947
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Synthesis and hypoglycemic activity of some new theophylline derivatives

, , , , , & show all
Pages 443-448 | Received 24 Mar 2013, Accepted 11 Apr 2013, Published online: 23 May 2013

References

  • De Fronzo RA, Bonasonna RC, Ferrannini E. Pathogenesis of INDDM: a balanced overview. Diabetes Care 1992;15:318–68
  • Jacobson KA, van Galen PJ, Williams M. Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. J Med Chem 1992;35:407–22
  • Scaccianoce S, Navarra D, Di Sciullo A, et al. Adenosine and pituitary-adrenocortical axis activity in the rat. Neuroendocrinology 1989;50:464–8
  • Schettini G, Landolfi E, Meucci O, et al. Adenosine and its analogue (−)-N6-phenylisopropyladenosine modulate anterior pituitary adenylate cyclase activity and prolactin secretion in the rat. J Mol Endocrinol 1990;5:69–76
  • Buxton DB, Fisher RA, Robertson SM, Olson MS. Stimulation of glycognolysis and vasoconstriction by adenosine and adenosine analogues in the perfused liver. Biochem J 1987;248:35–41
  • Mclane MP, Black PR, Law WR, Raymond RM. Adenosine reversal of in vivo hepatic responsiveness to insulin. Diabetes 1990;39:62–9
  • Chaliss RAJ, Budohiski L, MacManus B, Newsholme EA. Effects of an adenosine receptor antagonist in insulin resistance in Soleus Muscle from Obese Zucker rats. Biochem J 1984;221:915–17
  • Crist GH, LaNoue KF, Lang CH. Tissue-specific effects of in vivo adenosine receptor blockage on glucose uptake in Zucker rats. FASEB J 1998;12:1301–8
  • Camaioni E, Costanzi S, Vittori S, et al. New substituted 9-alkylpurinies as adenosine receptor ligands. Bioorg Med Chem. 1998;6:523–33
  • Harada H, Asano O, Hoshino Y, et al. 2-Alkynyl-8-aryl-9-methyladenine as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A2B receptors. J Med Chem 2001;44:170–9
  • Jeong LS, Choe SA, Kim AY, et al. Synthesis of N6-substituted 3′-ureidoadenosine derivatives as highly potent agonists at the mutant A3 adenosine receptor. Nucleosides Nucleotides Nucleic Acids 2007;26:717–19
  • Stefanachi A, Nicolotti O, Leonetti F, et al. 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships. Bioorg Med Chem 2008;16:9780–9
  • Katyal J, Gupta YK. Dopamine release is involved in antinociceptive effect of theophylline. Int J Neurosci 2012;122:17–21
  • Hierrezuelo J, Manuel López-Romero J, Rico R, et al. Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors. Bioorg Med Chem 2010;18:2081–8
  • Watanabe S, Yamakami J, Tsuchiya M, et al. Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system. J Pharmacol Sci 2008;106:566–70
  • Hasegawa M, Hada J, Abe T, et al. Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats. Neurosci Res 2009;65:156–9
  • Cunha RA, Ferré S, Vaugeois JM, Chen JF. Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Curr Pharm Des 2008;14:1512–24
  • Umrani DN, Goyal RK. Beneficial effects of fenoldopam treatment on renal function in streptozotocin-induced diabetic rats. Clin Exp Hypertens 2002;24:207–19
  • Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol 2004;56:101–5
  • Majithiya JB, Balaraman R. Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats. Life Sci 2006;78:2615–24
  • Tayek JA. Low-dose oral glyburide reduces fasting blood glucose by decreasing hepatic glucose production in healthy volunteers without increasing carbohydrate oxidation. Am J Med Sci 1995;309:134–9
  • El Tahir KE, Williams KI, Betteridge DJ. The effect of experimental diabetes on prostacyclin production by tissues from pregnant rats. Prostaglandins Leukot Med 1982;8:429–35

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.