Asymmetric dimethylarginine in normotensive pregnant women with isolated fetal intrauterine growth restriction: a comparison with preeclamptic women with and without intrauterine growth restriction

References

• Mandruzzato G, Antsaklis A, Botet F, Chervenak FA, Figueras F, Grunebaum A, Puerto B, Skupski D, Stanojevic M. Intrauterine restriction (IUGR). J Perinat Med 2008;36:277–281.
   PubMed Web of Science ®Google Scholar
• Froen JF, Gardosi JO, Thurmann A, Francis A, Stray-Pedersen B. Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand 2004;83:801–807.
   PubMed Web of Science ®Google Scholar
• Richardus JH, Graafmans WC, Verloove-Vanhorick SP, Mackenbach JP. Differences in perinatal mortality and suboptimal care between 10 European regions: results of an international audit. Br J Obstet Gynaecol 2003;110:97–105.
   Google Scholar
• Maynard SE, Min JJ, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003;111:649–658.
   PubMed Web of Science ®Google Scholar
• Maršál K. Intrauterine growth restriction. Curr Opin Obstet Gynecol 2002;14:127–135.
   PubMed Web of Science ®Google Scholar
• Robinson JS, Owens JA. Pathophysiology of intrauterine growth failure. In: Gluckman PD, Heymann MA, editors. Pediatrics and perinatology: the scientific basis. London: Arnold; 1996. pp 290–297.
   Google Scholar
• Bretelle F, Sabatier F, Blann A, D'Ercole, Boutiere B, Mutin M, Boubli L, Sampol J, Dignat-George F. Maternal endothelial soluble cell adhesion molecules with isolated small for gestational age fetuses; comparison with preeclampsia. Br J Obstet Gynaecol 2001;108:1277–1282.
   Google Scholar
• Buhimschi IA, Saade GR, Chwalisz K, Garfield RE. The nitric oxide pathway in pre-eclampsia: pathophysiological implications. Hum Reprod Update 1998;4:25–42.
   PubMed Web of Science ®Google Scholar
• Tsukahara H., Ohta N, Tokuriki S, Nishijima K, Kotsuji F, Kawakami H, Ohta N, Sekine K, Nagasaka H, Mayumi M. Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood. Metabol Clin Exp 2007;57:215–220.
   Google Scholar
• Kobayashi T, Tokunaga N, Isoda H, Kanayama N, Tearo T. Vasospams are characteristic in cases with eclampsia/preeclampsia and HELLP syndrome proposal an angiospastic syndrome of pregnancy. Semin Thromb Hemost 2001;27:131–135.
   PubMed Web of Science ®Google Scholar
• Nijveldt RJ, Teerlink T, Van Leeuwen PAM. The asymmetrical dimethylarginine (ADMA) – multiple organ failure hypothesis. Clin Nutr 2003;22:99–104.
   PubMed Web of Science ®Google Scholar
• Böger RH, Bode-Böger SM, Frölich JC. The l-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications. Atherosclerosis 1996, 127:1–11.
   PubMed Web of Science ®Google Scholar
• Wipff J, Avouac J, Borderie D, Zerkak D, Lemarechal H, Kahan A, Boileau C, Allanore Y. Disturbed angiogenesis in systemic sclerosis: high levels off soluble endoglin. Rheumatology 2008;47:972–975.
   PubMed Web of Science ®Google Scholar
• Andersen GN, Caidahl K, Kazzam E, petersson AS, Waldenström A, Mincheva-Nilsson L, Rantapää-Dahlqvist S. Correlation between increased nitric oxide productionand markers of endothelial activation in systemicsclerosis: findings with the soluble adhesion moleculesE-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1. Arthritis Rheum 2000;43:1085–1093.
   PubMed Web of Science ®Google Scholar
• Mao D, Che J, Li K, Han S, Yue Q, Zhu L, Zhang W, Li L. Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia. Arch Gynecol Obstet, 2010;282:371–375.
   PubMed Web of Science ®Google Scholar
• Siroen MP, Teerlink T, Nijveldt RJ, Prins HA, Richir MC, van Leeuwen PA. The clinical significance of asymmetric dimethylarginine. Annu Rev Nutr 2006;26:203–228.
   PubMed Web of Science ®Google Scholar
• Nijveldt RJ, Teerlin T, Siroen MPC, van Lambalgen AA, Rauwerda JA, van Leeuwen PAM. The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA). Clin Nutr 2003;22:17–22.
   PubMed Web of Science ®Google Scholar
• Savidou MD, Hingorani AD, Tsikas D, Frölich JC, Vallance P, Nicolaides KH. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop preeclampsia. Lancet 2003;361:1511–1517.
   PubMedGoogle Scholar
• Holden DP, Fickling SA, Whitley GS, Nussey SS. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol 1998;178:551–556.
   PubMed Web of Science ®Google Scholar
• Böger RH, Bode-Böger SM, Szuba A, Tangphao O, Tsao PS, Chan JR, Blaschke TF, Cooke JP. Asymmetric dimethylarginine: a novel risk factor for endothelial dysfunction. Its role in hypercholesterolemia. Circulation 1998;98:1842–1847.
   PubMed Web of Science ®Google Scholar
• Speer PD, Powers RW, Frank MP, Harger G, Markovic N, Roberts JM. Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, bt not pregnancies with small-for-gestational-age infants. Am J Obstet Gynecol 2008;198:112e1–112e7.
   Google Scholar
• Siroen MPC, Teerlink T, Bolte AC, van Elburg RM, Richir MC, Nijveldt RJ, van der Hoven B, van Leeuwen PAM. No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia. Gynecol Obstet Invest 2006;62:7–13.
   PubMed Web of Science ®Google Scholar
• Harbrecht BG, Billiar TR, Stadler J, Demetris AJ, Ochoa JB, Curran RD, Simmons RL. Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia. Crit Care Med 1992;20:1568–1574.
   PubMed Web of Science ®Google Scholar
• Cayatte AJ, Palacino JJ, Horten K, Cohen RA. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 1994;14:753–759.
   PubMedGoogle Scholar
• Mac Allister RJ, Parry H, Kimoto M, Ogawa T, Russell R, Hodson H, Whitley GSJ, vallance P. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br Pharmacol 1996;119:1533–1540.
   PubMedGoogle Scholar
• Kielstein JT, Impraim B, Simmel S, Bode-Böger SM, Tsikas D, Frolich JC, Hoeper MM, Haller H, Fliser D. Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans. Circulation 2004;109:172–177.
   PubMed Web of Science ®Google Scholar
• Braekke K, Ueland PM, Harsem NK, Staff AC. Asymmetric dimethylarginine (ADMA) in the maternal and fetal circulation in preeclampsia. Pediatr Res, 2009;66:411–415.
   PubMed Web of Science ®Google Scholar
• Roberts JM and Redman CW. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet 1993;341:1447–1451.
   PubMedGoogle Scholar
• Pettersson A, Hedner T, Milsom I. Increased circulating concentrations of asymmetric dimethylarginine (ADMA) an endogenous inhibitor of nitric oxide synthesis, in preeclampsia. Acta Obstet Gynecol Scand 1998;77:808–813.
   PubMed Web of Science ®Google Scholar
• Ellis J, Wennerholm UB, Bengtsson A, Lilja H, Pettersson A, Sultan B, Wennergren M, Hagberg H. Levels of dimethylarginine and cytokines in mild and severe preeclampsia. Acta Obstet Gynecol Scand 2001;80:602–608.
   PubMed Web of Science ®Google Scholar