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CASE REPORT

Case-based experience in the use of 5-fluorouracil cream 0.5% as monotherapy and in conjunction with glycolic acid peels for the treatment of actinic keratosis

Pages 42-46 | Received 07 Jul 2009, Accepted 29 Oct 2009, Published online: 19 Jan 2010

References

  • Jackson R. Elderly and sun-affected skin. Distinguishing between changes caused by aging and changes caused by habitual exposure to sun. Can Fam Physician. 2001;47:1236–43.
  • Clark E, Scerri L. Superficial and medium-depth chemical peels. Clin Dermatol.2008;26(2):209–18.
  • Glogau RG. Physiologic and structural changes associated with aging skin. Dermatol Clin. 1997;15:555–9.
  • McIntyre WJ, Downs MR, Bedwell SA. Treatment options for actinic keratoses. Am Fam Physician. 2007;76:667–71.
  • Schwartz RA, Bridges TM, Butani AK, Ehrlich A. Actinic keratosis: An occupational and environmental disorder. J Eur Acad Dermatol Venereol. 2008;22:606–15.
  • Yantsos VA, Conrad N, Zabawski E, Cockerell CJ. Incipient intraepidermal cutaneous squamous cell carcinoma: A proposal for reclassifying and grading solar (actinic) keratoses. Semin Cutan Med Surg. 1999;18:3–14.
  • Drake LA, Ceilley RI, Cornelison RL, Dobes WL, Dorner W, Goltz RW, . Guidelines of care for actinic keratoses. Committee on Guidelines of Care. J Am Acad Dermatol. 1995;32:95–8.
  • Stockfleth E, Kerl H. Guidelines for the management of actinic keratoses. Eur J Dermatol. 2006;16:599–606.
  • Moy RL. Clinical presentation of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol. 2000;42 (1 Pt 2):S8–10.
  • Jeffes EW III, Tang EH. Actinic keratosis. Current treatment options. Am J Clin Dermatol. 2000;1:167–79.
  • Jancin B. Study hikes risk of cancer from AKs. Skin & Allergy News. 2008;39:1–8.
  • Salasche SJ. Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol. 2000;42(1 Pt 2): S4–7.
  • Rossi R, Mori M, Lotti T. Actinic keratosis. Int J Dermatol. 2007;46:895–904.
  • Memon AA, Tomenson JA, Bothwell J, Friedmann PS. Prevalence of solar damage and actinic keratosis in a Merseyside population. Br J Dermatol. 2000;142:1154–9.
  • Zagula-Mally ZW, Rosenberg EW, Kashgarian M. Frequency of skin cancer and solar keratoses in a rural southern county as determined by population sampling. Cancer. 1974;34:345–9.
  • Engel A, Johnson ML, Haynes SG. Health effects of sunlight exposure in the United States. Results from the first National Health and Nutrition Examination Survey, 1971–1974. Arch Dermatol. 1988;124:72–9.
  • Warino L, Tusa M, Camacho F, Teuschler H, Fleischer AB Jr, Feldman SR. Frequency and cost of actinic keratosis treatment. Dermatol Surg. 2006;32:1045–9.
  • Berman B, Bienstock L, Kuritzky L, Mayeaux EJ Jr, Tyring SK. Actinic keratoses: Sequelae and treatments. Recommendations from a consensus panel. J Fam Pract. 2006;55(suppl): 1–8.
  • Thai K-E, Fergin P, Freeman M, Vinciullo C, Francis D, Spelman L, . A prospective study of the use of cryosurgery for the treatment of actinic keratoses. Int J Dermatol. 2004;43:687–92.
  • Gupta AK, Davey V, Mcphail H. Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies. J Cutan Med Surg. 2005;9:209–14.
  • Carac [package insert]. Bridgewater, NJ: Dermik Laboratories; 2006.
  • Weinberg JM. Topical therapy for actinic keratoses: Current and evolving therapies. Rev Recent Clin Trials. 2006;1:53–60.
  • Jorizzo J, Weiss J, Furst K, VandePol C, Levy SF. Effect of a 1-week treatment with 0. 5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: A randomized, vehicle-controlled clinical trial. Arch Dermatol. 2004;140:813–16.
  • Jorizzo J, Weiss J, Vamvakias G. One-week treatment with 0. 5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: A double-blind, vehicle-controlled, long-term study. J Drugs Dermatol. 2006;5:133–9.
  • Dinehart SM. The treatment of actinic keratoses. J Am Acad Dermatol. 2000;42(1 Pt 2):25–8.
  • Jorizzo JL, Carney PS, Ko WT, Robins P, Weinkle SH, Werschler WP. Fluorouracil 5% and 0. 5% creams for the treatment of actinic keratosis: Equivalent efficacy with a lower concentration and more convenient dosing schedule. Cutis. 2004;74(6 suppl):18–23.
  • Loven K, Stein L, Furst K, Levy S. Evaluation of the efficacy and tolerability of 0. 5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther. 2002;24:990–1000.
  • Landau M. Chemical peels. Clin Dermatol. 2008;26:200–8.
  • Lawrence N, Cox SE, Cockerell CJ, Freeman RG, Cruz PD Jr. A comparison of the efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses. Arch Dermatol. 1995;131:176–81.
  • Witheiler DD, Lawrence N, Cox SE, Cruz C, Cockerell CJ, Freemen RG. Long-term efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses. Dermatol Surg. 1997;23:191–6.
  • Marrero GM, Katz BE. The new fluor-hydroxy pulse peel. A combination of 5-fluorouracil and glycolic acid. Dermatol Surg. 1998;24:973–8.
  • Teixeira SP, de Nascimento MM, Bagatin E, Hassun KM, Talarico S, Michalany N. The use of fluor-hydroxy pulse peel in actinic porokeratosis. Dermatol Surg. 2005;31(9 Pt 1):1145–8.
  • Ditre CM. The treatment of photodamaged skin with 5% 5-fluorouracil peels. Cosmet Dermatol. 2007;20:568–72.
  • Labandeira J, Pereiro M Jr, Valdes F, Toribio J. Intermittent topical 5-fluorouracil is effective without significant irritation in the treatment of actinic keratoses but prolongs treatment duration. Dermatol Surg. 2004;30(4 Pt 1):517–20.
  • Robins P. Pulse therapy with 5-FU in eradicating actinic keratoses with less than recommended dosage. J Drugs Dermatol. 2002;1:25–30.
  • Jorizzo J, Stewart D, Bucko A, Davis SA, Espy P, Hino P, . Randomized trial evaluating a new 0. 5% fluorouracil formulation demonstrates efficacy after 1-, 2-, or 4-week treatment in patients with actinic keratosis. Cutis. 2002;70:335–9.
  • Weiss J, Menter A, Hevia O, Jones T, Ling M, Rist T, . Effective treatment of actinic keratosis with 0. 5% fluorouracil cream for 1, 2, or 4 weeks. Cutis. 2002;70(2 suppl): 22–9.
  • Current concepts in the management of actinic keratosis. J Drugs Dermatol. 2004;3:S3–16.

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