References
- Pedemonte N, Galietta LJ. Structure and function of TMEM16 proteins (anoctamins). Physiol Rev 2014;94:419–59.
- Picollo A, Malvezzi M, Accardi A. TMEM16 proteins: unknown structure and confusing functions. J Mol Biol 2015;427:94–105.
- Qu Z, Yao W, Yao R, et al. The Ca(2+)-activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis. Cancer Med 2014;3:453–61.
- Wanitchakool P, Wolf L, Koehl GE, et al. Role of anoctamins in cancer and apoptosis. Philos Trans R Soc Lond B Biol Sci 2014;369:20130096
- Huang F, Rock JR, Harfe BD, et al. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci USA 2009;106:21413–18.
- Rock JR, Futtner CR, Harfe BD. The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol 2008;321:141–9.
- Ousingsawat J, Martins JR, Schreiber R, et al. Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem 2009;284:28698–703.
- Rock JR, O’Neal WK, Gabriel SE, et al. Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem 2009;284:14875–80.
- Faria D, Rock JR, Romao AM, et al. The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney Int 2014;85:1369–81.
- Lee B, Cho H, Jung J, et al. Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol Pain 2014;10:5.
- Heinze C, Seniuk A, Sokolov MV, et al. Disruption of vascular Ca2+-activated chloride currents lowers blood pressure. J Clin Invest 2014;124:675–86.
- Yu K, Duran C, Qu Z, et al. Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology. Circ Res 2012;110:990–9.
- Fallah G, Römer T, Detro-Dassen S, et al. TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels. Mol Cell Proteomics 2011;10:M110 004697.
- Sheridan JT, Worthington EN, Yu K, et al. Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A. J Biol Chem 2011;286:1381–8.
- Tian Y, Kongsuphol P, Hug M, et al. Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J 2011;25:1058–68.
- Tian Y, Schreiber R, Kunzelmann K. Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci 2012;125:4991–8.
- Brunner JD, Lim NK, Schenck S, et al. X-ray structure of a calcium-activated TMEM16 lipid scramblase. Nature 2014;516:207–12.
- Mall MA, Galietta LJ. Targeting ion channels in cystic fibrosis. J Cyst Fibros 2015;14:561–70.
- Sondo E, Caci E, Galietta LJ. The TMEM16A chloride channel as an alternative therapeutic target in cystic fibrosis. Int J Biochem Cell Biol 2014;52:73–6.
- Namkung W, Yao Z, Finkbeiner WE, Verkman AS. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J 2011;25:4048–62.
- Sala-Rabanal M, Yurtsever Z, Berry KN, Brett TJ. Novel roles for chloride channels, exchangers, and regulators in chronic inflammatory airway diseases. Mediat Inflamm 2015;2015:497387
- De La Fuente R, Namkung W, Mills A, Verkman AS. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol 2008;73:758–68.
- Namkung W, Phuan PW, Verkman AS. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem 2011;286:2365–74.
- Davis AJ, Shi J, Pritchard HA, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) A01. Br J Pharmacol 2013;168:773–84.
- Sun H, Xia Y, Paudel O, et al. Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity. J Physiol 2012;590:3507–21.
- Mroz MS, Keely SJ. Epidermal growth factor chronically upregulates Ca(2+)-dependent Cl(-) conductance and TMEM16A expression in intestinal epithelial cells. J Physiol 2012;590:1907–20.
- Duvvuri U, Shiwarski DJ, Xiao D, et al. TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res 2012;72:3270–81.
- Kumar S, Namkung W, Verkman AS, Sharma PK. Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorg Med Chem 2012;20:4237–44.