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The Journal of Maternal-Fetal & Neonatal Medicine Volume 24, 2011 - Issue 3
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Original Article

Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly

Hilal ÖzkanFaculty of Medicine, Division of Neonatology, Department of Pediatrics, Uludag University, Bursa, Turkey
,
Merih ÇetinkayaFaculty of Medicine, Division of Neonatology, Department of Pediatrics, Uludag University, Bursa, TurkeyCorrespondence[email protected]
,
Nilgün KöksalFaculty of Medicine, Division of Neonatology, Department of Pediatrics, Uludag University, Bursa, Turkey
&
Şenay YapiciFaculty of Medicine, Department of Pediatrics, Uludag University, Bursa, Turkey
Pages 521-524 | Received 27 Feb 2009, Accepted 07 Jun 2010, Published online: 04 Feb 2011

References

  • SanderJW. The epidemiology of epilepsy revisited. Curr Opin Neurol 2003;16:165–170.
  • ArpinoC, BrescianiniS, RobertE, CastillaEE, CocchiG, CornelMC, de ViganC, LancasterPA, MerlobP, SumiyoshiY, et al. Teratogenic effects of antiepileptic drugs: use of an international database on malformations and drug exposure (MADRE). Epilepsia 2000;41:1436–1443.
  • HolmesLB, HarveyEA, CoullBA, HuntingtonKB, KhoshbinS, HayesAM, RyanLM. The teratogenicity of anticonvulsant drugs. N Engl J Med 2001;344:1132–1138.
  • LindhoutD, OmtzigtJG. Pregnancy and the risk of teratogenicity. Epilepsia 1992;33:S41–S48.
  • KiniU. Fetal valproate syndrome: a review. Paed Perinat Drug Ther 2006;7:123–130.
  • GentonP, SemahF, TrinkaE. Valproic acid in epilepsy. Drug Safety 2006;29:1–21.
  • DiLibertiJH, FarndonPA, DennisNR, CurryCJ. The fetal valproate syndrome. Am J Med Genet 1984;19:473–481.
  • MorrowJ, RussellA, GuthrieE, ParsonsL, RobertsonI, WaddellR, IrwinB, McGivernRC, MorrisonPJ, CraigJ. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK epilepsy and pregnancy register. J Neurol Neurosurg Psychiatry 2006;77:193–198.
  • Clayton-SmithJ, DonnaiD. Fetal valproate syndrome. J Med Genet 1995;32:724–727.
  • LajeunieE, BarcıkU, ThorneJA, GhouzziVE, BourgeoısM, RenierD. Craniosynostosis and fetal exposure to sodium valproate. J Neurosurg 2001;95:778–782.
  • KozmaCM. Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. Am J Med Genet 2001;98:168–175.
  • TomsonT, BattinoD. Teratogenic effects of antiepileptic drugs. Seizure 2008;17:166–171.
  • UzielD, RozentalR. Neurologic birth defects after prenatal exposure to antiepileptic drugs. Epilepsia 2008;49 (Suppl 9);35–42.
  • CetinkayaM, ÖzkanH, KöksalN. Unilateral radius aplasia due to lamotrigine and oxcarbazepine use in pregnancy. J Matern Fetal Neonatal Med 2008;21:927–930.
  • McElhattonP. Teratogenic drugs – part 1. Adverse Drug Reac Bull 2002;213:815–818.
  • VajdaFJ, O'BrienTJ, HitchcockA, GrahamJ, CookM, LanderC, EadieMJ. Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy. J Clin Neurosci 2004;11:854–858.
  • SamrenEB, van DuijnCM, ChristiaensGC, HofmanA, LindhoutD. Antiepileptic drug regimens and major congenital abnormalities in the offspring. Ann Neurol 1999;46:739–746.
  • MawerG, Clayton-SmithJ, CoyleH, KiniU. Outcome of pregnancy in women attending an outpatient epilepsy clinic: adverse features associated with higher doses of sodium valproate. Seizure 2002;11:512–518.
  • KanekoS, BattinoD, AndermannE, WadaK, KanR, TakedaA, NakaneY, OgawaY, AvanziniG, FumarolaC, et al. Congenital malformations due to antiepileptic drugs. Epilepsy Res 1999;33:145–158.
  • EadieMJ, VajdaFJ. Should valproate be taken during pregnancy? Ther Clin Risk Manag 2005;1:21–26.
  • MenegolaE, BrocciaML, NauH, PratiM, RicolfiR, GiaviniE. Teratogenic effects of sodium valproate in mice and rats at midgestation and at term. Teratog Carcinog Mutagen 1996;16:97–108.
  • SonodaT, OhdoS, OhbaK, OkishimaT, KayakawaK. Sodium valproate- induced cardiovascular abnormalities in the Jc1: ICR mouse fetus: peak sensitivity of gestational age and dose dependent effect. Teratology 1993;48:127–132.
  • SodhiP, PoddarP, ParmarV. Fetal cardiac malformation in fetal valproate syndrome. Indian J Pediatr 2001;68:989–990.
  • ten BergK, van OppenAC, NikkelsPG, Gittenberger-de GrootAC, van der VoetGB, BrilstraEH, LindhoutD. Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure. Prenat Diagn 2005;25:156–158.
  • VerloesA, FrikicheA, GremilletC, PaquayT, DecortisT, RigoJ, SenterreJ. Proximal phocomelia and radial ray aplasia in fetal valproic syndrome. Eur J Pediatr 1990;149:266–267.
  • MooreSJ, TurnperryPD, QuinnA, GloverS, LloydDJ, MontgomeryT, DeanJC. A clinical study of 57 children with fetal anticonvulsant syndromes. J Med Genet 2000;37:489–497.
  • LajeunieE, Le MerrerM, MarchacD, RenierD. Syndromal and nonsyndromal primary trigonocephaly: analysis of a series of 237 patients. Am J Med Genet 1998;75:211–215.
  • KucieneR, DulskieneV. Selected enviromental risk factors and congenital heart defects. Medicina (Kaunos) 2008;44:827–832.
  • HainsDS, BatesCM, IngrahamS, SchwadererAL. Management and etiology of the unilateral multicystic dysplastic kidney: a review. Pediatr Nephrol 2009;24:233–241.

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