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Research Article

Synthesis and pro-apoptotic effects of new sulfonamide derivatives via activating p38/ERK phosphorylation in cancer cells

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Pages 413-419 | Received 24 May 2014, Accepted 23 Jun 2014, Published online: 08 Sep 2014

References

  • Thun MJ, DeLancey JO, Center MM, et al. The global burden of cancer: priorities for prevention. Carcinogenesis 2010;1:100–10
  • Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002;108:153–64
  • Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997;326:1–16
  • Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770–6
  • Leelahavanichkul K, Amornphimoltham P, Molinolo AA, et al. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol 2014;1:105–18
  • Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 2007;1773:1358–75
  • Lenassi M, Plemenitaš A. The role of p38 MAP kinase in cancer cell apoptosis. Radiol Oncol 2006;40:51–6
  • Ostrowski J, Trzeciak L, Kolodziejski J, Bomsztyk K. Increased constitutive activity of mitogen-activated protein kinase and renaturable 85 kDa kinase in human-colorectal cancer. Brit J Cancer 1998;78:1301–6
  • Kim SC, Hahn JS, Min YH, et al. Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signalregulated kinase, and down regulation of a phosphatase, PAC1. Blood 1999;93:3893–9
  • Chen Z, Sun J, Pradines A, Favre G, et al. Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice. J Biol Chem 2000;275:17974–8
  • Ishikawa Y, Kitamura M. Dual potential of extracellular signal-regulated kinase for the control of cell survival. Biochem Biophys Res Commun 1999;264:696–701
  • Pavlovic D, Andersen NA, Mandrup-Poulsen T, Zizirik DL. Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokineinduced apoptosis in purified rat pancreatic beta-cells. Eur Cytokine Netw 2000;11:267–74
  • Shih A, Davis FB, Lin HY, Davis PJ. Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. J Clin Endocrinol Metab 2002;87:1223–32
  • Kim YH, Lee DH, Jeong JH, et al. Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol 2008;75:1946–58
  • Tewari R, Sharma V, Koul N, Sen E. Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation. J Neurochem 2008;107:616–27
  • Bacus SS, Gudkov AV, Lowe M, et al. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 2001;20:147–55
  • Jones DN. Comprehensive organic chemistry. Vol. 3. Oxford: Pergamon Press; 1979:345
  • González-Alvarez M, Alzuet G, Borrás J, et al. Comparison of protective effects against reactive oxygen species of mononuclear and dinuclear Cu(II) complexes with N-substituted benzothiazolesulfonamides. Inorg Chem 2005;44:9424–33
  • Shah SS, Rivera G, Ashfaq M. Recent advances in medicinal chemistry of sulfonamides. Rational design as anti-tumoral, anti-bacterial and anti-inflammatory agents. Mini Rev Med Chem 2013;13:70–86
  • Dayan S, Kalaycıoğlu NÖ, Dayan O, et al. Synthesis and characterization of SiO2-supported ruthenium complexes containing aromatic sulfonamides: as catalysts for transfer hydrogenation of acetophenone. Dalton Trans 2013;14:4957–69
  • Turkmen H, Zengin G, Buyukkircali B. Synthesis of sulfanilamide derivatives and investigation of in vitro inhibitory activities and antimicrobial and physical properties. Bioorg Chem 2011;3:114–19
  • Chohan ZH, Shad HA, Supuran CT. Synthesis, characterization and biological studies of sulfonamide Schiff's bases and some of their metal derivatives. J Enzyme Inhib Med Chem 2012;1:58–68
  • Gangapuram M, Mazzio E, Eyunni S, et al. Synthesis and biological evaluation of substituted N-[3-(1H-Pyrrol-1-yl)methyl]-1,2,5,6-tetrahydropyridin-1-yl]benzamide/benzene sulfonamides as anti-inflammatory agents. Arch Pharm (Weinheim) 2014;5:360–9
  • Chen Z, Xu W, Liu K, et al. Synthesis and antiviral activity of 5-(4-chlorophenyl)-1,3,4-thiadiazole sulfonamides. Molecules 2010;12:9046–56
  • Bashandy MS, Alsaid MS, Arafa RK, Ghorab MM. Design, synthesis and molecular docking of novel N,N-dimethylbenzenesulfonamide derivatives as potential antiproliferative agents. J Enzyme Inhib Med Chem 2013;3:1–9
  • Funahashi Y, Sugi NH, Semba T, et al. Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. Cancer Res 2002;21:6116–23
  • Güzel O, Innocenti A, Vullo D, et al. 3-phenyl-1H-indole-5-sulfonamides: structure-based drug design of a promising class of carbonic anhydrase inhibitors. Curr Pharm Des 2010;29:3317–26
  • Owa T, Okauchi T, Yoshimatsu K, et al. A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors. Bioorg Med Chem Lett 2000;11:1223–6
  • McCubrey JA, Steelman LS, Chappell WH, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 2007;8:1263–84
  • Ghorab MM, El-Gazzar MG, Alsaid MS. Synthesis and anti-breast cancer evaluation of Novel N-(Guanidinyl)benzenesulfonamides. Int J Mol Sci 2014;15:5582–95

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