Citrus medica L. cv Diamante (Rutaceae) peel extract improves glycaemic status of Zucker diabetic fatty (ZDF) rats and protects against oxidative stress

References

• Cutuli GD, Martino E, Lo Giudice V, et al. Trattato di agrumicoltura. Bologna, Italy: Edagricole; 1985
   Google Scholar
• Menichini F, Loizzo MR, Bonesi M, et al. Phytochemical profile, antioxidant, anti-inflammatory and hypoglycemic potential of hydroalcoholic extracts from Citrus medica L. cv Diamante flowers, leaves and fruits at two maturity stages. Food Chem Toxicol 2011;49:1549–55
   PubMed Web of Science ®Google Scholar
• Menichini F, Tundis R, Loizzo MR, et al. C. medica cv Diamante peel chemical composition and influence on glucose homeostasis and metabolic parameters. Food Chem 2011;124:1083–9
   Web of Science ®Google Scholar
• Stern MP, Williams K, González-Villalpando C, et al. Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care 2004;27:2676–81
   PubMed Web of Science ®Google Scholar
• Danaei G, Finucane MM, Lu Y, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2–7 million participants. Lancet 2011;378:31–40
   PubMed Web of Science ®Google Scholar
• Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011;94:311–21
   PubMed Web of Science ®Google Scholar
• Castellano JM, Guinda A, Delgado T, et al. Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 2013;62:1791–9
   PubMed Web of Science ®Google Scholar
• Chen J, Mangelinckx S, Adams A, et al. Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications. Nat Prod Commun 2015;10:187–200
   PubMed Web of Science ®Google Scholar
• Derosa G, Maffioli P. Alkaloids in the nature: pharmacological applications in clinical practice of berberine and mate tea. Curr Top Med Chem 2014;14:200–6
   PubMed Web of Science ®Google Scholar
• Clark JB, Palmer CJ, Shaw WN. The diabetic Zucker fatty rat. Proc Soc Exp Biol Med 1983;173:68–75
   PubMed Web of Science ®Google Scholar
• Mega C, de Lemos ET, Vala H, et al. Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat). Exp Diabetes Res 2011;2011:162092–103
   PubMedGoogle Scholar
• Bhasin MK, Chahal SMS. A laboratory manual for human blood analysis. Delhi: Kamal raj Enterprises; 1996
   Google Scholar
• Loizzo MR, Tundis R, Bonesi M, et al. Radical scavenging, antioxidant and metal chelating activities of Annona cherimola Mill. (cherimoya) peel and pulp in relation to their total phenolic and total flavonoid contents. J Food Comp Anal 2012;25:179–84
   Web of Science ®Google Scholar
• Benzie IF, Strains JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 1996;239:70–6
   PubMed Web of Science ®Google Scholar
• Inchingolo F, Marrelli M, Annibali S, et al. Influence of endodontic treatment on systemic oxidative stress. Int J Med Sci 2013;11:1–6
   PubMed Web of Science ®Google Scholar
• McGarry JD. Disordered metabolism in diabetes: have we underemphasized the fat component? J Cell Biochem 1994;55Suppl:29–38
   Web of Science ®Google Scholar
• Antolovich M, Prenzler PD, Patsalides E, et al. Methods for testing antioxidant activity. Analyst 2002;127:183–98
   PubMed Web of Science ®Google Scholar
• Pasquini A, Luchetti E, Marchetti V, et al. Analytical performances of d-ROMs test and BAP test in canine plasma. Definition of the normal range in healthy Labrador dogs. Vet Res Commun 2008;32:137–43
   PubMed Web of Science ®Google Scholar
• Hetyey CS, Manczur F, Dudás-Györki Z, et al. Plasma antioxidant capacity in dogs with naturally occurring heart diseases. J Vet Med A Physiol Pathol Clin Med 2007;54:36–9
   PubMedGoogle Scholar
• Palmieri B, Sblendorio V. Oxidative stress tests: overview on reliability and use. Part I. Eur Rev Med Pharmacol Sci 2007;11:309–42
   PubMed Web of Science ®Google Scholar
• Gosslau A, Chen KY, Ho CT, Li S. Anti-inflammatory effects of characterized orange peel extracts enriched with bioactive polymethoxyflavones. Food Sci Hum Wellness 2014;3:26–35
   Google Scholar
• Alam MA, Subhan N, Rahman MM, et al. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr 2014;5:404–17
   PubMed Web of Science ®Google Scholar
• Chanet A, Milenkovic D, Manach C, et al. Citrus flavanones: what is their role in cardiovascular protection? J Agric Food Chem 2012;60:8809–22
   PubMed Web of Science ®Google Scholar
• Rauter AP, Martins A, Borges C, et al. Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytother Res 2010;24:S133–8
   PubMed Web of Science ®Google Scholar
• Ohno M, Shibata C, Kishikawa T, et al. The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice. Sci Rep 2013;3:2553–9
   PubMed Web of Science ®Google Scholar
• Escande C, Nin V, Price NL, et al. Flavonoid apigenin is an inhibitor of the NAD + ase CD38: implications for cellular NAD + metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes 2013;62:1084–93
   PubMed Web of Science ®Google Scholar
• Jung UJ, Lee MK, Park YB, et al. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 2006;38:1134–45
   PubMed Web of Science ®Google Scholar
• Postic C, Shiota M, Niswender KD, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999;274:305–15
   PubMed Web of Science ®Google Scholar
• Osama MA, Ayman MM, Abdel M et al. Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats. Diabetol Croat 2012;412:53–67
   Google Scholar
• Borradaile NM, de Dreu LE, Huff MW. Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. Diabetes 2003;52:2554–61
   PubMed Web of Science ®Google Scholar
• Raz I, Eldor R, Cernea S, Shafrir E. Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes Metab Res Rev 2005;21:3–14
   PubMed Web of Science ®Google Scholar
• Suckling KE, Stange EF. Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 1985;26:647–71
   PubMed Web of Science ®Google Scholar
• Assini JM, Mulvihill EE, Huff MW. Citrus flavonoids and lipid metabolism. Curr Opin Lipidol 2013;24:34–40
   PubMed Web of Science ®Google Scholar
• Bok SH, Lee SH, Park YB, et al. Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. J Nutr 1999;129:1182–5
   PubMed Web of Science ®Google Scholar
• Yu J, Wang L, Walzem RL, et al. Antioxidant activity of citrus limonoids, flavonoids, and coumarins. J Agric Food Chem 2005;53:2009–14
   PubMed Web of Science ®Google Scholar
• Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008;585:325–37
   PubMed Web of Science ®Google Scholar
• Zhao P, Duan L, Guo L, et al. Chemical and biological comparison of the fruit extracts of Citrus wilsonii Tanaka and Citrus medica L. Food Chem 2015;173:54–60
   PubMed Web of Science ®Google Scholar