2,160
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Tyrosine and glycine derivatives as potential prodrugs: design, synthesis, and pharmacological evaluation of amide derivatives of mefenamic acid

&
Pages 804-811 | Received 01 Aug 2009, Accepted 05 Nov 2009, Published online: 28 Jun 2010

References

  • Ravichandran V, Mishra A, Agrawal RK, Dixit VK. Synthesis, characterization and pharmacological evaluation of amide prodrugs of flubiprofen. J Braz Chem Soc 2008;19:89–100.
  • Mishra A, Ravichandran V, Jain PK, Dixit VK, Agrawal RK. Synthesis, characterization and pharmacological evaluation of amide prodrugs of ketorolac. Eur J Med Chem 2008;43:2464–72.
  • Khan MYS, Akheter M. Synthesis, pharmacological activity and hydrolytic behaviour of glyceride prodrugs of ibuprofen. Eur J Med Chem 2005;40:371–6.
  • Streitweiser A Jr, Heathcock GH. Introduction to Organic Chemistry, 3rd ed. New York: Macmillan Publishing Company, 1989.
  • Norman ROC, Coxon JM. Principles of Organic Synthesis, 3rd ed. London: ELBS and Chapman & Hall, 1993.
  • Martin AN, Bustamante P, Chine AHC. Physical Pharmacy, 4th ed. New Delhi: BI Waverly Pvt. Ltd., 1993.
  • Zhao X, Tao X, Wei D, Song Q. Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates. Eur J Med Chem 2006;41:1352–8.
  • Metwally KA, Yaseen SH, Lashine EM, El-Fayomi HM, El-Sadek ME. Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential. Eur J Med Chem 2007;42:152–60.
  • D’Amour FE, Smith DL. A method for determining loss of pain sensation. J Pharmacol Exp Ther 1941;72:74–9.
  • Alagarsamy V, Shankar D, Solomon VR. Synthesis of some novel 2-mercapto-3-(substituted amino)-5,6,7,8-tetrahydro-3H-benzo[4,5] thieno[2,3d] pyrimidin-4-ones as analgesic and anti-inflammatory agents. ARKIVOC 2006;16:149–59.
  • Neha G, Deepika N, Suneela SD, Dhaneshwar SR, Chaturvedi SC. Synthesis, hydrolysis, kinetics and pharmacodynamic profiles of novel prodrugs of flubiprofen. Indian J Pharm Sci 2005;67:369–73.
  • Brodie DA, Cook PG, Bauer BJ, Dagle GE. Indomethacin-induced intestinal lesions in the rat. Toxicol Appl Pharmacol 1970;17:615–24.
  • Main LH, Whittle BJR. Investigation of the vascodilator and antisecretory role of prostaglandin in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs. Br J Pharmacol 1975;53:217–24.
  • Kulkarni SK. Handbook of Experimental Pharmacology, 3rd ed. New Delhi: Vallabh Prakash, 2001:128–30.
  • Yagmurca M, Ucar M, Fadillioglu E, Erdogan H, Ozturk F. The effects of nitric oxide on rat stomach injury induced by acetylsalicylic acid. Turk J Med Sci 2009;39:13–19.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.