V, Ulrichova J, Vicar J, Cvak L. 2000. Silymarin: what is in the name? An appeal for a change of editorial policy. Hepatology. 32:442–444.
  • Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. 2004. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem. 11:1135–1146.
  • Somanawat K, Thong-Ngam D, Klaikeaw N. 2013. Curcumin attenuated paracetamol overdose induced hepatitis. World J Gastroenterol. 19:1962–1967.
  • Sudhahar V, Ashok Kumar S, Varalakshmi P, Sujatha V. 2008a. Protective effect of lupeol and lupeol linoleate in hypercholesterolemia associated renal damage. Mol Cell Biochem. 317:11–20.
  • Sudhahar V, Veena CK, Varalakshmi P. 2008b. Antiurolithic effect of lupeol and lupeol linoleate in experimental hyperoxaluria. J Nat Prod. 71:1509–1512.
  • Suzuki YJ, Tsuchiya M, Packer L. 1991. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Radic Res Commun. 15:255–263.
  • Szeląg M, Mikulski D, Molski M. 2012. Quantum-chemical investigation of the structure and the antioxidant properties of α-lipoic acid and its metabolites. J Mol Model. 18:2907–2916.
  • Tepe B, Sokmen M, Akpulat HA, Sokmen A. 2006. Screening of the antioxidant potentials of six Salvia species from Turkey. Food Chem. 95:200–204.
  • Trujillo J, Chirino YI, Molina-Jijon E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. 2013. Renoprotective effect of the antioxidant curcumin: recent findings. Redox Biol. 1:448–456.
  • Tsai PJ, McIntosh J, Pearce P, Camden B, Jordan BR. 2002. Anthocyanin and antioxidant capacity in Roselle (Hibiscus sabdariffa L.) extract. Food Res Int. 35:351–356.
  • Tseng TH, Kao ES, Chu CY, Chou FP, Lin Wu HW, Wang CJ. 1997. Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes. Food Chem Toxicol. 35:1159–1164.
  • Vargas-Mendoza N, Madrigal-Santillan E, Morales-Gonzalez A, Esquivel-Soto J, Esquivel-Chirino C, García-Luna Y González-Rubio M, Gayosso-de-Lucio JA, Morales-González JA. 2014. Hepatoprotective effect of silymarin. World J Hepatol. 6:144–149.
  • Vasanthi HR, Mukherjee S, Das DK. 2009. Potential health benefits of broccoli-a chemico-biological overview. Mini Rev Med Chem. 9:749–759.
  • Vazquez B, Avila G, Segura D, Escalante B. 1996. Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol. 55:69–75.
  • Vela L, Lorenzo C, Perez AR. 2007. Antioxidant capacity of Spanish honeys and its correlation with polyphenol content and other physicochemical properties. J Sci Food Agric. 87:1069–1075.
  • Wang CJ, Wang JM, Lin WL, Chu CY, Chou FP, Tseng TH. 2000. Protective effect of Hibiscus anthocyanins against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol. 38:411–416.
  • Waseem M, Pandey P, Tomar B, Raisuddin S, Parvez S. 2014. Ameliorative action of curcumin in cisplatin-mediated hepatotoxicity: an in vivo study in Wistar rats. Arch Med Res. 45:1–7.
  • Werawatganon D, Linlawan S, Thanapirom K, Somanawat K, Klaikeaw N, Rerknimitr R, Siriviriyakul P. 2014. Aloe vera attenuated liver injury in mice with acetaminophen-induced hepatitis. BMC Complement Altern Med. 14:229.
  • Yang J, Wang XY, Xue J, Gu ZL, Xie ML. 2013. Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity. Food Funct. 4:939–943.

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