178
Views
6
CrossRef citations to date
0
Altmetric
Original Article

The effects of magnesium sulfate on maternal and fetal platelet aggregation

, , &
Pages 478-483 | Received 24 Nov 2010, Accepted 22 Apr 2011, Published online: 15 Jul 2011

References

  • Lucas MJ, Leveno KJ, Cunningham FG. A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med 1995;333:201–205.
  • Gordon MC, Iams JD. Magnesium sulfate. Clin Obstet Gynecol 1995;38:706–712.
  • Hall DG, McGaughey HS Jr, Corey EL, Thornton WN Jr. The effects of magnesium therapy on the duration of labor. Am J Obstet Gynecol 1959;78:27–32.
  • Kynczl-Leisure M, Cibils LA. Increased bleeding time after magnesium sulfate infusion. Am J Obstet Gynecol 1996;175:1293–1294.
  • Assaley J, Baron JM, Cibils LA. Effects of magnesium sulfate infusion upon clotting parameters in patients with pre-eclampsia. J Perinat Med 1998;26:115–119.
  • Rouse DJ, Leindecker S, Landon M, Bloom SL, Varner MW, Moawad AH, Spong CY, et al. The MFMU Cesarean Registry: uterine atony after primary cesarean delivery. Am J Obstet Gynecol 2005;193:1056–1060.
  • Rouse DJ, MacPherson C, Landon M, Varner MW, Leveno KJ, Moawad AH, Spong CY, et al. Blood transfusion and cesarean delivery. Obstet Gynecol 2006;108:891–897.
  • Crowther CA, Hiller JE, Doyle LW, Haslam RR. Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trial. JAMA 2003;290:2669–2676.
  • Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer BM, Iams JD, et al. A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med 2008;359:895–905.
  • Conde-Agudelo A, Romero R. Antenatal magnesium sulfate for the prevention of cerebral palsy in preterm infants less than 34 weeks’ gestation: a systematic review and metaanalysis. Am J Obstet Gynecol 2009;200:595–609.
  • Reynolds JD, Chestnut DH, Dexter F, McGrath J, Penning DH. Magnesium sulfate adversely affects fetal lamb survival and blocks fetal cerebral blood flow response during maternal hemorrhage. Anesth Analg 1996;83:493–499.
  • Mittendorf R, Dambrosia J, Dammann O, Pryde PG, Lee KS, Ben-Ami TE, Yousefzadeh D. Association between maternal serum ionized magnesium levels at delivery and neonatal intraventricular hemorrhage. J Pediatr 2002;140:540–546.
  • Scudiero R, Khoshnood B, Pryde PG, Lee KS, Wall S, Mittendorf R. Perinatal death and tocolytic magnesium sulfate. Obstet Gynecol 2000;96:178–182.
  • Golanski J, Pietrucha T, Baj Z, Greger J, Watala C. A novel approach to inhibit the anticoagulant-induced spontaneous activation of blood platelets—effect of magnesium on platelet release reaction in whole blood. Thromb Res 1997;85:127–132.
  • Hsiao G, Shen MY, Chou DS, Lin CH, Chen TF, Sheu JR. Involvement of the antiplatelet activity of magnesium sulfate in suppression of protein kinase C and the Na+/H+ exchanger. J Biomed Sci 2004;11:19–26.
  • Ravn HB, Kristensen SD, Vissinger H, Husted SE. Magnesium inhibits human platelets. Blood Coagul Fibrinolysis 1996;7:241–244.
  • Cantón R, Manzanares J, Alvarez E, Zaragozá F. In vitro and in vivo antiaggregant effects of magnesium halogenates. Thromb Haemost 1987;58:957–959.
  • Hardy E, Glenn J, Heptinstall S, Rubin PC, Horn EH. Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. Thromb Haemost 1995;74:1132–1137.
  • Adams JH, Mitchell JR. The effect of agents which modify platelet behaviour and of magnesium ions on thrombus formation in vivo. Thromb Haemost 1979;42:603–610.
  • Lenz T, Haller H, Lüdersdorf M, Thiede HM, Kribben A, Jendroska K, Distler A, Philipp T. Effects of acute hypermagnesaemia on intracellular calcium concentration and adrenergic activity. Clin Sci 1987;72:131–134.
  • Gries A, Bode C, Gross S, Peter K, Böhrer H, Martin E. The effect of intravenously administered magnesium on platelet function in patients after cardiac surgery. Anesth Analg 1999;88:1213–1219.
  • Shechter M, Merz CN, Paul-Labrador M, Meisel SR, Rude RK, Molloy MD, Dwyer JH, et al. Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease. Am J Cardiol 1999;84:152–156.
  • Leaphart WL, Meyer MC, Capeless EL, Tracy PB. Adenosine diphosphate-induced platelet activation inhibited by magnesium in a dose-dependent manner. Obstet Gynecol 1998;91:421–425.
  • Fuentes A, Rojas A, Porter KB, Saviello G, O’Brien WF. The effect of magnesium sulfate on bleeding time in pregnancy. Am J Obstet Gynecol 1995;173:1246–1249.
  • Watson KV, Moldow CF, Ogburn PL, Jacob HS. Magnesium sulfate: rationale for its use in preeclampsia. Proc Natl Acad Sci USA 1986;83:1075–1078.
  • Sheu JR, Hsiao G, Shen MY, Fong TH, Chen YW, Lin CH, Chou DS. Mechanisms involved in the antiplatelet activity of magnesium in human platelets. Br J Haematol 2002;119:1033–1041.
  • Lox CD, Dorsett MM, Hampton RM. Observations on clotting activity during pre-eclampsia. Clin Exp Hypertens B 1983;2:179–190.
  • Pryde PG, Borg MJ, Mittendorf R, Elin RJ. Cord-blood ionized magnesium levels exceed maternal levels in both untreated and tocolytic magnesium sulfate treated preterm infants. (Abstract). Am J Obstet Gynecol 1999;180:S106.
  • Janes SL, Kyle PM, Redman C, Goodall AH. Flow cytometric detection of activated platelets in pregnant women prior to the development of pre-eclampsia. Thromb Haemost 1995;74:1059–1063.
  • Niida K, Ejiri K, Suga K, Kudo T, Yamamura H. Effect of intracellular free calcium mobilization on aggregation of umbilical cord blood platelets. Acta Med Okayama 1996;50:47–52.
  • Kelton JG, Hunter DJ, Neame PB. A platelet function defect in preeclampsia. Obstet Gynecol 1985;65:107–109.
  • Hutt R, Ogunniyi SO, Sullivan MH, Elder MG. Increased platelet volume and aggregation precede the onset of preeclampsia. Obstet Gynecol 1994;83:146–149.
  • Douglas JT, Shah M, Lowe GD, Belch JJ, Forbes CD, Prentice CR. Plasma fibrinopeptide A and beta-thromboglobulin in pre-eclampsia and pregnancy hypertension. Thromb Haemost 1982;47:54–55.
  • Konijnenberg A, Stokkers EW, van der Post JA, Schaap MC, Boer K, Bleker OP, Sturk A. Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules. Am J Obstet Gynecol 1997;176:461–469.
  • Konijnenberg A, van der Post JA, Mol BW, Schaap MC, Lazarov R, Bleker OP, Boer K, Sturk A. Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of preeclampsia? A prospective study. Am J Obstet Gynecol 1997;177:434–442.
  • Jennings L, McCabe White M. Platelet aggregation. In: Michelson A, editor. Platelets. 2nd ed. Burlington, MA: Academic Press; 2007. pp. 495–507.
  • Spisso KR, Harbert GM Jr, Thiagarajah S. The use of magnesium sulfate as the primary tocolytic agent to prevent premature delivery. Am J Obstet Gynecol 1982;142:840–845.
  • Macones GA, Sehdev HM, Berlin M, Morgan MA, Berlin JA. Evidence for magnesium sulfate as a tocolytic agent. Obstet Gynecol Surv 1997;52:652–658.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.