923
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Synthesis and biological evaluation of some novel tetrahydroquinolines as anticancer and antimicrobial agents

, , , &
Pages 367-378 | Received 27 Nov 2012, Accepted 15 Mar 2013, Published online: 22 Apr 2013

References

  • Goda FE, Badria FA. Synthesis and biological evaluation of certain new substituted pyrido[2,3-D]pyrimidin-4(1H)-one and pyrido[2,3-D]triazolo[3,4-B]pyrimidine analogs. Saudi Pharmaceutical J 2005;13:64–72
  • Srivastava BK, Solanki M, Mishra B, et al. Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones. Bioorg Med Chem 2007;15:1924–9
  • Aanandhi MV, George S, Vaidhyalingam V. Synthesis and antimicrobial activities of 1-(5-substituted-2-oxoindolin-3-ylidene)-4-(substituted pyridin-2-yl)thio-semicarbazide. ARKIVOC 2008;2008(xi):187–94
  • Goebel T, Ulmer D, Projahn H, et al. In search of novel agents for therapy of tropical diseases and human immunodeficiency virus. J Med Chem 2008;51:238–50
  • Gudmundsson KS, Johns BA, Wang Z, et al. Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses. Bioorg Med Chem 2005;13:5346–61
  • Allen SH, Johns BA, Gudmundsson KS, et al. Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses. Bioorg Med Chem 2006;14:944–54
  • Kamal A, Khan MNA, Reddy KS, et al. Synthesis of a new class of 2-anilino substituted nicotinyl arylsulfonylhydrazides as potential anticancer and antibacterial agents. Bioorg Med Chem 2007;15:1004–13
  • Perez-Rebolledo A, Ayala JD, de Lima GM, et al. Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes. Eur J Med Chem 2005;40:467–72
  • Poreba K, Opolski A, Wietrzyk J, et al. Synthesis and antiproliferative activity in vitro of new derivatives of 3-aminopyrazolo[3,4-b]pyridine. Part 1. Reaction of 3-aminopyrazolo[3,4-b]pyridine with 1,3-,1,4-diketones and α, β-unsaturated ketones. Arch Pharm Pharm Med Chem 2001;334:219–23
  • Huang S, Lin R, Yu Y, et al. Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyra-zolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 inhibitor. Bioorg Med Chem Lett 2007;17:1243–5
  • Tatsumi K, Yamauchi T, Kiyono K, et al. 3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase. J Biochem (Tokyo) 1993;114:912–18
  • Zhu G-D, Gong J, Gandhi VB, et al. Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt. Bioorg Med Chem 2007;15:2441–5
  • Warshakoon NC, Wu S, Boyer A, et al. Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors. Bioorg Med Chem Lett 2006;16:5687–90
  • Faidallah HM, Khan KA, Asiri AM. Synthesis of some new 2-oxo-1,4-disubstituted-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carbonitriles and their biological evaluation as cytotoxic and antiviral agents. J Chem Sci 2012;124:625–31
  • Rostom SAF, Faidallah HM, Al-Saadi MSM. A Facile synthesis of some 3-cyano-1,4,6-trisubstituted -2-(1H)-pyridinones and their biological evaluation as anticancer agents. Med Chem Res 2011;20:1260–72
  • Faidallah HM, Rostom SAF, Asiri AM, et al. 3-Cyano-8-methyl-2-oxo-1,4-disubstituted-1,2,5,6,7,8-hexahydroquinolines: synthesis and biological evaluation as antimicrobial and cytotoxic agent. J Enzyme Inhibition Med Chem 2013; 28:123--30
  • Faidallah HM, Rostom SAF, Khan KA, Basaif SA. Synthesis and characterization of some hydroxypyridone derivatives and their evaluation as antimicrobial agents. J Enzyme Inhibition Med Chem 2013; 28:495--508
  • Mosmann T. Rapid colourimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55–63
  • Denizot F, Lang R. Rapid colourimetric assay for cellular growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986;22:271–7
  • Scott AC. In: Collee JG, Duguid JP, Fraser AG, Marmion BP, eds. Mackie & McCartney practical medical microbiology. 13th ed. New York: Churchill Livingstone; 1989:161–81
  • Khaksar S, Yaghoobi M. A concise and versatile synthesis of 2-amino-3-cyanopyridine derivatives in 2,2,2-trifluoroethanol. J Fluorine Chem 2012;142:41–4
  • Wan Y, Yuan R, Zhang F-R, et al. One-pot synthesis of N2-substituted 2-amino-4-aryl-5,6,7,8-tetrahydroquinoline-3-carbonitrile in basic ionic liquid [bmim]OH. Synth Commun 2011;41:2997–3015
  • Paul S, Gupta R, Loupy A. Improved synthesis of 2-amino-3-cyanopyridines in solvent free conditions under microwave irradiation. J Chem Res (Synop) 1998;330–1
  • Elkholy YM, Morsy MA. Facile synthesis of 5,6,7,8-tetrahydropyrimido [4,5-b]-quinoline derivatives. Molecules 2006;11:890–903
  • Asiri AM, Faidallah HM, Al-Youbi AO, et al. 1-Benzoyl-3-[3-cyano-8-methyl-4-(1-methyl-1H-pyrrol-2-yl)-5,6,7,8-tetra-hydro-quinolin-2-yl]thiourea. Acta Crystallogr Sect E: Struct Rep. Online 2011;E67:o2430

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.