39
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Unexplained elevated midtrimester maternal serum levels of alpha fetoprotein, human chorionic gonadotropin, or low unconjugated estriol: Recurrence risk and association with adverse perinatal outcome

, , , , &
Pages 161-164 | Received 08 Sep 1999, Accepted 06 Jan 2000, Published online: 07 Jul 2009

References

  • Merkatz I R, Nitkowsky H M, Macri J N, Johnson W E. An associatior between low maternal serum alpha‐fetoprotein and fetal chromosome abnormalities. Am J Obstet Gynecol 1984; 148: 886–894
  • Haddow J E, Palomaki G E, Knight G J, Williams J, Pulkkinen A, Canick J A, Saller D N, Bowers G B. Prenatal screening for Down': syndrome with use of maternal serum markers. N Engl J Med 1992; 327: 588–593
  • Brazerol W F, Grover S, Donnenfeld A E. Unexplained elevated maternal serum alphafetoprotein levels and perinatal outcome in ar urban clinic population. Am J Obstet Gynecol 1994; 171: 1030–1035
  • Hsieh T T, Hung T H, Hsu J J, Shau W Y, Su C W, Hsieh F J. Predictior of adverse perinatal outcome by maternal serum screening for Dowr syndrome in an Asian population. Obstet Gynecol 1997; 89: 937–940
  • Cho S, Durfee K K, Keel B A, Parks L H. Perinatal outcomes in prospective matched pair study of pregnancy and unexplained ele vated or low AFP screening. J Perinatal 1997; 25: 476–483
  • Gonen R, Perez R, David M, Dar H, Merksamer R, Sharf M. The association between unexplained second trimester maternal satin hCG elevation and pregnancy complications. Obstet Gynecol 1992; 80: 83–86
  • Benn P A, Home D, Brigand S, Rodis J F, Clive J M. Elevated seconc trimester maternal serum hCG alone or in combination with elevatec alpha‐fetoprotein. Obstet Gynecol 1996; 87: 271–222
  • Lieppman R E, Williams M A, Cheng E Y, Resta R, Zingheim R, Hickok D E, Luthy D A. An association between elevated levels of human chorionic gonadotropin in the midtrimester and adverse pregnancy outcome. Am J Obstet Gynecol 1993; 168: 1852–1857
  • Santolaya‐Forgas J, Jessup J, Burd L I, Prins G S, Burton B K. Pregnancy outcome in women with low midtrimester maternal serum unconjugated estriol. J Reprod Med 1996; 41: 87–90
  • Schleifer R A, Bradley L A, Richards D S, Ponting N R. Pregnancy outcome for women with very low levels of maternal serum unconjugated estriol on second‐trimester screening. Am J Obstet Gynecol 1995; 173: 1152–1156
  • Wald N J, Cuckle H S. Raised maternal serum alpha‐fetoprotein levels in subsequent pregnancies (Letter). Lancet 1981; I: 1103
  • Dar H, Merksamer R, Berdichevsky D, David M. Maternal serum markers in consecutive pregnancies: a possible genetic predisposition to abnormal levels. Am J Med Genet 1996; 61: 154–157
  • Spencer K. Between‐pregnancy biological variability of maternal serum alpha‐fetoprotein and free beta hCG: implications for Down syndrome screening in subsequent pregnancies. Prenat Diagn 1997; 17: 39–45
  • Benn P A, Home D, Brigante S, Greenstein R M. Prenatal diagnosis of diverse chromosome abnormalities in a population of patients identified by triple‐marker testing as screen positive for Down syndrome. Am J Obstet Gynecol 1995; 173: 496–501
  • Benn P A, Borgida A, Home D, Briganti S, Collins R, Rodis J F. Down syndrome and neural tube defect screening: the value of using gestational age by ultrasonography. Am J Obstet Gynecol 1997; 176: 1056–1061
  • Williams R L, Creasy R K, Cunninghan G C, Hawes W E, Tashiro M. Fetal growth and perinatal viability in California. Obstet Gynecol 1982; 59: 624–632
  • Holding S, Cuckle H. Maternal serum screening for Down's syndrome taking account of the result in a previous pregnancy (Letter). Prenat Diagn 1994; 321–324
  • Zimmerman R, Streicher A, Huch R, Huch A. Effect of gravidity and parity on the parameters used in serum screening for trisomy 21 (Letter). Prenat Diag 1995; 15: 781–782
  • Wald N J, Watt H C. Serum markers for Down's syndrome in relation to number of previous births and maternal age. Prenat Diagn 1996; 16: 699–703
  • Larsen S O, Christiansen M, Norgaard‐Pedersen B. Inclusion of serum marker measurements from a previous pregnancy improves Down syndrome screening performance. Prenat Diagn 1998; 18: 706–712
  • Cusick W, Rodis J F, Vintzileos A M, Albini S M, McMahon M, Campbell W A. Predicting pregnancy outcome from the degree of maternal serum alpha‐fetoprotein elevation. J Reprod Med 1996; 41: 327–332
  • Phillips O P, Simpson J L, Morgan C D, Anderson R N, Shulman L P, Meyers C M, Sibai B, Shaver D C, Tolley E A, Elias S. Unexplained elevated maternal serum alpha‐fetoprotein is not predictive of adverse outcome in an indigent urban population. Am J Obstet Gynecol 1992; 166: 978–982
  • Walton D, Norem C, Schoen E, Colby C. Does elevated hCG have clinical utility as a predictor of adverse pregnancy outcome [Abstract]?. Am J Obstet Gynecol 1999; 180: S68

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.