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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 6
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Short Communication

Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives

Ahmed G. EissaSchool of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff, Wales, UK and ;Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
,
James A. BlaxlandSchool of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff, Wales, UK and
,
Rhodri O. WilliamsSchool of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff, Wales, UK and
,
Kamel A. MetwallyDepartment of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
,
Sobhy M. El-AdlDepartment of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
,
El-Sayed M. LashineDepartment of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
,
Leslie W. J. BaillieSchool of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff, Wales, UK and
&
Claire SimonsSchool of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff, Wales, UK and Correspondence[email protected]
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Pages 1694-1697 | Received 16 Dec 2015, Accepted 05 Jan 2016, Published online: 22 Feb 2016

References

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  • Evans R, Green L, Sun X, et al. Co-crystal structure of REP3123 bound to Clostridium difficile methionyl tRNA synthetase. ICAAC 2007, Abstracts of the 47th Interscience Conferenceon Antimicrobial Agents and Chemotherapy, Proceedings of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, IL. 17–20 September 2007; Washington, DC, USA: American Society for Microbiology. Poster no. F1-2114.

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