2,137
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Synthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids

, &
Pages 688-695 | Received 28 Mar 2010, Accepted 09 Dec 2010, Published online: 21 Jan 2011

References

  • Kaehler ST, Phleps W, Hesse E. Dexibuprofen: pharmacology, therapeutic, use and safety. Inflammaopharm 2003;11:371–383.
  • Halen PK, Murumkar PR, Giridhar R, Yadav MR. Prodrug designing of NSAIDs. Mini-Rev Med Chem 2009;9:124–139.
  • Bajpai AK, Mishra A. Carboxymethyl cellulose (CMC) based semi-IPNs as carriers for controlled release of ciprofloxacine: an in-vitro dynamic study. J Mater Sci Mater Med 2008;19:2121–2130.
  • Mishra A, Ravichandran V, Jain PK, Dixit VK, Agrawal RK. Synthesis, characterization and pharmacological evaluation of amide prodrugs of ketorolac. Europ J Med Chem 2008;43:2464–2472.
  • Bhosle D, Bharambe S, Gairola N, Dhaneshwar SS. Mutual prodrug concept: fundamentals and applications. Indian J Pharm Sci 2006;68:286–294.
  • Rasheed A, Kumar CKA. Novel approaches on prodrug based drug design, Pharm Chem J 2008;42:677–686
  • Roy SD, Manoukian E. Permeability of ketorolac acid and its ester analogs (prodrug) through human cadaver skin. J Pharm Sci 1994;83:1548–1553.
  • Idle JR, Millburn P, Williams RT. Taurine conjugates as metabolites of arylacetic acids in the ferret. Xenobiotica 1978;8:253–264.
  • Nielsenw NW, Bundgaard H. Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties. J Pharm Sci 1988;77:285–298.
  • Mohan R, Ramaa CS. Ester prodrugs of Flubiprofen: Synthesis, plasma hydrolysis and gastrointestinal toxicity. Indian J Chem 2007;46B:1164–1168.
  • Dev S, Deepali VM, Kadam SS, Dhaneshwar SR. Synthesis and pharmacological evaluation of cyclodextrin conjugate prodrug of Mefenamic acid. Indian J Pharm Sci 2007;69: 69–72.
  • Winter CA, Risely EA, Nuss GW. Carregeenan induced oedema in hind paw of the rat as assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 1962;111:544–547.
  • Kulkarni SK. Handbook of Experimental Pharmacology, 3rd ed., Vallabh Prakash, New Delhi, 2001;128–130.
  • Coili V, Putzolu S, Rossi V, Barcellona PS, Corradino C. The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats. Toxicol Appl Pharmacol 1979;50:283–289.
  • Yagmurca M, Ucar M, Fadillioglu E, Erdogan H, Ozturk F. The effects of nitric oxide on rat stomach injury induced by acetylsalicylic acid. Turk J Med Sci 2009; 39:13–19.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.