Insights from the ganglionic acetylcholine receptor autoantibodies in patients with Sjögren’s syndrome

References

• Chai J, Logigian EL. Neurological manifestations of primary Sjogren's syndrome. Curr Opin Neurol. 2010;23(5):509–13.
   PubMed Web of Science ®Google Scholar
• Pavlakis PP, Alexopoulos H, Kosmidis ML, Mamali I, Moutsopoulos HM, Tzioufas AG, Dalakas MC. Peripheral neuropathies in Sjögren's syndrome: a critical update on clinical features and pathogenetic mechanisms. J Autoimmun. 2012;39(1–2):27–33.
   PubMed Web of Science ®Google Scholar
• Mandl T, Hammar O, Theander E, Wollmer P, Ohlsson B. Autonomic nervous dysfunction development in patients with primary Sjogren's syndrome: a follow-up study. Rheumatology. 2010;49(6):1101–6.
   PubMed Web of Science ®Google Scholar
• Mandl T, Granberg V, Apelqvist J, Wollmer P, Manthorpe R, Jacobsson LT. Autonomic nervous symptoms in primary Sjogren's syndrome. Rheumatology. 2008;47(6):914–19.
   PubMed Web of Science ®Google Scholar
• Mandl T, Wollmer P, Manthorpe R, Jacobsson LT. Autonomic and orthostatic dysfunction in primary Sjögren's syndrome. J Rheumatol. 2007;34(9):1869–74.
   PubMed Web of Science ®Google Scholar
• Ng WF, Stangroom AJ, Davidson A, Wilton K, Mitchell S, Newton JL. Primary Sjögren's syndrome is associated with impaired autonomic response to orthostasis and sympathetic failure. QJM. 2012;105(12):1191–9.
   PubMed Web of Science ®Google Scholar
• Newton JL, Frith J, Powell D, Hackett K, Wilton K, Bowman P, et al. Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome. Ann Rheum Dis. 2012;71(12):1973–9.
   PubMed Web of Science ®Google Scholar
• Cai FZ, Lester S, Lu T, Keen H, Boundy K, Proudman SM, et al. Mild autonomic dysfunction in primary Sjögren's syndrome: a controlled study. Arthritis Res Ther. 2008;10(2):R31.
   Google Scholar
• Goto H, Matsuo H, Fukudome T, Shibuya N, Ohnishi A, Nakamura H. Chronic autonomic neuropathy in a patient with primary Sjögren's syndrome. J Neurol Neurosurg Psychiatry. 2000;69(1):135.
   PubMed Web of Science ®Google Scholar
• Sumida T, Tsuboi H, Iizuka M, Asashima H, Matsumoto I. Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome. Mod Rheumatol. 2013;23(5):841–5.
   PubMed Web of Science ®Google Scholar
• Dawson LJ, Stanbury J, Venn N, Hasdimir B, Rogers SN, Smith PM. Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum. 2006;54(4):1165–73.
   PubMed Web of Science ®Google Scholar
• Kondo T, Inoue H, Usui T, Mimori T, Tomimoto H, Vernino S, et al. Autoimmune autonomic ganglionopathy with Sjögren's syndrome: significance of ganglionic acetylcholine receptor antibody and therapeutic approach. Auton Neurosci. 2009;146(1–2):33–5.
   PubMed Web of Science ®Google Scholar
• Vernino S, Sandroni P, Singer W, Low PA. Invited article: Autonomic ganglia: target and novel therapeutic tool. Neurology. 2008;70(20):1926–32.
   PubMed Web of Science ®Google Scholar
• Skok MV, Voitenko LP, Voitenko SV, Lykhmus EY, Kalashnik EN, Litvin Tl, et al. Alpha subunit composition of nicotinic acetylcholine receptors in the rat autonomic ganglia neurons as determined with subunit-specific anti-alpha (181–92) peptide antibodies. Neuroscience. 1999;93(4):1427–36.
   PubMed Web of Science ®Google Scholar
• Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med. 2000;343(12):847–55.
   PubMed Web of Science ®Google Scholar
• Nakane S, Higuchi O, Koga M, Kanda T, Murata K, Suzuki T, et al. Clinical features of autoimmune autonomic ganglionopathy and the detection of subunit-specific autoantibodies to the ganglionic acetylcholine receptor in Japanese patients. PLoS One. 2015;10(3):e0118312.
   Web of Science ®Google Scholar
• Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61(6):554–8.
   PubMed Web of Science ®Google Scholar
• Tsuboi H, Hagiwara S, Asashima H, Umehara H, Kawakami A, Nakamura H, et al. Validation of different sets of criteria for the diagnosis of Sjögren's syndrome in Japanese patients. Mod Rheumatol. 2013;23(2):219–25.
   PubMed Web of Science ®Google Scholar
• Spiegel J, Hellwig D, Farmakis G, Jost WH, Samnick S, Fassbender K, et al. Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease. Mov Disord. 2007;22(7):1004–8.
   PubMed Web of Science ®Google Scholar
• Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol. 1968;21(7):656–60.
   PubMed Web of Science ®Google Scholar
• Chisholm DM, Waterhouse JP, Mason DK. Lymphocytic sialadenitis in the major and minor glands: a correlation in postmortem subjects. J Clin Pathol. 1970;23(8):690–4.
   PubMed Web of Science ®Google Scholar
• Fukuda M, Morimoto T, Matsuda H, Nagao H, Wakamoto H, Ohnishi A. A case of acute idiopathic pandysautonomia with SIADH. No To Hattatsu. 1995;27(1):41–6.
   PubMedGoogle Scholar
• Philip NS, Carpenter LL, Tyrka AR, Price LH. Nicotinic acetylcholine receptors and depression: a review of the preclinical and clinical literature. Psychopharmacology (Berl). 2010;212(1):1–12.
   PubMed Web of Science ®Google Scholar
• Reuter M, Markett S, Melchers M, Montag C. Interaction of the cholinergic system and the hypothalamic-pituitary-adrenal axis as a risk factor for depression: evidence from a genetic association study. Neuroreport. 2012;23(12):717–20.
   PubMed Web of Science ®Google Scholar
• Amaral TN, Peres FA, Lapa AT, Marques-Neto JF, Appenzeller S. Neurologic involvement in scleroderma: a systematic review. Semin Arthritis Rheum. 2013;43(3):335–47.
   PubMed Web of Science ®Google Scholar
• Streifler JY, Molad Y. Connective tissue disorders: systemic lupus erythematosus, Sjögren's syndrome, and scleroderma. Handb Clin Neurol. 2014;119:463–73.
   PubMedGoogle Scholar
• Ramos-Remus C, Duran-Barragan S, Castillo-Ortiz JD. Beyond the joints: neurological involvement in rheumatoid arthritis. Clin Rheumatol. 2012;31(1):1–12.
   PubMed Web of Science ®Google Scholar
• Stojanovich L, Milovanovich B, de Luka SR, Popovich-Kuzmanovich D, Bisenich V, Djukanovich B, et al. Cardiovascular autonomic dysfunction in systemic lupus, rheumatoid arthritis, primary Sjögren syndrome and other autoimmune diseases. Lupus. 2007;16(3):181–5.
   PubMed Web of Science ®Google Scholar
• Stacher G, Merio R, Budka C, Schneider C, Smolen J, Tappeiner G. Cardiovascular autonomic function, autoantibodies, and esophageal motor activity in patients with systemic sclerosis and mixed connective tissue disease. J Rheumatol. 2000;27(3):692–7.
   PubMed Web of Science ®Google Scholar
• Stojanovich L. Autonomic dysfunction in autoimmune rheumatic disease. Autoimmun Rev. 2009;8(7):569–72.
   PubMed Web of Science ®Google Scholar
• Nakamura H, Kawakami A, Hayashi T, Iwamoto N, Okada A, Tamai M, et al. Anti-centromere antibody-seropositive Sjögren's syndrome differs from conventional subgroup in clinical and pathological study. BMC Musculoskelet Disord. 2010;11:140.
   PubMed Web of Science ®Google Scholar
• Vernino S, Ermilov LG, Sha L, Szurszewski JH, Low PA, Lennon VA. Passive transfer of autoimmune autonomic neuropathy to mice. J Neurosci. 2004;24(32):7037–42.
   PubMed Web of Science ®Google Scholar
• Mori K, Iijima M, Koike H, Hattori N, Tanaka F, Watanabe H, et al. The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy. Brain. 2005;128(Pt 11):2518–34.
   PubMed Web of Science ®Google Scholar
• Pavlakis PP, Alexopoulos H, Kosmidis ML, Stamboulis E, Routsias JG, Tzartos SJ, et al. Peripheral neuropathies in Sjögren syndrome: a new reappraisal. J Neurol Neurosurg Psychiatry. 2011;82(7):798–802.
   PubMed Web of Science ®Google Scholar
• Waterschoot MP, Guerit JM, Lambert M, de Barsy T. Bilateral tonic pupils and polyneuropathy in Sjögren’s syndrome: a common pathophysiological mechanism? Eur Neurol. 1991;31(2):114–16.
   PubMed Web of Science ®Google Scholar
• Wright RA, Grant IA, Low PA. Autonomic neuropathy associated with sicca complex. J Auton Nerv Syst. 1999;75(1):70–6.
   PubMedGoogle Scholar
• Vernino S, Hopkins S, Wang Z. Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy. Auton Neurosci. 2009;146(1–2):3–7.
   PubMed Web of Science ®Google Scholar
• Delalande S, de Seze J, Fauchais AL, Hachulla E, Stojkovic T, Ferriby D, et al. Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients. Medicine (Baltimore). 2004;83(5):280–91.
   PubMed Web of Science ®Google Scholar
• Grant IA, Hunder GG, Homburger HA, Dyck PJ. Peripheral neuropathy associated with sicca complex. Neurology. 1997;48(4):855–62.
   PubMed Web of Science ®Google Scholar
• Skopouli FN, Dafni U, Ioannidis JP, Moutsopoulos HM. Clinical evolution, and morbidity and mortality of primary Sjögren's syndrome. Semin Arthritis Rheum. 2000;29(5):296–304.
   PubMed Web of Science ®Google Scholar