Targeted deletion of regulatory T cells attenuates the protective effects of myocardial ischemic preconditioning in rats

References

• Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357:1074–135.
   Google Scholar
• Vinten-Johansen J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res. 2004;61:481–97.
   PubMed Web of Science ®Google Scholar
• Hansen PR. Role of neutrophils in myocardial ischemia and reperfusion. Circulation 1995;91:1872–85.
   PubMed Web of Science ®Google Scholar
• Wang NP, Bufkin BL, Nakamura M, Zhao ZQ, Wilcox JN, Hewan-Lowe KO, et al. Ischemic preconditioning reduces neutrophil accumulation and myocardial apoptosis. Ann Thorac Surg. 1999;67:1689–95.
   PubMed Web of Science ®Google Scholar
• Nakamura M, Wang NP, Zhao ZQ, Wilcox JN, Thourani V, Guyton RA, et al. Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart. Cardiovasc Res. 2000;45:661–70.
   PubMed Web of Science ®Google Scholar
• Huang SS, Wei FC, Hung LM. Ischemic preconditioning attenuates postischemic leukocyte–endothelial cell interactions: role of nitric oxide and protein kinase C. Circ J. 2006; 70:1070–5.
   PubMed Web of Science ®Google Scholar
• Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, et al. Expression of ectonucleotidase CD39 by FoxP3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007;110: 1225–32.
   PubMed Web of Science ®Google Scholar
• Buckner JH, Ziegler SF. Regulating the immune system: the induction of regulatory T cells in the periphery. Arthritis Res Ther. 2004;6:215–22.
   PubMed Web of Science ®Google Scholar
• Kobie JJ, Shah PR, Yang L, Rebhahn JA, Fowell DJ, Mosmann TR. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5’-adenosine monophosphate to adenosine. J Immunol. 2006;177:6780–6.
   PubMed Web of Science ®Google Scholar
• Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008; 28:546–58.
   PubMed Web of Science ®Google Scholar
• Ke D, Fang J, Fan L, Chen Z, Chen L. Regulatory T cells contribute to
   Google Scholar
• Huehn J, Hamann A. Homing to suppress: address codes for Treg migration. Trends Immunol. 2005;26:632–6.
   PubMed Web of Science ®Google Scholar
• Wei S, Kryczek I, Zou W. Regulatory T-cell compartmentalization and trafficking. Blood 2006;108:426–31.
   PubMed Web of Science ®Google Scholar
• Burne-Taney MJ, Liu M, Baldwin WM, Racusen L, Rabb H. Decreased capacity of immune cells to cause tissue injury mediates kidney ischemic preconditioning. J Immunol. 2006; 176:7015–20.
   PubMed Web of Science ®Google Scholar
• Arias-Diaz J, Ildefonso JA, Muñoz JJ, Zapata A, Jiménez E. Both tacrolimus and sirolimus decrease Th1/Th2 ratio, and increase regulatory T lymphocytes in the liver after ischemia/reperfusion. Lab Invest. 2009;89:433–45.
   PubMed Web of Science ®Google Scholar
• Zuidema MY, Zhang C. Ischemia/reperfusion injury: The role of immune cells. World J Cardiol. 2010;2: 325–32.
   PubMedGoogle Scholar
• Svendsen JH, Hansen PR, Ali S, Baandrup U, Haunsø S. Leucocyte depletion attenuates the early increase in myocardial capillary permeability to small hydrophilic solutes following ischaemia and reperfusion. Cardiovasc Res. 1993; 27:1288–94.
   PubMed Web of Science ®Google Scholar
• Gao XM, Liu Y, White D, Su Y, Drew BG, Bruce CR, et al. Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: A predominant role of anti-inflammation. J Mol Cell Cardiol. 2011;50:991–9.
   PubMed Web of Science ®Google Scholar
• Yang Z, Day YJ, Toufektsian MC, Xu Y, Ramos SI, Marshall MA, et al. Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4 + T lymphocytes. Circulation. 2006;114:2056–64.
   PubMed Web of Science ®Google Scholar
• Shi Y, Fukuoka M, Li G, Liu Y, Chen M, Konviser M, et al. Regulatory T cells protect mice against coxsackievirus- induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway. Circulation. 2010;121:2624–34.
   PubMed Web of Science ®Google Scholar
• Kinsey GR, Sharma R, Huang L, Li L, Vergis AL, Ye H, et al. Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. J Am Soc Nephrol. 2009;20: 1744–53.
   PubMed Web of Science ®Google Scholar
• Hausenloy DJ, Yellon DM. Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res. 2006; 70:240–53.
   PubMed Web of Science ®Google Scholar
• Speechly-Dick ME, Mocanu MM, Yellon DM. Protein kinase C. Its role in ischemic preconditioning in the rat. Circ Res. 1994;75:586–90.
   Google Scholar
• Gross ER, Hsu AK, Gross GJ. The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3β. Am J Physiol Heart Circ Physiol. 2006;291:H827–34.
   PubMed Web of Science ®Google Scholar
• Boengler K, Buechert A, Heinen Y, Roeskes C, Hilfiker-Kleiner D, Heusch G, et al. Cardioprotection by ischemic postconditioning is lost in aged and STAT3- deficient mice. Circ Res. 2008;102:131–5.
   PubMed Web of Science ®Google Scholar
• Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124–36.
   PubMed Web of Science ®Google Scholar
• Baxter GF, Goma FM, Yellon DM. Characterisation of the infarct-limiting effect of delayed preconditioning: time course and dose-dependency studies in rabbit myocardium. Basic Res Cardiol. 1997;92:159–67.
   PubMed Web of Science ®Google Scholar
• Okubo S, Xi L, Bernardo NL, Yoshida K, Kukreja RC. Myocardial preconditioning: basic concepts and potential mechanisms. Mol Cell Biochem. 1999;196:3–12.
   PubMed Web of Science ®Google Scholar
• Nakano A, Cohen MV, Downey JM. Ischemic preconditioning. From basic mechanisms to clinical applications. Pharmacol Ther. 2000;86:263–75.
   Web of Science ®Google Scholar
• Rubino A, Yellon DM. Ischemic preconditioning of vasculature: an overlooked phenomenon for protecting the heart? Trends Pharmacol Sci. 2000;21:225–30.
   PubMed Web of Science ®Google Scholar