Advanced search
Publication Cover
Scandinavian Cardiovascular Journal Volume 46, 2012 - Issue 6
Submit an article Journal homepage
526
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Diazoxide may protect endothelial glycocalyx integrity during coronary artery bypass grafting

Ari Adolf MennanderHeart Center, Cardiac Research, Tampere University Hospital and Tampere University, Tampere, FinlandCorrespondence[email protected]
,
Ahmed ShalabyHeart Center, Cardiac Research, Tampere University Hospital and Tampere University, Tampere, Finland
,
Niku OksalaDepartment of Vascular Surgery, Tampere University Hospital, Tampere, Finland
,
Tiina LeppänenThe Immunopharmacology Research Group, University of Tampere School of Medicine, and Tampere University Hospital, Tampere, Finland
,
Mari HämäläinenThe Immunopharmacology Research Group, University of Tampere School of Medicine, and Tampere University Hospital, Tampere, Finland
,
Sanna HuovinenDepartment of Pathology, Tampere University Hospital and Tampere University, Tampere, Finland
,
Fang ZhaoAdvanced Microscopy Unit, Haartman Institute, Helsinki University, Helsinki, Finland
,
Eeva MoilanenAdvanced Microscopy Unit, Haartman Institute, Helsinki University, Helsinki, Finland
&
Matti TarkkaHeart Center, Cardiac Research, Tampere University Hospital and Tampere University, Tampere, Finland
 show all
Pages 339-344 | Received 10 Jul 2012, Accepted 26 Jul 2012, Published online: 31 Aug 2012

References

  • Al-Dadah AS, Voeller R, Shuessler RB, Damiano R, Lawton JS. Maintenance of myocyte volume homeostasis during stress by Diazoxide is cardioprotective. Ann Thorac Surg. 2007;84:857–62.
  • Mizutani S, Al-Dadah AS, Bloch JB, Prasad SM, Diodato MD, Shuessler RB, . Hyperkalemic cardioplegia-induced myocyte swelling and contractile dysfunction: Prevention by Diazoxide. Ann Thorac Surg. 2006;81: 154–9.
  • Broadhead MW, Kharbanda RK, Peters MJ, MacAllister RJ. KATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo. Circulation. 2004;110: 2077–82.
  • Van den Berg BM, Vink H, Spaan JAE. The endothelial glycocalyx protects against myocardial edema. Circulation Res. 2003;4:592–4.
  • Rehm M, Bruegger D, Christ F, Conzen P, Thiel M, Jacob M, . Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation. 2007;116:1896–906.
  • Svennevig K, Hoel TN, Thiara AS, Kolset SO, Castelheim A, Mollnes TE, . Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass. Perfusion. 2008;23:165–71.
  • Shalaby A, Mennander A, Rinne T, Oksala N, Aanismaa R, Narkilahti S, . Aquaporin-7 expression during coronary artery bypass grafting with Diazoxide. Scand Cardiovasc J. 2001;45:354–9.
  • McCully JD, Wakiyama H, Cowan DB, Federman M, Parker RA, Levitsky S. Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery. Ann Thorac Surg. 2002;74:2138–46.
  • Beresewicz A, Maczewski M, Duda M. Effect of classic preconditioning and Diazoxide on endothelial function and O2 and NO generation in the post-ischemic guinea-pig heart. Cardiovasc Res. 2004;63:118–29.
  • Deja MA, Malinowski M, Golba K, Kajor M, Lebda-Wyborny T, Hudziak D, . Diazoxide protects myocardial mitochondria, metabolism, and function during cardiac surgery: A double-blind randomized feasibility study of diazoxide-supplemented cardioplegia. J Thorac Cardiovasc Surg. 2009;137:997–1004.
  • Chappell D, Jacob M, Hofmann-Kiefer K, Bruegger D, Rehm M, Conzen P, . Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007;107:776–84.
  • Annecke T, Chappell D, Chen C, Jacob M, Welsch U, Sommerhoff CP, . Sevoflurane preserves the endothelial glycocalyx against ischaemia-reperfusion injury. Br J Anaesth. 2010;104:414–21.
  • Chappell D, Jacob M, Hofmann-Kiefer K, Rehm M, Welsch U, Conzen P, . Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion. Cardiovasc Res. 2009;83:388–96.
  • Jacob M, Paul O, Mahringer L, Chappell D, Rehm M, Welsch U, . Albumin augmentation improves condition of guinea pig hearts after 4 hr of cold ischemia. Transplantation. 2009;87:956–65.
  • Brands J, Spaan JAE, Van den Berg BM, Vink H, VanTeeffelen JWGE. Acute attenuation of glycocalyx barrier properties increases coronary blood volume independently of coronary flow reserve. Am J Physiol Heart Circ Physiol. 2010;298:H515–23.
  • Nelson A, Berkestedt I, Schmidtchen A, Ljunggren L, Bodelsson M. Increased levels of Glycosaminoglycans during septic shock: Relation to mortality and the antibacterial actions of plasma. Shock. 2008;30:623–7.
  • Johansson PI, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, . High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. J Thromb Haemost. 2012;10: 207–16.
  • Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission Syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg. 2011;254:194–200.
  • Johansson P, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, . Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study. Critical Care. 2011;15:272–82.
  • Bruegger D, Rehm M, Abicht J, Paul JO, Stoeckelhuber M, Pfirrmann M, . Shedding of the endothelial glycocalyx during cardiac surgery: On-pump versus off-pump coronary artery bypass graft surgery. J Thorac Cardiovasc Surg. 2009;138:1445–7.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.