Metabolomics in paediatric oncology: a potential still to be exploited

References

• Steliarova-Foucher E, Coebergh JW, Kaatsch P, et al. (Eds.). Cancer in children and adolescents in Europe. Eur J Cancer 2006;42:1913–2190
   Web of Science ®Google Scholar
• Gu H-W, Qi Y-P, Xu N, et al. Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics for cancer diagnosis. Chin J Anal Chem 2012;40:1933–7
   Web of Science ®Google Scholar
• Casado-Vela J, Cebrián A, Gomez del Pulgar M, Lacal J. Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics. Clin Transl Oncol 2011;13:617–28
   PubMed Web of Science ®Google Scholar
• Fanos V, Barberini L, Antonucci R, Atzori L. Metabolomics in neonatology and pediatrics. Clin Biochem 2011;44:452–4
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature 2008;455:1054–6
   PubMed Web of Science ®Google Scholar
• Lindon JC, Nicholson JK, Everett JR. 1999. NMR spectroscopy of biofluids. Annual Reports on NMR Spectroscopy. Vol. 38. San Diego: Academic Press Inc. pp. 1–88
   Google Scholar
• Lindon JC, Holmes E, Nicholson JK. Metabonomics: systems biology in pharmaceutical research and development. Curr Opin Mol Ther 2004;6:265–72
   PubMed Web of Science ®Google Scholar
• Griffin JL. Understanding mouse models of disease through metabolomics. Curr Opin Chem Biol 2006;10:309–15
   PubMed Web of Science ®Google Scholar
• Robertson DG, Watkins PB, Reily MD. Metabolomics in toxicology: preclinical and clinical applications. Toxicol Sci 2011;120:S146–70
   PubMed Web of Science ®Google Scholar
• Claudino WM, Quattrone A, Biganzoli L, et al. Metabolomics: available results, current research projects in breast cancer, and future applications. J Clin Oncol 2007;25:2840–6
   PubMed Web of Science ®Google Scholar
• Fossel ET, Carr JM, McDonagh J. Detection of malignant tumors. Water-suppressed proton nuclear magnetic resonance spectroscopy of plasma. N Engl J Med 1986;315:1369–76
   PubMed Web of Science ®Google Scholar
• Odunsi K, Wollman RM, Ambrosone CB, et al. Detection of epithelial ovarian cancer using 1HNMR- based metabonomics. Int J Cancer 2005;113:782–8
   PubMed Web of Science ®Google Scholar
• Dunn WB, Bailey NJ, Johnson HE. Measuring the metabolome: current analytical technologies. Analyst 2005;130:606–25
   PubMed Web of Science ®Google Scholar
• Griffin JL, Shockcor JP. Metabolic profiles of cancer cells. Nat Rev Cancer 2004;4:551–61
   PubMed Web of Science ®Google Scholar
• Spratlin JL, Serkova NJ, Eckhardt SG. Clinical applications of metabolomics in oncology: a review. Clin Cancer Res 2009;15: 431–40
   PubMed Web of Science ®Google Scholar
• Wu H, Xue R, Tang Z, et al. Metabolomic investigation of gastric cancer tissue using gas chromatography/mass spectrometry. Anal Bioanal Chem 2010;396:1385–95
   PubMed Web of Science ®Google Scholar
• Ouyang D, Xu J, Huang H, Chen Z. Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis. Appl Biochem Biotechnol 2011;165:148–54
   PubMed Web of Science ®Google Scholar
• Slupsky CM, Steed H, Wells TH, et al. Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers. Clin Cancer Res 2010;16:5835–41
   PubMed Web of Science ®Google Scholar
• Lin L, Huang Z, Gao Y, et al. LC–MS based serum analysis for renal cell carcinoma diagnosis, staging, and biomarker discovery. J Proteome Res 2011;10:1396–405
   PubMed Web of Science ®Google Scholar
• Putluri N, Shojaie A, Vasu VT, et al. Metabolomic profiling reveals potential markers and bioprocessors altered in bladder cancer progression. Cancer Res 2011;71:7376–86
   PubMed Web of Science ®Google Scholar
• Cavill R, Kamburov A, Ellis JK, et al. Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells. PLoS Comput Biol 2011;7:pe1001113
   Web of Science ®Google Scholar
• Erb G, Elbayed K, Piotto M, et al. Toward improved grading of malignancy in oligodendrogliomas using metabolomics. Magn Reson Med 2008;59:959–65
   PubMed Web of Science ®Google Scholar
• Al-Saffar NM, Jackson LE, Raynaud FI, et al. The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy. Cancer Res 2010;70:5507–17
   PubMed Web of Science ®Google Scholar
• Beloueche-Babari M, Jackson LE, Al-Saffar NM, et al. Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition. Cancer Res 2005;65:3356–63
   PubMed Web of Science ®Google Scholar
• Parsons SK, Skapek SX, Neufeld EJ, et al. Asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia. Blood 1997;89: 1886–95
   PubMed Web of Science ®Google Scholar
• Cuellar-Baena S, Morales JM, Martinetto H, et al. Comparative metabolic profiling of paediatric ependymoma, medulloblastoma and pilocytic astrocytoma. Int J Mol Med 2010;26: 941–8
   PubMed Web of Science ®Google Scholar
• Imperiale A, Elbayed K, Moussallieh FM. Metabolomic pattern of childhood neuroblastoma obtained by 1H-high-resolution magic angle spinning (HRMAS) NMR spectroscopy. Pediatr Blood Cancer 2011;56:24–34
   PubMed Web of Science ®Google Scholar
• Baykal AT, Jain MR, Li H. Aberrant regulation of choline metabolism by mitochondrial electron transport system inhibition in neuroblastoma cells. Metabolomics 2008;4: 347–56
   PubMed Web of Science ®Google Scholar
• Hecht SS, Ye M, Carmella SG, et al. Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children. Cancer Epidemiol Biomarkers Prev 2001;10:1109–16
   PubMed Web of Science ®Google Scholar
• Stepanov I, Hecht SS, Duca G, et al. Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan. Children Cancer Epidemiol Biomarkers Prev 2006;15:7–11
   PubMed Web of Science ®Google Scholar