Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 26, Issue 5 (2011)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 26, Issue 5 (2011)

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Original Article

Article
Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation
Ghassan Abu Sheikha, Mahmoud A. Al-Sha’er & Mutasem O. Taha
Pages: 603-609
Published online: 29 Dec 2010
AbstractforSome sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation | Full Text | References | PDF (867.6 KB)
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Article
Quinoxalin-2-carboxamides: synthesis and pharmacological evaluation as serotonin type-3 (5-HT3) receptor antagonists
Radhakrishnan Mahesh, Thangaraj Devadoss, Dilip Kumar Pandey & Shushil Kumar Yadav
Pages: 610-615
Published online: 11 Jan 2011
AbstractforQuinoxalin-2-carboxamides: synthesis and pharmacological evaluation as serotonin type-3 (5-HT3) receptor antagonists | Full Text | References | PDF (621.1 KB)
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Review Article

Review Article
Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product
Nighat Sultana
Pages: 616-642
Published online: 22 Mar 2011
AbstractforClinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product | Full Text | References | PDF (1.1 MB) | Supplemental
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Original Article

Article
Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)
Lei Ma, Zhengyi Yang, Chenjing Li, Zhiyuan Zhu, Xu Shen & Lihong Hu
Pages: 643-648
Published online: 11 Jan 2011
AbstractforDesign, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1) | Full Text | References | PDF (638.9 KB)
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Article
Synthesis and antibacterial properties of new N4-acetylated hexahydro-2,7-dioxopyrido[2,3-f]quinoxaline-8-carboxylic acids
Yusuf M. Al-Hiari, Ashok K. Shakya, Muhammed H. Alzweiri, Tariq M Al-Qirim, Ghassan Shattat & Mustafa M. El-Abadelah
Pages: 649-656
Published online: 11 Jan 2011
AbstractforSynthesis and antibacterial properties of new N4-acetylated hexahydro-2,7-dioxopyrido[2,3-f]quinoxaline-8-carboxylic acids | Full Text | References | PDF (694.4 KB)
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Article
Synthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives
Vanessa Desplat, Stéphane Moreau, Solene Belisle-Fabre, Denis Thiolat, Juliette Uranga, Romain Lucas, Laure de Moor, Stéphane Massip, Christian Jarry, Djavad M. Mossalayi, Pascal Sonnet, Gérard Déléris & Jean Guillon
Pages: 657-667
Published online: 21 Jan 2011
AbstractforSynthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives | Full Text | References | PDF (785.6 KB)
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Research Article

Article
Synthesis, QSAR and anti-HIV activity of new 5-benzylthio-1,3,4-oxadiazoles derived from α-amino acids
Tayyaba Syed, Tashfeen Akhtar, Najim A. Al-Masoudi, Peter G. Jones & Shahid Hameed
Pages: 668-680
Published online: 21 Jan 2011
AbstractforSynthesis, QSAR and anti-HIV activity of new 5-benzylthio-1,3,4-oxadiazoles derived from α-amino acids | Full Text | References | PDF (825.2 KB)
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Article
Potentiation of the reductase activity of protein disulphide isomerase (PDI) by 19-nortestosterone, bacitracin, fluoxetine, and ammonium sulphate
Maya Haj Hassan, Eva Alvarez, Claire Cahoreau, Danièle Klett, François Lecompte & Yves Combarnous
Pages: 681-687
Published online: 21 Jan 2011
AbstractforPotentiation of the reductase activity of protein disulphide isomerase (PDI) by 19-nortestosterone, bacitracin, fluoxetine, and ammonium sulphate | Full Text | References | PDF (1 MB)
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Article
Synthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids
Arun Rasheed, C. K. Ashok Kumar & Ashutosh Mishra
Pages: 688-695
Published online: 21 Jan 2011
AbstractforSynthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids | Full Text | References | PDF (938.4 KB)
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Article
Consensus features of CP-MLR and GA in modeling HIV-1 RT inhibitory activity of 4-benzyl/benzoylpyridin-2-one analogues
Shreekant Deshpande, Rinki Singh, Mohammad Goodarzi, Seturam B. Katti & Yenamandra S. Prabhakar
Pages: 696-705
Published online: 01 Feb 2011
AbstractforConsensus features of CP-MLR and GA in modeling HIV-1 RT inhibitory activity of 4-benzyl/benzoylpyridin-2-one analogues | Full Text | References | PDF (729.3 KB) | Supplemental
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Article
Synthesis and biological evaluation of novel N,N′-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands
Wen Luo, Yan-Ping Li, Jia-Heng Tan, Lian-Quan Gu & Zhi-Shu Huang
Pages: 706-711
Published online: 21 Jan 2011
AbstractforSynthesis and biological evaluation of novel N,N′-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands | Full Text | References | PDF (671.2 KB)
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Article
Steroidal 5α-reductase inhibitors using 4-androstenedione as substrate
Marisa Cabeza, Karla Valeria Trejo, Claudia González, Perla García, Juan Soriano, Yvonne Heuze & Eugene Bratoeff
Pages: 712-719
Published online: 08 Feb 2011
AbstractforSteroidal 5α-reductase inhibitors using 4-androstenedione as substrate | Full Text | References | PDF (836.3 KB)
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Article
Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones
Balasubramanian Narasimhan, Deepika Sharma, Pradeep Kumar, Perumal Yogeeswari & Dharmarajan Sriram
Pages: 720-727
Published online: 21 Jan 2011
AbstractforSynthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones | Full Text | References | PDF (669 KB)
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Article
Suicide inactivation of tyrosinase in its action on tetrahydropterines
Jose Luis Muñoz-Muñoz, Francisco Garcia-Molina, Enrique Arribas, Pedro Antonio Garcia-Ruíz, Jose Tudela, Francisco Garcia-Cánovas & Jose Neptuno Rodríguez-López
Pages: 728-733
Published online: 08 Feb 2011
AbstractforSuicide inactivation of tyrosinase in its action on tetrahydropterines | Full Text | References | PDF (936.8 KB) | Supplemental
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Article
Synthesis, characterization and DNA binding and cleavage properties of ruthenium(II) complexes with various polypyridyls
Mohan N. Patel, Pradhuman A. Parmar & Deepen S. Gandhi
Pages: 734-741
Published online: 12 Jul 2011
AbstractforSynthesis, characterization and DNA binding and cleavage properties of ruthenium(II) complexes with various polypyridyls | Full Text | References | PDF (1 MB)
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Short Communications

Synthesis and biological evaluation of some new pyridazinone derivatives
Asif Husain, Sushma Drabu, Nitin Kumar, M. Mumtaz Alam & Aftab Ahmad
Pages: 742-748
Published online: 27 Jan 2011
AbstractforSynthesis and biological evaluation of some new pyridazinone derivatives | Full Text | References | PDF (629.8 KB)
  • 655 Views
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Article
Carbonic anhydrase inhibitors: purification and inhibition studies of pigeon (Columba livia var. domestica) red blood cell carbonic anhydrase with sulfonamides
Özen Özensoy, Mikail Arslan & Claudiu T. Supuran
Pages: 749-753
Published online: 11 Apr 2011
AbstractforCarbonic anhydrase inhibitors: purification and inhibition studies of pigeon (Columba livia var. domestica) red blood cell carbonic anhydrase with sulfonamides | Full Text | References | PDF (620.9 KB)
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