References
- Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 2003;13:49–58.
- Hershko A. The Ubiquitin System for Protein Degradation and Some of Its Roles in the Control of the Cell-Division Cycle Nobel Lecture. Israel J Chem 2006;46:113–120.
- Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 2003;15:164–171.
- Hochstrasser M. Ubiquitin-dependent protein degradation. Annu Rev Genet 1996;30:405–439.
- Brazhnik P, Kohn KW. HAUSP-regulated switch from auto- to p53 ubiquitination by Mdm2 (in silico discovery). Math Biosci 2007;210:60–77.
- Iwakuma T, Lozano G. MDM2, an introduction. Mol Cancer Res 2003;1:993–1000.
- Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997;387:299–303.
- Chène P. Inhibiting the p53-MDM2 interaction: an important target for cancer therapy. Nat Rev Cancer 2003;3:102–109.
- Riedinger C, Noble ME, Wright DJ, Mulks F, Hardcastle IR, Endicott JA et al. Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy. Chem Biol Drug Des 2011;77:301–308.
- Vaz JA, Heleno SA, Martins A, Almeida GM, Vasconcelos MH, Ferreira IC. Wild mushrooms Clitocybe alexandri and Lepista inversa: in vitro antioxidant activity and growth inhibition of human tumour cell lines. Food Chem Toxicol 2010;48:2881–2884.
- Borchers AT, Keen CL, Gershwin ME. Mushrooms, tumors, and immunity: an update. Exp Biol Med (Maywood) 2004;229:393–406.
- Poucheret P, Fons F, Rapior S. Biological and pharmacological activity of higher fungi: 20-year retrospective analysis. Cryptogamie Mycol 2006;27:311–333.
- Lindequist U, Niedermeyer TH, Jülich WD. The pharmacological potential of mushrooms. Evid Based Complement Alternat Med 2005;2:285–299.
- Russell R, Paterson M. Ganoderma – a therapeutic fungal biofactory. Phytochemistry 2006;67:1985–2001.
- Ferreira IC, Vaz JA, Vasconcelos MH, Martins A. Compounds from wild mushrooms with antitumor potential. Anticancer Agents Med Chem 2010;10:424–436.
- Zaidman BZ, Yassin M, Mahajna J, Wasser SP. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 2005;67:453–468.
- Moradali MF, Mostafavi H, Ghods S, Hedjaroude GA. Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). Int Immunopharmacol 2007;7:701–724.
- ACD/ChemSketch Freeware 12.0 software. Available at: (http://www.acdlabs.com/resources/freeware/). Accessed on 03, December 2012.
- Pedretti A, Villa L, Vistoli G. VEGA–an open platform to develop chemo-bio-informatics applications, using plug-in architecture and script programming. J Comput Aided Mol Des 2004;18:167–173.
- Sanner MF. A component-based software environment for visualizing large macromolecular assemblies. Structure 2005;13:447–462.
- O’Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR. Open Babel: An open chemical toolbox. J Cheminform 2011;3:33.
- Grasberger BL, Lu T, Schubert C, Parks DJ, Carver TE, Koblish HK et al. Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J Med Chem 2005;48:909–912.
- Popowicz GM, Czarna A, Wolf S, Wang K, Wang W, Dömling A et al. Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle 2010;9:1104–1111.
- Allen JG, Bourbeau MP, Wohlhieter GE, Bartberger MD, Michelsen K, Hungate R et al. Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J Med Chem 2009;52:7044–7053.
- Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, Olson AJ. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 1998;19:1639–1662.
- Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem 2009;30:2785–2791.
- Abreu RM, Froufe HJ, Queiroz MJ, Ferreira IC. MOLA: a bootable, self-configuring system for virtual screening using AutoDock4/Vina on computer clusters. J Cheminform 2010;2:10.
- The PyMOL Molecular Graphics System, Version 1.3, Schrödinger, LLC. Available at: (http://www.pymol.org/). Accessed on 03 December, 2012.
- Phosrithong E, Ungwitayatorn J. Molecular docking study on anticancer activity of plant-derived natural products. Med Chem Res 2010;19:817–835.
- Jiang J, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. Int J Mol Med 2008;21:577–584.
- Li CH, Chen PY, Chang UM, Kan LS, Fang WH, Tsai KS et al. Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells. Life Sci 2005;77:252–265.
- Calviño E, Pajuelo L, Casas JA, Manjón JL, Tejedor MC, Herráez A et al. Cytotoxic action of Ganoderma lucidum on interleukin-3 dependent lymphoma DA-1 cells: involvement of apoptosis proteins. Phytother Res 2011;25:25–32.
- Bok JW, Lermer L, Chilton J, Klingeman HG, Towers GH. Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry 1999;51:891–898.