Role of protein kinase A signaling pathway in cyclosporine nephrotoxicity

References

• Abdel-latif RG, Morsy MA, El-Moselhy MA, Khalifa MA. (2013). Sildenafil protects against nitric oxide deficiency-related nephrotoxicity in cyclosporine A treated rats. Eur J Pharmacol 705:126–34
   PubMed Web of Science ®Google Scholar
• Amore A, Emancipator SN, Cirina P. (2000). Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells. Kidney Int 57:1549–59
   PubMed Web of Science ®Google Scholar
• Aubry JP, Blaecke A, Lecoanet-Henchoz S, et al. (1999). Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity. Cytometry 37:197–204
   PubMedGoogle Scholar
• Austin HA, Illei GG, Braun MJ, Balow JE. (2009). Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy. J Am Soc Nephrol 20:901–11
   PubMed Web of Science ®Google Scholar
• Behr J, Zimmermann G, Baumgartner R, et al. (2009). Lung deposition of a liposomal cyclosporine A inhalation solution in patients after lung transplantation. J Aerosol Med Pulm Drug Deliv 22:121–30
   PubMed Web of Science ®Google Scholar
• Bichet DG. (2006). Lithium, cyclic AMP signaling, A-kinase anchoring proteins, and aquaporin-2. J Am Soc Nephrol 17:920–2
   PubMedGoogle Scholar
• Bobadilla NA, Gamba G, Tapia E, et al. (1998). Role of NO in cyclosporin nephrotoxicity: effects of chronic NO inhibition and NO synthases gene expression. Am J Physiol 274:791–8
   Google Scholar
• Bracken N, Elkadri M, Hart G, Hussain M. (2006). The role of constitutive PKA-mediated phosphorylation in the regulation of basal I(Ca) in isolated rat cardiac myocytes. Br J Pharmacol 148:1108–15
   PubMedGoogle Scholar
• Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann Biochem 7:248–54
   Google Scholar
• Burgos PV, Klattenhoff C, Fuente E, et al. (2004). Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells. PNAS 101:3845–50
   PubMed Web of Science ®Google Scholar
• Chai LY, Netea MG, Tai BC, et al. (2013). An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity. J Antimicrob Chemother 68:1655–9
   PubMed Web of Science ®Google Scholar
• Chander V, Chopra K. (2005). Role of nitric oxide in resveratrol-induced renal protective effects of ischemic preconditioning. J Vasc Surg 42:1198–205
   PubMed Web of Science ®Google Scholar
• Chander V, Tirkey N, Chopra K. (2005). Resveratrol, a polyphenolic phytoalexin protects against cyclosporine-induced nephrotoxicity through nitric oxide dependent mechanism. Toxicology 210:55–64
   PubMed Web of Science ®Google Scholar
• Chaves MM, Costa DC, Oliveira BF, et al. (2009). Role PKA and p38 MAPK on ROS production in neutrophil age-related: lack of IL-10 effect in older subjects. Mech Ageing Dev 130:588–91
   PubMed Web of Science ®Google Scholar
• Colasanti M, Suzuki H. (2000). The dual personality of NO. Trends Pharmacol Sci 21:249–52
   PubMed Web of Science ®Google Scholar
• Donnahoo KK, Meldrum DR, Shenkar R, et al. (2000). Early renal ischemia, with or without reperfusion, activates NFKappa B and increases TNF-alpha bioactivity in the kidney. J Urol 163:1328–32
   PubMed Web of Science ®Google Scholar
• Du C, Jiang J, Guan Q, et al. (2007). NOs2 (iNOS) deficiency in kidney donor accelerates allograft loss in a murine model. Am J Transplant 7:17–26
   PubMedGoogle Scholar
• El Mouedden M, Laurent G, Mingeot-leclercq MP, Tulkens PM. (2000). Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts. Toxicol Sci 56:229–39
   PubMed Web of Science ®Google Scholar
• Fotakis G, Timbrell JA. (2006). In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 160:171–7
   PubMed Web of Science ®Google Scholar
• Franklin RA, McCubrey JA. (2000). Kinases: positive and negative regulators of apoptosis. Leukemia 14:2019–34
   PubMed Web of Science ®Google Scholar
• Gabr MM, Hussein AM, Sherif IO, et al. (2011). Renal ischemia/reperfusion injury in type II DM: possible role of proinflammatory cytokines, apoptosis, and nitric oxide. J Physiol Pathophysiol 2:6–17
   Google Scholar
• Genestra M, Echevarria A, Cysne-Finkelstein L, Leon LL. (2001). Protein kinase A of Leishmania amazonensis as a potential target for methoxy-amidine. Arzneimittelforschung 51:920–3
   PubMed Web of Science ®Google Scholar
• Gerits N, Kostenko S, Shiryaev A, et al. (2008). Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostility. Cell Signal 20:1592–607
   Google Scholar
• Grandjean-Laquerriere A, Le Naour R, Gangloff SC, Guenounou M. (2003). Differential regulation of TNF-alpha, IL-6 and IL-10 in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway. Cytokine 7:138–49
   Google Scholar
• Green LC, Wagner DA, Glogowski J, et al. (1982). Analysis of nitrate, nitrite and {15N}nitrate in biological fluids. Anal Biochem 126:131–8
   PubMed Web of Science ®Google Scholar
• Han SY, Chang EJ, Choi HJ, et al. (2006). Apoptosis by cyclosporine in mesangial cells. Transplant Proc 38:2244–6
   PubMedGoogle Scholar
• Harada H, Becknell B, Wilm M, et al. (1999). Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell 3:413–22
   PubMed Web of Science ®Google Scholar
• Hashimoto K, Minagawa H, Yanagi Y. (2003). Caspase-dependent apoptosis in fulminant hepatic failure induced by herpes simplex virus in mice. J Hepatol 39:773–8
   PubMedGoogle Scholar
• Hauser IA, Koziolek M, Hopfer U, Thevenod, F. (1998). Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells. Kidney Int 54:1139–49
   PubMed Web of Science ®Google Scholar
• Hauser IA, Schaeffeler E, Gauer S, et al. (2005). ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation. J Am Soc Nephrol 16:1501–11
   PubMed Web of Science ®Google Scholar
• Hegarty JN, Watson RWG, Young LS, et al. (2002). Cytoprotective effects of nitrates in a cellular model of hydronephrosis. Kidney Int 62:70–7
   PubMedGoogle Scholar
• Hogan WJ, Storb R. (2004). Use of cyclosporine in hematopoietic cell transplantation. Transplant Proc 36:367–71S
   PubMedGoogle Scholar
• Jeon SH, Piao YJ, Choi KJ, et al. (2005). Prednisolone suppresses cyclosporine A induced apoptosis but not cell cycle arrest in MDCK cells. Arch Biochem Biophys 435:382–92
   PubMed Web of Science ®Google Scholar
• Jiang T, Acosta D. (1993). An in vitro model of cyclosporine-induced nephrotoxicity. Fundam Appl Toxicol 20:486–95
   PubMedGoogle Scholar
• Jung SH, Lim DH, Jung SH, et al. (2009). Amphotericin B entrapping lipid nanoparticles and their in vitro and in vivo characteristics. Eur J Pharm Sci 37:313–20
   PubMed Web of Science ®Google Scholar
• Justo P, Lorz C, Sanz A, et al. (2003). Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis. J Am Soc Nephrol 14:3072–80
   PubMed Web of Science ®Google Scholar
• Kopperud R, Krakstad C, Selheim F, Doskeland SO. (2003). cAMP effector mechanisms. Novel twists for an ‘old’ signaling system. FEBS 546:121–6
   Google Scholar
• Kohda Y, Gemba M. (2001). Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices. Jpn J Pharmacol 85:54–9
   PubMedGoogle Scholar
• Komeima K, Hayashi Y, Naito Y, Watanabe Y. (2000). Inhibition of neuronal nitric-oxide synthase by calcium/calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. J Biol Chem 275:28139–43
   PubMed Web of Science ®Google Scholar
• Kovarik JM, Hoyer PF, Ettenger R, et al. (2003). Cyclosporine absorption profiles in pediatric kidney and liver transplant patients. Pediatr Nephrol 18:1275–9
   PubMedGoogle Scholar
• Kukreja RC, Salloum F, Das A, et al. (2005). Pharmacological preconditioning with sildenafil: basic mechanisms and clinical implications. Vascul Pharmacol 42:219–32
   PubMed Web of Science ®Google Scholar
• Lincopan N, Mamizuka EM, Carmona-ribeiro AM. (2005). Low nephrotoxicity of an effective amphotericin B formulation with cationic bilayer fragments. Antimicrob Agents Chemother 55:727–34
   Google Scholar
• Martinez-Mier G, Toledo-Pereyra LH, Bussell S, et al. (2000). Nitric oxide diminishes apoptosis and p53 gene expression after renal ischemia and reperfusion injury. Transplantation 70:1431–7
   PubMed Web of Science ®Google Scholar
• Mariappan N, Soorappan RN, Haque M, et al. (2007). TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol. Am J Physiol Heart Circ Physiol 293:2726–37
   PubMed Web of Science ®Google Scholar
• Meyrier AY. (2009). Treatment of focal segmental glomerulosclerosis with immunophilin modulation: when did we stop thinking about pathogenesis? Kidney Int 76:487–91
   PubMed Web of Science ®Google Scholar
• Mosmann T. (1983). Rapid colorimetric assay for cellular growth and survival. Application to proliferation and cytotoxicity assays. J Immunol Methods 6:55–63
   Web of Science ®Google Scholar
• Myklebust JH, Josefsen D, Blomhoff HK, et al. (1999). Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression. J Cell Physiol 180:71–80
   PubMedGoogle Scholar
• Naesens M, Kuypers DRS, Sarwal M. (2009). Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol 4:481–508
   PubMed Web of Science ®Google Scholar
• Nascimento CR, Braga F, Capella LS, et al. (2005). Comparative study on the effects of cyclosporin an in renal cells in culture. Nephron Exp Nephrol 9:77–86
   Google Scholar
• Nicoletti I, Migliorati G, Pagliacci MC, et al. (1991). A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271–9
   PubMed Web of Science ®Google Scholar
• Peyrou M, Hanna PE, Cribb AE. (2005). Cisplatin, gentamicin, and p-aminophenol induce markers of phospholipases on fungizone®-induced cytotoxicity within human kidney proximal tubular (HK-2) cells and Aspergillus fumigates. Int J Pharm 298:211–18
   PubMedGoogle Scholar
• Pfaller W, Gstraunthaler G. (1998). Nephrotoxicity testing in vitro – what we know and what we need to know. Environ Health Persp 106:559–69
   PubMed Web of Science ®Google Scholar
• Price PM, Safirstein RL, Megyesi J. (2004). Protection of renal cells from cisplatin toxicity by cell cycle inhibitors. Am J Physiol Renal 286:378–84
   PubMed Web of Science ®Google Scholar
• Ramseyer VD, Garvin JL. (2013). Tumor necrosis factor-α: regulation of renal function and blood pressure. Am J Physiol Renal Physiol 304:1231–42
   PubMed Web of Science ®Google Scholar
• Rao M, Wong C, Kanetsky P, et al. (2007). Cytokine gene polymorphism and progression of renal and cardiovascular diseases. Kidney Int 72:549–56
   PubMed Web of Science ®Google Scholar
• Romero JC, Laheja V, Salom MG, Biondi ML. (1992). Role of the endothelium-dependent relaxing factor nitric oxide on renal function. J Am Soc Nephrol 2:1371–87
   PubMed Web of Science ®Google Scholar
• Rodriguez-enriquez S, He L, Lemasters JJ. (2004). Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol 36:2463–72
   PubMedGoogle Scholar
• Sambrook J, Fritschi EF, Maniatis T. (1989). Molecular cloning: a laboratory manual. New York: Cold Spring Harbor Laboratory Press
   Google Scholar
• Sánchez-Pozos K, Lee-Montiel F, Pérez-Villalva R, et al. (2010). A polymerized type I collagen reduces chronic cyclosporine nephrotoxicity. Nephrol Dial Transpl 25:2150–8
   PubMed Web of Science ®Google Scholar
• Schrem H, Luck R, Becker T, et al. (2004). Update on liver transplantation using cyclosporine. Transplant Proc 36:2525–31
   PubMedGoogle Scholar
• Servais H, Van der Smissen P, Thirion G, et al. (2006). Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria. Toxicol Appl Pharm 206:321–33
   Google Scholar
• Shihab FS, Yi H, Bennett WM, Andoh TF. (2000). Effect of nitric oxide modulation on TGF-beta1 and matrix proteins in chronic cyclosporine nephrotoxicity. Kidney Int 58:1174–85
   PubMed Web of Science ®Google Scholar
• Shin HJ, Lee CH, Park SJ, et al. (2010). Establishment and characterization of Mardin-Darby canine kidney cells stably expressing human organic anion transporters. Arch Pharm Res 33:709–16
   PubMed Web of Science ®Google Scholar
• Stroes ES, Lüscher TF, de Groot FG, et al. (1997). Cyclosporin A increases nitric oxide activity in vivo. Hypertension 29:570–5
   PubMedGoogle Scholar
• Tarze A, Deniaud A, Le Bras M, et al. (2007). GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization. Oncogene 26:2606–20
   PubMed Web of Science ®Google Scholar
• Vianna HR, Soares CMBM, Tavares MS, et al. (2011). Inflamação na doença renal crônica: papel de citocinas. J Bras Nefrol 33:351–64
   PubMedGoogle Scholar
• Walker RJ, Endre ZH. (2008). Cellular mechanisms of drug nephrotoxicity. Kidney 87:2507–35
   Google Scholar
• Wang P, Zhu F, Konstantopoulos K. (2011). Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-D12,14-PGJ2. PLoS One 6:11
   Google Scholar
• Wilmes A, Crean D, Aydin S, et al. (2011). Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity. Toxicol In Vitro 25:613–22
   PubMed Web of Science ®Google Scholar
• Xiao Z, Shan J, Li C, et al. (2012). Mechanisms of cyclosporine-induced renal cell apoptosis: a systematic review. Am J Nephrol 37:30–40
   PubMedGoogle Scholar
• Yano T, Itohm Y, Kawamura E, et al. (2009). Amphotericin B-induced renal tubular cell injury is mediated by Na+ influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2 concentration. Antimicrob Agents Chemother 53:1420–6
   PubMed Web of Science ®Google Scholar
• Yoon HE, Yang CW. (2009). Established and newly proposed mechanisms of chronic cyclosporine nephropathy. Korean J Intern Med 24:81–92
   PubMedGoogle Scholar
• Yuan ZX, Li JJ, Zhu D, et al. (2011). Enhanced accumulation of low-molecular-weight chitosan in kidneys: a study on the influence of N-acetylation of chitosan on the renal targeting. J Drug Target 19(7):540–51
   PubMed Web of Science ®Google Scholar
• Zhu S, Wang Y, Chen M, et al. (2012). Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo. Am J Chin Med 40:551–66
   PubMedGoogle Scholar