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Short Communication

Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase

, , , , , , & show all
Pages 1666-1671 | Received 31 Aug 2015, Accepted 08 Nov 2015, Published online: 10 Dec 2015

References

  • Kohanski MA, Dwyer DJ, Collins JJ. How antibiotics kill bacteria: from targets to networks. Nat Rev Microbiol 2010;8:423–35
  • Floss HG, Yu TW. Rifamycin – mode of action, resistance, and biosynthesis. Chem Rev 2005;105:621
  • Tomasz A. The mechanism of the irreversible antimicrobial effects of penicillins: how the beta-lactam antibiotics kill and lyse bacteria. Annu Rev Microbiol 1979;33:113–37
  • Vakulenko SB, Mobashery S. Versatility of aminoglycosides and prospects for their future. Clin Microbiol Rev 2003;16:430–50
  • Otto M. Methicillin-resistant Staphylococcus aureus infection is associated with increased mortality. Future Microbiol 2012;7:189–91
  • Chalfine A, Kitzis M-D, Bezie Y, et al. Ten-year decrease of acquired methicillin-resistant Staphylococcus aureus (MRSA) bacteremia at a single institution: the result of a multifaceted program combining cross-transmission prevention and antimicrobial stewardship. Antimicrob Resist Infect Control 2012;1:18
  • Deleo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet 2010;375:1557–68
  • Meir S, Weber R, Zbinden R, et al. Extended-spectrum β-lactamase-producing Gram-negative pathogens in community-acquired urinary tract infections: an increasing challenge for antimicrobial therapy. Infection 2011;39:333–40
  • Kumarasamy KK, Toleman MA, Walsh TR. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 2010;10:597–602
  • Motomasa K, Shunji A, Gato K, et al. Marine natural products. XXXIV. Trisindoline, a new antibiotic indole trimer, produced by a bacterium of Vibrio sp. separated from the marine sponge Hyrtios altum. Chem Pharm Bull 1994;42:2449–51
  • Oka R, Wagner-Döbler V, Laatsch IIH. New indole alkaloids from the North Sea bacterium Vibrio parahaemolyticus Bio249. J Nat Prod 2003;66:1520–3
  • Zoraghi R, Worrall L, See RH, et al. Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities. J Biol Chem 2011;286:44716–25
  • Raju BC, Rao JM. An easy and efficient synthesis of bisindolylmethanes and tetraindolylmethane Tröger's base catalyzed by AgBF4. Ind J Chem 2008;47B:623
  • Sujatha K, Perumal PT, Muralidharan D, Rajendran M. Synthesis and biological evaluation of some novel heterocyclic derivatives of paracetamole as potential analgesic and antipyretic agents. Ind J Che 2009;48B:267
  • Pore D-M, Desai U-V, Thopate TS, Wadgaonkar P-P. A mild, expedient, solventless synthesis of bis(indolyl)alkanes using silica sulphuric acid as a reusable catalyst. Arkivoc 2006;12–75
  • Karthik M, Tripathi AK, Gupta NM, et al. Zeolite catalyzed electrophilic substitution reaction of indoles with aldehydes: synthesis of bis(indolyl)methanes. Catal Commun 2004;5:371–5
  • Kidwai M, Bura N, Mishra NK. Nioboum(V) pentachloride-catalyzed efficient and highly rapid synthesis of bis(indolyl)-methanes under mild conditions. Ind J Chem 2011;50B:229
  • Ke BW, Qin Y, Wang Y, Wang FP. Synth Commun 2005;35:1209–12
  • The compound stereochemistry has been additionally proved by X-ray structure analysis of trisacetylated derivative 2a with published crystallographic data under CCDC-939747 which can be obtained free of charge via http://www.ccdc.cam.ac.uk/data_request/cif
  • Cherkasov A, Hsing M, Zoraghi R, et al. Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus. J Proteome Res 2011;10:1139–50
  • Zoraghi R, See RH, Axerio-Cilies P, et al. Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target. Antimicrob Agents Chemother 2011;55:2042–53
  • Valentini G, Chiarelli L, Fortin R, et al. The allosteric regulation of pyruvate kinase. J Biol Chem 2000;275:18145

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